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Entry version 111 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation EC:3.1.11.1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Protein family/group databases

MEROPS protease database

More...
MEROPSi
N10.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase II large subunit (EC:2.7.7.7UniRule annotation)
Short name:
Pol II
Alternative name(s):
Exodeoxyribonuclease large subunitUniRule annotation (EC:3.1.11.1UniRule annotation)
Cleaved into the following chain:
Alternative name(s):
Hsp-NRC1 pol2 intein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polC
Synonyms:polA2
Ordered Locus Names:VNG_2338G
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri64091 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000554 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000073011 – 925DNA polymerase II large subunit, 1st partSequence analysisAdd BLAST925
ChainiPRO_0000007302926 – 1120Hsp-NRC1 polC inteinSequence analysisAdd BLAST195
ChainiPRO_00000073031121 – 1370DNA polymerase II large subunit, 2nd partSequence analysisAdd BLAST250

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HMX8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a large subunit and a small subunit.

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001154_0_0_2

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HMX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRRNCDG

Database of Orthologous Groups

More...
OrthoDBi
559at2157

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HMX8

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00324, DNApol_II_L_arch, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003586, Hint_dom_C
IPR003587, Hint_dom_N
IPR036844, Hint_dom_sf
IPR030934, Intein_C
IPR006141, Intein_N
IPR004475, PolC_DP2
IPR016033, PolC_DP2_N

The PANTHER Classification System

More...
PANTHERi
PTHR42210, PTHR42210, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03833, PolC_DP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00305, HintC, 1 hit
SM00306, HintN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51294, SSF51294, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01443, intein_Cterm, 1 hit
TIGR01445, intein_Nterm, 1 hit
TIGR00354, polC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50817, INTEIN_N_TER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HMX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPTDETYFE TLETGLDDAF EVAEAARERG EDPTPNVEIP VAKDMADRVE
60 70 80 90 100
NILGIDGVAE RVRDLDGEMS REEAALELVA DFVDGRVGDY DTDAGKIEGA
110 120 130 140 150
VRTAVALLTE GVVAAPIEGI DRVEVNDNDD GTQYVAVYYA GPIRSAGGTA
160 170 180 190 200
QALSVLVADY ARAMLGIDAF KPRDDEIERY AEEVDLYDSE TGLQYSPKDA
210 220 230 240 250
ETTFITEHCP VMLDGEATGN EEVDGFRDLE RIDTNSPRGG MCLVLAEGIA
260 270 280 290 300
LKAPKIQRYT RNLDEVAWPW LQDLIDGTIG ADDADEDTPD AGSDSDATDE
310 320 330 340 350
GDAPSASTDA EEPPRAAPSD KFLRDLIAGR PVFGHPSKNG GFRLRYGRAR
360 370 380 390 400
NHGNATAGVH PATMHLLDDF LATGTQIKTE RPGKAAGIVP VDSIEGPTVK
410 420 430 440 450
LANGDVRHIN DPADALDVRN GVAEILDVGE YLVNYGEFVE NNHELAPASY
460 470 480 490 500
APEWWIQDLD AAGADVQALR DSPYVDLTAP TADQAMAWAT DYDAPLHPAY
510 520 530 540 550
TYLWHDIDVE QFRALADAVA DAHTDASDDD DRGVLVLDHT TTVRETLEAL
560 570 580 590 600
LVTHHQGDDT IRVDDWLPLA RSLGVTESLD REWETLSEAA AEWPNAVRAV
610 620 630 640 650
NEVAPFSVQE RAPTRIGNRM GRPEKSESRD LSPAVHTLFP IGDAGGSQRD
660 670 680 690 700
VADAARYAPD MSDTPGEIPV RVGDRVCPSC DEHTYESRCP DCGDWTDPHY
710 720 730 740 750
ECRDCGAVAT PDESGRVECP NCGRDLDNVT TQVIDINDEY HGALRAVGER
760 770 780 790 800
ENAFDQLKGV KGLLSAEKTP EPMAKGVLRA KHDVTAFKDG TVRYDMTDLP
810 820 830 840 850
VTAVTPAELD VTAGQFRELG YNQDIHGDPL EHDDQLVELR VQDVVLSDGA
860 870 880 890 900
ADHMLKTADF VDDLLTQYYG LDAFYDLDDR DDLVGELVFG MAPHTSAAVV
910 920 930 940 950
GRVAGFTSAS VGYAHPYFHA AKRRNCFHPE TNVWFRDESG EWHHDPIETL
960 970 980 990 1000
VEARLDPDTA DEDDFGALVQ ALDGDVFVPS VTEDGEETLQ RVEAVSKHPA
1010 1020 1030 1040 1050
PDHLLAVETK RGRELTVTPD HSMRRWTGDG IERVDARELT AGDALPAPTQ
1060 1070 1080 1090 1100
VPGDGETATS ELRSESLDGT HPQRRFGDGG SVRTDEVVSV EPVRSSVDHT
1110 1120 1130 1140 1150
YSLTVAETNT LVANGLFTGQ CDGDEDCVML LMDGLINFSK SYLPDKRGGR
1160 1170 1180 1190 1200
MDAPLVMSSR IDPAEIDDEA HNIDIDREYP REFYEATREL ADPEDVADLI
1210 1220 1230 1240 1250
TLAESTVGTD EEYTGFGHTH ATSNIHLGPS LSAYKTLGSM MDKMDAQLEL
1260 1270 1280 1290 1300
ARKLRSVAET DVAERVIEYH FLPDLIGNLR AFSRQETRCL DCGEKYRRMP
1310 1320 1330 1340 1350
LSGDCRECGG RVNLTVHEGS VNKYMDTAMR VATEYDCREY TKQRLEIMDR
1360 1370
RLESVFEDDT NKQSGISDFM
Length:1,370
Mass (Da):150,296
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07878AA9976790C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20443.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G84384

