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Protein

Unconventional myosin-X

Gene

MYO10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.2 Publications
Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-10 (MYH10).Curated
Originally predicted to contain a coiled coil domain but shown to contain a stable SAH domain instead.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi157 – 164ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-373752 Netrin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-X
Alternative name(s):
Unconventional myosin-10
Gene namesi
Name:MYO10
Synonyms:KIAA0799
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145555.14
HGNCiHGNC:7593 MYO10
MIMi601481 gene
neXtProtiNX_Q9HD67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi795F → A: Abolishes interaction with CALM3. 1 Publication1
Mutagenesisi893L → Q: Abolishes dimerization. 1 Publication1
Mutagenesisi904K → A: Abolishes dimerization. 1 Publication1
Mutagenesisi1647K → D: Abolishes interaction with tubulin; when associated with D-1650. 1 Publication1
Mutagenesisi1650K → D: Abolishes interaction with tubulin; when associated with D-1647. 1 Publication1
Mutagenesisi1718 – 1719SH → AA: Almost abolishes interaction with DCC. 1 Publication2
Mutagenesisi2002F → K: Abolishes interaction with DCC. 1 Publication1

Organism-specific databases

DisGeNETi4651
OpenTargetsiENSG00000145555
PharmGKBiPA31394

Polymorphism and mutation databases

BioMutaiMYO10
DMDMi205371854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234731 – 2058Unconventional myosin-XAdd BLAST2058

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei962PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1
Modified residuei968PhosphoserineBy similarity1
Modified residuei1158PhosphothreonineBy similarity1

Post-translational modificationi

The initiator methionine for isoform Headless is removed.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HD67
MaxQBiQ9HD67
PaxDbiQ9HD67
PeptideAtlasiQ9HD67
PRIDEiQ9HD67
ProteomicsDBi81840

PTM databases

iPTMnetiQ9HD67
PhosphoSitePlusiQ9HD67

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000145555 Expressed in 228 organ(s), highest expression level in amygdala
CleanExiHS_MYO10
ExpressionAtlasiQ9HD67 baseline and differential
GenevisibleiQ9HD67 HS

Organism-specific databases

HPAiCAB015224
HPA024223

Interactioni

Subunit structurei

Monomer, when in an inactive confomation in the cytosol. Homodimer in its active, membrane-bound conformation; antiparallel coiled coil-mediated dimer formation. Interacts strongly with CALM3 and weakly with CALM, the CALM3 interaction is essential for function in filopodial extension and motility. Interacts with ECPAS. Interacts with NEO1. Interacts with ITGB1 and ITGB3. Interacts with VASP (By similarity). Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin; ITGB5 or DCC binding inhibits tubulin binding.By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110735, 20 interactors
DIPiDIP-46151N
IntActiQ9HD67, 23 interactors
MINTiQ9HD67
STRINGi9606.ENSP00000421280

Structurei

Secondary structure

12058
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HD67
SMRiQ9HD67
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HD67

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 739Myosin motorPROSITE-ProRule annotationAdd BLAST677
Domaini742 – 763IQ 1PROSITE-ProRule annotationAdd BLAST22
Domaini764 – 787IQ 2PROSITE-ProRule annotationAdd BLAST24
Domaini788 – 817IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini1212 – 1310PH 1PROSITE-ProRule annotationAdd BLAST99
Domaini1392 – 1497PH 2PROSITE-ProRule annotationAdd BLAST106
Domaini1547 – 1695MyTH4PROSITE-ProRule annotationAdd BLAST149
Domaini1700 – 2044FERMPROSITE-ProRule annotationAdd BLAST345

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni619 – 641Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni815 – 908SAHBy similarityAdd BLAST94
Regioni883 – 933Mediates antiparallel dimerization1 PublicationAdd BLAST51

Domaini

Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity).By similarity
Interacts with membranes containing phosphatidylinositol-3,4,5-trisphosphate via the PH domains.By similarity
IQ 3 domain mediates high-affinity calcium-dependent binding to CALM3/CLP.
The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric; however, in its distal part seems to form a semirigid helical structure which overlaps with a region shown to mediate antiparallel coiled coil-mediated dimerization.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000007044
HOVERGENiHBG052553
InParanoidiQ9HD67
KOiK12559
PhylomeDBiQ9HD67
TreeFamiTF316834

