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Protein

Receptor-type tyrosine-protein phosphatase H

Gene

PTPRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity).By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Regulated by reversible dimerization. Dimerization reduces its catalytic activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1020Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processApoptosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9HD43

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase H (EC:3.1.3.48)
Short name:
R-PTP-H
Alternative name(s):
Stomach cancer-associated protein tyrosine phosphatase 1
Short name:
SAP-1
Transmembrane-type protein-tyrosine phosphatase type H
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRH
Synonyms:SAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000080031.9

Human Gene Nomenclature Database

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HGNCi
HGNC:9672 PTPRH

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602510 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HD43

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 754ExtracellularSequence analysisAdd BLAST727
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei755 – 775HelicalSequence analysisAdd BLAST21
Topological domaini776 – 1115CytoplasmicSequence analysisAdd BLAST340

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi986D → A: Loss of activity. Acts as a dominant negative mutant. 1 Publication1
Mutagenesisi1020C → S: Loss of activity. No induction of apoptosis. 2 Publications1

Organism-specific databases

DisGeNET

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DisGeNETi
5794

Open Targets

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OpenTargetsi
ENSG00000080031

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34017

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PTPRH

Domain mapping of disease mutations (DMDM)

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DMDMi
296452983

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031895028 – 1115Receptor-type tyrosine-protein phosphatase HAdd BLAST1088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi556N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi642N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1094PhosphotyrosineBy similarity1
Modified residuei1102PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HD43

PeptideAtlas

More...
PeptideAtlasi
Q9HD43

PRoteomics IDEntifications database

More...
PRIDEi
Q9HD43

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81830
81831 [Q9HD43-2]

PTM databases

DEPOD human dephosphorylation database

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DEPODi
Q9HD43

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9HD43

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HD43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differentiation status of the tumor and expression is inversely related to tumor aggressiveness.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced at the early stage of hepatocellular carcinoma and is suppressed at later stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000080031 Expressed in 146 organ(s), highest expression level in duodenum

CleanEx database of gene expression profiles

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CleanExi
HS_PTPRH

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HD43 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA042300

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (Probable). Interacts with LCK (PubMed:12837766). Interacts (phosphorylated form) with GRB2 (via SH2 domain) (By similarity). Interacts (phosphorylated form) with FYN (via SH2 domain) (By similarity). Interacts (via extracellular domain) with CEACAM20 (via extracellular domain); the interaction dephosphorylates CEACAM20 (By similarity).By similarity1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9HD43, 12 interactors

Molecular INTeraction database

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MINTi
Q9HD43

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365528

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9HD43

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HD43

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 121Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST90
Domaini122 – 209Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST88
Domaini210 – 299Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini300 – 387Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST88
Domaini388 – 477Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini478 – 563Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST86
Domaini564 – 666Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST103
Domaini665 – 749Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST85
Domaini820 – 1079Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST260

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular domain mediates homodimerization. One or more cysteines in the extracellular domain is essential for the formation of dimers probably by forming a disulfide bond.
The cytoplasmic domain mediates the interaction with LCK.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0791 Eukaryota
COG5599 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162227

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000170539

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108307

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HD43

KEGG Orthology (KO)

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KOi
K18034

Identification of Orthologs from Complete Genome Data

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OMAi
QNLTYWV

Database of Orthologous Groups

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OrthoDBi
EOG091G08FR

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9HD43

TreeFam database of animal gene trees

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TreeFami
TF351926

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 7 hits
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR028855 R-PTP-H
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

