We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9HSF8 (GGGPS_HALSA)
Protein
Geranylgeranylglyceryl phosphate synthase
Gene
VNG_0252C
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Functioni
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
UniRule annotationCatalytic activityi
- (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphateUniRule annotationEC:2.5.1.41UniRule annotation
Cofactori
Mg2+UniRule annotation
: glycerophospholipid metabolism Pathwayi
This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 13 | Glycerol-1-phosphateUniRule annotation | 1 | |
Metal bindingi | 15 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 42 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 191 | Glycerol-1-phosphate; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- magnesium ion binding Source: UniProtKB-UniRule
- phosphoglycerol geranylgeranyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- glycerophospholipid biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00940 |
Names & Taxonomyi
Protein namesi | Recommended name: Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)Short name: GGGP synthaseUniRule annotation Short name: GGGPSUniRule annotation Alternative name(s): (S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation Phosphoglycerol geranylgeranyltransferaseUniRule annotation |
Gene namesi | Ordered Locus Names:VNG_0252C |
Organismi | Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) |
Taxonomic identifieri | 64091 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Stenosarchaea group › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000138730 | 1 – 236 | Geranylgeranylglyceryl phosphate synthaseAdd BLAST | 236 |
Proteomic databases
PaxDbi | Q9HSF8 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 161 – 166 | Glycerol-1-phosphate bindingUniRule annotation | 6 | |
Regioni | 211 – 212 | Glycerol-1-phosphate bindingUniRule annotation | 2 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_095211_0_0_2 |
InParanoidi | Q9HSF8 |
OrthoDBi | 74340at2157 |
PhylomeDBi | Q9HSF8 |
Family and domain databases
CDDi | cd02812, PcrB_like, 1 hit |
Gene3Di | 3.20.20.390, 1 hit |
HAMAPi | MF_00112, GGGP_HepGP_synthase, 1 hit |
InterProi | View protein in InterPro IPR039074, GGGP/HepGP_synthase_I IPR038597, GGGP/HepGP_synthase_sf IPR008205, GGGP_HepGP_synthase IPR026417, GGGPS_Halobacteria |
PANTHERi | PTHR40029, PTHR40029, 1 hit |
Pfami | View protein in Pfam PF01884, PcrB, 1 hit |
TIGRFAMsi | TIGR01768, GGGP-family, 1 hit TIGR04147, GGGPS_Halobact, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HSF8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAPWADWDH VLKIDPDKSL VDGETFDDIA QTGTDAIEIG GTLDVTTEKM
60 70 80 90 100
RRVIDACRTH EVPLYQEPSN PAVVVEDEAL DGYLVPVVLN AGDPFWITGA
110 120 130 140 150
HKEWVRIADL DWERTTTEAY IVMNPDASVA EYTGADCGLD ADEVGAYATV
160 170 180 190 200
AERLLGQEVV YVEYSGTLGD PAVVEAAAGG VDDAAVFYGG GIDGYDAAYR
210 220 230
MGAHADTIVV GDLVHEAGVD AVRETVSGVR DAQAEE
Sequence cautioni
The sequence AAG18849 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004437 Genomic DNA Translation: AAG18849.1 Different initiation. |
PIRi | E84185 |
RefSeqi | WP_010902143.1, NC_002607.1 |
Genome annotation databases
EnsemblBacteriai | AAG18849; AAG18849; VNG_0252C |
GeneIDi | 5953929 |
KEGGi | hal:VNG_0252C |
PATRICi | fig|64091.14.peg.184 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004437 Genomic DNA Translation: AAG18849.1 Different initiation. |
PIRi | E84185 |
RefSeqi | WP_010902143.1, NC_002607.1 |
3D structure databases
SMRi | Q9HSF8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 64091.VNG_0252C |
Proteomic databases
PaxDbi | Q9HSF8 |
Genome annotation databases
EnsemblBacteriai | AAG18849; AAG18849; VNG_0252C |
GeneIDi | 5953929 |
KEGGi | hal:VNG_0252C |
PATRICi | fig|64091.14.peg.184 |
Phylogenomic databases
HOGENOMi | CLU_095211_0_0_2 |
InParanoidi | Q9HSF8 |
OrthoDBi | 74340at2157 |
PhylomeDBi | Q9HSF8 |
Enzyme and pathway databases
UniPathwayi | UPA00940 |
Family and domain databases
CDDi | cd02812, PcrB_like, 1 hit |
Gene3Di | 3.20.20.390, 1 hit |
HAMAPi | MF_00112, GGGP_HepGP_synthase, 1 hit |
InterProi | View protein in InterPro IPR039074, GGGP/HepGP_synthase_I IPR038597, GGGP/HepGP_synthase_sf IPR008205, GGGP_HepGP_synthase IPR026417, GGGPS_Halobacteria |
PANTHERi | PTHR40029, PTHR40029, 1 hit |
Pfami | View protein in Pfam PF01884, PcrB, 1 hit |
TIGRFAMsi | TIGR01768, GGGP-family, 1 hit TIGR04147, GGGPS_Halobact, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GGGPS_HALSA | |
Accessioni | Q9HSF8Primary (citable) accession number: Q9HSF8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2003 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 23, 2022 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families