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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:VNG_0243C
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525381 – 434Probable tRNA pseudouridine synthase DAdd BLAST434

Proteomic databases

PaxDbiQ9HSG5

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG0243Cm

Structurei

3D structure databases

ProteinModelPortaliQ9HSG5
SMRiQ9HSG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 396TRUDUniRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
InParanoidiQ9HSG5
KOiK06176
OrthoDBiPOG093Z087N
PhylomeDBiQ9HSG5

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 2 hits
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HSG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREAHPIERA VGMAYYASDS DGTGGRLRDS PADFRVRELE AFDTQPADAP
60 70 80 90 100
TGDYPWLVVR ATLHEWDTND FARELANTVG MSRERVRWAG TKDRHAVTTQ
110 120 130 140 150
LFAVRDLDAA QVPEIRNADI EVVGRAGRGL EFGDLAGNAF EIVVRDPDAP
160 170 180 190 200
ERAAAVADEL AAFGGGTVGT PNYFGQQRFG SKRPVTHEVG LAILRDDWEA
210 220 230 240 250
AAMAYLGAPT EHEPADSQRA REYVAETRDW TGALAEFPQR LRYERTMLHE
260 270 280 290 300
LADGGSFRDA VETFPSNLQQ LFVHAAQSYV FNRIVSERMA RGLPFGEPVA
310 320 330 340 350
GDVVWFADSD ADAAVAQPDA ARQQRVTDSR VDVMARHCER GRAFVTAPLV
360 370 380 390 400
GTDTEFADGD PGEITRGVLD DLGLSRADFD LPGEFDSAGS RRAILLRPDL
410 420 430
TVSHDPLAFE FALPSGSYAT VVLREFLKPS PLAL
Length:434
Mass (Da):47,551
Last modified:May 24, 2004 - v2
Checksum:iF1A487C997916D60
GO

Sequence cautioni

The sequence AAG18841 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG18841.1 Different initiation.
PIRiE84184
RefSeqiWP_010902134.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG18841; AAG18841; VNG_0243C
GeneIDi5952439
KEGGihal:VNG_0243C
PATRICifig|64091.14.peg.175

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG18841.1 Different initiation.
PIRiE84184
RefSeqiWP_010902134.1, NC_002607.1

3D structure databases

ProteinModelPortaliQ9HSG5
SMRiQ9HSG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG0243Cm

Proteomic databases

PaxDbiQ9HSG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG18841; AAG18841; VNG_0243C
GeneIDi5952439
KEGGihal:VNG_0243C
PATRICifig|64091.14.peg.175

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
InParanoidiQ9HSG5
KOiK06176
OrthoDBiPOG093Z087N
PhylomeDBiQ9HSG5

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 2 hits
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_HALSA
AccessioniPrimary (citable) accession number: Q9HSG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 24, 2004
Last modified: October 10, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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