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Entry version 119 (10 Feb 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Ubiquitin conjugation factor E4

Gene

ufd2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin conjugation factor E4 (EC:2.3.2.-By similarity)
Alternative name(s):
Ubiquitin fusion degradation protein 2
Short name:
UB fusion protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ufd2
ORF Names:SPAC145.04, SPAC20H4.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC20H4.10, ufd2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC20H4.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949961 – 1010Ubiquitin conjugation factor E4Add BLAST1010

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HE05

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HE05

PRoteomics IDEntifications database

More...
PRIDEi
Q9HE05

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HE05

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278506, 136 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HE05, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9HE05

STRING: functional protein association networks

More...
STRINGi
4896.SPAC20H4.10.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HE05

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini930 – 1004U-boxAdd BLAST75

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The U-box domain is required for the ubiquitin protein ligase activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2042, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003224_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HE05

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHDTSTQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HE05

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019474, Ub_conjug_fac_E4_core
IPR003613, Ubox_domain
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04564, U-box, 1 hit
PF10408, Ufd2P_core, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00504, Ubox, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51698, U_BOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HE05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDLEKIRLK RLAKLQQTNS EANSSKEPKE SNIAPEPKKP DLKKRFIGSK
60 70 80 90 100
ATTSNSEQKE ISPPVTSGAP KHRLFSKDEW MHFITCQALN ITLSETDSSK
110 120 130 140 150
YYLEGFKKDL EEEGSPLLFN ENNVDSALLS RLSTTGNNTF SYLLQSWSFL
160 170 180 190 200
YQYKKRLPKD ENQDFKIHYL SLLKSLLVSY AGIVVMLPDT FNSETIDLAE
210 220 230 240 250
VLIGAEGIPL EFLSEFVQRF EHENLDELFI PVLESLSLKI GLMNVDTVQM
260 270 280 290 300
NVMQIILQLV SLKPIALLLP KLPSWNPTNN AGEIEYKTFL GRISSLSVFT
310 320 330 340 350
QDVASRYFSN STERSAQNIS SSISSLKLTM STYQDVLFQI FNTLIRTSTS
360 370 380 390 400
LRESVLDFFA MVVNANHKRQ SIQVNHFDIT SDACMLNFSH VLSRLSEPFL
410 420 430 440 450
DIGCSKIDRV QVEYFRRNPR VDIKEETKLN ADQKASESFY SKPAEGSNNF
460 470 480 490 500
ISDIFFLNLA FHHYGVNATF KALEQLVQSI RDSEKLKERL ETEQQNMSGS
510 520 530 540 550
FQATRLTAQL SRLDQRLDLD RSFVHCYEIM LTQTSDTSRS FSFLNFVAIW
560 570 580 590 600
LSRLADGQSS TYPKMPLSLP FNENAPEAFK CLPEYFIETI TDYMLSLFKT
610 620 630 640 650
SSSTLTLHSL EPLCEFCVSF LTQANYIKNP YLRAKLAEIL YFGVQTHVGR
660 670 680 690 700
SELLLDVVRT SKVATRWLLP ALMAFYIEIE STGQSTQFYD KFNIRFYICE
710 720 730 740 750
VFRTIWKQPA YFGKLEQEQK TNLPFFVKFV ALMLNDATYL LDEALLKLTE
760 770 780 790 800
IHNLQSLLAD AISNSNSNQN VQESQSNLAA AERQASTYCQ LGNETIFMLK
810 820 830 840 850
LFTSSIPKAF CAVEIVDRLA AMLNYNLQAL CGPKCSNLKV EDPTKYHFNA
860 870 880 890 900
KTLLSIIFDV YLNLCNEPAF VEAVAHDGRS YSKEIFERAT SIMTKHNLKS
910 920 930 940 950
SFDIEAIKEF VNRVEAFRLQ EATEEEDMGD IPDYFLDPLM FTIMKDPVVL
960 970 980 990 1000
PRSGISIDRS TIKAHLLSDA TDPFNRTPLT LDDVTPNDTL REEINTFLKS
1010
KRNKHSRNSE
Length:1,010
Mass (Da):115,276
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60A3E5B5E790FE6E
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC80427 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80 – 86WMHFITC → MDAFYNS in AAC80427 (Ref. 1) Curated7
Sequence conflicti137N → D in AAC80427 (Ref. 1) Curated1
Sequence conflicti331 – 332ST → LS in AAC80427 (Ref. 1) Curated2
Sequence conflicti474E → Y in AAC80427 (Ref. 1) Curated1
Sequence conflicti530 – 531ML → YC in AAC80427 (Ref. 1) Curated2
Sequence conflicti644V → W in AAC80427 (Ref. 1) Curated1
Sequence conflicti671A → T in AAC80427 (Ref. 1) Curated1
Sequence conflicti683G → A in AAC80427 (Ref. 1) Curated1
Sequence conflicti687Q → P in AAC80427 (Ref. 1) Curated1
Sequence conflicti700E → A in AAC80427 (Ref. 1) Curated1
Sequence conflicti707K → T in AAC80427 (Ref. 1) Curated1
Sequence conflicti809 – 811AFC → PFV in AAC80427 (Ref. 1) Curated3
Sequence conflicti890 – 891TS → PG in AAC80427 (Ref. 1) Curated2
Sequence conflicti897N → P in AAC80427 (Ref. 1) Curated1
Sequence conflicti907 – 909IKE → LKA in AAC80427 (Ref. 1) Curated3
Sequence conflicti912 – 914NRV → HRA in AAC80427 (Ref. 1) Curated3
Sequence conflicti921E → Q in AAC80427 (Ref. 1) Curated1
Sequence conflicti992E → D in BAA84654 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF059906 mRNA Translation: AAC80427.1 Different initiation.
CU329670 Genomic DNA Translation: CAC19740.1
AB027791 Genomic DNA Translation: BAA87095.1
AB032715 mRNA Translation: BAA84654.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43725

