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Entry version 126 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Ran guanine nucleotide release factor

Gene

RANGRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).5 Publications

Miscellaneous

Overexpression can rescue the trafficking defect caused by some SCN5A mutations that impair trafficking to the cell membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5576892 Phase 0 - rapid depolarisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ran guanine nucleotide release factor
Short name:
RanGNRF
Alternative name(s):
Ran-binding protein MOG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RANGRF
Synonyms:MOG1, RANGNRF
ORF Names:HSPC165, HSPC236, MDS5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000108961.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17679 RANGRF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607954 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HD47

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27D → K: Decreased binding to RAN. 1 Publication1
Mutagenesisi50E → K: Strongly decreased binding to RAN. Abolishes binding to RAN; when associated with K-53. 1 Publication1
Mutagenesisi53E → K: Decreased binding to RAN. Abolishes binding to RAN; when associated with K-50. 1 Publication1
Mutagenesisi70D → K: Decreased binding to RAN. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
29098

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
RANGRF

MalaCards human disease database

More...
MalaCardsi
RANGRF

Open Targets

More...
OpenTargetsi
ENSG00000108961

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
130 Brugada syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400661

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HD47 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RANGRF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74718913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003306361 – 186Ran guanine nucleotide release factorAdd BLAST186

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HD47

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HD47

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HD47

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HD47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HD47

PeptideAtlas

More...
PeptideAtlasi
Q9HD47

PRoteomics IDEntifications database

More...
PRIDEi
Q9HD47

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81833 [Q9HD47-1]
81834 [Q9HD47-2]
81835 [Q9HD47-3]
81836 [Q9HD47-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HD47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HD47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108961 Expressed in 212 organ(s), highest expression level in left testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HD47 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057280
HPA057888

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with RAN, both RAN-GTP and RAN-GDP (PubMed:11290418, PubMed:29040603). Competes with RCC1 for a common binding site on RAN and thereby inhibits RCC1-mediated nucleotide exchange (PubMed:29040603).

Forms a complex with RAN-GTP and RANBP1 (By similarity).

Interacts with the cytoplasmic loop 2 of SCN5A (PubMed:18184654).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118866, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HD47, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000226105

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HD47 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HD47

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 70Interaction with RAN1 PublicationAdd BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MOG1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3329 Eukaryota
ENOG4111I9Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013834

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HD47

Identification of Orthologs from Complete Genome Data

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OMAi
ITFNDPQ

Database of Orthologous Groups

More...
OrthoDBi
1013743at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HD47

TreeFam database of animal gene trees

More...
TreeFami
TF332074

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00224 Mog1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1000.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007681 Mog1
IPR016123 Mog1/PsbP_a/b/a-sand

The PANTHER Classification System

More...
PANTHERi
PTHR15837 PTHR15837, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04603 Mog1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55724 SSF55724, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HD47-1) [UniParc]FASTAAdd to basket
Also known as: MOG1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE
60 70 80 90 100
LLELQAHVRG EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ
110 120 130 140 150
EAWVLSGKQQ IAKENQQVAK DVTLHQALLR LPQYQTDLLL TFNQPPPDNR
160 170 180
SSLGPENLSP APWSLGDFEQ LVTSLTLHDP NIFGPQ
Length:186
Mass (Da):20,448
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE2C459C90459042
GO
Isoform 2 (identifier: Q9HD47-2) [UniParc]FASTAAdd to basket
Also known as: MOG1b

The sequence of this isoform differs from the canonical sequence as follows:
     147-186: Missing.

Show »
Length:146
Mass (Da):16,118
Checksum:i2EA661B68733EF9B
GO
Isoform 3 (identifier: Q9HD47-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-163: AKDVTLHQAL...GPENLSPAPW → RARECVMSWK...GLAEAAPVPD
     164-186: Missing.

Show »
Length:165
Mass (Da):17,711
Checksum:iE69ECDD84D5B4011
GO
Isoform 4 (identifier: Q9HD47-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-118: V → P
     119-186: Missing.

Show »
Length:118
Mass (Da):12,900
Checksum:i464DE437624F7A9B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29129 differs from that shown. Reason: Frameshift.Curated
The sequence AAF87316 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94 – 96ALR → PE in AAF36156 (PubMed:11042152).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08007961 – 186Missing Found in patients with cardiac arrhythmia and in patients with Brugada syndrome; loss of function in enhancing the expression of SCN5A at the cell membrane; unknown pathological significance. 2 PublicationsAdd BLAST126
Natural variantiVAR_08008083E → D Found in patients with Brugada syndrome; loss of function in enhancing the expression of SCN5A at the cell membrane; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs751751942EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033057118V → P in isoform 4. 1 Publication1
Alternative sequenceiVSP_033058119 – 186Missing in isoform 4. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_033059119 – 163AKDVT…SPAPW → RARECVMSWKGGSGDAEIQV SILTLIPLGSKGRDTSSGLA EAAPVPD in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_033060147 – 186Missing in isoform 2. 4 PublicationsAdd BLAST40
Alternative sequenceiVSP_033061164 – 186Missing in isoform 3. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF265205 mRNA Translation: AAG01291.1
AF265206 mRNA Translation: AAG01292.1
AF168714 mRNA Translation: AAF87316.1 Frameshift.
AF151070 mRNA Translation: AAF36156.1
AF161514 mRNA Translation: AAF29129.1 Frameshift.
AK290399 mRNA Translation: BAF83088.1
CR457206 mRNA Translation: CAG33487.1
CR749387 mRNA Translation: CAH18237.1
CH471108 Genomic DNA Translation: EAW90064.1
CH471108 Genomic DNA Translation: EAW90065.1
CH471108 Genomic DNA Translation: EAW90066.1
BC006486 mRNA Translation: AAH06486.1
BC012552 mRNA Translation: AAH12552.1
BC100017 mRNA Translation: AAI00018.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11137.1 [Q9HD47-1]
CCDS54086.1 [Q9HD47-2]
CCDS54087.1 [Q9HD47-3]
CCDS82066.1 [Q9HD47-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001171272.1, NM_001177801.1 [Q9HD47-2]
NP_001171273.1, NM_001177802.1 [Q9HD47-3]
NP_001317056.1, NM_001330127.1 [Q9HD47-4]
NP_057576.2, NM_016492.4 [Q9HD47-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000226105; ENSP00000226105; ENSG00000108961 [Q9HD47-1]
ENST00000407006; ENSP00000383940; ENSG00000108961 [Q9HD47-2]
ENST00000439238; ENSP00000413190; ENSG00000108961 [Q9HD47-3]
ENST00000580434; ENSP00000462310; ENSG00000108961 [Q9HD47-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29098