The PANTHER Classification System

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PANTHERi
PTHR19134:SF297 PTHR19134:SF297, 5 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 6 hits
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 7 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49265 SSF49265, 4 hits
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 7 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HD43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAGGGLGV WGNLVLLGLC SWTGARAPAP NPGRNLTVET QTTSSISLSW
60 70 80 90 100
EVPDGLDSQN SNYWVQCTGD GGTTETRNTT ATNVTVDGLG PGSLYTCSVW
110 120 130 140 150
VEKDGVNSSV GTVTTATAPN PVRNLRVEAQ TNSSIALTWE VPDGPDPQNS
160 170 180 190 200
TYGVEYTGDG GRAGTRSTAH TNITVDGLEP GCLYAFSMWV GKNGINSSRE
210 220 230 240 250
TRNATTAHNP VRNLRVEAQT TSSISLSWEV PDGTDPQNST YCVQCTGDGG
260 270 280 290 300
RTETRNTTDT RVTVDGLGPG SLYTCSVWVE KDGVNSSVEI VTSATAPNPV
310 320 330 340 350
RNLTVEAQTN SSIALTWEVP DGPDPQNSTY GVEYTGDGGR AGTRSTAHTN
360 370 380 390 400
ITVDRLEPGC LYVFSVWVGK NGINSSRETR NATTAPNPVR NLHMETQTNS
410 420 430 440 450
SIALCWEVPD GPYPQDYTYW VEYTGDGGGT ETRNTTNTSV TAERLEPGTL
460 470 480 490 500
YTFSVWAEKN GARGSRQNVS ISTVPNAVTS LSKQDWTNST IALRWTAPQG
510 520 530 540 550
PGQSSYSYWV SWVREGMTDP RTQSTSGTDI TLKELEAGSL YHLTVWAERN
560 570 580 590 600
EVRGYNSTLT AATAPNEVTD LQNETQTKNS VMLWWKAPGD PHSQLYVYWV
610 620 630 640 650
QWASKGHPRR GQDPQANWVN QTSRTNETWY KVEALEPGTL YNFTVWAERN
660 670 680 690 700
DVASSTQSLC ASTYPDTVTI TSCVSTSAGY GVNLIWSCPQ GGYEAFELEV
710 720 730 740 750
GGQRGSQDRS SCGEAVSVLG LGPARSYPAT ITTIWDGMKV VSHSVVCHTE
760 770 780 790 800
SAGVIAGAFV GILLFLILVG LLIFFLKRRN KKKQQKPELR DLVFSSPGDI
810 820 830 840 850
PAEDFADHVR KNERDSNCGF ADEYQQLSLV GHSQSQMVAS ASENNAKNRY
860 870 880 890 900
RNVLPYDWSR VPLKPIHEEP GSDYINASFM PGLWSPQEFI ATQGPLPQTV
910 920 930 940 950
GDFWRLVWEQ QSHTLVMLTN CMEAGRVKCE HYWPLDSQPC THGHLRVTLV
960 970 980 990 1000
GEEVMENWTV RELLLLQVEE QKTLSVRQFH YQAWPDHGVP SSPDTLLAFW
1010 1020 1030 1040 1050
RMLRQWLDQT MEGGPPIVHC SAGVGRTGTL IALDVLLRQL QSEGLLGPFS
1060 1070 1080 1090 1100
FVRKMRESRP LMVQTEAQYV FLHQCILRFL QQSAQAPAEK EVPYEDVENL
1110
IYENVAAIQA HKLEV
Length:1,115
Mass (Da):122,353
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E6C1DF86DCFB26C
GO
Isoform 2 (identifier: Q9HD43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-261: Missing.

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Length:937
Mass (Da):103,483
Checksum:iB79A28C8FA00CED5
GO
Isoform 3 (identifier: Q9HD43-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-303: Missing.

Show »
Length:937
Mass (Da):103,413
Checksum:i4D89583E2CA5B866
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA03645 differs from that shown. Reason: Frameshift at positions 213, 244, 264, 287 and 291.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti294A → T in BAA03645 (PubMed:8294459).Curated1
Sequence conflicti422E → G in BAA03645 (PubMed:8294459).Curated1
Sequence conflicti951G → D in AAI11716 (PubMed:15489334).Curated1
Sequence conflicti1109Q → K in AAI11716 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061762232D → N. Corresponds to variant dbSNP:rs55870162Ensembl.1
Natural variantiVAR_061763243V → I. Corresponds to variant dbSNP:rs45535035Ensembl.1
Natural variantiVAR_038918348H → Y1 PublicationCorresponds to variant dbSNP:rs2288515Ensembl.1
Natural variantiVAR_038919543L → F. Corresponds to variant dbSNP:rs16986309Ensembl.1
Natural variantiVAR_038920781K → N. Corresponds to variant dbSNP:rs2288523Ensembl.1
Natural variantiVAR_038921823E → K1 PublicationCorresponds to variant dbSNP:rs890870Ensembl.1
Natural variantiVAR_061764831G → D. Corresponds to variant dbSNP:rs36092369Ensembl.1
Natural variantiVAR_0389221076I → V. Corresponds to variant dbSNP:rs2288419Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03131884 – 261Missing in isoform 2. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_054222126 – 303Missing in isoform 3. CuratedAdd BLAST178

