Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Magnesium transporter MRS2 homolog, mitochondrial

Gene

MRS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).2 Publications

Miscellaneous

Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport
LigandMagnesium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5223345 Miscellaneous transport and binding events

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.35.5.7 the cora metal ion transporter (mit) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Magnesium transporter MRS2 homolog, mitochondrial
Alternative name(s):
MRS2-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRS2
Synonyms:HPT, MRS2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13785 MRS2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HD23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini50 – 339Mitochondrial matrixSequence analysisAdd BLAST290
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 372Mitochondrial intermembraneSequence analysisAdd BLAST12
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 443Mitochondrial matrixSequence analysisAdd BLAST50

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57380

Open Targets

More...
OpenTargetsi
ENSG00000124532

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162396189

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HD23

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MRS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752816

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004283750 – 443Magnesium transporter MRS2 homolog, mitochondrialAdd BLAST394

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HD23

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HD23

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HD23

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HD23

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HD23

PeptideAtlas

More...
PeptideAtlasi
Q9HD23

PRoteomics IDEntifications database

More...
PRIDEi
Q9HD23

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4888
81814 [Q9HD23-1]
81815 [Q9HD23-2]
81816 [Q9HD23-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HD23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HD23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124532 Expressed in 221 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HD23 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HD23 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017642

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121498, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HD23, 31 interactors

Molecular INTeraction database

More...
MINTi
Q9HD23

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000399585

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HD23

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2662 Eukaryota
ENOG410XNNZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009988

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013083

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HD23

KEGG Orthology (KO)

More...
KOi
K16075

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYYMQAE

Database of Orthologous Groups

More...
OrthoDBi
1363588at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HD23

TreeFam database of animal gene trees

More...
TreeFami
TF328433

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12823 Mrs2_Mfm1p-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039204 MRS2-like

The PANTHER Classification System

More...
PANTHERi
PTHR13890 PTHR13890, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HD23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR
60 70 80 90 100
AAQLCGPDRL RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF
110 120 130 140 150
ERKKTELYQE LGLQARDLRF QHVMSITVRN NRIIMRMEYL KAVITPECLL
160 170 180 190 200
ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY PLPFEFRAIE ALLQYWINTL
210 220 230 240 250
QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS LSELETDIKI
260 270 280 290 300
FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY
310 320 330 340 350
RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS
360 370 380 390 400
LFGLMGVAFG MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL
410 420 430 440
EAPLPPMMAS LPKKTLLADR SMELKNSLRL DGLGSGRSIL TNR
Length:443
Mass (Da):50,318
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i396EEFB64A8BB14F
GO
Isoform 2 (identifier: Q9HD23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-408: M → V
     409-443: Missing.

Show »
Length:408
Mass (Da):46,491
Checksum:i5BC6550A6444D27E
GO
Isoform 3 (identifier: Q9HD23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-117: ERKKTELYQELGLQARD → VFESCDNSRVSSDIRLS
     118-443: Missing.

Note: No experimental confirmation available.
Show »
Length:117
Mass (Da):12,691
Checksum:i27AAD2D247E889C2
GO
Isoform 4 (identifier: Q9HD23-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-159: YLKAVITPECLLILDYRNLNL → KYSLLLESVASILQNSVSFMERQT

Note: No experimental confirmation available.
Show »
Length:446
Mass (Da):50,584
Checksum:i5E2C71D8F6A34181
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQX2A0A0A0MQX2_HUMAN
Magnesium transporter
MRS2
393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ29H7BZ29_HUMAN
Magnesium transporter MRS2 homolog,...
MRS2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02378235P → S. Corresponds to variant dbSNP:rs2295651Ensembl.1
Natural variantiVAR_061129412P → S. Corresponds to variant dbSNP:rs35261004Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016207101 – 117ERKKT…LQARD → VFESCDNSRVSSDIRLS in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_016208118 – 443Missing in isoform 3. 1 PublicationAdd BLAST326
Alternative sequenceiVSP_055287139 – 159YLKAV…RNLNL → KYSLLLESVASILQNSVSFM ERQT in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_016209408M → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_016210409 – 443Missing in isoform 2. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF293076 mRNA Translation: AAK38615.1
AF293078 Genomic DNA Translation: AAK38617.1
AF288288 mRNA Translation: AAG01170.1
AK054587 mRNA Translation: BAG51394.1
AK291058 mRNA Translation: BAF83747.1
AK298849 mRNA Translation: BAG60974.1
AL359713 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55445.1
CH471087 Genomic DNA Translation: EAW55446.1
BC001028 mRNA Translation: AAH01028.2
BC069009 mRNA Translation: AAH69009.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4552.1 [Q9HD23-1]
CCDS69055.1 [Q9HD23-4]
CCDS75408.1 [Q9HD23-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273193.1, NM_001286264.1 [Q9HD23-4]
NP_001273194.1, NM_001286265.1 [Q9HD23-2]
NP_001273195.1, NM_001286266.1
NP_065713.1, NM_020662.3 [Q9HD23-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378353; ENSP00000367604; ENSG00000124532 [Q9HD23-2]
ENST00000378386; ENSP00000367637; ENSG00000124532 [Q9HD23-1]
ENST00000443868; ENSP00000399585; ENSG00000124532 [Q9HD23-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57380

