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Protein

DASH complex subunit dam1

Gene

dam1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
DASH complex subunit dam1
Alternative name(s):
Outer kinetochore protein dam1
Gene namesi
Name:dam1
ORF Names:SPAC589.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC589.08c
PomBaseiSPAC589.08c dam1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001276611 – 155DASH complex subunit dam1Add BLAST155

Proteomic databases

MaxQBiQ9HDZ6
PaxDbiQ9HDZ6
PRIDEiQ9HDZ6

PTM databases

iPTMnetiQ9HDZ6

Interactioni

Subunit structurei

The DASH complex oligomerizes to form rings that encircle the microtubules. Integrity of the complex and interactions with central kinetochore proteins are regulated by the spindle assembly checkpoint kinase ark1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278948, 141 interactors
STRINGi4896.SPAC589.08c.1

Family & Domainsi

Sequence similaritiesi

Belongs to the DASH complex DAM1 family.Curated

Phylogenomic databases

InParanoidiQ9HDZ6
KOiK02307
OrthoDBiEOG092C5P0B
PhylomeDBiQ9HDZ6

Family and domain databases

InterProiView protein in InterPro
IPR013962 DASH_Dam1
PfamiView protein in Pfam
PF08653 DASH_Dam1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD398536 DASH_Dam1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKYQKATQN PLENVDNVKI ESENAIPSNL QAFTKSLAVL DDNVSEFRKR
60 70 80 90 100
MNHLSATKQI LDNFNESFSS FLYGLQINAF CVDYENAPLS ESFLLQAKKD
110 120 130 140 150
QFKATLMTRT GHSISDPPYD GGVISHDPNF ATADETFATN DTSFIERPET

YSASR
Length:155
Mass (Da):17,444
Last modified:March 1, 2001 - v1
Checksum:iBED2A5612EBE2D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC19765.1
RefSeqiNP_594056.1, NM_001019480.2

Genome annotation databases

EnsemblFungiiSPAC589.08c.1; SPAC589.08c.1:pep; SPAC589.08c
GeneIDi2542489
KEGGispo:SPAC589.08c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC19765.1
RefSeqiNP_594056.1, NM_001019480.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278948, 141 interactors
STRINGi4896.SPAC589.08c.1

PTM databases

iPTMnetiQ9HDZ6

Proteomic databases

MaxQBiQ9HDZ6
PaxDbiQ9HDZ6
PRIDEiQ9HDZ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC589.08c.1; SPAC589.08c.1:pep; SPAC589.08c
GeneIDi2542489
KEGGispo:SPAC589.08c

Organism-specific databases

EuPathDBiFungiDB:SPAC589.08c
PomBaseiSPAC589.08c dam1

Phylogenomic databases

InParanoidiQ9HDZ6
KOiK02307
OrthoDBiEOG092C5P0B
PhylomeDBiQ9HDZ6

Miscellaneous databases

PROiPR:Q9HDZ6

Family and domain databases

InterProiView protein in InterPro
IPR013962 DASH_Dam1
PfamiView protein in Pfam
PF08653 DASH_Dam1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD398536 DASH_Dam1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAM1_SCHPO
AccessioniPrimary (citable) accession number: Q9HDZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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Main funding by: National Institutes of Health

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