CHMP1A

Functionⁱ

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.4 Publications

Caution

Was originally (PubMed:8863740) thought to be a metalloprotease (PRSM1). This was based on a wrong translation of the ORF which gave rise to a putative protein of 318 AA containing a pattern reminiscent of zinc metalloproteases.1 Publication

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16730941
metallopeptidase activity
Source: ProtInc
Traceable author statementⁱ
- 8863740
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17928862
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 14505570
- 14519844
zinc ion binding
Source: ProtInc
Traceable author statementⁱ
- 8863740

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19129479
endosome transport via multivesicular body sorting pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ESCRT III complex disassembly
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
gene silencing
Source: UniProtKB
Inferred from direct assayⁱ
- 11559747
late endosome to vacuole transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
midbody abscission
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
mitotic chromosome condensation
Source: UniProtKB
Inferred from direct assayⁱ
- 11559747
mitotic metaphase plate congression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
multivesicular body assembly
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
negative regulation of cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11559747
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 11559747
nucleus organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of centrosome duplication
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
regulation of mitotic spindle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
septum digestion after cytokinesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle-mediated transport
Source: UniProtKB
Inferred from direct assayⁱ
- 11559748
viral budding via host ESCRT complex
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Cell cycle, Cell division, Protein transport, Transcription, Transcription regulation, Transport

Protein family/group databases

MoonDBⁱ	Q9HD42 Curated

MoonDBⁱ

Q9HD42 Curated

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Charged multivesicular body protein 1a Alternative name(s): Chromatin-modifying protein 1a Short name: CHMP1a Vacuolar protein sorting-associated protein 46-1 Short name: Vps46-1 Short name: hVps46-1
Gene namesⁱ	Name:CHMP1A Synonyms:CHMP11 Publication, KIAA00471 Publication, PCOLN3, PRSM11 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131165.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8740 CHMP1A
MIMⁱ	164010 gene
neXtProtⁱ	NX_Q9HD42

Keywords - Cellular componentⁱ

Cytoplasm, Endosome, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Pontocerebellar hypoplasia 8 (PCH8)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by severe psychomotor retardation, abnormal movements, hypotonia, spasticity, and variable visual defects. Brain MRI shows pontocerebellar hypoplasia, decreased cerebral white matter, and a thin corpus callosum.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	191	L → A: No effect on interaction with IST1; when associated with L-194. 1 Publication		1
Mutagenesisⁱ	194	L → A: No effect on interaction with IST1; when associated with L-194. 1 Publication		1

Keywords - Diseaseⁱ

Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5119
MalaCards human disease database More...MalaCardsⁱ	CHMP1A
MIMⁱ	614961 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000131165
Orphanetⁱ	324569 Pontocerebellar hypoplasia type 8
PharmGKBⁱ	PA33085

Polymorphism and mutation databases

DMDMⁱ	62510514

DMDMⁱ

62510514

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211448	1 – 196	Charged multivesicular body protein 1aAdd BLAST		196

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	101	PhosphoserineCombined sources	1
Modified residueⁱ	173	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9HD42
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HD42
PaxDbⁱ	Q9HD42
PeptideAtlas More...PeptideAtlasⁱ	Q9HD42
PRIDEⁱ	Q9HD42
ProteomicsDBⁱ	81828 81829 [Q9HD42-2]

PTM databases

iPTMnetⁱ	Q9HD42
PhosphoSitePlusⁱ	Q9HD42

Expressionⁱ

Tissue specificityⁱ

Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.1 Publication

Inductionⁱ

By muristerone.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131165 Expressed in 227 organ(s), highest expression level in right testis
CleanExⁱ	HS_CHMP1A
ExpressionAtlasⁱ	Q9HD42 baseline and differential
Genevisibleⁱ	Q9HD42 HS

Interactionⁱ

Subunit structureⁱ

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Interacts with MITD1.7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		5	EBI-1057156,EBI-1057156
MITD1	Q8WV92	4	EBI-1057156,EBI-2691489
STAMBP	O95630	6	EBI-1057156,EBI-396676
USP8	P40818	3	EBI-1057156,EBI-1050865
VPS4A	Q9UN37	6	EBI-1057156,EBI-1171942

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111148, 49 interactors
ComplexPortalⁱ	CPX-329 ESCRT-III complex
CORUMⁱ	Q9HD42
Database of interacting proteins More...DIPⁱ	DIP-50647N
IntActⁱ	Q9HD42, 36 interactors
Molecular INTeraction database More...MINTⁱ	Q9HD42
STRINGⁱ	9606.ENSP00000380998

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	184 – 195	Combined sources		12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9HD42
SMRⁱ	Q9HD42
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9HD42

