BRMS1

Functionⁱ

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.3 Publications

GO - Molecular functionⁱ

histone deacetylase activity Source: Reactome
histone deacetylase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
NF-kappaB binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17000776

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
histone deacetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17000776
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 20830743
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of anoikis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17000776
positive regulation of protein deacetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 17000776
regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17000776

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214815 HDACs deacetylate histones

Reactomeⁱ

R-HSA-3214815 HDACs deacetylate histones

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Breast cancer metastasis-suppressor 1
Gene namesⁱ	Name:BRMS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174744.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17262 BRMS1
MIMⁱ	606259 gene
neXtProtⁱ	NX_Q9HCU9

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25855
Open Targets More...OpenTargetsⁱ	ENSG00000174744
PharmGKBⁱ	PA164741342

Polymorphism and mutation databases

BioMutaⁱ	BRMS1
DMDMⁱ	18202959

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064988	1 – 246	Breast cancer metastasis-suppressor 1Add BLAST		246

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	184	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	242	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9HCU9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HCU9
PaxDbⁱ	Q9HCU9
PeptideAtlas More...PeptideAtlasⁱ	Q9HCU9
PRIDEⁱ	Q9HCU9
ProteomicsDBⁱ	81803

PTM databases

iPTMnetⁱ	Q9HCU9
PhosphoSitePlusⁱ	Q9HCU9

Expressionⁱ

Tissue specificityⁱ

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000174744 Expressed in 199 organ(s), highest expression level in testis
CleanExⁱ	HS_BRMS1
ExpressionAtlasⁱ	Q9HCU9 baseline and differential
Genevisibleⁱ	Q9HCU9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010824 HPA019637

HPAⁱ

CAB010824
HPA019637

Interactionⁱ

Subunit structureⁱ

Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3.Curated5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP70	Q8NHQ1	3	EBI-714781,EBI-739624
DNAJB6	O75190	2	EBI-714781,EBI-1053164
HDAC1	Q13547	4	EBI-714781,EBI-301834
HDAC2	Q92769	4	EBI-714781,EBI-301821
HDAC4	P56524	2	EBI-714781,EBI-308629
HDAC5	Q9UQL6	2	EBI-714781,EBI-715576
HDAC6	Q9UBN7	2	EBI-714781,EBI-301697
NMI	Q13287	6	EBI-714781,EBI-372942
SMARCE1	Q969G3	3	EBI-714781,EBI-455078
SUDS3	Q9H7L9	2	EBI-714781,EBI-540496

GO - Molecular functionⁱ

histone deacetylase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
NF-kappaB binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17000776

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117379, 67 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9HCU9
Database of interacting proteins More...DIPⁱ	DIP-24250N
IntActⁱ	Q9HCU9, 37 interactors
Molecular INTeraction database More...MINTⁱ	Q9HCU9
STRINGⁱ	9606.ENSP00000396052

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	55 – 93	Combined sources		39

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9HCU9
SMRⁱ	Q9HCU9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9HCU9

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	51 – 98	1 PublicationAdd BLAST		48

Domainⁱ

Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.

Sequence similaritiesⁱ

Belongs to the BRMS1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4466 Eukaryota ENOG410Y9N9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144178
HOGENOMⁱ	HOG000007483
HOVERGENⁱ	HBG050734
InParanoidⁱ	Q9HCU9
KEGG Orthology (KO) More...KOⁱ	K19196
PhylomeDBⁱ	Q9HCU9

Family and domain databases

InterProⁱ	View protein in InterPro IPR013907 Sds3
PANTHERⁱ	PTHR21964 PTHR21964, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08598 Sds3, 1 hit
SMARTⁱ	View protein in SMART SM01401 Sds3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9HCU9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD 
        60         70         80         90        100
EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE 
       110        120        130        140        150
YTEPLGGLQR SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL 
       160        170        180        190        200
LLYDTLQGEL QERIQRLEED RQSLDLSSEW WDDKLHARGS SRSWDSLPPS 
       210        220        230        240 
KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKSDGP

Length:246

Mass (Da):28,461

Last modified:March 1, 2001 - v1

Checksum:ⁱ89FB59FB96ECD4DB

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G5E9I4	G5E9I4_HUMAN	Breast cancer metastasis suppressor... Breast cancer metastasis suppressor 1, isoform CRA_c (Breast cancer metastasis-suppressor 1)	BRMS1 hCG_20309	290	Annotation score:
E9PJF5	E9PJF5_HUMAN	Breast cancer metastasis-suppressor... Breast cancer metastasis-suppressor 1	BRMS1	244	Annotation score:
E9PPD1	E9PPD1_HUMAN	Breast cancer metastasis-suppressor... Breast cancer metastasis-suppressor 1	BRMS1	126	Annotation score:
H0YCF7	H0YCF7_HUMAN	Breast cancer metastasis-suppressor... Breast cancer metastasis-suppressor 1	BRMS1	267	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159141 mRNA Translation: AAG00075.1 AF281036 Genomic DNA Translation: AAK69131.1 CR457173 mRNA Translation: CAG33454.1 AK313773 mRNA Translation: BAG36511.1 BC009834 mRNA Translation: AAH09834.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8135.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056214.1, NM_015399.3
UniGeneⁱ	Hs.100426

