UniProtKB - Q9HD26 (GOPC_HUMAN)
Golgi-associated PDZ and coiled-coil motif-containing protein
GOPC
Functioni
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- ion channel binding Source: UniProtKB
GO - Biological processi
- apical protein localization Source: UniProtKB
- cytoplasmic sequestering of CFTR protein Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- Golgi to plasma membrane transport Source: UniProtKB
- negative regulation of anion channel activity Source: UniProtKB
- negative regulation of protein localization to cell surface Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9HD26 |
Reactomei | R-HSA-5627083, RHO GTPases regulate CFTR trafficking |
SIGNORi | Q9HD26 |
Protein family/group databases
TCDBi | 8.A.24.1.10, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi-associated PDZ and coiled-coil motif-containing proteinAlternative name(s): CFTR-associated ligand Fused in glioblastoma PDZ protein interacting specifically with TC10 Short name: PIST |
Gene namesi | Name:GOPC Synonyms:CAL, FIG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000047932.13 |
HGNCi | HGNC:17643, GOPC |
MIMi | 606845, gene |
neXtProti | NX_Q9HD26 |
Subcellular locationi
Golgi apparatus
Other locations
- Cytoplasm
- synapse By similarity
- postsynaptic density By similarity
- dendrite By similarity
Note: Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.By similarity
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB-SubCell
- Golgi-associated vesicle membrane Source: Reactome
- membrane Source: UniProtKB
- postsynaptic density Source: UniProtKB-SubCell
- protein-containing complex Source: MGI
- trans-Golgi network transport vesicle Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Golgi apparatus, Membrane, SynapsePathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 175 | L → V: No effect on subcellular location; when associated with V-182; V-189 and V-196. 1 Publication | 1 | |
Mutagenesisi | 182 | L → V: No effect on subcellular location; when associated with V-175; V-189 and V-196. 1 Publication | 1 | |
Mutagenesisi | 189 | L → V: No effect on subcellular location; when associated with V-175; V-182 and V-196. 1 Publication | 1 | |
Mutagenesisi | 196 | L → V: No effect on subcellular location; when associated with V-175; V-182 and V-189. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 419 – 420 | Breakpoint for translocation to form GOPC-ROS1 fusion protein | 2 |
Organism-specific databases
DisGeNETi | 57120 |
GeneReviewsi | GOPC |
MalaCardsi | GOPC |
OpenTargetsi | ENSG00000047932 |
Orphaneti | 171709, Male infertility due to globozoospermia |
PharmGKBi | PA134904944 |
Miscellaneous databases
Pharosi | Q9HD26, Tbio |
Polymorphism and mutation databases
BioMutai | GOPC |
DMDMi | 74762751 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000087542 | 2 – 462 | Golgi-associated PDZ and coiled-coil motif-containing proteinAdd BLAST | 461 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9HD26 |
jPOSTi | Q9HD26 |
MassIVEi | Q9HD26 |
MaxQBi | Q9HD26 |
PaxDbi | Q9HD26 |
PeptideAtlasi | Q9HD26 |
PRIDEi | Q9HD26 |
ProteomicsDBi | 81817 [Q9HD26-1] 81818 [Q9HD26-2] 81819 [Q9HD26-3] |
PTM databases
iPTMneti | Q9HD26 |
MetOSitei | Q9HD26 |
PhosphoSitePlusi | Q9HD26 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000047932, Expressed in metanephros and 219 other tissues |
ExpressionAtlasi | Q9HD26, baseline and differential |
Genevisiblei | Q9HD26, HS |
Organism-specific databases
HPAi | ENSG00000047932, Low tissue specificity |
Interactioni
Subunit structurei
Homooligomer.
Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By similarity).
Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ.
