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Entry version 115 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The catalytic activity of the enzyme increases with increasing salt concentrations and has its maximum at 3 M potassium chloride.
  1. KM=1.39 µM for tRNA(Cys)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi29ZincUniRule annotation1
    Metal bindingi230ZincUniRule annotation1
    Metal bindingi255ZincUniRule annotation1
    Metal bindingi259ZincUniRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminoacyl-tRNA synthetase, Ligase
    Biological processProtein biosynthesis
    LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
    Alternative name(s):
    Cysteinyl-tRNA synthetaseUniRule annotation
    Short name:
    CysRSUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:cysSUniRule annotation
    Ordered Locus Names:VNG_1097G
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri64091 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000554 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001595351 – 494Cysteine--tRNA ligaseAdd BLAST494

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9HQL9

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9HQL9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi31 – 41'HIGH' regionAdd BLAST11
    Motifi287 – 291'KMSKS' region5

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_013528_0_1_2

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9HQL9

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    AKYWMHN

    Database of Orthologous Groups

    More...
    OrthoDBi
    20883at2157

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9HQL9

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00672, CysRS_core, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.620, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00041, Cys_tRNA_synth, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR015803, Cys-tRNA-ligase
    IPR015273, Cys-tRNA-synt_Ia_DALR
    IPR024909, Cys-tRNA/MSH_ligase
    IPR014729, Rossmann-like_a/b/a_fold
    IPR032678, tRNA-synt_1_cat_dom
    IPR009080, tRNAsynth_Ia_anticodon-bd

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10890, PTHR10890, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF09190, DALR_2, 1 hit
    PF01406, tRNA-synt_1e, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00983, TRNASYNTHCYS

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00840, DALR_2, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47323, SSF47323, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00435, cysS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9HQL9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTQYVSNTRS GEQEAFEPDD PENVLVYTCG LTVSDDAHLG HARLWVQSDV
    60 70 80 90 100
    MTRWLSHAGY GVRHVQNVTD VNEKIVARVG ADGLGDTEAA VAAHYTQSVI
    110 120 130 140 150
    DDMRALNLAR ADVYPRVSEH VPEIIDLIGD LVDAGYAYEA GGSVYFDVRR
    160 170 180 190 200
    FEEYGALSGQ QVDELDPQGP DAEQAEKRHP ADFALWKAGG VSPDDANTHR
    210 220 230 240 250
    DDELPPLDGE RGQTWASPWG EGRPGWHIEC SAMAMTHLDD HIDIHVGGQD
    260 270 280 290 300
    LVFPHHENEI AQSEAASGER FADHWLHVRL LETDGEKMSS SLGNFFTVSN
    310 320 330 340 350
    AVAERGPNVV RMLLVSTSYT QRQTYSEATV SEATQRWERL QRAHERAADA
    360 370 380 390 400
    IDSVAAHAKP ADDALRTAVA DARGEFAAAM RADFNTRAAV SALLELASAV
    410 420 430 440 450
    NRHVDGTDTY DYQGLHDAVD AFETLGGDVL GLQFDDGAGE DAVSLADDVI
    460 470 480 490
    DLVLDVREQE RTAGNYERAD DLRDRLEALG VSVEDTDDGA TVRR
    Length:494
    Mass (Da):54,035
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EBEB9461A557D87
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AE004437 Genomic DNA Translation: AAG19494.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    B84266

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_010902789.1, NC_002607.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAG19494; AAG19494; VNG_1097G

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5952831

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hal:VNG_1097G

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|64091.14.peg.840

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AE004437 Genomic DNA Translation: AAG19494.1
    PIRiB84266
    RefSeqiWP_010902789.1, NC_002607.1

    3D structure databases

    SMRiQ9HQL9
    ModBaseiSearch...

    Proteomic databases

    PaxDbiQ9HQL9

    Genome annotation databases

    EnsemblBacteriaiAAG19494; AAG19494; VNG_1097G
    GeneIDi5952831
    KEGGihal:VNG_1097G
    PATRICifig|64091.14.peg.840

    Phylogenomic databases

    HOGENOMiCLU_013528_0_1_2
    InParanoidiQ9HQL9
    OMAiAKYWMHN
    OrthoDBi20883at2157
    PhylomeDBiQ9HQL9

    Family and domain databases

    CDDicd00672, CysRS_core, 1 hit
    Gene3Di3.40.50.620, 1 hit
    HAMAPiMF_00041, Cys_tRNA_synth, 1 hit
    InterProiView protein in InterPro
    IPR015803, Cys-tRNA-ligase
    IPR015273, Cys-tRNA-synt_Ia_DALR
    IPR024909, Cys-tRNA/MSH_ligase
    IPR014729, Rossmann-like_a/b/a_fold
    IPR032678, tRNA-synt_1_cat_dom
    IPR009080, tRNAsynth_Ia_anticodon-bd
    PANTHERiPTHR10890, PTHR10890, 1 hit
    PfamiView protein in Pfam
    PF09190, DALR_2, 1 hit
    PF01406, tRNA-synt_1e, 1 hit
    PRINTSiPR00983, TRNASYNTHCYS
    SMARTiView protein in SMART
    SM00840, DALR_2, 1 hit
    SUPFAMiSSF47323, SSF47323, 1 hit
    TIGRFAMsiTIGR00435, cysS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYC_HALSA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HQL9
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: March 1, 2001
    Last modified: December 2, 2020
    This is version 115 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families
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