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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei71Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei79PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi83Magnesium 1UniRule annotation1
Binding sitei102Anthranilate 1UniRule annotation1
Binding sitei111Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei157Anthranilate 2UniRule annotation1
Metal bindingi215Magnesium 2UniRule annotation1
Metal bindingi216Magnesium 1UniRule annotation1
Metal bindingi216Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00041

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Ta0804
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaDiaforarchaea groupThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545251 – 322Anthranilate phosphoribosyltransferaseAdd BLAST322

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta0804

Structurei

3D structure databases

ProteinModelPortaliQ9HK06
SMRiQ9HK06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 75Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni81 – 84Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni99 – 107Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02012 Archaea
COG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiPOG093Z0D7V

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HK06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYESFLTGKP MDRATAMDLM QYMASPECSD AFRAAVLSVL RVRGVTEDEM
60 70 80 90 100
MGFYEAMHAP NDVTDATDIV GTGGDMAHTI NVSTASAIVA ASMGLKIAKF
110 120 130 140 150
GNRSASGNHG AADFMSETGY AFPKSTGEAL RRLSRTNFVF LYAPDFLKEF
160 170 180 190 200
ALFAGVRKML GFPTVLNFLG PILNPLSPIR RVIGTSDPSF MELYAGIARR
210 220 230 240 250
SGMRAIILHS ADGMDEISPF AKARIMHVSD LVSESYVDAS SLTGPLERRN
260 270 280 290 300
IASADPGAIS GLTLSAIRGE NEDGARFVAL NTAPVLIING LASDFQEGYE
310 320
AALEHIMSGG PAEFLKVIAG DR
Length:322
Mass (Da):34,442
Last modified:March 1, 2001 - v1
Checksum:i0E73235BB26AF063
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445065 Genomic DNA Translation: CAC11933.1

Genome annotation databases

EnsemblBacteriaiCAC11933; CAC11933; CAC11933
KEGGitac:Ta0804

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445065 Genomic DNA Translation: CAC11933.1

3D structure databases

ProteinModelPortaliQ9HK06
SMRiQ9HK06
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0804

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11933; CAC11933; CAC11933
KEGGitac:Ta0804

Phylogenomic databases

eggNOGiarCOG02012 Archaea
COG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiPOG093Z0D7V

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00041

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_THEAC
AccessioniPrimary (citable) accession number: Q9HK06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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