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Protein

X antigen family member 1

Gene

XAGE1A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.

Caution

PubMed:17335148, examines the translation products of theses four XAGE1A transcripts, and finds that the XAGE-1c transcript is possibly translated to 9- and 17-aa polypeptides and not to a protein consisting of 160 amino acids as shown in PubMed:11992404.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 1
Short name:
XAGE-1
Alternative name(s):
Cancer/testis antigen 12.1
Short name:
CT12.1
G antigen family D member 2
Gene namesi
Name:XAGE1A
Synonyms:GAGED2, XAGE1
AND
Name:XAGE1B
AND
Name:XAGE1C
AND
Name:XAGE1D
AND
Name:XAGE1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000204379.10
HostDB:ENSG00000204382.11
HGNCiHGNC:4111 XAGE1A
HGNC:25400 XAGE1B
HGNC:30679 XAGE1C
HGNC:21508 XAGE1D
HGNC:18372 XAGE1E
MIMi300289 gene
300742 gene
300743 gene
300744 gene
300745 gene
neXtProtiNX_Q9HD64

Pathology & Biotechi

Organism-specific databases

DisGeNETi653067
653220
OpenTargetsiENSG00000204382
PharmGKBiPA28526

Polymorphism and mutation databases

DMDMi334302901

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483491 – 81X antigen family member 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei20PhosphoserineCombined sources1
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9HD64
PaxDbiQ9HD64
PeptideAtlasiQ9HD64
PRIDEiQ9HD64
ProteomicsDBi81838
81839 [Q9HD64-4]

PTM databases

iPTMnetiQ9HD64
PhosphoSitePlusiQ9HD64

Expressioni

Tissue specificityi

In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing's sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.2 Publications

Gene expression databases

BgeeiENSG00000204379 Expressed in 42 organ(s), highest expression level in testis
CleanExiHS_XAGE1D
GenevisibleiQ9HD64 HS

Organism-specific databases

HPAiHPA077164

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi575500, 6 interactors
575617, 38 interactors
IntActiQ9HD64, 8 interactors
STRINGi9606.ENSP00000364766

Structurei

3D structure databases

ProteinModelPortaliQ9HD64
SMRiQ9HD64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003361
InParanoidiQ9HD64
OMAiVICKSCV
OrthoDBiEOG091G0PP6
TreeFamiTF342350

Family and domain databases

InterProiView protein in InterPro
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: Q9HD64-2) [UniParc]FASTAAdd to basket
Also known as: XAGE-1a, XAGE-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESPKKKNQQ LKVGILHLGS RQKKIRIQLR SQCATWKVIC KSCISQTPGI
60 70 80
NLDLGSGVKV KIIPKEEHCK MPEAGEEQPQ V
Note: XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.
Length:81
Mass (Da):9,078
Last modified:May 31, 2011 - v3
Checksum:iC73337C4C94C01D1
GO
Isoform D (identifier: Q9HD64-4) [UniParc]FASTAAdd to basket
Also known as: XAGE-1d

The sequence of this isoform differs from the canonical sequence as follows:
     33-81: CATWKVICKS...PEAGEEQPQV → VLGREMRDME...GFRRQGEDNT

Show »
Length:69
Mass (Da):7,965
Checksum:i0480A160F893AF81
GO

Sequence cautioni

The sequence AAG01401 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH09538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC82986 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI41526 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41531 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41534 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00159633 – 81CATWK…EQPQV → VLGREMRDMEGDLQELHQSN TGDKSGFGFRRQGEDNT in isoform D. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251237 mRNA Translation: AAG01401.1 Different initiation.
AJ290447 mRNA Translation: CAC38107.1
AJ400997 Genomic DNA Translation: CAC38108.1
AJ318878 mRNA Translation: CAC82986.1 Different initiation.
AJ318879 mRNA Translation: CAC82987.1
BT007099 mRNA Translation: AAP35763.1
AL772246 Genomic DNA Translation: CAI41526.1 Sequence problems.
AL772246 Genomic DNA Translation: CAI41527.1
AL772246 Genomic DNA Translation: CAI41528.1
AL772246 Genomic DNA Translation: CAI41530.1
AL772246 Genomic DNA Translation: CAI41531.1 Sequence problems.
AL772246 Genomic DNA Translation: CAI41532.1
AL772246 Genomic DNA Translation: CAI41533.1
AL772246 Genomic DNA Translation: CAI41534.1 Sequence problems.
BX088602 Genomic DNA No translation available.
BC009538 mRNA Translation: AAH09538.2 Different initiation.
CCDSiCCDS48126.2 [Q9HD64-2]
CCDS48128.1 [Q9HD64-4]
CCDS75982.1 [Q9HD64-2]
CCDS75983.1 [Q9HD64-4]
RefSeqiNP_001091063.2, NM_001097594.2 [Q9HD64-2]
NP_001091065.1, NM_001097596.2 [Q9HD64-4]
NP_001091073.2, NM_001097604.2 [Q9HD64-2]
NP_001091074.1, NM_001097605.2 [Q9HD64-4]
XP_016885236.1, XM_017029747.1
XP_016885238.1, XM_017029749.1
UniGeneiHs.112208
Hs.546096
Hs.584511

