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UniProtKB - Q9HD26 (GOPC_HUMAN)

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Protein

Golgi-associated PDZ and coiled-coil motif-containing protein

Gene

GOPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.3 Publications

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • apical protein localization Source: UniProtKB
  • cytoplasmic sequestering of CFTR protein Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • Golgi to plasma membrane transport Source: UniProtKB
  • negative regulation of anion channel activity Source: UniProtKB
  • negative regulation of protein localization to cell surface Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5627083 RHO GTPases regulate CFTR trafficking
SIGNORiQ9HD26

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi-associated PDZ and coiled-coil motif-containing protein
Alternative name(s):
CFTR-associated ligand
Fused in glioblastoma
PDZ protein interacting specifically with TC10
Short name:
PIST
Gene namesi
Name:GOPC
Synonyms:CAL, FIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000047932.13
HGNCiHGNC:17643 GOPC
MIMi606845 gene
neXtProtiNX_Q9HD26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi175L → V: No effect on subcellular location; when associated with V-182; V-189 and V-196. 1 Publication1
Mutagenesisi182L → V: No effect on subcellular location; when associated with V-175; V-189 and V-196. 1 Publication1
Mutagenesisi189L → V: No effect on subcellular location; when associated with V-175; V-182 and V-196. 1 Publication1
Mutagenesisi196L → V: No effect on subcellular location; when associated with V-175; V-182 and V-189. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei419 – 420Breakpoint for translocation to form GOPC-ROS1 fusion protein2

Organism-specific databases

DisGeNETi57120
MalaCardsiGOPC
OpenTargetsiENSG00000047932
PharmGKBiPA134904944

Polymorphism and mutation databases

BioMutaiGOPC
DMDMi74762751

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000875422 – 462Golgi-associated PDZ and coiled-coil motif-containing proteinAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9HD26
MaxQBiQ9HD26
PaxDbiQ9HD26
PeptideAtlasiQ9HD26
PRIDEiQ9HD26
ProteomicsDBi81817
81818 [Q9HD26-2]
81819 [Q9HD26-3]

PTM databases

iPTMnetiQ9HD26
PhosphoSitePlusiQ9HD26

Expressioni

Tissue specificityi

Ubiquitously expressed.3 Publications

Gene expression databases

BgeeiENSG00000047932
CleanExiHS_GOPC
ExpressionAtlasiQ9HD26 baseline and differential
GenevisibleiQ9HD26 HS

Organism-specific databases

HPAiHPA019477
HPA024018

Interactioni

Subunit structurei

Homooligomer. Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By similarity). Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ.By similarity7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi121384, 138 interactors
IntActiQ9HD26, 79 interactors
MINTiQ9HD26
STRINGi9606.ENSP00000357484

Structurei

Secondary structure

1462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi287 – 292Combined sources6
Beta strandi295 – 297Combined sources3
Beta strandi301 – 306Combined sources6
Helixi307 – 309Combined sources3
Beta strandi311 – 318Combined sources8
Helixi323 – 327Combined sources5
Beta strandi334 – 339Combined sources6
Beta strandi342 – 344Combined sources3
Beta strandi346 – 348Combined sources3
Helixi349 – 357Combined sources9
Beta strandi361 – 369Combined sources9

3D structure databases

ProteinModelPortaliQ9HD26
SMRiQ9HD26
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HD26

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 371PDZPROSITE-ProRule annotationAdd BLAST84

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 200Sequence analysisAdd BLAST118

Domaini

The PDZ domain mediates interactions with FZD5, FZD8, ASIC3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.By similarity2 Publications
The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity).By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITAF Eukaryota
ENOG410XT8J LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000280727
HOVERGENiHBG057507
InParanoidiQ9HD26
OMAiLHSLYHK
OrthoDBiEOG091G0DXX
PhylomeDBiQ9HD26
TreeFamiTF317932

Family and domain databases

InterProiView protein in InterPro
IPR038879 GOPC
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR16528 PTHR16528, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HD26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGGPCPAA AGGGPGGASC SVGAPGGVSM FRWLEVLEKE FDKAFVDVDL 
        60         70         80         90        100
LLGEIDPDQA DITYEGRQKM TSLSSCFAQL CHKAQSVSQI NHKLEAQLVD 
       110        120        130        140        150
LKSELTETQA EKVVLEKEVH DQLLQLHSIQ LQLHAKTGQS ADSGTIKAKL 
       160        170        180        190        200
SGPSVEELER ELEANKKEKM KEAQLEAEVK LLRKENEALR RHIAVLQAEV 
       210        220        230        240        250
YGARLAAKYL DKELAGRVQQ IQLLGRDMKG PAHDKLWNQL EAEIHLHRHK 
       260        270        280        290        300
TVIRACRGRN DLKRPMQAPP GHDQDSLKKS QGVGPIRKVL LLKEDHEGLG 
       310        320        330        340        350
ISITGGKEHG VPILISEIHP GQPADRCGGL HVGDAILAVN GVNLRDTKHK 
       360        370        380        390        400
EAVTILSQQR GEIEFEVVYV APEVDSDDEN VEYEDESGHR YRLYLDELEG 
       410        420        430        440        450
GGNPGASCKD TSGEIKVLQG FNKKAVTDTH ENGDLGTASE TPLDDGASKL 
       460 
DDLHTLYHKK SY
Length:462
Mass (Da):50,520
Last modified:March 1, 2001 - v1
Checksum:i8A19DDC376DCD0F4
GO
Isoform 2 (identifier: Q9HD26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-157: Missing.

Show »
Length:454
Mass (Da):49,721
Checksum:i7D02D85423A31BAB
GO
Isoform 3 (identifier: Q9HD26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-319: GGKEHGVPILISEIH → VRSSTSSIIFYSYLV
     320-462: Missing.

Note: No experimental confirmation available.
Show »
Length:319
Mass (Da):35,130
Checksum:i54A09D9CC46A245D
GO

Sequence cautioni

The sequence BAD92622 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016062150 – 157Missing in isoform 2. 3 Publications8
Alternative sequenceiVSP_016063305 – 319GGKEH…ISEIH → VRSSTSSIIFYSYLV in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_016064320 – 462Missing in isoform 3. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287894 mRNA Translation: AAG00572.1
AY033606 mRNA Translation: AAK57733.1
AF450008 mRNA Translation: AAL47160.1
AB209385 mRNA Translation: BAD92622.1 Different initiation.
AL589939 Genomic DNA No translation available.
Z85999 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48205.1
BC009553 mRNA Translation: AAH09553.1
CCDSiCCDS34523.1 [Q9HD26-2]
CCDS5117.1 [Q9HD26-1]
RefSeqiNP_001017408.1, NM_001017408.2 [Q9HD26-2]
NP_065132.1, NM_020399.3 [Q9HD26-1]
UniGeneiHs.191539

Genome annotation databases

EnsembliENST00000052569; ENSP00000052569; ENSG00000047932 [Q9HD26-2]
ENST00000368498; ENSP00000357484; ENSG00000047932 [Q9HD26-1]
GeneIDi57120
KEGGihsa:57120
UCSCiuc003pxu.4 human [Q9HD26-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiGOPC_HUMAN
AccessioniPrimary (citable) accession number: Q9HD26
Secondary accession number(s): A6NM30, Q59FS4, Q969U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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