By similarity7 PublicationsBinary interactionsi
Hide detailsQ9HD26
Isoform 2 [Q9HD26-2]
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- ion channel binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121384, 161 interactors |
CORUMi | Q9HD26 |
IntActi | Q9HD26, 121 interactors |
MINTi | Q9HD26 |
STRINGi | 9606.ENSP00000357484 |
Miscellaneous databases
RNActi | Q9HD26, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9HD26 |
SMRi | Q9HD26 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HD26 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 288 – 371 | PDZPROSITE-ProRule annotationAdd BLAST | 84 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 83 – 200 | Sequence analysisAdd BLAST | 118 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00940000156535 |
HOGENOMi | CLU_045744_0_0_1 |
InParanoidi | Q9HD26 |
OMAi | FPGYNKK |
OrthoDBi | 1038418at2759 |
PhylomeDBi | Q9HD26 |
TreeFami | TF317932 |
Family and domain databases
DisProti | DP02150 |
Gene3Di | 2.30.42.10, 1 hit |
IDEALi | IID00520 |
InterProi | View protein in InterPro IPR038879, GOPC IPR001478, PDZ IPR036034, PDZ_sf |
PANTHERi | PTHR16528, PTHR16528, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAGGPCPAA AGGGPGGASC SVGAPGGVSM FRWLEVLEKE FDKAFVDVDL
60 70 80 90 100
LLGEIDPDQA DITYEGRQKM TSLSSCFAQL CHKAQSVSQI NHKLEAQLVD
110 120 130 140 150
LKSELTETQA EKVVLEKEVH DQLLQLHSIQ LQLHAKTGQS ADSGTIKAKL
160 170 180 190 200
SGPSVEELER ELEANKKEKM KEAQLEAEVK LLRKENEALR RHIAVLQAEV
210 220 230 240 250
YGARLAAKYL DKELAGRVQQ IQLLGRDMKG PAHDKLWNQL EAEIHLHRHK
260 270 280 290 300
TVIRACRGRN DLKRPMQAPP GHDQDSLKKS QGVGPIRKVL LLKEDHEGLG
310 320 330 340 350
ISITGGKEHG VPILISEIHP GQPADRCGGL HVGDAILAVN GVNLRDTKHK
360 370 380 390 400
EAVTILSQQR GEIEFEVVYV APEVDSDDEN VEYEDESGHR YRLYLDELEG
410 420 430 440 450
GGNPGASCKD TSGEIKVLQG FNKKAVTDTH ENGDLGTASE TPLDDGASKL
460
DDLHTLYHKK SY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H1Y4 | F5H1Y4_HUMAN | Golgi-associated PDZ and coiled-coi... | GOPC | 407 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016062 | 150 – 157 | Missing in isoform 2. 3 Publications | 8 | |
Alternative sequenceiVSP_016063 | 305 – 319 | GGKEH…ISEIH → VRSSTSSIIFYSYLV in isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_016064 | 320 – 462 | Missing in isoform 3. 1 PublicationAdd BLAST | 143 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF287894 mRNA Translation: AAG00572.1 AY033606 mRNA Translation: AAK57733.1 AF450008 mRNA Translation: AAL47160.1 AB209385 mRNA Translation: BAD92622.1 Different initiation. AL589939 Genomic DNA No translation available. Z85999 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48205.1 BC009553 mRNA Translation: AAH09553.1 |
CCDSi | CCDS34523.1 [Q9HD26-2] CCDS5117.1 [Q9HD26-1] |
RefSeqi | NP_001017408.1, NM_001017408.2 [Q9HD26-2] NP_065132.1, NM_020399.3 [Q9HD26-1] |
Genome annotation databases
Ensembli | ENST00000052569; ENSP00000052569; ENSG00000047932 [Q9HD26-2] ENST00000368498; ENSP00000357484; ENSG00000047932 [Q9HD26-1] |
GeneIDi | 57120 |
KEGGi | hsa:57120 |
UCSCi | uc003pxu.4, human [Q9HD26-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF287894 mRNA Translation: AAG00572.1 AY033606 mRNA Translation: AAK57733.1 AF450008 mRNA Translation: AAL47160.1 AB209385 mRNA Translation: BAD92622.1 Different initiation. AL589939 Genomic DNA No translation available. Z85999 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48205.1 BC009553 mRNA Translation: AAH09553.1 |
CCDSi | CCDS34523.1 [Q9HD26-2] CCDS5117.1 [Q9HD26-1] |
RefSeqi | NP_001017408.1, NM_001017408.2 [Q9HD26-2] NP_065132.1, NM_020399.3 [Q9HD26-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DC2 | NMR | - | A | 278-371 | [»] | |
2LOB | NMR | - | A | 286-370 | [»] | |
4E34 | X-ray | 1.40 | A/B | 284-370 | [»] | |
4E35 | X-ray | 1.40 | A/B | 284-370 | [»] | |
4JOE | X-ray | 1.14 | A/B | 284-370 | [»] | |
