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Protein

Short transient receptor potential channel 7

Gene

TRPC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel activity Source: Reactome
  • inositol 1,4,5 trisphosphate binding Source: GO_Central
  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short transient receptor potential channel 7
Short name:
TrpC7
Alternative name(s):
Transient receptor protein 7
Short name:
TRP-7
Short name:
hTRP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPC7
Synonyms:TRP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000069018.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20754 TRPC7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCX4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 351CytoplasmicSequence analysisAdd BLAST351
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 383ExtracellularSequence analysisAdd BLAST11
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 465CytoplasmicSequence analysisAdd BLAST61
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 537ExtracellularSequence analysisAdd BLAST51
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 581CytoplasmicSequence analysisAdd BLAST23
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 651ExtracellularSequence analysisAdd BLAST49
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 862CytoplasmicSequence analysisAdd BLAST190

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57113

Open Targets

More...
OpenTargetsi
ENSG00000069018

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164742693

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
492

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRPC7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18202960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153241 – 862Short transient receptor potential channel 7Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15Phosphothreonine; by PKG/PRKG11 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HCX4

PeptideAtlas

More...
PeptideAtlasi
Q9HCX4

PRoteomics IDEntifications database

More...
PRIDEi
Q9HCX4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81805
81806 [Q9HCX4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000069018 Expressed in 32 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_TRPC7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HCX4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCX4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022592
HPA031126

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121378, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9HCX4

Protein interaction database and analysis system

More...
IntActi
Q9HCX4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000426070

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HCX4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HCX4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 71ANK 1Add BLAST30
Repeati77 – 106ANK 2Add BLAST30
Repeati108 – 134ANK 3Add BLAST27
Repeati163 – 192ANK 4Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3609 Eukaryota
ENOG410XQ0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020590

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG068337

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCX4

KEGG Orthology (KO)

More...
KOi
K04970

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEQCKQY

Database of Orthologous Groups

More...
OrthoDBi
1018075at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCX4

TreeFam database of animal gene trees

More...
TreeFami
TF313147

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005463 TRPC7_channel
IPR002153 TRPC_channel

The PANTHER Classification System

More...
PANTHERi
PTHR10117 PTHR10117, 1 hit
PTHR10117:SF9 PTHR10117:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01097 TRNSRECEPTRP
PR01648 TRPCHANNEL7

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRNSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS
60 70 80 90 100
AEYGNIPVVR KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK
110 120 130 140 150
ENLARVGDAL LLAISKGYVR IVEAILNHPA FAQGQRLTLS PLEQELRDDD
160 170 180 190 200
FYAYDEDGTR FSHDITPIIL AAHCQEYEIV HILLLKGARI ERPHDYFCKC
210 220 230 240 250
NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL TALELSNELA
260 270 280 290 300
RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNFQVW
310 320 330 340 350
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV
360 370 380 390 400
KFLAVFGVSI GLPFLAIAYW IAPCSKLGRT LRSPFMKFVA HAVSFTIFLG
410 420 430 440 450
LLVVNASDRF EGVKTLPNET FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM
460 470 480 490 500
IWSECKEIWE EGPREYVLHL WNLLDFGMLS IFVASFTARF MAFLKATEAQ
510 520 530 540 550
LYVDQHVQDD TLHNVSLPPE VAYFTYARDK WWPSDPQIIS EGLYAIAVVL
560 570 580 590 600
SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
610 620 630 640 650
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY
660 670 680 690 700
VLYGVYNVTM VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD
710 720 730 740 750
EGRTLPAPFN LVPSPKSFYY LIMRIKMCLI KLCKSKAKSC ENDLEMGMLN
760 770 780 790 800
SKFKKTRYQA GMRNSENLTA NNTLSKPTRY QKIMKRLIKR YVLKAQVDRE
810 820 830 840 850
NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ LSEKFGKNLN
860
KDHLRVNKGK DI
Length:862
Mass (Da):99,562
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC516E59E80AEF4B0
GO
Isoform 2 (identifier: Q9HCX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-375: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):86,277
Checksum:iDBF64B392022D797
GO
Isoform 3 (identifier: Q9HCX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-320: Missing.