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd14873 MYSc_Myo10, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 5 hits
3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR031971 MYO10_CC
IPR001609 Myosin_head_motor_dom
IPR036124 MYSc_Myo10
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 3 hits
PF16735 MYO10_CC, 1 hit
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 1 hit
PF00169 PH, 2 hits
PF00788 RA, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF47031 SSF47031, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HD67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNFFTEGTR VWLRENGQHF PSTVNSCAEG IVVFRTDYGQ VFTYKQSTIT
60 70 80 90 100
HQKVTAMHPT NEEGVDDMAS LTELHGGSIM YNLFQRYKRN QIYTYIGSIL
110 120 130 140 150
ASVNPYQPIA GLYEPATMEQ YSRRHLGELP PHIFAIANEC YRCLWKRHDN
160 170 180 190 200
QCILISGESG AGKTESTKLI LKFLSVISQQ SLELSLKEKT SCVERAILES
210 220 230 240 250
SPIMEAFGNA KTVYNNNSSR FGKFVQLNIC QKGNIQGGRI VDYLLEKNRV
260 270 280 290 300
VRQNPGERNY HIFYALLAGL EHEEREEFYL STPENYHYLN QSGCVEDKTI
310 320 330 340 350
SDQESFREVI TAMDVMQFSK EEVREVSRLL AGILHLGNIE FITAGGAQVS
360 370 380 390 400
FKTALGRSAE LLGLDPTQLT DALTQRSMFL RGEEILTPLN VQQAVDSRDS
410 420 430 440 450
LAMALYACCF EWVIKKINSR IKGNEDFKSI GILDIFGFEN FEVNHFEQFN
460 470 480 490 500
INYANEKLQE YFNKHIFSLE QLEYSREGLV WEDIDWIDNG ECLDLIEKKL
510 520 530 540 550
GLLALINEES HFPQATDSTL LEKLHSQHAN NHFYVKPRVA VNNFGVKHYA
560 570 580 590 600
GEVQYDVRGI LEKNRDTFRD DLLNLLRESR FDFIYDLFEH VSSRNNQDTL
610 620 630 640 650
KCGSKHRRPT VSSQFKDSLH SLMATLSSSN PFFVRCIKPN MQKMPDQFDQ
660 670 680 690 700
AVVLNQLRYS GMLETVRIRK AGYAVRRPFQ DFYKRYKVLM RNLALPEDVR
710 720 730 740 750
GKCTSLLQLY DASNSEWQLG KTKVFLRESL EQKLEKRREE EVSHAAMVIR
760 770 780 790 800
AHVLGFLARK QYRKVLYCVV IIQKNYRAFL LRRRFLHLKK AAIVFQKQLR
810 820 830 840 850
GQIARRVYRQ LLAEKREQEE KKKQEEEEKK KREEEERERE RERREAELRA
860 870 880 890 900
QQEEETRKQQ ELEALQKSQK EAELTRELEK QKENKQVEEI LRLEKEIEDL
910 920 930 940 950
QRMKEQQELS LTEASLQKLQ ERRDQELRRL EEEACRAAQE FLESLNFDEI
960 970 980 990 1000
DECVRNIERS LSVGSEFSSE LAESACEEKP NFNFSQPYPE EEVDEGFEAD
1010 1020 1030 1040 1050
DDAFKDSPNP SEHGHSDQRT SGIRTSDDSS EEDPYMNDTV VPTSPSADST
1060 1070 1080 1090 1100
VLLAPSVQDS GSLHNSSSGE STYCMPQNAG DLPSPDGDYD YDQDDYEDGA
1110 1120 1130 1140 1150
ITSGSSVTFS NSYGSQWSPD YRCSVGTYNS SGAYRFSSEG AQSSFEDSEE
1160 1170 1180 1190 1200
DFDSRFDTDD ELSYRRDSVY SCVTLPYFHS FLYMKGGLMN SWKRRWCVLK
1210 1220 1230 1240 1250
DETFLWFRSK QEALKQGWLH KKGGGSSTLS RRNWKKRWFV LRQSKLMYFE
1260 1270 1280 1290 1300
NDSEEKLKGT VEVRTAKEII DNTTKENGID IIMADRTFHL IAESPEDASQ
1310 1320 1330 1340 1350
WFSVLSQVHA STDQEIQEMH DEQANPQNAV GTLDVGLIDS VCASDSPDRP
1360 1370 1380 1390 1400
NSFVIITANR VLHCNADTPE EMHHWITLLQ RSKGDTRVEG QEFIVRGWLH
1410 1420 1430 1440 1450
KEVKNSPKMS SLKLKKRWFV LTHNSLDYYK SSEKNALKLG TLVLNSLCSV
1460 1470 1480 1490 1500
VPPDEKIFKE TGYWNVTVYG RKHCYRLYTK LLNEATRWSS AIQNVTDTKA
1510 1520 1530 1540 1550
PIDTPTQQLI QDIKENCLNS DVVEQIYKRN PILRYTHHPL HSPLLPLPYG
1560 1570 1580 1590 1600
DINLNLLKDK GYTTLQDEAI KIFNSLQQLE SMSDPIPIIQ GILQTGHDLR
1610 1620 1630 1640 1650
PLRDELYCQL IKQTNKVPHP GSVGNLYSWQ ILTCLSCTFL PSRGILKYLK
1660 1670 1680 1690 1700
FHLKRIREQF PGSEMEKYAL FTYESLKKTK CREFVPSRDE IEALIHRQEM
1710 1720 1730 1740 1750
TSTVYCHGGG SCKITINSHT TAGEVVEKLI RGLAMEDSRN MFALFEYNGH
1760 1770 1780 1790 1800
VDKAIESRTV VADVLAKFEK LAATSEVGDL PWKFYFKLYC FLDTDNVPKD
1810 1820 1830 1840 1850
SVEFAFMFEQ AHEAVIHGHH PAPEENLQVL AALRLQYLQG DYTLHAAIPP
1860 1870 1880 1890 1900
LEEVYSLQRL KARISQSTKT FTPCERLEKR RTSFLEGTLR RSFRTGSVVR
1910 1920 1930 1940 1950
QKVEEEQMLD MWIKEEVSSA RASIIDKWRK FQGMNQEQAM AKYMALIKEW
1960 1970 1980 1990 2000
PGYGSTLFDV ECKEGGFPQE LWLGVSADAV SVYKRGEGRP LEVFQYEHIL
2010 2020 2030 2040 2050
SFGAPLANTY KIVVDERELL FETSEVVDVA KLMKAYISMI VKKRYSTTRS