4JOF | X-ray | 1.20 | A/B | 284-370 | [»] | |
4JOG | X-ray | 1.46 | A/B | 284-370 | [»] | |
4JOH | X-ray | 1.47 | A/B | 284-370 | [»] | |
4JOJ | X-ray | 1.20 | A/B | 284-370 | [»] | |
4JOK | X-ray | 1.09 | A/B | 284-370 | [»] | |
4JOP | X-ray | 1.80 | A/B | 284-370 | [»] | |
4JOR | X-ray | 1.34 | A/B | 284-370 | [»] | |
4K6Y | X-ray | 1.48 | A/B | 284-370 | [»] | |
4K72 | X-ray | 1.90 | A/B | 284-370 | [»] | |
4K75 | X-ray | 1.50 | A | 284-370 | [»] | |
4K76 | X-ray | 1.75 | A/B/C/D | 284-370 | [»] | |
4K78 | X-ray | 1.80 | A | 284-370 | [»] | |
4NMO | X-ray | 1.40 | A/B | 284-370 | [»] | |
4NMP | X-ray | 1.30 | A/B | 284-370 | [»] | |
4NMQ | X-ray | 1.40 | A/B | 284-370 | [»] | |
4NMR | X-ray | 1.55 | A/B | 284-370 | [»] | |
4NMS | X-ray | 1.70 | A/B | 284-370 | [»] | |
4NMT | X-ray | 1.40 | A/B | 284-370 | [»] | |
4NMV | X-ray | 1.40 | A/B | 284-370 | [»] | |
4Q6H | X-ray | 1.90 | A | 284-370 | [»] | |
4Q6S | X-ray | 1.45 | A/B | 284-370 | [»] | |
5IC3 | X-ray | 1.70 | A/B | 284-370 | [»] | |
5K4F | X-ray | 1.36 | A/B | 284-370 | [»] | |
6OV7 | X-ray | 1.71 | A/B | 284-370 | [»] | |
6XNJ | X-ray | 1.85 | A | 280-370 | [»] | |
BMRBi | Q9HD26 | |||||
SMRi | Q9HD26 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121384, 161 interactors |
CORUMi | Q9HD26 |
IntActi | Q9HD26, 121 interactors |
MINTi | Q9HD26 |
STRINGi | 9606.ENSP00000357484 |
Protein family/group databases
TCDBi | 8.A.24.1.10, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
PTM databases
iPTMneti | Q9HD26 |
MetOSitei | Q9HD26 |
PhosphoSitePlusi | Q9HD26 |
Polymorphism and mutation databases
BioMutai | GOPC |
DMDMi | 74762751 |
Proteomic databases
EPDi | Q9HD26 |
jPOSTi | Q9HD26 |
MassIVEi | Q9HD26 |
MaxQBi | Q9HD26 |
PaxDbi | Q9HD26 |
PeptideAtlasi | Q9HD26 |
PRIDEi | Q9HD26 |
ProteomicsDBi | 81817 [Q9HD26-1] 81818 [Q9HD26-2] 81819 [Q9HD26-3] |
Protocols and materials databases
Antibodypediai | 19468, 453 antibodies |
DNASUi | 57120 |
Genome annotation databases
Ensembli | ENST00000052569; ENSP00000052569; ENSG00000047932 [Q9HD26-2] ENST00000368498; ENSP00000357484; ENSG00000047932 [Q9HD26-1] |
GeneIDi | 57120 |
KEGGi | hsa:57120 |
UCSCi | uc003pxu.4, human [Q9HD26-1] |
Organism-specific databases
CTDi | 57120 |
DisGeNETi | 57120 |
EuPathDBi | HostDB:ENSG00000047932.13 |
GeneCardsi | GOPC |
GeneReviewsi | GOPC |
HGNCi | HGNC:17643, GOPC |
HPAi | ENSG00000047932, Low tissue specificity |
MalaCardsi | GOPC |
MIMi | 606845, gene |
neXtProti | NX_Q9HD26 |
OpenTargetsi | ENSG00000047932 |
Orphaneti | 171709, Male infertility due to globozoospermia |
PharmGKBi | PA134904944 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00940000156535 |
HOGENOMi | CLU_045744_0_0_1 |
InParanoidi | Q9HD26 |
OMAi | FPGYNKK |
OrthoDBi | 1038418at2759 |
PhylomeDBi | Q9HD26 |
TreeFami | TF317932 |
Enzyme and pathway databases
PathwayCommonsi | Q9HD26 |
Reactomei | R-HSA-5627083, RHO GTPases regulate CFTR trafficking |
SIGNORi | Q9HD26 |
Miscellaneous databases
BioGRID-ORCSi | 57120, 9 hits in 841 CRISPR screens |
ChiTaRSi | GOPC, human |
EvolutionaryTracei | Q9HD26 |
GeneWikii | GOPC |
GenomeRNAii | 57120 |
Pharosi | Q9HD26, Tbio |
PROi | PR:Q9HD26 |
RNActi | Q9HD26, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000047932, Expressed in metanephros and 219 other tissues |
ExpressionAtlasi | Q9HD26, baseline and differential |
Genevisiblei | Q9HD26, HS |
Family and domain databases
DisProti | DP02150 |
Gene3Di | 2.30.42.10, 1 hit |
IDEALi | IID00520 |
InterProi | View protein in InterPro IPR038879, GOPC IPR001478, PDZ IPR036034, PDZ_sf |
PANTHERi | PTHR16528, PTHR16528, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GOPC_HUMAN | |
Accessioni | Q9HD26Primary (citable) accession number: Q9HD26 Secondary accession number(s): A6NM30, Q59FS4, Q969U8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references