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Entry version 88 (22 Apr 2020)
Sequence version 1 (01 Mar 2001)
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Protein
Submitted name:

ABC-type transport system periplasmic substrate-binding protein (Probable substratedipeptide/oligopeptide)

Gene

appA

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ABC-type transport system periplasmic substrate-binding protein (Probable substratedipeptide/oligopeptide)Imported
Submitted name:
Oligopeptide binding proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:appAImported
Synonyms:dppA3Imported
Ordered Locus Names:VNG_2358GImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri64091 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000554 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HMW4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 562SBP_bac_5InterPro annotationAdd BLAST438

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni41 – 79DisorderedSequence analysisAdd BLAST39
Regioni502 – 528DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 79PolarSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG01534 Archaea
COG0747 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027778_0_0_2

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HMW4

KEGG Orthology (KO)

More...
KOi
K02035

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARIELVM

Database of Orthologous Groups

More...
OrthoDBi
6658at2157

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HMW4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR000914 SBP_5_dom
IPR006311 TAT_signal
IPR019546 TAT_signal_bac_arc

The PANTHER Classification System

More...
PANTHERi
PTHR30290 PTHR30290, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00496 SBP_bac_5, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002741 MppA, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01409 TAT_signal_seq, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51318 TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HMW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANRDNHARP SRPNTDQSTS EAHSRRRVLK ALGATGVAAG VAGCLGGGSD
60 70 80 90 100
DSAATATSEE TSSPDTETLQ PENIPRGGTF KVATTSTTNG LNAFRIGDGQ
110 120 130 140 150
TSARVNSVMD AGFSRTGEAY EDILPLWFED FSVSEPVDQI EITLRDNLEY
160 170 180 190 200
GNGYGELTAD DYLWNLNNLW RPDWTAFTYS HLFNVGADNT PITFEKVDKY
210 220 230 240 250
TIRETIPEPR PFFPYNEPLG GMYPIPKALA KPYVEAEDAD GLEQDEEVMR
260 270 280 290 300
AAFNGNLGPW DLKRWSQQSV MAFERAEDYY LRQWAKRDDR VPEVMANAPY
310 320 330 340 350
FDEFHMQYFN KASTAREALK GGEIDRVSIP STDVPEFRDQ GGIELYKNPY
360 370 380 390 400
RSWSGYLGIN HRANGWTQLR NKKVRHAMAH IYHNEFIVEN ILNGRAGVQN
410 420 430 440 450
TLHPTWGPYA PENPTTFSGS LDEARRLLKE GTSNDYGYSG DTFVGPDGNQ
460 470 480 490 500
VELTIVYQSG QTDDLRAAYL KKRLGKVGIK LNQETTSWPN LMSNYFKTTE
510 520 530 540 550
TAPGFSGEPG YGDENRQPSD YNRGPQDEAV SAQPWDFMLT LGFDYGPNTP
560 570 580 590 600
ASTITNLFGT EQSFNSYGYA PDRDLVGMRD AAQTAASRDA AKAKITEMLE
610 620 630 640 650
YLSEERPVIF EYNPYNFYAY NDSVENIPDS PANDYYVEER YSEMYFSDGA

SGR
Length:653
Mass (Da):73,182
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEA4C8906E8B9450
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20457.1
BK010829 Genomic DNA Translation: DAC79214.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E84386

NCBI Reference Sequences

More...
RefSeqi
WP_010903759.1, NC_002607.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG20457; AAG20457; VNG_2358G

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5953356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hal:VNG_2358G

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|64091.14.peg.1825

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004437 Genomic DNA Translation: AAG20457.1
BK010829 Genomic DNA Translation: DAC79214.1
PIRiE84386
RefSeqiWP_010903759.1, NC_002607.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiQ9HMW4

Genome annotation databases

EnsemblBacteriaiAAG20457; AAG20457; VNG_2358G
GeneIDi5953356
KEGGihal:VNG_2358G
PATRICifig|64091.14.peg.1825

Phylogenomic databases

eggNOGiarCOG01534 Archaea
COG0747 LUCA
HOGENOMiCLU_027778_0_0_2
InParanoidiQ9HMW4
KOiK02035
OMAiARIELVM
OrthoDBi6658at2157
PhylomeDBiQ9HMW4

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR000914 SBP_5_dom
IPR006311 TAT_signal
IPR019546 TAT_signal_bac_arc
PANTHERiPTHR30290 PTHR30290, 1 hit
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 2 hits
TIGRFAMsiTIGR01409 TAT_signal_seq, 1 hit
PROSITEiView protein in PROSITE
PS51318 TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9HMW4_HALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HMW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: April 22, 2020
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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