UCSC genome browser

More...
UCSCi
uc003nea.5 human [Q9HD23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293076 mRNA Translation: AAK38615.1
AF293078 Genomic DNA Translation: AAK38617.1
AF288288 mRNA Translation: AAG01170.1
AK054587 mRNA Translation: BAG51394.1
AK291058 mRNA Translation: BAF83747.1
AK298849 mRNA Translation: BAG60974.1
AL359713 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55445.1
CH471087 Genomic DNA Translation: EAW55446.1
BC001028 mRNA Translation: AAH01028.2
BC069009 mRNA Translation: AAH69009.1
CCDSiCCDS4552.1 [Q9HD23-1]
CCDS69055.1 [Q9HD23-4]
CCDS75408.1 [Q9HD23-2]
RefSeqiNP_001273193.1, NM_001286264.1 [Q9HD23-4]
NP_001273194.1, NM_001286265.1 [Q9HD23-2]
NP_001273195.1, NM_001286266.1
NP_065713.1, NM_020662.3 [Q9HD23-1]

3D structure databases

SMRiQ9HD23
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121498, 39 interactors
IntActiQ9HD23, 31 interactors
MINTiQ9HD23
STRINGi9606.ENSP00000399585

Protein family/group databases

TCDBi1.A.35.5.7 the cora metal ion transporter (mit) family

PTM databases

iPTMnetiQ9HD23
PhosphoSitePlusiQ9HD23

Polymorphism and mutation databases

BioMutaiMRS2
DMDMi74752816

Proteomic databases

EPDiQ9HD23
jPOSTiQ9HD23
MassIVEiQ9HD23
MaxQBiQ9HD23
PaxDbiQ9HD23
PeptideAtlasiQ9HD23
PRIDEiQ9HD23
ProteomicsDBi4888
81814 [Q9HD23-1]
81815 [Q9HD23-2]
81816 [Q9HD23-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57380

Genome annotation databases

EnsembliENST00000378353; ENSP00000367604; ENSG00000124532 [Q9HD23-2]
ENST00000378386; ENSP00000367637; ENSG00000124532 [Q9HD23-1]
ENST00000443868; ENSP00000399585; ENSG00000124532 [Q9HD23-4]
GeneIDi57380
KEGGihsa:57380
UCSCiuc003nea.5 human [Q9HD23-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57380
DisGeNETi57380

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MRS2
HGNCiHGNC:13785 MRS2
HPAiHPA017642
neXtProtiNX_Q9HD23
OpenTargetsiENSG00000124532
PharmGKBiPA162396189

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2662 Eukaryota
ENOG410XNNZ LUCA
GeneTreeiENSGT00390000009988
HOGENOMiHOG000013083
InParanoidiQ9HD23
KOiK16075
OMAiNYYMQAE
OrthoDBi1363588at2759
PhylomeDBiQ9HD23
TreeFamiTF328433

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MRS2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MRS2L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57380
PharosiQ9HD23

Protein Ontology

More...
PROi
PR:Q9HD23

Gene expression databases

BgeeiENSG00000124532 Expressed in 221 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ9HD23 baseline and differential
GenevisibleiQ9HD23 HS

Family and domain databases

CDDicd12823 Mrs2_Mfm1p-like, 1 hit
InterProiView protein in InterPro
IPR039204 MRS2-like
PANTHERiPTHR13890 PTHR13890, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HD23
Secondary accession number(s): A8K4U3
, B3KNN2, B4DQL2, Q5T3Y1, Q6NTG4, Q96KF8, Q9BVP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again