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Protein

Calpain-like protease palB/RIM13

Gene

RIM13

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.1 Publication

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158PROSITE-ProRule annotation1
Active sitei326PROSITE-ProRule annotation1
Active sitei362PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-like protease palB/RIM13 (EC:3.4.22.-)
Alternative name(s):
Cysteine protease RIM13
Gene namesi
Name:RIM13
Ordered Locus Names:YALI0D14740g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome D

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077451 – 795Calpain-like protease palB/RIM13Add BLAST795

Proteomic databases

PRIDEiQ9HFC8

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_502833.1

Structurei

3D structure databases

ProteinModelPortaliQ9HFC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 408Calpain catalyticPROSITE-ProRule annotationAdd BLAST320

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9HFC8
OrthoDBiEOG092C185F

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR038765 Papain_like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HFC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPEEIYTS AMLAIACNDD KKAQEILVSL LQTYPDLVDY AKSISPATGK
60 70 80 90 100
LVLRQAKRSM DAYDSIKKGG SVLSLAEKIV YLSSRTNYGY ALPWEYATPV
110 120 130 140 150
SALKKSDDLY VDATDGGLRQ SQHRDVSWLR IPHVFASSDA VFTWSGFETL
160 170 180 190 200
YQDGLENCSF VASLLSIGVM EKRCNYSLLK EALLDKSSNH HLGTPPSSGR
210 220 230 240 250
YDIKLFINGC DRRITIDDRF PIREPSLPNM YLRSYTNPTL VWPALLEKAF
260 270 280 290 300
MKVLDGYDYA GSHAGGDTFV LCKWFPEFVS LTSYHDTNGL WRYIYDSWLQ
310 320 330 340 350
GDVLLCLGTG SFSREEADYK GLLGEHDYAV LELREIQDGC NTAHILRIRD
360 370 380 390 400
PLLFGPFSNP KNPLVEESNR LAKLVDGKNV DMASRGEIWM DFNQATREYQ
410 420 430 440 450
SLYLNWRPER FFCRLEQHFF WKTSDIMDFQ MCGSFVQNPQ YTITNNGTKT
460 470 480 490 500
ATGKLVLLRH TQGRETDAKS FCCIHLFEGA TRVVLQETSH AVYKGKLMNL
510 520 530 540 550
HYYTVSLTLK PGESTTAVMA CSGMTDSEPM YRFSLFLYAN NPLTMSKPTA
560 570 580 590 600
PLAYSQIFKG KWSEDQAGGN WAKPMYIHNP QFLLTVNEHC DQLYIYLTSS
610 620 630 640 650
SRQPIAAQLF WGSKSLKEYK ESAIETSSGK YKTGSTHLKT RNIDAGSNLI
660 670 680 690 700
LIISTFDSAP QTDYNIRVFS SGNFSLTQLA RHTAGKFTKS HKSKFYNSCS
710 720 730 740 750
EQVEFSVQQS TQHLSLAARM IKTRPFIRLT IREAQSNTVV ATTNTFSDSI
760 770 780 790
YGVHLDGVRV SRGLVYLAVI EKMEHSNNEP YVMEFAADTL VTLGH
Length:795
Mass (Da):89,799
Last modified:March 1, 2001 - v1
Checksum:iB29D4B04526227DC
GO

Sequence cautioni

The sequence CAG81021 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277150 Genomic DNA Translation: CAC14603.1
CR382130 Genomic DNA Translation: CAG81021.1 Different initiation.
RefSeqiXP_502833.1, XM_502833.1

Genome annotation databases

GeneIDi2910310
KEGGiyli:YALI0D14740g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277150 Genomic DNA Translation: CAC14603.1
CR382130 Genomic DNA Translation: CAG81021.1 Different initiation.
RefSeqiXP_502833.1, XM_502833.1

3D structure databases

ProteinModelPortaliQ9HFC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.XP_502833.1

Proteomic databases

PRIDEiQ9HFC8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2910310
KEGGiyli:YALI0D14740g

Phylogenomic databases

InParanoidiQ9HFC8
OrthoDBiEOG092C185F

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR038765 Papain_like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPALB_YARLI
AccessioniPrimary (citable) accession number: Q9HFC8
Secondary accession number(s): Q6C929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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