Genome annotation databases

EnsembliENST00000375600; ENSP00000364750; ENSG00000204379 [Q9HD64-4]
ENST00000375602; ENSP00000364752; ENSG00000204379 [Q9HD64-2]
ENST00000375613; ENSP00000364763; ENSG00000204382 [Q9HD64-4]
ENST00000375616; ENSP00000364766; ENSG00000204382 [Q9HD64-2]
ENST00000518075; ENSP00000430130; ENSG00000204382 [Q9HD64-2]
GeneIDi653067
653220
KEGGihsa:653067
hsa:653220
UCSCiuc004dqf.4 human [Q9HD64-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251237 mRNA Translation: AAG01401.1 Different initiation.
AJ290447 mRNA Translation: CAC38107.1
AJ400997 Genomic DNA Translation: CAC38108.1
AJ318878 mRNA Translation: CAC82986.1 Different initiation.
AJ318879 mRNA Translation: CAC82987.1
BT007099 mRNA Translation: AAP35763.1
AL772246 Genomic DNA Translation: CAI41526.1 Sequence problems.
AL772246 Genomic DNA Translation: CAI41527.1
AL772246 Genomic DNA Translation: CAI41528.1
AL772246 Genomic DNA Translation: CAI41530.1
AL772246 Genomic DNA Translation: CAI41531.1 Sequence problems.
AL772246 Genomic DNA Translation: CAI41532.1
AL772246 Genomic DNA Translation: CAI41533.1
AL772246 Genomic DNA Translation: CAI41534.1 Sequence problems.
BX088602 Genomic DNA No translation available.
BC009538 mRNA Translation: AAH09538.2 Different initiation.
CCDSiCCDS48126.2 [Q9HD64-2]
CCDS48128.1 [Q9HD64-4]
CCDS75982.1 [Q9HD64-2]
CCDS75983.1 [Q9HD64-4]
RefSeqiNP_001091063.2, NM_001097594.2 [Q9HD64-2]
NP_001091065.1, NM_001097596.2 [Q9HD64-4]
NP_001091073.2, NM_001097604.2 [Q9HD64-2]
NP_001091074.1, NM_001097605.2 [Q9HD64-4]
XP_016885236.1, XM_017029747.1
XP_016885238.1, XM_017029749.1
UniGeneiHs.112208
Hs.546096
Hs.584511

3D structure databases

ProteinModelPortaliQ9HD64
SMRiQ9HD64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575500, 6 interactors
575617, 38 interactors
IntActiQ9HD64, 8 interactors
STRINGi9606.ENSP00000364766

PTM databases

iPTMnetiQ9HD64
PhosphoSitePlusiQ9HD64

Polymorphism and mutation databases

DMDMi334302901

Proteomic databases

EPDiQ9HD64
PaxDbiQ9HD64
PeptideAtlasiQ9HD64
PRIDEiQ9HD64
ProteomicsDBi81838
81839 [Q9HD64-4]

Protocols and materials databases

DNASUi9503
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375600; ENSP00000364750; ENSG00000204379 [Q9HD64-4]
ENST00000375602; ENSP00000364752; ENSG00000204379 [Q9HD64-2]
ENST00000375613; ENSP00000364763; ENSG00000204382 [Q9HD64-4]
ENST00000375616; ENSP00000364766; ENSG00000204382 [Q9HD64-2]
ENST00000518075; ENSP00000430130; ENSG00000204382 [Q9HD64-2]
GeneIDi653067
653220
KEGGihsa:653067
hsa:653220
UCSCiuc004dqf.4 human [Q9HD64-2]

Organism-specific databases

CTDi653067
653220
DisGeNETi653067
653220
EuPathDBiHostDB:ENSG00000204379.10
HostDB:ENSG00000204382.11
GeneCardsiXAGE1A
XAGE1B
XAGE1C
XAGE1D
XAGE1E
HGNCiHGNC:4111 XAGE1A
HGNC:25400 XAGE1B
HGNC:30679 XAGE1C
HGNC:21508 XAGE1D
HGNC:18372 XAGE1E
HPAiHPA077164
MIMi300289 gene
300742 gene
300743 gene
300744 gene
300745 gene
neXtProtiNX_Q9HD64
OpenTargetsiENSG00000204382
PharmGKBiPA28526
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000003361
InParanoidiQ9HD64
OMAiVICKSCV
OrthoDBiEOG091G0PP6
TreeFamiTF342350

Miscellaneous databases

PROiPR:Q9HD64
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204379 Expressed in 42 organ(s), highest expression level in testis
CleanExiHS_XAGE1D
GenevisibleiQ9HD64 HS

Family and domain databases

InterProiView protein in InterPro
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9HD64
Secondary accession number(s): A6NJ94
, Q5JPN8, Q5JPP0, Q5JPP3, Q8WWG5, Q8WWG6, Q969J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 31, 2011
Last modified: September 12, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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