EvolutionaryTraceⁱ

Q9HD42

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	5 – 47	Sequence analysisAdd BLAST		43
Coiled coilⁱ	102 – 124	Sequence analysisAdd BLAST		23

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	185 – 195	MIT-interacting motifAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the SNF7 family.Sequence analysis

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3232 Eukaryota COG5491 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074957
HOGENOMⁱ	HOG000241980
HOVERGENⁱ	HBG080200
InParanoidⁱ	Q9HD42
KEGG Orthology (KO) More...KOⁱ	K12197
OMAⁱ	KFASKQM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0S04
PhylomeDBⁱ	Q9HD42
TreeFamⁱ	TF300076

Family and domain databases

InterProⁱ	View protein in InterPro IPR029888 CHMP1A IPR005024 Snf7_fam
PANTHERⁱ	PTHR10476:SF17 PTHR10476:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03357 Snf7, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 Publication (identifier: Q9HD42-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDTLFQLKF TAKQLEKLAK KAEKDSKAEQ AKVKKALLQK NVECARVYAE 
        60         70         80         90        100
NAIRKKNEGV NWLRMASRVD AVASKVQTAV TMKGVTKNMA QVTKALDKAL 
       110        120        130        140        150
STMDLQKVSS VMDRFEQQVQ NLDVHTSVME DSMSSATTLT TPQEQVDSLI 
       160        170        180        190 
MQIAEENGLE VLDQLSQLPE GASAVGESSV RSQEDQLSRR LAALRN

Length:196

Mass (Da):21,703

Last modified:March 1, 2001 - v1

Checksum:ⁱ85D0ED7D10828D60

GO

Isoform 2Curated (identifier: Q9HD42-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-128: Missing.

« Hide

        10         20         30         40         50
MEDSMSSATT LTTPQEQVDS LIMQIAEENG LEVLDQLSQL PEGASAVGES 
        60 
SVRSQEDQLS RRLAALRN

Note: No experimental confirmation available.Curated

Show »

Length:68

Mass (Da):7,363

Checksum:ⁱF58834B1C0E254DB

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VUA2	F8VUA2_HUMAN	Charged multivesicular body protein... Charged multivesicular body protein 1a	CHMP1A	181	Annotation score:
F8VVT7	F8VVT7_HUMAN	Charged multivesicular body protein... Charged multivesicular body protein 1a	CHMP1A	187	Annotation score:
F5H875	F5H875_HUMAN	Charged multivesicular body protein... Charged multivesicular body protein 1a	CHMP1A	132	Annotation score:

Sequence cautionⁱ

The sequence AAC50775 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

The sequence BAA07557 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	77	Q → D in AAC50775 (PubMed:8863740).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_051716	1 – 128	Missing in isoform 2. 1 PublicationAdd BLAST		128

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58048 mRNA Translation: AAC50775.1 Sequence problems. AF281063 mRNA Translation: AAG01448.1 D38554 mRNA Translation: BAA07557.1 Sequence problems. BT006841 mRNA Translation: AAP35487.1 AC010538 Genomic DNA No translation available. BC007527 mRNA No translation available. BC010000 mRNA Translation: AAH10000.2 BC132711 mRNA Translation: AAI32712.1 BC132713 mRNA Translation: AAI32714.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45552.1 [Q9HD42-1]
PIRⁱ	JC4963
NCBI Reference Sequences More...RefSeqⁱ	NP_002759.2, NM_002768.4 [Q9HD42-1]
UniGeneⁱ	Hs.589427

Genome annotation databases

Ensemblⁱ	ENST00000397901; ENSP00000380998; ENSG00000131165 [Q9HD42-1]
GeneIDⁱ	5119
KEGGⁱ	hsa:5119
UCSC genome browser More...UCSCⁱ	uc002fnu.5 human [Q9HD42-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HD42	Charged multivesicular body protein 1a		PONAB		196	UniRef100_Q9HD42
CHMP1A isoform 1		PANTR		196
Uncharacterized protein		PANPA		196
CHMP1A isoform 1		PONAB		196

Protein	Similar proteins		Species	Score	Length	Source
Q9HD42	Charged multivesicular body protein 1a		PONAB		196	UniRef90_Q9HD42
Charged multivesicular body protein 1a		XENLA		196
CHMP1A isoform 1		PANTR		196
Uncharacterized protein		PANPA		196
Charged multivesicular body protein 1a		MYOBR		240
+26
Q9HD42-2	Charged multivesicular body protein 1a		HUMAN		132	UniRef90_Q9HD42-2
Uncharacterized protein		PAPAN		202
CHMP1A isoform 4		PONAB		132
CHMP1A isoform 4		PANTR		132
UPI00032B05D1		OCHPR		251
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9HD42	Charged multivesicular body protein 1a		PONAB		196	UniRef50_Q9HD42
Charged multivesicular body protein 1a		XENLA		196
Charged multivesicular body protein 1a		MOUSE		196
CHMP1A isoform 1		PANTR		196
Uncharacterized protein		PANPA		196
+187

