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Protein

Calcium-transporting ATPase 2

Gene

pmc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5454-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • calcium ion transmembrane transport Source: PomBase
  • cellular calcium ion homeostasis Source: PomBase

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-418359 Reduction of cytosolic Ca++ levels
R-SPO-5578775 Ion homeostasis
R-SPO-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.2.35 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 2 (EC:3.6.3.8)
Gene namesi
Name:pmc1
ORF Names:SPAPB2B4.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAPB2B4.04c
PomBaseiSPAPB2B4.04c pmc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 236CytoplasmicSequence analysisAdd BLAST236
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 273ExtracellularSequence analysisAdd BLAST16
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 448CytoplasmicSequence analysisAdd BLAST154
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 488ExtracellularSequence analysisAdd BLAST19
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21
Topological domaini510 – 938CytoplasmicSequence analysisAdd BLAST429
Transmembranei939 – 959HelicalSequence analysisAdd BLAST21
Topological domaini960 – 966ExtracellularSequence analysis7
Transmembranei967 – 987HelicalSequence analysisAdd BLAST21
Topological domaini988 – 1016CytoplasmicSequence analysisAdd BLAST29
Transmembranei1017 – 1037HelicalSequence analysisAdd BLAST21
Topological domaini1038 – 1084ExtracellularSequence analysisAdd BLAST47
Transmembranei1085 – 1105HelicalSequence analysisAdd BLAST21
Topological domaini1106 – 1115CytoplasmicSequence analysis10
Transmembranei1116 – 1136HelicalSequence analysisAdd BLAST21
Topological domaini1137 – 1292ExtracellularSequence analysisAdd BLAST156

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003621411 – 1292Calcium-transporting ATPase 2Add BLAST1292

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HDW7
PaxDbiQ9HDW7
PRIDEiQ9HDW7

PTM databases

iPTMnetiQ9HDW7

Interactioni

Protein-protein interaction databases

BioGridi279897, 17 interactors
STRINGi4896.SPAPB2B4.04c.1

Structurei

3D structure databases

ProteinModelPortaliQ9HDW7
SMRiQ9HDW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 9Poly-Asp4
Compositional biasi10 – 105Ser-richAdd BLAST96

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000265623
InParanoidiQ9HDW7
KOiK01537
OMAiHYKKIPE
OrthoDBiEOG092C12IX
PhylomeDBiQ9HDW7

