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UniProtKB - Q9HD26 (GOPC_HUMAN)

Entry version 183 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Golgi-associated PDZ and coiled-coil motif-containing protein

Gene

GOPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HD26

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5627083, RHO GTPases regulate CFTR trafficking
R-HSA-9013406, RHOQ GTPase cycle

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9HD26

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.24.1.10, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi-associated PDZ and coiled-coil motif-containing protein
Alternative name(s):
CFTR-associated ligand
Fused in glioblastoma
PDZ protein interacting specifically with TC10
Short name:
PIST
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOPC
Synonyms:CAL, FIG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17643, GOPC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606845, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HD26

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000047932

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi175L → V: No effect on subcellular location; when associated with V-182; V-189 and V-196. 1 Publication1
Mutagenesisi182L → V: No effect on subcellular location; when associated with V-175; V-189 and V-196. 1 Publication1
Mutagenesisi189L → V: No effect on subcellular location; when associated with V-175; V-182 and V-196. 1 Publication1
Mutagenesisi196L → V: No effect on subcellular location; when associated with V-175; V-182 and V-189. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei419 – 420Breakpoint for translocation to form GOPC-ROS1 fusion protein2

Organism-specific databases

DisGeNET

More...DisGeNETi		57120

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		GOPC

MalaCards human disease database

More...MalaCardsi		GOPC

Open Targets

More...OpenTargetsi		ENSG00000047932

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		171709, Male infertility due to globozoospermia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134904944

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HD26, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GOPC

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762751

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875422 – 462Golgi-associated PDZ and coiled-coil motif-containing proteinAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HD26

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HD26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HD26

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HD26

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HD26

PeptideAtlas

More...PeptideAtlasi		Q9HD26

PRoteomics IDEntifications database

More...PRIDEi		Q9HD26

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81817 [Q9HD26-1]
81818 [Q9HD26-2]
81819 [Q9HD26-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9HD26, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HD26

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9HD26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HD26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000047932, Expressed in metanephros and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HD26, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HD26, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000047932, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer.

Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By similarity).

Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ.