NCBI Reference Sequences

More...
RefSeqi
NP_593630.1, NM_001019061.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC20H4.10.1; SPAC20H4.10.1:pep; SPAC20H4.10

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542023

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC20H4.10

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059906 mRNA Translation: AAC80427.1 Different initiation.
CU329670 Genomic DNA Translation: CAC19740.1
AB027791 Genomic DNA Translation: BAA87095.1
AB032715 mRNA Translation: BAA84654.1
PIRiT43725
RefSeqiNP_593630.1, NM_001019061.2

3D structure databases

SMRiQ9HE05
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi278506, 136 interactors
IntActiQ9HE05, 3 interactors
MINTiQ9HE05
STRINGi4896.SPAC20H4.10.1

PTM databases

iPTMnetiQ9HE05

Proteomic databases

MaxQBiQ9HE05
PaxDbiQ9HE05
PRIDEiQ9HE05

Genome annotation databases

EnsemblFungiiSPAC20H4.10.1; SPAC20H4.10.1:pep; SPAC20H4.10
GeneIDi2542023
KEGGispo:SPAC20H4.10

Organism-specific databases

PomBaseiSPAC20H4.10, ufd2
VEuPathDBiFungiDB:SPAC20H4.10

Phylogenomic databases

eggNOGiKOG2042, Eukaryota
HOGENOMiCLU_003224_2_1_1
InParanoidiQ9HE05
OMAiEHDTSTQ
PhylomeDBiQ9HE05

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9HE05

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR019474, Ub_conjug_fac_E4_core
IPR003613, Ubox_domain
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF04564, U-box, 1 hit
PF10408, Ufd2P_core, 1 hit
SMARTiView protein in SMART
SM00504, Ubox, 1 hit
PROSITEiView protein in PROSITE
PS51698, U_BOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUFD2_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HE05
Secondary accession number(s): O60009
, Q9P7A3, Q9UTT4, Q9UU63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: February 10, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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