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Entry version 35 (28 Feb 2018)
Sequence version 1 (01 Mar 2001)
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Protein
Submitted name:

Beta-1,3-glucan synthase GSC-1

Gene
N/A
Organism
Pneumocystis carinii
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT48 Glycosyltransferase Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Beta-1,3-glucan synthase GSC-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPneumocystis cariniiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4754 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaPneumocystidomycetesPneumocystidaceaePneumocystis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei516 – 537HelicalSequence analysisAdd BLAST22
Transmembranei560 – 583HelicalSequence analysisAdd BLAST24
Transmembranei603 – 621HelicalSequence analysisAdd BLAST19
Transmembranei641 – 666HelicalSequence analysisAdd BLAST26
Transmembranei691 – 712HelicalSequence analysisAdd BLAST22
Transmembranei1372 – 1395HelicalSequence analysisAdd BLAST24
Transmembranei1428 – 1445HelicalSequence analysisAdd BLAST18
Transmembranei1515 – 1535HelicalSequence analysisAdd BLAST21
Transmembranei1541 – 1559HelicalSequence analysisAdd BLAST19
Transmembranei1631 – 1654HelicalSequence analysisAdd BLAST24
Transmembranei1674 – 1701HelicalSequence analysisAdd BLAST28
Transmembranei1713 – 1736HelicalSequence analysisAdd BLAST24
Transmembranei1748 – 1770HelicalSequence analysisAdd BLAST23
Transmembranei1875 – 1895HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini370 – 482FKS1_dom1InterPro annotationAdd BLAST113

