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UniProtKB - Q9HCX3 (ZN304_HUMAN)

Entry version 170 (29 Sep 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Zinc finger protein 304

Gene

ZNF304

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979).

Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306).

Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306).

Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979).

Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979).

Promotes angiogenesis (PubMed:26081979).

Promotes tumor growth (PubMed:24623306, PubMed:26081979).

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri89 – 111C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 139C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri251 – 273C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding
Biological processAngiogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HCX3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 304Imported
Alternative name(s):
KRAB-containing zinc finger protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF304Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13505, ZNF304

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613840, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HCX3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131845

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57343

Open Targets

More...OpenTargetsi		ENSG00000131845

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37791

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HCX3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF304

Domain mapping of disease mutations (DMDM)

More...DMDMi		296453049

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475231 – 659Zinc finger protein 304Add BLAST659

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Deubiquitinated by USP28; the deubiquitination leads to the stabilization of ZNF304 from proteolytic degradation (PubMed:24623306).1 Publication

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HCX3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HCX3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HCX3

PeptideAtlas

More...PeptideAtlasi		Q9HCX3

PRoteomics IDEntifications database

More...PRIDEi		Q9HCX3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81804

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9HCX3, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HCX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HCX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Expressed strongly in colorectal cancers cells (CRCs) (PubMed:24623306). Expressed strongly in ovarian carcinoma (OC) tumor cell lines compared to non-transformed ovarian epithelial cells (at protein level) (PubMed:26081979). Expressed in lymphoid tissues, thyroid, adrenal gland, prostate, pancreas and skeletal muscles (PubMed:12051768).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated during embryonic stem cells (ESCs) differentiation by retinoic acid treatment (PubMed:24623306).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131845, Expressed in secondary oocyte and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HCX3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HCX3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131845, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1; leading to promoter hypermethylation and transcriptional silencing (PubMed:24623306). Probably associates with Polycomb group (PcG) complexes; leading to trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306).

Interacts with USP28 (PubMed:24623306).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121493, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9HCX3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000375586

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HCX3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HCX3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 88KRABPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 111C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 139C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri251 – 273C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161016

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HCX3

Identification of Orthologs from Complete Genome Data

More...OMAi		KPHECNS

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HCX3

TreeFam database of animal gene trees

More...TreeFami		TF339848

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9HCX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVLMDRV QSCVTFEDVF VYFSREEWEL LEEAQRFLYR DVMLENFALV 
        60         70         80         90        100
ATLGFWCEAE HEAPSEQSVS VEGVSQVRTA ESGLFQKAHP CEMCDPLLKD 
       110        120        130        140        150
ILHLAEHQGS HLTQKLCTRG LCRRRFSFSA NFYQHQKQHN GENCFRGDDG 
       160        170        180        190        200
GASFVKSCTV HMLGRSFTCR EEGMDLPDSS GLFQHQTTYN RVSPCRRTEC 
       210        220        230        240        250
MESFPHSSSL RQHQGDYDGQ MLFSCGDEGK AFLDTFTLLD SQMTHAEVRP 
       260        270        280        290        300
FRCLPCGNVF KEKSALINHR KIHSGEISHV CKECGKAFIH LHHLKMHQKF 
       310        320        330        340        350
HTGKRHYTCS ECGKAFSRKD TLVQHQRVHT GERSYDCSEC GKAYSRSSHL 
       360        370        380        390        400
VQHQRIHTGE RPYKCNKCGK AFSRKDTLVQ HQRFHTGERP YECSECGKFF 
       410        420        430        440        450
SQSSHLIEHW RIHTGARPYE CIECGKFFSH NSSLIKHRRV HTGARSYVCS 
       460        470        480        490        500
KCGKAFGCKD TLVQHQIIHT GARPYECSEC GKAFSRKDTL VQHQKIHTGE 
       510        520        530        540        550
RPYECGECGK FFSHSSNLIV HQRIHTGAKP YECNECGKCF SHNSSLILHQ 
       560        570        580        590        600
RVHTGARPYV CSECGKAYIS SSHLVQHKKV HTGARPYECS ECGKFFSRNS 
       610        620        630        640        650
GLILHQRVHT GEKPYVCSEC GKAYSRSSHL VRHQKAHTGE RAHECNSFGG 

PLAASLKLV
Length:659
Mass (Da):75,047
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11B5263F41DB2704
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQD3E7EQD3_HUMAN
Zinc finger protein 304
ZNF304
706Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ59M0QZ59_HUMAN
Zinc finger protein 304
ZNF304
617Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti323V → A in CAC06610 (PubMed:12051768).Curated1
Sequence conflicti334S → P in CAC06610 (PubMed:12051768).Curated1
Sequence conflicti445R → S in CAC06610 (PubMed:12051768).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019979121L → P. Corresponds to variant dbSNP:rs862708Ensembl.1
Natural variantiVAR_033563367K → E1 PublicationCorresponds to variant dbSNP:rs862709Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ276316 mRNA Translation: CAC06610.1
AC005261 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12950.1

NCBI Reference Sequences

More...RefSeqi		NP_065708.2, NM_020657.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282286; ENSP00000282286; ENSG00000131845
ENST00000391705; ENSP00000375586; ENSG00000131845

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57343

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57343

UCSC genome browser

More...UCSCi		uc010ygw.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276316 mRNA Translation: CAC06610.1
AC005261 Genomic DNA No translation available.
CCDSiCCDS12950.1
RefSeqiNP_065708.2, NM_020657.3

3D structure databases

SMRiQ9HCX3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121493, 4 interactors
CORUMiQ9HCX3
STRINGi9606.ENSP00000375586

PTM databases

GlyGeniQ9HCX3, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9HCX3
PhosphoSitePlusiQ9HCX3

Genetic variation databases

BioMutaiZNF304
DMDMi296453049

Proteomic databases

MassIVEiQ9HCX3
MaxQBiQ9HCX3
PaxDbiQ9HCX3
PeptideAtlasiQ9HCX3
PRIDEiQ9HCX3
ProteomicsDBi81804

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46525, 20 antibodies

The DNASU plasmid repository

More...DNASUi		57343

Genome annotation databases

EnsembliENST00000282286; ENSP00000282286; ENSG00000131845
ENST00000391705; ENSP00000375586; ENSG00000131845
GeneIDi57343
KEGGihsa:57343
UCSCiuc010ygw.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57343
DisGeNETi57343

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF304
HGNCiHGNC:13505, ZNF304
HPAiENSG00000131845, Low tissue specificity
MIMi613840, gene
neXtProtiNX_Q9HCX3
OpenTargetsiENSG00000131845
PharmGKBiPA37791
VEuPathDBiHostDB:ENSG00000131845

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161016
HOGENOMiCLU_002678_44_5_1
InParanoidiQ9HCX3
OMAiKPHECNS
PhylomeDBiQ9HCX3
TreeFamiTF339848

Enzyme and pathway databases

PathwayCommonsiQ9HCX3
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57343, 4 hits in 1040 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57343
PharosiQ9HCX3, Tbio

Protein Ontology

More...PROi		PR:Q9HCX3
RNActiQ9HCX3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131845, Expressed in secondary oocyte and 225 other tissues
ExpressionAtlasiQ9HCX3, baseline and differential
GenevisibleiQ9HCX3, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN304_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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