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UniProtKB - Q9HMP7 (DPS_HALSA)
Protein
DNA protection during starvation protein
Gene
dps
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Functioni
Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity).
By similarityMiscellaneous
The dps dodecamer comprises iron-binding sites for iron translocation, oxidation and nucleation. Fe2+ atoms are initially bound to the outer surface in proximity to the iron entry pore from which they are translocated toward the inter-subunit ferroxidase centers via two discrete steps. Iron oxidation proceeds by transient formation of tri-iron ferroxidase centers and Fe3+ atoms move to two distinct iron nucleation centers where iron mineralization occurs.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 52 | Iron 1; shared with dodecameric partner1 Publication | 1 | |
Sitei | 53 | Involved in iron translocation | 1 | |
Sitei | 56 | Involved in iron translocation | 1 | |
Sitei | 75 | Involved in iron nucleation | 1 | |
Metal bindingi | 79 | Iron 11 Publication | 1 | |
Metal bindingi | 83 | Iron 11 Publication | 1 | |
Metal bindingi | 83 | Iron 2Sequence analysis | 1 | |
Sitei | 85 | Involved in iron translocation | 1 | |
Sitei | 86 | Involved in iron translocation | 1 | |
Sitei | 154 | Involved in iron nucleation | 1 | |
Sitei | 164 | Involved in iron translocation | 1 | |
Sitei | 168 | Involved in iron translocation | 1 | |
Sitei | 171 | Involved in iron translocation | 1 |
GO - Molecular functioni
- ferric iron binding Source: InterPro
- oxidoreductase activity Source: UniProtKB-KW
GO - Biological processi
- cellular iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Iron storage |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.16.3.2, 2552 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA protection during starvation protein (EC:1.16.-.-)Alternative name(s): Bacterioferritin DpsA |
Gene namesi | Name:dps Synonyms:dpsA Ordered Locus Names:VNG_2443G ORF Names:OE4427R |
Organismi | Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) |
Taxonomic identifieri | 64091 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Stenosarchaea group › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201656 | 1 – 182 | DNA protection during starvation proteinAdd BLAST | 182 |
Post-translational modificationi
The N-terminus is blocked.
Proteomic databases
PaxDbi | Q9HMP7 |
Interactioni
Subunit structurei
Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 110 Fe3+ can be deposited.
1 PublicationProtein-protein interaction databases
STRINGi | 64091.VNG_2443G |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9HMP7 |
SMRi | Q9HMP7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HMP7 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Dps family.Curated
Phylogenomic databases
HOGENOMi | CLU_098183_0_1_2 |
InParanoidi | Q9HMP7 |
OMAi | KKYHWDV |
OrthoDBi | 102179at2157 |
PhylomeDBi | Q9HMP7 |
Family and domain databases
CDDi | cd01043, DPS, 1 hit |
Gene3Di | 1.20.1260.10, 1 hit |
InterProi | View protein in InterPro IPR002177, DPS_DNA-bd IPR012347, Ferritin-like IPR009078, Ferritin-like_SF IPR008331, Ferritin_DPS_dom |
PANTHERi | PTHR42932, PTHR42932, 1 hit |
Pfami | View protein in Pfam PF00210, Ferritin, 1 hit |
PIRSFi | PIRSF005900, Dps, 1 hit |
PRINTSi | PR01346, HELNAPAPROT |
SUPFAMi | SSF47240, SSF47240, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HMP7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTQKNARAT AGEVEGSDAL RMDADRAEQC VDALNADLAN VYVLYHQLKK
60 70 80 90 100
HHWNVEGAEF RDLHLFLGEA AETAEEVADE LAERVQALGG VPHASPETLQ
110 120 130 140 150
AEASVDVEDE DVYDIRTSLA NDMAIYGDII EATREHTELA ENLGDHATAH
160 170 180
MLREGLIELE DDAHHIEHYL EDDTLVTQGA LE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004437 Genomic DNA Translation: AAG20524.1 |
PIRi | H84394 |
RefSeqi | WP_010903826.1, NC_002607.1 |
Genome annotation databases
EnsemblBacteriai | AAG20524; AAG20524; VNG_2443G |
GeneIDi | 5953388 62887690 |
KEGGi | hal:VNG_2443G |
PATRICi | fig|64091.14.peg.1892 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004437 Genomic DNA Translation: AAG20524.1 |
PIRi | H84394 |
RefSeqi | WP_010903826.1, NC_002607.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MOJ | X-ray | 1.90 | A/B/C/D | 1-182 | [»] | |
1TJO | X-ray | 1.60 | A/B/C/D | 1-182 | [»] | |
1TK6 | X-ray | 2.20 | A/B/C/D | 1-182 | [»] | |
1TKO | X-ray | 2.90 | A/B/C/D | 1-182 | [»] | |
1TKP | X-ray | 2.20 | A/B/C/D | 1-182 | [»] | |
AlphaFoldDBi | Q9HMP7 | |||||
SMRi | Q9HMP7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 64091.VNG_2443G |
Proteomic databases
PaxDbi | Q9HMP7 |
Genome annotation databases
EnsemblBacteriai | AAG20524; AAG20524; VNG_2443G |
GeneIDi | 5953388 62887690 |
KEGGi | hal:VNG_2443G |
PATRICi | fig|64091.14.peg.1892 |
Phylogenomic databases
HOGENOMi | CLU_098183_0_1_2 |
InParanoidi | Q9HMP7 |
OMAi | KKYHWDV |
OrthoDBi | 102179at2157 |
PhylomeDBi | Q9HMP7 |
Enzyme and pathway databases
BRENDAi | 1.16.3.2, 2552 |
Miscellaneous databases
EvolutionaryTracei | Q9HMP7 |
Family and domain databases
CDDi | cd01043, DPS, 1 hit |
Gene3Di | 1.20.1260.10, 1 hit |
InterProi | View protein in InterPro IPR002177, DPS_DNA-bd IPR012347, Ferritin-like IPR009078, Ferritin-like_SF IPR008331, Ferritin_DPS_dom |
PANTHERi | PTHR42932, PTHR42932, 1 hit |
Pfami | View protein in Pfam PF00210, Ferritin, 1 hit |
PIRSFi | PIRSF005900, Dps, 1 hit |
PRINTSi | PR01346, HELNAPAPROT |
SUPFAMi | SSF47240, SSF47240, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPS_HALSA | |
Accessioni | Q9HMP7Primary (citable) accession number: Q9HMP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families