UniProtKB - Q9HCU9 (BRMS1_HUMAN)
Protein
Breast cancer metastasis-suppressor 1
Gene
BRMS1
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.3 Publications
GO - Molecular functioni
- histone deacetylase binding Source: GO_Central
- NF-kappaB binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- histone deacetylation Source: GO_Central
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of anoikis Source: UniProtKB
- positive regulation of protein deacetylation Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
Keywordsi
Molecular function | Repressor |
Biological process | Apoptosis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9HCU9 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-9679191, Potential therapeutics for SARS |
Names & Taxonomyi
Protein namesi | Recommended name: Breast cancer metastasis-suppressor 1 |
Gene namesi | Name:BRMS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17262, BRMS1 |
MIMi | 606259, gene |
neXtProti | NX_Q9HCU9 |
VEuPathDBi | HostDB:ENSG00000174744.13 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- Sin3-type complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 25855 |
OpenTargetsi | ENSG00000174744 |
PharmGKBi | PA164741342 |
Miscellaneous databases
Pharosi | Q9HCU9, Tbio |
Genetic variation databases
BioMutai | BRMS1 |
DMDMi | 18202959 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064988 | 1 – 246 | Breast cancer metastasis-suppressor 1Add BLAST | 246 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 184 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 242 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Post-translational modificationi
Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.1 Publication
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9HCU9 |
jPOSTi | Q9HCU9 |
MassIVEi | Q9HCU9 |
MaxQBi | Q9HCU9 |
PaxDbi | Q9HCU9 |
PeptideAtlasi | Q9HCU9 |
PRIDEi | Q9HCU9 |
ProteomicsDBi | 81803 |
PTM databases
iPTMneti | Q9HCU9 |
PhosphoSitePlusi | Q9HCU9 |
Expressioni
Tissue specificityi
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.1 Publication
Gene expression databases
Bgeei | ENSG00000174744, Expressed in testis and 212 other tissues |
ExpressionAtlasi | Q9HCU9, baseline and differential |
Genevisiblei | Q9HCU9, HS |
Organism-specific databases
HPAi | ENSG00000174744, Low tissue specificity |
Interactioni
Subunit structurei
Homohexamer (Potential).
Interacts with SNX6, HDAC1 and RELA.
Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2.
Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3.
Curated5 PublicationsBinary interactionsi
Hide detailsQ9HCU9
GO - Molecular functioni
- histone deacetylase binding Source: GO_Central
- NF-kappaB binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117379, 74 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9HCU9 |
DIPi | DIP-24250N |
IntActi | Q9HCU9, 48 interactors |
MINTi | Q9HCU9 |
STRINGi | 9606.ENSP00000396052 |
Miscellaneous databases
RNActi | Q9HCU9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9HCU9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HCU9 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 51 – 98 | 1 PublicationAdd BLAST | 48 |
Domaini
Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.
Sequence similaritiesi
Belongs to the BRMS1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4466, Eukaryota |
GeneTreei | ENSGT00940000161779 |
InParanoidi | Q9HCU9 |
OMAi | HMAVDNL |
OrthoDBi | 1456563at2759 |
PhylomeDBi | Q9HCU9 |
Family and domain databases
IDEALi | IID00501 |
InterProi | View protein in InterPro IPR013907, Sds3 |
PANTHERi | PTHR21964, PTHR21964, 1 hit |
Pfami | View protein in Pfam PF08598, Sds3, 1 hit |
SMARTi | View protein in SMART SM01401, Sds3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9HCU9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD