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HEZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQQQHYYDD SYGGQNGGYY GEHSYDNTGF NNGSYGSGVY EQGGYYGPEY
60 70 80 90 100
GQEYYDEYDG GGAMYNGQGH EMYNSGEEGY YRQEEGYYDY PQDGYVGDTY
110 120 130 140 150
GIKKDILRGN GYFQGQDEYY TYDRKGKRRG SSEASETFSD FTMRSDMVRA
160 170 180 190 200
AEYDSYGRFD ERYRSYEPST ESLNQMASRQ RGYRPDSQIS YTGNRSSGAS
210 220 230 240 250
TPIYGMYYNQ AAMMTSARSR EPYPTWTAEN QIPISKEEIE DIFIDLTNKF
260 270 280 290 300
GFQRDSMRNM YDHMMVLLDS RASRMTPNQA LLSLHADYIG GDNANYRNWY
310 320 330 340 350
FAAQFDLDDA VGFSNMDLDK NRKSNYSQKS SKKFQKNSAS KSILQALDGD
360 370 380 390 400
NSLESAIYRW KTRCTQMSQY DRARELALYL LCWGEANQVR FTPECLCFIF
410 420 430 440 450
KCANDYLNSP QCQAMVEPAP EGSYLNDVIT PLYAYMRDQG YEIINGRYVR
460 470 480 490 500
RERDHNKIIG YDDINQLFWY PEGIQRIVLS DKTRMVDLPL DQRYPRFKDV
510 520 530 540 550
VWKKAFFKTY RETRSWFHLF TNFNRIWIIH ITVYWFYTAA NSPTVYTHNY
560 570 580 590 600
QQSLDNQPPF AYRMSAVGFG GGVASLLMIV ATLAEWAYVP RKWPGAQHLT
610 620 630 640 650
RRLLFLILFF IINVAPGVYV IKFAPWKPNV SIVTTLISIM HFLIAIFTFL
660 670 680 690 700
FFAIMPLGGL FGNYLYKKTR RYVASQTFTA NFAKLKGNDL WLSYGLWIAV
710 720 730 740 750
FACKFAESYF FLSLSLRDPI RYLNTMTIGH CGIRYLGSSL CPYQAKITLG
760 770 780 790 800
IMYITDLVLF FLDTYLWYII WNTICSVARS FYLGVSIWTP WRNIFSRMPK
810 820 830 840 850
RIYSKILATN DMEIKYKPKV LISQVWNAVV ISMYREHLLA IDHVQKLLYH
860 870 880 890 900
QVPSEQEGKR TLRAPTFFIS QEDHSFKTEF FPSHSEAERR ISFFAQSLST
910 920 930 940 950
PIPEPLPVDN MPTFTVLVPH YGEKILYSLR EIIREDDQLS RVTLLEYLKQ
960 970 980 990 1000
LHPVEWDCFV KDTKILAEET SLYNGGVPFD KDEKDTVKSK IDDLPFYCVG
1010 1020 1030 1040 1050
FKSSAPEYTL RTRIWASLRS QTLYRTVSGF MNYSRAIKLL YRVENPDVVQ
1060 1070 1080 1090 1100
MFGGNTDKLE HELERMARRK FKFDISMQRF FKFSKEELEN TEFLLRAYPD
1110 1120 1130 1140 1150
LQIAYLDEEP PMNEGDEPKI YSSLIDGYSE IMENGKRRPK FRIQLSGNPI
1160 1170 1180 1190 1200
LGDGKSDNQN HAIIFYRGEY IQLIDANQDN YLEECLKIRS VLAEFEEMTP
1210 1220 1230 1240 1250
TEESPYNPNE ISSATNPVAI LGAREYIFSE NIGVLGDVAA GKEQTFGTLF
1260 1270 1280 1290 1300
ARTLAQIGGK LHYGHPDFLN GPFMTTRGGV SKAQKGLHLN EDIYAGMTAL
1310 1320 1330 1340 1350
LRGGRIKHCE YYQCGKGRDL GFGSILNFTT KVGTGMGEQM LSREYYYLGT
1360 1370 1380 1390 1400
QLPLDRFLSF YYAHPGFHIN NLFIILSVQL LMIVMINLGS MYNILLICRP
1410 1420 1430 1440 1450
RRGQPITDPY LPVGCYSIAP VLDWIKRSII SIFIVFFIAF IPLVVQELTE
1460 1470 1480 1490 1500
RGVWRASTRL AKHFGSLSPL FEVFVSQIYA NSLLQNLAFG GARYIGTGRG
1510 1520 1530 1540 1550
FATTRIPFSI LFSRFAGASI YLGSRTLIML LFATVTMWIP HLVYFWVSVL
1560 1570 1580 1590 1600
ALCISPFIFN PHQFSWTDFF VDYREFIRWL SRGNSRSHAN SWIGYCRLSR
1610 1620 1630 1640 1650
TRITGFKRKA LGQPSEKLSG DIPRAGFSNV FFSEVIGPMI LVLLSLVPYC
1660 1670 1680 1690 1700
FINSRPGFEP FGKSNPAKNG SNPLIRIAIV SFAPICVNAM VAFVFFGMAC
1710 1720 1730 1740 1750
CMGPILTICC KKFAAVLATI SHAIAVIILV TFFEVLWFLE GWSFSKTILG
1760 1770 1780 1790 1800
LVTMISLQRA FLKILTIMIL TREFKHDGSN LAWWTGRWYS NNLGVYAMSQ
1810 1820 1830 1840 1850
PAREFVCKVI ELSLFAADFC LGHLLLFILT PILAIPYIDR WHSMLLFWLR
1860 1870 1880 1890 1900
PSRQIRPPIF SLKQNKLRKR IVRRYATLFF GLFLLFLMII LVPALGHSKF
1910 1920 1930 1940
PKSLNNIAFL KNLGLIQPSN DPRGATGRTT RPGNSNGTYK LFIY
Length:1,944
Mass (Da):223,923
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32BE52DF78485295
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF291999 mRNA Translation: AAG02216.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291999 mRNA Translation: AAG02216.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT48 Glycosyltransferase Family 48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9HEZ4_PNECA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HEZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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