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Protein

39S ribosomal protein L47, mitochondrial

Gene

MRPL47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L47, mitochondrial
Short name:
L47mt
Short name:
MRP-L47
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL29m1 Publication
Nasopharyngeal carcinoma metastasis-related protein 1
Gene namesi
Name:MRPL47
Synonyms:NCM1
ORF Names:CGI-204
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000136522.13
HGNCiHGNC:16652 MRPL47
MIMi611852 gene
neXtProtiNX_Q9HD33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136522
PharmGKBiPA30979

Polymorphism and mutation databases

BioMutaiMRPL47
DMDMi212276461

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030567? – 25039S ribosomal protein L47, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9HD33
MaxQBiQ9HD33
PaxDbiQ9HD33
PeptideAtlasiQ9HD33
PRIDEiQ9HD33
ProteomicsDBi81820
81821 [Q9HD33-2]
81822 [Q9HD33-3]

PTM databases

iPTMnetiQ9HD33
PhosphoSitePlusiQ9HD33

Expressioni

Gene expression databases

BgeeiENSG00000136522
CleanExiHS_MRPL47
GenevisibleiQ9HD33 HS

Organism-specific databases

HPAiHPA037553
HPA047779

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi121392, 81 interactors
CORUMiQ9HD33
IntActiQ9HD33, 21 interactors
MINTiQ9HD33
STRINGi9606.ENSP00000417602

Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 67Combined sources4
Helixi71 – 73Combined sources3
Helixi87 – 90Combined sources4
Helixi95 – 121Combined sources27
Helixi130 – 157Combined sources28
Beta strandi161 – 164Combined sources4
Beta strandi166 – 170Combined sources5
Beta strandi176 – 180Combined sources5
Beta strandi182 – 186Combined sources5
Helixi188 – 190Combined sources3
Helixi194 – 196Combined sources3
Helixi206 – 237Combined sources32

3D structure databases

ProteinModelPortaliQ9HD33
SMRiQ9HD33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3331 Eukaryota
ENOG41121MX LUCA
GeneTreeiENSGT00390000002837
HOGENOMiHOG000019703
HOVERGENiHBG050019
InParanoidiQ9HD33
KOiK17428
OMAiTMEHECN
OrthoDBiEOG091G0K6O
PhylomeDBiQ9HD33
TreeFamiTF314327

Family and domain databases

Gene3Di1.20.1280.190, 1 hit
InterProiView protein in InterPro
IPR038340 MRP-L47_sf
IPR010729 Ribosomal_L47_mit
PANTHERiPTHR21183 PTHR21183, 1 hit
PfamiView protein in Pfam
PF06984 MRP-L47, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HD33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH
60 70 80 90 100
QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQL RNKSNEDLHK
110 120 130 140 150
LWYVLLKERN MLLTLEQEAK RQRLPMPSPE RLDKVVDSMD ALDKVVQERE
160 170 180 190 200
DALRLLQTGQ ERARPGAWRR DIFGRIIWHK FKQWVIPWHL NKRYNRKRFF
210 220 230 240 250
ALPYVDHFLR LEREKRARIK ARKENLERKK AKILLKKFPH LAEAQKSSLV
Length:250
Mass (Da):29,450
Last modified:November 4, 2008 - v2
Checksum:i53EE4FF6E6BF5645
GO
Isoform 2 (identifier: Q9HD33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-53: Missing.

Show »
Length:230
Mass (Da):27,086
Checksum:i40C145F4E1BFBB05
GO
Isoform 3 (identifier: Q9HD33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:140
Mass (Da):16,991
Checksum:iBBA27B6CC4C9D29C
GO

Sequence cautioni

The sequence AAG01157 differs from that shown. Chimeric cDNA. Seems to include a portion of the orthologous murine sequence.Curated
The sequence AAO92749 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 5AAAG → DATY in AAO92749 (Ref. 4) Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05204210C → G. Corresponds to variant dbSNP:rs2339844Ensembl.1
Natural variantiVAR_052043213R → H. Corresponds to variant dbSNP:rs10513762Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356491 – 110Missing in isoform 3. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_03565034 – 53Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090425 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78395.1
CH471052 Genomic DNA Translation: EAW78396.1
BC021575 mRNA Translation: AAH21575.1
BC032522 mRNA Translation: AAH32522.1
AY212270 mRNA Translation: AAO92749.1 Different initiation.
AF285120 mRNA Translation: AAG01157.1 Sequence problems.
CCDSiCCDS3232.1 [Q9HD33-1]
CCDS3233.1 [Q9HD33-3]
RefSeqiNP_065142.2, NM_020409.2 [Q9HD33-1]
NP_817125.1, NM_177988.1 [Q9HD33-3]
UniGeneiHs.283734

Genome annotation databases

EnsembliENST00000259038; ENSP00000259038; ENSG00000136522 [Q9HD33-2]
ENST00000392659; ENSP00000376427; ENSG00000136522 [Q9HD33-3]
ENST00000476781; ENSP00000417602; ENSG00000136522 [Q9HD33-1]
GeneIDi57129
KEGGihsa:57129
UCSCiuc003fjz.5 human [Q9HD33-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM47_HUMAN
AccessioniPrimary (citable) accession number: Q9HD33
Secondary accession number(s): Q6XRG1, Q8N5D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 4, 2008
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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