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9HD26
With#Exp.IntAct
AKIRIN1 [Q9H9L7]3EBI-349832,EBI-10309796
BATF [Q16520]3EBI-349832,EBI-749503
C17orf67 [Q0P5P2]3EBI-349832,EBI-10226540
CCDC102B [Q68D86]3EBI-349832,EBI-10171570
CFTR [P13569]3EBI-349832,EBI-349854
DPYD [Q12882]3EBI-349832,EBI-2839838
FAM90A1 [Q86YD7]3EBI-349832,EBI-6658203
FOSL2 [P15408]4EBI-349832,EBI-3893419
HCK [P08631]3EBI-349832,EBI-346340
HEL-S-42 [V9HWD0]4EBI-349832,EBI-10330219
JUN [P05412]3EBI-349832,EBI-852823
LCLAT1 [Q6UWP7]3EBI-349832,EBI-10254507
MORN4 [Q8WVZ3]3EBI-349832,EBI-10277137
MRPL1 [Q9BYD6]3EBI-349832,EBI-5325394
MYLK [Q15746]3EBI-349832,EBI-968482
MYOCD [Q8IZQ8]4EBI-349832,EBI-493384
PARK7 [Q99497]3EBI-349832,EBI-1164361
PID1 [Q7Z2X4]3EBI-349832,EBI-10256685
PWWP3A - isoform 2 [Q2TAK8-2]3EBI-349832,EBI-10239402
RNF183 [Q96D59]3EBI-349832,EBI-743938
RNF220 [Q9BWG1]3EBI-349832,EBI-10300482
SEMA4G [Q9NTN9]3EBI-349832,EBI-6447340
SLC25A18 [Q9H1K4]3EBI-349832,EBI-6269587
SLC26A9 - isoform 1 [Q7LBE3-1]2EBI-349832,EBI-25464835
SPATA8 [Q6RVD6]3EBI-349832,EBI-8635958
SSNA1 [O43805]3EBI-349832,EBI-2515299
STARD3 [Q14849]3EBI-349832,EBI-9819324
VTN [P04004]4EBI-349832,EBI-1036653
ZBTB49 [Q6ZSB9]5EBI-349832,EBI-2859943
ZNF509 [Q32MK9]3EBI-349832,EBI-10239929
ZNF564 [Q8TBZ8]3EBI-349832,EBI-10273713
ZNF581 [Q9P0T4]3EBI-349832,EBI-745520
ZNF587 [Q96SQ5]3EBI-349832,EBI-6427977
ZSCAN1 [Q8NBB4]3EBI-349832,EBI-5292994
mGluR1a [Q9R0W0] from Rattus norvegicus.7EBI-349832,EBI-8505383
Isoform 2 [Q9HD26-2]
With#Exp.IntAct
ATG9A - isoform 3 [Q7Z3C6-3]5EBI-11102276,EBI-12006308
CCDC102B [Q68D86]4EBI-11102276,EBI-10171570
CCDC198 [E9PSE9]3EBI-11102276,EBI-11748295
FAM9B [Q8IZU0]3EBI-11102276,EBI-10175124
GEM [P55040]3EBI-11102276,EBI-744104
HCK - isoform 2 [P08631-2]3EBI-11102276,EBI-9834454
MYLK - isoform 5 [Q15746-7]5EBI-11102276,EBI-12189939
OSBP2 - isoform 2 [Q969R2-2]3EBI-11102276,EBI-12211505
PPP1R18 [Q6NYC8]3EBI-11102276,EBI-2557469
RALGAPB [Q86X10]3EBI-11102276,EBI-1755842
RNF183 [Q96D59]3EBI-11102276,EBI-743938
SNX31 - isoform 2 [Q8N9S9-2]3EBI-11102276,EBI-11745060
VTN [P04004]3EBI-11102276,EBI-1036653
ZBTB49 [Q6ZSB9]3EBI-11102276,EBI-2859943
ZDHHC1 [Q8WTX9]3EBI-11102276,EBI-2818796
ZNF835 [Q9Y2P0]3EBI-11102276,EBI-5667516

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121384, 182 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9HD26

Protein interaction database and analysis system

More...IntActi		Q9HD26, 122 interactors

Molecular INTeraction database

More...MINTi		Q9HD26

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357484

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HD26, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9HD26

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HD26

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9HD26

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini288 – 371PDZPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni426 – 449DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili83 – 200Sequence analysisAdd BLAST118

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain mediates interactions with FZD5, FZD8, ASIC3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.By similarity2 Publications
The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity).By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3528, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156535

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045744_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HD26

Identification of Orthologs from Complete Genome Data

More...OMAi		QADIMFE

Database of Orthologous Groups

More...OrthoDBi		1038418at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HD26

TreeFam database of animal gene trees

More...TreeFami		TF317932

Family and domain databases

Database of protein disorder

More...DisProti		DP02150

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00520

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038879, GOPC
IPR001478, PDZ
IPR036034, PDZ_sf

