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Protein

Protein S100-A14

Gene

S100A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.3 Publications

Caution

Part of the residues that are essential for calcium binding are not conserved, resulting in loss of calcium binding at physiological calcium concentrations.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • calcium ion homeostasis Source: UniProtKB
  • defense response to bacterium Source: UniProtKB
  • positive regulation of granulocyte chemotaxis Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • response to lipopolysaccharide Source: UniProtKB
  • toll-like receptor 4 signaling pathway Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A14
Alternative name(s):
S100 calcium-binding protein A14
Short name:
S114
Gene namesi
Name:S100A14
Synonyms:S100A15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000189334.8
HGNCiHGNC:18901 S100A14
MIMi607986 gene
neXtProtiNX_Q9HCY8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi57402
OpenTargetsiENSG00000189334
PharmGKBiPA134905502

Polymorphism and mutation databases

BioMutaiS100A14
DMDMi20178118

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440211 – 104Protein S100-A14Add BLAST104

Proteomic databases

EPDiQ9HCY8
MaxQBiQ9HCY8
PaxDbiQ9HCY8
PeptideAtlasiQ9HCY8
PRIDEiQ9HCY8
ProteomicsDBi81807
TopDownProteomicsiQ9HCY8

PTM databases

iPTMnetiQ9HCY8
PhosphoSitePlusiQ9HCY8
SwissPalmiQ9HCY8

Expressioni

Tissue specificityi

Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000189334
CleanExiHS_S100A14
GenevisibleiQ9HCY8 HS

Organism-specific databases

HPAiHPA027613

Interactioni

Subunit structurei

Homodimer. Interacts with AGER.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121504, 22 interactors
IntActiQ9HCY8, 13 interactors
MINTiQ9HCY8
STRINGi9606.ENSP00000340463

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Helixi19 – 32Combined sources14
Turni34 – 39Combined sources6
Helixi43 – 53Combined sources11
Turni55 – 57Combined sources3
Helixi60 – 62Combined sources3
Helixi65 – 71Combined sources7
Helixi81 – 94Combined sources14
Beta strandi98 – 100Combined sources3

3D structure databases

ProteinModelPortaliQ9HCY8
SMRiQ9HCY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 61EF-handAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGiENOG410IZKB Eukaryota
ENOG4111EF5 LUCA
GeneTreeiENSGT00530000063972
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiQ9HCY8
OMAiNLGNCND
OrthoDBiEOG091G0YGX
PhylomeDBiQ9HCY8
TreeFamiTF332727

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013787 S100_Ca-bd_sub
IPR028493 S100A14
PANTHERiPTHR11639:SF4 PTHR11639:SF4, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HCY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV
60 70 80 90 100
TQQLPHLMPS NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP

VRGH
Length:104
Mass (Da):11,662
Last modified:March 1, 2001 - v1
Checksum:i97EF31A46B388E79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007220 mRNA Translation: AAG01893.1
AF426828 Genomic DNA Translation: AAM19206.1
BX470102 Genomic DNA No translation available.
BC005019 mRNA Translation: AAH05019.1
CCDSiCCDS1046.1
RefSeqiNP_065723.1, NM_020672.2
XP_005245419.1, XM_005245362.1
XP_016857364.1, XM_017001875.1
UniGeneiHs.288998

Genome annotation databases

EnsembliENST00000344616; ENSP00000340463; ENSG00000189334
ENST00000368701; ENSP00000357690; ENSG00000189334
ENST00000368702; ENSP00000357691; ENSG00000189334
ENST00000476873; ENSP00000420296; ENSG00000189334
GeneIDi57402
KEGGihsa:57402
UCSCiuc001fce.4 human

Similar proteinsi

Entry informationi

Entry nameiS10AE_HUMAN
AccessioniPrimary (citable) accession number: Q9HCY8
Secondary accession number(s): Q5RHT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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