Note: No experimental confirmation available.
Show »
Length:801
Mass (Da):92,429
Checksum:i01106D703524DA00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q70T25Q70T25_HUMAN
Short transient receptor potential ...
TRPC7
807Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1A4Z5A1A4Z5_HUMAN
Short transient receptor potential ...
TRPC7
380Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q70T24Q70T24_HUMAN
Short transient receptor potential ...
TRPC7
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti412G → S in CAD70161 (Ref. 3) Curated1
Sequence conflicti486F → S in CAD70161 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043035260 – 375Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_044897260 – 320Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ272034 mRNA Translation: CAC03489.1
AY167927 mRNA Translation: AAO12125.1
AJ549088 mRNA Translation: CAD70161.1
AC008661 Genomic DNA No translation available.
BC128185 mRNA Translation: AAI28186.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47267.2 [Q9HCX4-1]
CCDS54905.1 [Q9HCX4-2]
CCDS54906.1 [Q9HCX4-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001161048.1, NM_001167576.1 [Q9HCX4-2]
NP_001161049.1, NM_001167577.1 [Q9HCX4-3]
NP_065122.1, NM_020389.2 [Q9HCX4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.591263

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000352189; ENSP00000330322; ENSG00000069018 [Q9HCX4-2]
ENST00000378459; ENSP00000367720; ENSG00000069018 [Q9HCX4-3]
ENST00000513104; ENSP00000426070; ENSG00000069018 [Q9HCX4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57113

UCSC genome browser

More...
UCSCi
uc003lbn.3 human [Q9HCX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272034 mRNA Translation: CAC03489.1
AY167927 mRNA Translation: AAO12125.1
AJ549088 mRNA Translation: CAD70161.1
AC008661 Genomic DNA No translation available.
BC128185 mRNA Translation: AAI28186.1
CCDSiCCDS47267.2 [Q9HCX4-1]
CCDS54905.1 [Q9HCX4-2]
CCDS54906.1 [Q9HCX4-3]
RefSeqiNP_001161048.1, NM_001167576.1 [Q9HCX4-2]
NP_001161049.1, NM_001167577.1 [Q9HCX4-3]
NP_065122.1, NM_020389.2 [Q9HCX4-1]
UniGeneiHs.591263

3D structure databases

ProteinModelPortaliQ9HCX4
SMRiQ9HCX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121378, 4 interactors
CORUMiQ9HCX4
IntActiQ9HCX4, 1 interactor
STRINGi9606.ENSP00000426070

Chemistry databases

GuidetoPHARMACOLOGYi492

PTM databases

iPTMnetiQ9HCX4
PhosphoSitePlusiQ9HCX4

Polymorphism and mutation databases

BioMutaiTRPC7
DMDMi18202960

Proteomic databases

PaxDbiQ9HCX4
PeptideAtlasiQ9HCX4
PRIDEiQ9HCX4
ProteomicsDBi81805
81806 [Q9HCX4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352189; ENSP00000330322; ENSG00000069018 [Q9HCX4-2]
ENST00000378459; ENSP00000367720; ENSG00000069018 [Q9HCX4-3]
ENST00000513104; ENSP00000426070; ENSG00000069018 [Q9HCX4-1]
GeneIDi57113
KEGGihsa:57113
UCSCiuc003lbn.3 human [Q9HCX4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57113
DisGeNETi57113
EuPathDBiHostDB:ENSG00000069018.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRPC7
HGNCiHGNC:20754 TRPC7
HPAiCAB022592
HPA031126
neXtProtiNX_Q9HCX4
OpenTargetsiENSG00000069018
PharmGKBiPA164742693

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00940000153138
HOGENOMiHOG000020590
HOVERGENiHBG068337
InParanoidiQ9HCX4
KOiK04970
OMAiSEQCKQY
OrthoDBi1018075at2759
PhylomeDBiQ9HCX4
TreeFamiTF313147

Enzyme and pathway databases

ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRPC7 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRPC7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57113

Protein Ontology

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PROi
PR:Q9HCX4

Gene expression databases

BgeeiENSG00000069018 Expressed in 32 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TRPC7
ExpressionAtlasiQ9HCX4 baseline and differential
GenevisibleiQ9HCX4 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005463 TRPC7_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF9 PTHR10117:SF9, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01648 TRPCHANNEL7
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPC7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCX4
Secondary accession number(s): A1A4Z4
, F5H5U9, Q70T26, Q8IWP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: January 16, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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