The PANTHER Classification System

More...PANTHERi		PTHR16528, PTHR16528, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HD26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAGGPCPAA AGGGPGGASC SVGAPGGVSM FRWLEVLEKE FDKAFVDVDL 
        60         70         80         90        100
LLGEIDPDQA DITYEGRQKM TSLSSCFAQL CHKAQSVSQI NHKLEAQLVD 
       110        120        130        140        150
LKSELTETQA EKVVLEKEVH DQLLQLHSIQ LQLHAKTGQS ADSGTIKAKL 
       160        170        180        190        200
SGPSVEELER ELEANKKEKM KEAQLEAEVK LLRKENEALR RHIAVLQAEV 
       210        220        230        240        250
YGARLAAKYL DKELAGRVQQ IQLLGRDMKG PAHDKLWNQL EAEIHLHRHK 
       260        270        280        290        300
TVIRACRGRN DLKRPMQAPP GHDQDSLKKS QGVGPIRKVL LLKEDHEGLG 
       310        320        330        340        350
ISITGGKEHG VPILISEIHP GQPADRCGGL HVGDAILAVN GVNLRDTKHK 
       360        370        380        390        400
EAVTILSQQR GEIEFEVVYV APEVDSDDEN VEYEDESGHR YRLYLDELEG 
       410        420        430        440        450
GGNPGASCKD TSGEIKVLQG FNKKAVTDTH ENGDLGTASE TPLDDGASKL 
       460 
DDLHTLYHKK SY
Length:462
Mass (Da):50,520
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A19DDC376DCD0F4
GO
Isoform 2 (identifier: Q9HD26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-157: Missing.

Show »
Length:454
Mass (Da):49,721
Checksum:i7D02D85423A31BAB
GO
Isoform 3 (identifier: Q9HD26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-319: GGKEHGVPILISEIH → VRSSTSSIIFYSYLV
     320-462: Missing.

Show »
Length:319
Mass (Da):35,130
Checksum:i54A09D9CC46A245D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H1Y4F5H1Y4_HUMAN
Golgi-associated PDZ and coiled-coi...
GOPC
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92622 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016062150 – 157Missing in isoform 2. 3 Publications8
Alternative sequenceiVSP_016063305 – 319GGKEH…ISEIH → VRSSTSSIIFYSYLV in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_016064320 – 462Missing in isoform 3. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF287894 mRNA Translation: AAG00572.1
AY033606 mRNA Translation: AAK57733.1
AF450008 mRNA Translation: AAL47160.1
AB209385 mRNA Translation: BAD92622.1 Different initiation.
AL589939 Genomic DNA No translation available.
Z85999 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48205.1
BC009553 mRNA Translation: AAH09553.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34523.1 [Q9HD26-2]
CCDS5117.1 [Q9HD26-1]

NCBI Reference Sequences

More...RefSeqi		NP_001017408.1, NM_001017408.2 [Q9HD26-2]
NP_065132.1, NM_020399.3 [Q9HD26-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000052569; ENSP00000052569; ENSG00000047932 [Q9HD26-2]
ENST00000368498; ENSP00000357484; ENSG00000047932 [Q9HD26-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57120

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57120

UCSC genome browser

More...UCSCi		uc003pxu.4, human [Q9HD26-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287894 mRNA Translation: AAG00572.1
AY033606 mRNA Translation: AAK57733.1
AF450008 mRNA Translation: AAL47160.1
AB209385 mRNA Translation: BAD92622.1 Different initiation.
AL589939 Genomic DNA No translation available.
Z85999 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48205.1
BC009553 mRNA Translation: AAH09553.1
CCDSiCCDS34523.1 [Q9HD26-2]
CCDS5117.1 [Q9HD26-1]
RefSeqiNP_001017408.1, NM_001017408.2 [Q9HD26-2]
NP_065132.1, NM_020399.3 [Q9HD26-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DC2NMR-A278-371[»]
2LOBNMR-A286-370[»]
4E34X-ray1.40A/B284-370[»]
4E35X-ray1.40A/B284-370[»]
4JOEX-ray1.14A/B284-370[»]
4JOFX-ray1.20A/B284-370[»]
4JOGX-ray1.46A/B284-370[»]
4JOHX-ray1.47A/B284-370[»]
4JOJX-ray1.20A/B284-370[»]
4JOKX-ray1.09A/B284-370[»]
4JOPX-ray1.80A/B284-370[»]
4JORX-ray1.34A/B284-370[»]
4K6YX-ray1.48A/B284-370[»]
4K72X-ray1.90A/B284-370[»]
4K75X-ray1.50A284-370[»]
4K76X-ray1.75A/B/C/D284-370[»]
4K78X-ray1.80A284-370[»]
4NMOX-ray1.40A/B284-370[»]
4NMPX-ray1.30A/B284-370[»]
4NMQX-ray1.40A/B284-370[»]
4NMRX-ray1.55A/B284-370[»]
4NMSX-ray1.70A/B284-370[»]
4NMTX-ray1.40A/B284-370[»]
4NMVX-ray1.40A/B284-370[»]
4Q6HX-ray1.90A284-370[»]
4Q6SX-ray1.45A/B284-370[»]
5IC3X-ray1.70A/B284-370[»]
5K4FX-ray1.36A/B284-370[»]
6OV7X-ray1.71A/B284-370[»]
6V84X-ray1.64A/B284-370[»]
6XNJX-ray1.85A280-370[»]
BMRBiQ9HD26
SMRiQ9HD26
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121384, 182 interactors
CORUMiQ9HD26
IntActiQ9HD26, 122 interactors
MINTiQ9HD26
STRINGi9606.ENSP00000357484