Genome annotation databases

Ensemblⁱ	ENST00000359957; ENSP00000353042; ENSG00000174744
GeneIDⁱ	25855
KEGGⁱ	hsa:25855
UCSC genome browser More...UCSCⁱ	uc001ohp.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HCU9	BRMS1 isoform 2		PANTR		246	UniRef100_Q9HCU9
BRMS1 isoform 2		PONAB		246
Uncharacterized protein		AOTNA		246
Uncharacterized protein		PANPA		246
UPI000624F6B2		AOTNA		199

Protein	Similar proteins		Species	Score	Length	Source
Q9HCU9	Breast cancer metastasis-suppressor 1 homolog		BOVIN		246	UniRef90_Q9HCU9
BRMS1 isoform 2		PANTR		246
BRMS1 isoform 2		PONAB		246
Uncharacterized protein		AOTNA		246
Uncharacterized protein		PANPA		246
+57

Protein	Similar proteins		Species	Score	Length	Source
Q9HCU9	Breast cancer metastasis-suppressor 1 homolog		BOVIN		246	UniRef50_Q9HCU9
Breast cancer metastasis-suppressor 1 homolog		MOUSE		246
Breast cancer metastasis-suppressor 1 homolog		RAT		246
BRMS1 isoform 2		PANTR		246
BRMS1 isoform 2		PONAB		246
+199

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159141 mRNA Translation: AAG00075.1 AF281036 Genomic DNA Translation: AAK69131.1 CR457173 mRNA Translation: CAG33454.1 AK313773 mRNA Translation: BAG36511.1 BC009834 mRNA Translation: AAH09834.1
CCDSⁱ	CCDS8135.1
RefSeqⁱ	NP_056214.1, NM_015399.3
UniGeneⁱ	Hs.100426

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2XUS	X-ray	1.91	A/B	51-98	[»]
	4AUV	X-ray	2.00	A/B/C/D/E/F/G/H	51-84	[»]
ProteinModelPortalⁱ	Q9HCU9
SMRⁱ	Q9HCU9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117379, 67 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9HCU9
DIPⁱ	DIP-24250N
IntActⁱ	Q9HCU9, 37 interactors
MINTⁱ	Q9HCU9
STRINGⁱ	9606.ENSP00000396052

PTM databases

iPTMnetⁱ	Q9HCU9
PhosphoSitePlusⁱ	Q9HCU9

Polymorphism and mutation databases

BioMutaⁱ	BRMS1
DMDMⁱ	18202959

Proteomic databases

EPDⁱ	Q9HCU9
MaxQBⁱ	Q9HCU9
PaxDbⁱ	Q9HCU9
PeptideAtlasⁱ	Q9HCU9
PRIDEⁱ	Q9HCU9
ProteomicsDBⁱ	81803

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	25855
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359957; ENSP00000353042; ENSG00000174744
GeneIDⁱ	25855
KEGGⁱ	hsa:25855
UCSCⁱ	uc001ohp.2 human

Organism-specific databases

CTDⁱ	25855
DisGeNETⁱ	25855
EuPathDBⁱ	HostDB:ENSG00000174744.13
GeneCardsⁱ	BRMS1
HGNCⁱ	HGNC:17262 BRMS1
HPAⁱ	CAB010824 HPA019637
MIMⁱ	606259 gene
neXtProtⁱ	NX_Q9HCU9
OpenTargetsⁱ	ENSG00000174744
PharmGKBⁱ	PA164741342
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4466 Eukaryota ENOG410Y9N9 LUCA
GeneTreeⁱ	ENSGT00910000144178
HOGENOMⁱ	HOG000007483
HOVERGENⁱ	HBG050734
InParanoidⁱ	Q9HCU9
KOⁱ	K19196
PhylomeDBⁱ	Q9HCU9

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214815 HDACs deacetylate histones

Reactomeⁱ

R-HSA-3214815 HDACs deacetylate histones

Miscellaneous databases

EvolutionaryTraceⁱ	Q9HCU9
GeneWikiⁱ	BRMS1
GenomeRNAiⁱ	25855
Protein Ontology More...PROⁱ	PR:Q9HCU9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174744 Expressed in 199 organ(s), highest expression level in testis
CleanExⁱ	HS_BRMS1
ExpressionAtlasⁱ	Q9HCU9 baseline and differential
Genevisibleⁱ	Q9HCU9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013907 Sds3
PANTHERⁱ	PTHR21964 PTHR21964, 1 hit
Pfamⁱ	View protein in Pfam PF08598 Sds3, 1 hit
SMARTⁱ	View protein in SMART SM01401 Sds3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BRMS1_HUMAN
Accessionⁱ	Q9HCU9Primary (citable) accession number: Q9HCU9 Secondary accession number(s): Q6IAI2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q9HCU9 (BRMS1_HUMAN)

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Breast cancer metastasis-suppressor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