ASSQGSSR
Length:2,058
Mass (Da):237,347
Last modified:September 2, 2008 - v3
Checksum:i269C9E6566BD6D0B
GO
Isoform 2 (identifier: Q9HD67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-97: TYIG → VQIG
     98-2058: Missing.

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,184
Checksum:iBA4CD8AFA3376564
GO
Isoform Headless (identifier: Q9HD67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:1,415
Mass (Da):163,554
Checksum:i23E2CD27439D8A7E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQX1A0A0A0MQX1_HUMAN
Unconventional myosin-X
MYO10
2,069Annotation score:
E9PEW5E9PEW5_HUMAN
Unconventional myosin-X
MYO10
1,397Annotation score:
E9PCN3E9PCN3_HUMAN
Unconventional myosin-X
MYO10
212Annotation score:
D6RGD1D6RGD1_HUMAN
Unconventional myosin-X
MYO10
830Annotation score:

Sequence cautioni

The sequence BAA34519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98S → P in AAF36524 (Ref. 3) Curated1
Sequence conflicti256G → W in AAF68025 (PubMed:10984435).Curated1
Sequence conflicti1186G → C in AAF36524 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04632832V → I. Corresponds to variant dbSNP:rs17707947Ensembl.1
Natural variantiVAR_061366148H → Y1 PublicationCorresponds to variant dbSNP:rs7737765Ensembl.1
Natural variantiVAR_046329273E → D. Corresponds to variant dbSNP:rs6870170Ensembl.1
Natural variantiVAR_046330324R → W2 PublicationsCorresponds to variant dbSNP:rs11750538Ensembl.1
Natural variantiVAR_046331700R → Q. Corresponds to variant dbSNP:rs26740Ensembl.1
Natural variantiVAR_0463321663S → T4 PublicationsCorresponds to variant dbSNP:rs25901Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0549751 – 643Missing in isoform Headless. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_05497694 – 97TYIG → VQIG in isoform 2. 1 Publication4
Alternative sequenceiVSP_05497798 – 2058Missing in isoform 2. 1 PublicationAdd BLAST1961

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247457 mRNA Translation: AAF68025.2
AF234532 mRNA Translation: AAF37875.1
AF132021 mRNA Translation: AAF36524.1
AF132022 mRNA Translation: AAF36525.1
AB018342 mRNA Translation: BAA34519.2 Different initiation.
AC010310 Genomic DNA No translation available.
AC010607 Genomic DNA No translation available.
AC024588 Genomic DNA No translation available.
BC041694 mRNA Translation: AAH41694.1
BC050682 mRNA Translation: AAH50682.1
BC108736 mRNA Translation: AAI08737.1
BC137168 mRNA Translation: AAI37169.1
BC150285 mRNA Translation: AAI50286.1
AI878891 mRNA No translation available.
AF184153 mRNA Translation: AAF17363.1
CCDSiCCDS54834.1 [Q9HD67-1]
PIRiA59267
RefSeqiNP_036466.2, NM_012334.2 [Q9HD67-1]
XP_005248364.1, XM_005248307.2 [Q9HD67-3]
XP_011512348.1, XM_011514046.2 [Q9HD67-3]
UniGeneiHs.481720