UCSC genome browser

More...
UCSCi
uc002gkv.4 human [Q9HD47-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265205 mRNA Translation: AAG01291.1
AF265206 mRNA Translation: AAG01292.1
AF168714 mRNA Translation: AAF87316.1 Frameshift.
AF151070 mRNA Translation: AAF36156.1
AF161514 mRNA Translation: AAF29129.1 Frameshift.
AK290399 mRNA Translation: BAF83088.1
CR457206 mRNA Translation: CAG33487.1
CR749387 mRNA Translation: CAH18237.1
CH471108 Genomic DNA Translation: EAW90064.1
CH471108 Genomic DNA Translation: EAW90065.1
CH471108 Genomic DNA Translation: EAW90066.1
BC006486 mRNA Translation: AAH06486.1
BC012552 mRNA Translation: AAH12552.1
BC100017 mRNA Translation: AAI00018.1
CCDSiCCDS11137.1 [Q9HD47-1]
CCDS54086.1 [Q9HD47-2]
CCDS54087.1 [Q9HD47-3]
CCDS82066.1 [Q9HD47-4]
RefSeqiNP_001171272.1, NM_001177801.1 [Q9HD47-2]
NP_001171273.1, NM_001177802.1 [Q9HD47-3]
NP_001317056.1, NM_001330127.1 [Q9HD47-4]
NP_057576.2, NM_016492.4 [Q9HD47-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YFGNMR-A1-186[»]
SMRiQ9HD47
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi118866, 28 interactors
IntActiQ9HD47, 14 interactors
STRINGi9606.ENSP00000226105

PTM databases

iPTMnetiQ9HD47
PhosphoSitePlusiQ9HD47

Polymorphism and mutation databases

BioMutaiRANGRF
DMDMi74718913

Proteomic databases

EPDiQ9HD47
jPOSTiQ9HD47
MassIVEiQ9HD47
MaxQBiQ9HD47
PaxDbiQ9HD47
PeptideAtlasiQ9HD47
PRIDEiQ9HD47
ProteomicsDBi81833 [Q9HD47-1]
81834 [Q9HD47-2]
81835 [Q9HD47-3]
81836 [Q9HD47-4]

Genome annotation databases

EnsembliENST00000226105; ENSP00000226105; ENSG00000108961 [Q9HD47-1]
ENST00000407006; ENSP00000383940; ENSG00000108961 [Q9HD47-2]
ENST00000439238; ENSP00000413190; ENSG00000108961 [Q9HD47-3]
ENST00000580434; ENSP00000462310; ENSG00000108961 [Q9HD47-4]
GeneIDi29098
KEGGihsa:29098
UCSCiuc002gkv.4 human [Q9HD47-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29098
DisGeNETi29098
EuPathDBiHostDB:ENSG00000108961.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RANGRF
GeneReviewsiRANGRF
HGNCiHGNC:17679 RANGRF
HPAiHPA057280
HPA057888
MalaCardsiRANGRF
MIMi607954 gene
neXtProtiNX_Q9HD47
OpenTargetsiENSG00000108961
Orphaneti130 Brugada syndrome
PharmGKBiPA162400661

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3329 Eukaryota
ENOG4111I9Z LUCA
GeneTreeiENSGT00390000013834
InParanoidiQ9HD47
OMAiITFNDPQ
OrthoDBi1013743at2759
PhylomeDBiQ9HD47
TreeFamiTF332074

Enzyme and pathway databases

ReactomeiR-HSA-5576892 Phase 0 - rapid depolarisation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29098
PharosiQ9HD47 Tbio

Protein Ontology

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PROi
PR:Q9HD47
RNActiQ9HD47 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000108961 Expressed in 212 organ(s), highest expression level in left testis
GenevisibleiQ9HD47 HS

Family and domain databases

CDDicd00224 Mog1, 1 hit
Gene3Di3.40.1000.10, 1 hit
InterProiView protein in InterPro
IPR007681 Mog1
IPR016123 Mog1/PsbP_a/b/a-sand
PANTHERiPTHR15837 PTHR15837, 1 hit
PfamiView protein in Pfam
PF04603 Mog1, 1 hit
SUPFAMiSSF55724 SSF55724, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HD47
Secondary accession number(s): D3DTR6
, Q68DI3, Q9BR68, Q9HD48, Q9NRU9, Q9P001, Q9P0P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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