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58048 mRNA Translation: AAC50775.1 Sequence problems. AF281063 mRNA Translation: AAG01448.1 D38554 mRNA Translation: BAA07557.1 Sequence problems. BT006841 mRNA Translation: AAP35487.1 AC010538 Genomic DNA No translation available. BC007527 mRNA No translation available. BC010000 mRNA Translation: AAH10000.2 BC132711 mRNA Translation: AAI32712.1 BC132713 mRNA Translation: AAI32714.1
CCDSⁱ	CCDS45552.1 [Q9HD42-1]
PIRⁱ	JC4963
RefSeqⁱ	NP_002759.2, NM_002768.4 [Q9HD42-1]
UniGeneⁱ	Hs.589427

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JQ9	NMR	-	B	180-196	[»]
	2YMB	X-ray	3.40	F/H	184-196	[»]
	4A5X	X-ray	1.91	C/D	184-196	[»]
ProteinModelPortalⁱ	Q9HD42
SMRⁱ	Q9HD42
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111148, 49 interactors
ComplexPortalⁱ	CPX-329 ESCRT-III complex
CORUMⁱ	Q9HD42
DIPⁱ	DIP-50647N
IntActⁱ	Q9HD42, 36 interactors
MINTⁱ	Q9HD42
STRINGⁱ	9606.ENSP00000380998

Protein family/group databases

MoonDBⁱ	Q9HD42 Curated

MoonDBⁱ

Q9HD42 Curated

PTM databases

iPTMnetⁱ	Q9HD42
PhosphoSitePlusⁱ	Q9HD42

Polymorphism and mutation databases

DMDMⁱ	62510514

DMDMⁱ

62510514

Proteomic databases

EPDⁱ	Q9HD42
MaxQBⁱ	Q9HD42
PaxDbⁱ	Q9HD42
PeptideAtlasⁱ	Q9HD42
PRIDEⁱ	Q9HD42
ProteomicsDBⁱ	81828 81829 [Q9HD42-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5119
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000397901; ENSP00000380998; ENSG00000131165 [Q9HD42-1]
GeneIDⁱ	5119
KEGGⁱ	hsa:5119
UCSCⁱ	uc002fnu.5 human [Q9HD42-1]

Organism-specific databases

CTDⁱ	5119
DisGeNETⁱ	5119
EuPathDBⁱ	HostDB:ENSG00000131165.14
GeneCardsⁱ	CHMP1A
H-InvDBⁱ	HIX0013363
HGNCⁱ	HGNC:8740 CHMP1A
MalaCardsⁱ	CHMP1A
MIMⁱ	164010 gene 614961 phenotype
neXtProtⁱ	NX_Q9HD42
OpenTargetsⁱ	ENSG00000131165
Orphanetⁱ	324569 Pontocerebellar hypoplasia type 8
PharmGKBⁱ	PA33085
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3232 Eukaryota COG5491 LUCA
GeneTreeⁱ	ENSGT00550000074957
HOGENOMⁱ	HOG000241980
HOVERGENⁱ	HBG080200
InParanoidⁱ	Q9HD42
KOⁱ	K12197
OMAⁱ	KFASKQM
OrthoDBⁱ	EOG091G0S04
PhylomeDBⁱ	Q9HD42
TreeFamⁱ	TF300076

Miscellaneous databases

ChiTaRSⁱ	CHMP1A human
EvolutionaryTraceⁱ	Q9HD42
GeneWikiⁱ	CHMP1A
GenomeRNAiⁱ	5119
Protein Ontology More...PROⁱ	PR:Q9HD42
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131165 Expressed in 227 organ(s), highest expression level in right testis
CleanExⁱ	HS_CHMP1A
ExpressionAtlasⁱ	Q9HD42 baseline and differential
Genevisibleⁱ	Q9HD42 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029888 CHMP1A IPR005024 Snf7_fam
PANTHERⁱ	PTHR10476:SF17 PTHR10476:SF17, 1 hit
Pfamⁱ	View protein in Pfam PF03357 Snf7, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CHM1A_HUMAN
Accessionⁱ	Q9HD42Primary (citable) accession number: Q9HD42 Secondary accession number(s): A2RU09 , Q14468, Q15779, Q96G31
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9HD42 (CHM1A_HUMAN)

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Charged multivesicular body protein 1a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endosome

Other locations

Cytoskeleton

Endosome

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