Protein family/group databases

TCDBi8.A.24.1.10, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

PTM databases

GlyGeniQ9HD26, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9HD26
MetOSiteiQ9HD26
PhosphoSitePlusiQ9HD26

Genetic variation databases

BioMutaiGOPC
DMDMi74762751

Proteomic databases

EPDiQ9HD26
jPOSTiQ9HD26
MassIVEiQ9HD26
MaxQBiQ9HD26
PaxDbiQ9HD26
PeptideAtlasiQ9HD26
PRIDEiQ9HD26
ProteomicsDBi81817 [Q9HD26-1]
81818 [Q9HD26-2]
81819 [Q9HD26-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19468, 465 antibodies

The DNASU plasmid repository

More...DNASUi		57120

Genome annotation databases

EnsembliENST00000052569; ENSP00000052569; ENSG00000047932 [Q9HD26-2]
ENST00000368498; ENSP00000357484; ENSG00000047932 [Q9HD26-1]
GeneIDi57120
KEGGihsa:57120
UCSCiuc003pxu.4, human [Q9HD26-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57120
DisGeNETi57120

GeneCards: human genes, protein and diseases

More...GeneCardsi		GOPC
GeneReviewsiGOPC
HGNCiHGNC:17643, GOPC
HPAiENSG00000047932, Low tissue specificity
MalaCardsiGOPC
MIMi606845, gene
neXtProtiNX_Q9HD26
OpenTargetsiENSG00000047932
Orphaneti171709, Male infertility due to globozoospermia
PharmGKBiPA134904944
VEuPathDBiHostDB:ENSG00000047932

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3528, Eukaryota
GeneTreeiENSGT00940000156535
HOGENOMiCLU_045744_0_0_1
InParanoidiQ9HD26
OMAiQADIMFE
OrthoDBi1038418at2759
PhylomeDBiQ9HD26
TreeFamiTF317932

Enzyme and pathway databases

PathwayCommonsiQ9HD26
ReactomeiR-HSA-5627083, RHO GTPases regulate CFTR trafficking
R-HSA-9013406, RHOQ GTPase cycle
SIGNORiQ9HD26

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57120, 9 hits in 1017 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GOPC, human
EvolutionaryTraceiQ9HD26

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GOPC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57120
PharosiQ9HD26, Tbio

Protein Ontology

More...PROi		PR:Q9HD26
RNActiQ9HD26, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000047932, Expressed in metanephros and 220 other tissues
ExpressionAtlasiQ9HD26, baseline and differential
GenevisibleiQ9HD26, HS

Family and domain databases

DisProtiDP02150
Gene3Di2.30.42.10, 1 hit
IDEALiIID00520
InterProiView protein in InterPro
IPR038879, GOPC
IPR001478, PDZ
IPR036034, PDZ_sf
PANTHERiPTHR16528, PTHR16528, 1 hit
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOPC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HD26
Secondary accession number(s): A6NM30, Q59FS4, Q969U8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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