Genome annotation databases

EnsembliENST00000507288; ENSP00000426664; ENSG00000145555 [Q9HD67-2]
ENST00000513610; ENSP00000421280; ENSG00000145555 [Q9HD67-1]
GeneIDi4651
KEGGihsa:4651
UCSCiuc003jft.5 human [Q9HD67-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247457 mRNA Translation: AAF68025.2
AF234532 mRNA Translation: AAF37875.1
AF132021 mRNA Translation: AAF36524.1
AF132022 mRNA Translation: AAF36525.1
AB018342 mRNA Translation: BAA34519.2 Different initiation.
AC010310 Genomic DNA No translation available.
AC010607 Genomic DNA No translation available.
AC024588 Genomic DNA No translation available.
BC041694 mRNA Translation: AAH41694.1
BC050682 mRNA Translation: AAH50682.1
BC108736 mRNA Translation: AAI08737.1
BC137168 mRNA Translation: AAI37169.1
BC150285 mRNA Translation: AAI50286.1
AI878891 mRNA No translation available.
AF184153 mRNA Translation: AAF17363.1
CCDSiCCDS54834.1 [Q9HD67-1]
PIRiA59267
RefSeqiNP_036466.2, NM_012334.2 [Q9HD67-1]
XP_005248364.1, XM_005248307.2 [Q9HD67-3]
XP_011512348.1, XM_011514046.2 [Q9HD67-3]
UniGeneiHs.481720

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LW9NMR-A/B883-933[»]
3AU4X-ray1.90A1486-2058[»]
3AU5X-ray2.55A/B1486-2058[»]
3PZDX-ray2.50A1503-2047[»]
5I0HX-ray1.80A/B1-741[»]
5I0IX-ray3.15A/B3-793[»]
5KG8electron microscopy9.10A3-741[»]
ProteinModelPortaliQ9HD67
SMRiQ9HD67
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110735, 20 interactors
DIPiDIP-46151N
IntActiQ9HD67, 23 interactors
MINTiQ9HD67
STRINGi9606.ENSP00000421280

PTM databases

iPTMnetiQ9HD67
PhosphoSitePlusiQ9HD67

Polymorphism and mutation databases

BioMutaiMYO10
DMDMi205371854

Proteomic databases

EPDiQ9HD67
MaxQBiQ9HD67
PaxDbiQ9HD67
PeptideAtlasiQ9HD67
PRIDEiQ9HD67
ProteomicsDBi81840

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507288; ENSP00000426664; ENSG00000145555 [Q9HD67-2]
ENST00000513610; ENSP00000421280; ENSG00000145555 [Q9HD67-1]
GeneIDi4651
KEGGihsa:4651
UCSCiuc003jft.5 human [Q9HD67-1]

Organism-specific databases

CTDi4651
DisGeNETi4651
EuPathDBiHostDB:ENSG00000145555.14
GeneCardsiMYO10
H-InvDBiHIX0021772
HIX0164320
HGNCiHGNC:7593 MYO10
HPAiCAB015224
HPA024223
MIMi601481 gene
neXtProtiNX_Q9HD67
OpenTargetsiENSG00000145555
PharmGKBiPA31394
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000007044
HOVERGENiHBG052553
InParanoidiQ9HD67
KOiK12559
PhylomeDBiQ9HD67
TreeFamiTF316834

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-373752 Netrin-1 signaling

Miscellaneous databases

ChiTaRSiMYO10 human
EvolutionaryTraceiQ9HD67
GeneWikiiMYO10
GenomeRNAii4651
PROiPR:Q9HD67
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145555 Expressed in 228 organ(s), highest expression level in amygdala
CleanExiHS_MYO10
ExpressionAtlasiQ9HD67 baseline and differential
GenevisibleiQ9HD67 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd14873 MYSc_Myo10, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 5 hits
3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR031971 MYO10_CC
IPR001609 Myosin_head_motor_dom
IPR036124 MYSc_Myo10
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 3 hits
PF16735 MYO10_CC, 1 hit
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 1 hit
PF00169 PH, 2 hits
PF00788 RA, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF47031 SSF47031, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYO10_HUMAN
AccessioniPrimary (citable) accession number: Q9HD67
Secondary accession number(s): A7E2D1
, O94893, Q8IVX5, Q9NYM7, Q9P110, Q9P111, Q9UHF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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