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D15049 mRNA Translation: BAA03645.2 Frameshift.
AF275150
, AF275131, AF275132, AF275133, AF275134, AF275135, AF275136, AF275137, AF275138, AF275139, AF275140, AF275141, AF275142, AF275143, AF275144, AF275145, AF275146, AF275147, AF275148, AF275149 Genomic DNA Translation: AAF91411.1
AC010327 Genomic DNA No translation available.
BC111715 mRNA Translation: AAI11716.1
BC111716 mRNA Translation: AAI11717.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33110.1 [Q9HD43-1]
CCDS54321.1 [Q9HD43-3]

Protein sequence database of the Protein Information Resource

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PIRi
A49724

NCBI Reference Sequences

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RefSeqi
NP_001154912.2, NM_001161440.2 [Q9HD43-3]
NP_002833.4, NM_002842.4 [Q9HD43-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.179770

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000263434; ENSP00000263434; ENSG00000080031 [Q9HD43-3]
ENST00000376350; ENSP00000365528; ENSG00000080031 [Q9HD43-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5794

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5794

UCSC genome browser

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UCSCi
uc002qjq.4 human [Q9HD43-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15049 mRNA Translation: BAA03645.2 Frameshift.
AF275150
, AF275131, AF275132, AF275133, AF275134, AF275135, AF275136, AF275137, AF275138, AF275139, AF275140, AF275141, AF275142, AF275143, AF275144, AF275145, AF275146, AF275147, AF275148, AF275149 Genomic DNA Translation: AAF91411.1
AC010327 Genomic DNA No translation available.
BC111715 mRNA Translation: AAI11716.1
BC111716 mRNA Translation: AAI11717.1
CCDSiCCDS33110.1 [Q9HD43-1]
CCDS54321.1 [Q9HD43-3]
PIRiA49724
RefSeqiNP_001154912.2, NM_001161440.2 [Q9HD43-3]
NP_002833.4, NM_002842.4 [Q9HD43-1]
UniGeneiHs.179770

3D structure databases

ProteinModelPortaliQ9HD43
SMRiQ9HD43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HD43, 12 interactors
MINTiQ9HD43
STRINGi9606.ENSP00000365528

PTM databases

DEPODiQ9HD43
iPTMnetiQ9HD43
PhosphoSitePlusiQ9HD43

Polymorphism and mutation databases

BioMutaiPTPRH
DMDMi296452983

Proteomic databases

PaxDbiQ9HD43
PeptideAtlasiQ9HD43
PRIDEiQ9HD43
ProteomicsDBi81830
81831 [Q9HD43-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263434; ENSP00000263434; ENSG00000080031 [Q9HD43-3]
ENST00000376350; ENSP00000365528; ENSG00000080031 [Q9HD43-1]
GeneIDi5794
KEGGihsa:5794
UCSCiuc002qjq.4 human [Q9HD43-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5794
DisGeNETi5794
EuPathDBiHostDB:ENSG00000080031.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPRH
HGNCiHGNC:9672 PTPRH
HPAiHPA042300
MIMi602510 gene
neXtProtiNX_Q9HD43
OpenTargetsiENSG00000080031
PharmGKBiPA34017

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000162227
HOGENOMiHOG000170539
HOVERGENiHBG108307
InParanoidiQ9HD43
KOiK18034
OMAiQNLTYWV
OrthoDBiEOG091G08FR
PhylomeDBiQ9HD43
TreeFamiTF351926

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
SIGNORiQ9HD43

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9HD43

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000080031 Expressed in 146 organ(s), highest expression level in duodenum
CleanExiHS_PTPRH
GenevisibleiQ9HD43 HS

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.60.40.10, 7 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR028855 R-PTP-H
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR19134:SF297 PTHR19134:SF297, 5 hits
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 7 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 4 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 7 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HD43
Secondary accession number(s): C9JCH2
, Q15426, Q2NKN9, Q2NKP0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 147 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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