NCBI Reference Sequences

More...
RefSeqi
WP_010903745.1, NC_002607.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG20443; AAG20443; VNG_2338G

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5953348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hal:VNG_2338G

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|64091.14.peg.1810

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20443.1
PIRiG84384
RefSeqiWP_010903745.1, NC_002607.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiN10.006

Proteomic databases

PaxDbiQ9HMX8

Genome annotation databases

EnsemblBacteriaiAAG20443; AAG20443; VNG_2338G
GeneIDi5953348
KEGGihal:VNG_2338G
PATRICifig|64091.14.peg.1810

Phylogenomic databases

HOGENOMiCLU_001154_0_0_2
InParanoidiQ9HMX8
OMAiKRRNCDG
OrthoDBi559at2157
PhylomeDBiQ9HMX8

Family and domain databases

HAMAPiMF_00324, DNApol_II_L_arch, 1 hit
InterProiView protein in InterPro
IPR003586, Hint_dom_C
IPR003587, Hint_dom_N
IPR036844, Hint_dom_sf
IPR030934, Intein_C
IPR006141, Intein_N
IPR004475, PolC_DP2
IPR016033, PolC_DP2_N
PANTHERiPTHR42210, PTHR42210, 1 hit
PfamiView protein in Pfam
PF03833, PolC_DP2, 1 hit
SMARTiView protein in SMART
SM00305, HintC, 1 hit
SM00306, HintN, 1 hit
SUPFAMiSSF51294, SSF51294, 1 hit
TIGRFAMsiTIGR01443, intein_Cterm, 1 hit
TIGR01445, intein_Nterm, 1 hit
TIGR00354, polC, 1 hit
PROSITEiView protein in PROSITE
PS50817, INTEIN_N_TER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDP2L_HALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HMX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Intein-containing proteins
    List of intein-containing protein entries
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