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UniProtKB - Q9HDX4 (MFC1_SCHPO)
Protein
Uncharacterized transporter mfc1
Gene
mfc1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
GO - Molecular functioni
- copper ion transmembrane transporter activity Source: PomBase
- xenobiotic transmembrane transporter activity Source: GO_Central
GO - Biological processi
- copper ion import across prospore membrane Source: PomBase
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: GO_Central
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.1.2.76, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized transporter mfc1 |
Gene namesi | Name:mfc1 ORF Names:SPAPB1A11.01, SPAPB24D3.11 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAPB1A11.01, mfc1 |
VEuPathDBi | FungiDB:SPAPB1A11.01 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- cytoplasm Source: PomBase
- integral component of membrane Source: GO_Central
- prospore membrane Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 128 – 148 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 168 – 188 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 284 – 304 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 323 – 343 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 390 – 410 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 426 – 446 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 461 – 481 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
Lead to sensitivity to camptothecin and DNA damaging agents.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173447 | 1 – 495 | Uncharacterized transporter mfc1Add BLAST | 495 |
Proteomic databases
PaxDbi | Q9HDX4 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 280556, 1 interactor |
STRINGi | 4896.SPAPB1A11.01.1 |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
HOGENOMi | CLU_008455_1_1_1 |
InParanoidi | Q9HDX4 |
OMAi | YSIYTNM |
PhylomeDBi | Q9HDX4 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HDX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVSDKDFKD IELLPVKSIE SKDSIDQCDP LTWPIRIRII NTIIISFMTM
60 70 80 90 100
LCMYGSSVFM PSIPELCEKF GEPETLVVLG ATLYVIGVML GPLIFSPLSE
110 120 130 140 150
LYGRRPLNIF GYTLFALMQI PTALSVNLAM FVVFRFFSGF FGSVGLGIGA
160 170 180 190 200
GSLSDMFSKR DRGKYIGIYF LGICLGPAIA PIASGFIAGS SISWRWEFWI
210 220 230 240 250
LLMLSGVSLL AGVVFLKETY APVLKRKQAK KLLEKQENQK SVEVKISEIT
260 270 280 290 300
ESSQQIDPDK SFAEVVHILV TTIRRPLHLL CTQPIMILIS LIVGTVYGIL
310 320 330 340 350
YLLFTAFAEV WISQYHFTSG LSGLTYISLS IGQVFAVFVL LPLNQKYWLS
360 370 380 390 400
AVQKNNGVPE PEFRLPMAFL GCFAIMTGMF IFGWTVQYKV FWFVPLIGTT
410 420 430 440 450
LVGAGFVMTF NPMNMFIVDN YGRYAASAMA AIAIPRNIFG ACFPLFAEKL
460 470 480 490
FERLGYGWGS SLLAFLLVAI NFSIAALYMF GKTIREKRPF DHTKY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAC36907.1 |
RefSeqi | XP_001713075.1, XM_001713023.2 |
Genome annotation databases
EnsemblFungii | SPAPB1A11.01.1; SPAPB1A11.01.1:pep; SPAPB1A11.01 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAC36907.1 |
RefSeqi | XP_001713075.1, XM_001713023.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 280556, 1 interactor |
STRINGi | 4896.SPAPB1A11.01.1 |
Protein family/group databases
TCDBi | 2.A.1.2.76, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | Q9HDX4 |
Genome annotation databases
EnsemblFungii | SPAPB1A11.01.1; SPAPB1A11.01.1:pep; SPAPB1A11.01 |
Organism-specific databases
PomBasei | SPAPB1A11.01, mfc1 |
VEuPathDBi | FungiDB:SPAPB1A11.01 |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
HOGENOMi | CLU_008455_1_1_1 |
InParanoidi | Q9HDX4 |
OMAi | YSIYTNM |
PhylomeDBi | Q9HDX4 |
Miscellaneous databases
PROi | PR:Q9HDX4 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MFC1_SCHPO | |
Accessioni | Q9HDX4Primary (citable) accession number: Q9HDX4 Secondary accession number(s): Q9C0Y3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2004 |
Last sequence update: | March 29, 2004 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families