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTYNDDDDS SRPPSVHSER NQKPSSSQFL GVPSSNYNQR ENSSRSGSST
60 70 80 90 100
ISREPSSSGT MYPMASRDSM KESYDKNKGT PPDYTSYVSH SDAEPEQASS
110 120 130 140 150
KSSTSIEDLL HTEYDDAPFA FSIPLLQRLQ DPKNTSLLHA IHGLKGLCKG
160 170 180 190 200
LKVDPSTGIS THEPHYADKL QMSDILNDDS NPKLVVHLDR IRSQDNNPEA
210 220 230 240 250
KVSHDSDRVK YYGKNVLPEH DSKGLIRLML EAFKDKVLIL LSIAAVVSLA
260 270 280 290 300
LGLYQTFGQP PTLDPITGKP EPRVEWVEGV AIMAAIVIVV TVGGVNDWQK
310 320 330 340 350
ELQFKKLNAK VSNFDVQVLR DGAVHSTSVF DLVVGDVLFV EAGDVVPVDG
360 370 380 390 400
VLIESNNLVL DESAMTGETD NIKKVDANTA IERTSPDVEY RKNADPYLIS
410 420 430 440 450
GTTILEGNGK LLVTAVGVNS FNGRTTMAMR TEGQATPLQL RLSRVADAIA
460 470 480 490 500
KLGGAASALL FIVLLIEFLV RLKSNDSSSK NKGQEFLQIL IVSVTLLVVA
510 520 530 540 550
VPEGLPLAVT LALAFATNRM QKDNNLVRHL QACETMGTAT NICSDKTGTL
560 570 580 590 600
TQNRMTVVAG GFGTDVLFFD HNDETPTNVD QGSDSSKFED AGASAFAFKR
610 620 630 640 650
LSPELRDLTL YSIAVNSTCR QLFEDNSDTP RFIGSKTETA LLDMSVKELG
660 670 680 690 700
LTNVDSMRSS VDIKQFFSFS SDRKASGAIF EYKDKYYFVV KGMPERVLQQ
710 720 730 740 750
STSVITNGSL DEVEDMHSHA DYFKEMITGY AKRSLRTLGL CYRVFDSWPP
760 770 780 790 800
KDIPTNDEDS SNPLKWEDAF TDMTFLGFFG IMDPIRPDVP LAVKVCQGAG
810 820 830 840 850
VTVRMVTGDN IVTAKAIASQ CGIYTEDGIS MEGPEFRSLS DEKRLEILPK
860 870 880 890 900
LDVLARSSPL DKQLLIEGLQ KLGNVVAVTG DGTNDAPALK KANVGFSMGK
910 920 930 940 950
SGTEVAKEAS DIILMDDNFS SIVKAIAWGR TVNDAVKKFL QFQITVNITA
960 970 980 990 1000
VFLTIISAVA STDQSSVLTA VQLLWVNLIM DTLAALALAT DPPTPEVLKR
1010 1020 1030 1040 1050
KPEKPGASLF TFDMWKMIIC QSMYQLAVTL VLHFAGNSIF HYPSNTADMN
1060 1070 1080 1090 1100
TIVFNTFVWL QLFNEINNRR LDNKLNIFER INHNFLFIAI FVIVAGIQVI
1110 1120 1130 1140 1150
IVFFGGAAFS VKRIDGKGWA ISIVFGVISI PLGALIRCVP NNFLRKVLPV
1160 1170 1180 1190 1200
KTIDTVFSWI LNPRFRSKRR STDHDVESLS LIPYEPTSPN EVIDSIRHSL
1210 1220 1230 1240 1250
GFVQRIRGGR IRHLLNNSKF DKQMEALPER LRPRVKQRFM KIRSPSVSSA
1260 1270 1280 1290
TSVALMIPIS TLVSEASGRL GGHDIWISHN RQALDKKSSN VH
Length:1,292
Mass (Da):142,235
Last modified:March 1, 2001 - v1
Checksum:i1499E90144A2B07B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC21470.1
AB027950 Genomic DNA Translation: BAA87254.1
RefSeqiNP_593890.1, NM_001019320.2

Genome annotation databases

EnsemblFungiiSPAPB2B4.04c.1; SPAPB2B4.04c.1:pep; SPAPB2B4.04c
GeneIDi2543477
KEGGispo:SPAPB2B4.04c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC21470.1
AB027950 Genomic DNA Translation: BAA87254.1
RefSeqiNP_593890.1, NM_001019320.2

3D structure databases

ProteinModelPortaliQ9HDW7
SMRiQ9HDW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279897, 17 interactors
STRINGi4896.SPAPB2B4.04c.1

Protein family/group databases

TCDBi3.A.3.2.35 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiQ9HDW7

Proteomic databases

MaxQBiQ9HDW7
PaxDbiQ9HDW7
PRIDEiQ9HDW7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAPB2B4.04c.1; SPAPB2B4.04c.1:pep; SPAPB2B4.04c
GeneIDi2543477
KEGGispo:SPAPB2B4.04c

Organism-specific databases

EuPathDBiFungiDB:SPAPB2B4.04c
PomBaseiSPAPB2B4.04c pmc1

Phylogenomic databases

HOGENOMiHOG000265623
InParanoidiQ9HDW7
KOiK01537
OMAiHYKKIPE
OrthoDBiEOG092C12IX
PhylomeDBiQ9HDW7

Enzyme and pathway databases

ReactomeiR-SPO-418359 Reduction of cytosolic Ca++ levels
R-SPO-5578775 Ion homeostasis
R-SPO-936837 Ion transport by P-type ATPases

Miscellaneous databases

PROiPR:Q9HDW7

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATC2_SCHPO
AccessioniPrimary (citable) accession number: Q9HDW7
Secondary accession number(s): Q9UTX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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Main funding by: National Institutes of Health

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