60 70 80 90 100
EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE
110 120 130 140 150
YTEPLGGLQR SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL
160 170 180 190 200
LLYDTLQGEL QERIQRLEED RQSLDLSSEW WDDKLHARGS SRSWDSLPPS
210 220 230 240
KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKSDGP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9I4 | G5E9I4_HUMAN | Breast cancer metastasis suppressor... | BRMS1 hCG_20309 | 290 | Annotation score: | ||
E9PJF5 | E9PJF5_HUMAN | Breast cancer metastasis-suppressor... | BRMS1 | 244 | Annotation score: | ||
H0YCF7 | H0YCF7_HUMAN | Breast cancer metastasis-suppressor... | BRMS1 | 267 | Annotation score: | ||
E9PPD1 | E9PPD1_HUMAN | Breast cancer metastasis-suppressor... | BRMS1 | 126 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159141 mRNA Translation: AAG00075.1 AF281036 Genomic DNA Translation: AAK69131.1 CR457173 mRNA Translation: CAG33454.1 AK313773 mRNA Translation: BAG36511.1 BC009834 mRNA Translation: AAH09834.1 |
CCDSi | CCDS8135.1 |
RefSeqi | NP_056214.1, NM_015399.3 |
Genome annotation databases
Ensembli | ENST00000359957; ENSP00000353042; ENSG00000174744 |
GeneIDi | 25855 |
KEGGi | hsa:25855 |
UCSCi | uc001ohp.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159141 mRNA Translation: AAG00075.1 AF281036 Genomic DNA Translation: AAK69131.1 CR457173 mRNA Translation: CAG33454.1 AK313773 mRNA Translation: BAG36511.1 BC009834 mRNA Translation: AAH09834.1 |
CCDSi | CCDS8135.1 |
RefSeqi | NP_056214.1, NM_015399.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2XUS | X-ray | 1.91 | A/B | 51-98 | [»] | |
4AUV | X-ray | 2.00 | A/B/C/D/E/F/G/H | 51-84 | [»] | |
SMRi | Q9HCU9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117379, 74 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9HCU9 |
DIPi | DIP-24250N |
IntActi | Q9HCU9, 48 interactors |
MINTi | Q9HCU9 |
STRINGi | 9606.ENSP00000396052 |
PTM databases
iPTMneti | Q9HCU9 |
PhosphoSitePlusi | Q9HCU9 |
Genetic variation databases
BioMutai | BRMS1 |
DMDMi | 18202959 |
Proteomic databases
EPDi | Q9HCU9 |
jPOSTi | Q9HCU9 |
MassIVEi | Q9HCU9 |
MaxQBi | Q9HCU9 |
PaxDbi | Q9HCU9 |
PeptideAtlasi | Q9HCU9 |
PRIDEi | Q9HCU9 |
ProteomicsDBi | 81803 |
Protocols and materials databases
Antibodypediai | 4414, 290 antibodies |
DNASUi | 25855 |
Genome annotation databases
Ensembli | ENST00000359957; ENSP00000353042; ENSG00000174744 |
GeneIDi | 25855 |
KEGGi | hsa:25855 |
UCSCi | uc001ohp.2, human |
Organism-specific databases
CTDi | 25855 |
DisGeNETi | 25855 |
GeneCardsi | BRMS1 |
HGNCi | HGNC:17262, BRMS1 |
HPAi | ENSG00000174744, Low tissue specificity |
MIMi | 606259, gene |
neXtProti | NX_Q9HCU9 |
OpenTargetsi | ENSG00000174744 |
PharmGKBi | PA164741342 |
VEuPathDBi | HostDB:ENSG00000174744.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4466, Eukaryota |
GeneTreei | ENSGT00940000161779 |
InParanoidi | Q9HCU9 |
OMAi | HMAVDNL |
OrthoDBi | 1456563at2759 |
PhylomeDBi | Q9HCU9 |
Enzyme and pathway databases
PathwayCommonsi | Q9HCU9 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-9679191, Potential therapeutics for SARS |
Miscellaneous databases
BioGRID-ORCSi | 25855, 77 hits in 999 CRISPR screens |
ChiTaRSi | BRMS1, human |
EvolutionaryTracei | Q9HCU9 |
GeneWikii | BRMS1 |
GenomeRNAii | 25855 |
Pharosi | Q9HCU9, Tbio |
PROi | PR:Q9HCU9 |
RNActi | Q9HCU9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174744, Expressed in testis and 212 other tissues |
ExpressionAtlasi | Q9HCU9, baseline and differential |
Genevisiblei | Q9HCU9, HS |
Family and domain databases
IDEALi | IID00501 |
InterProi | View protein in InterPro IPR013907, Sds3 |
PANTHERi | PTHR21964, PTHR21964, 1 hit |
Pfami | View protein in Pfam PF08598, Sds3, 1 hit |
SMARTi | View protein in SMART SM01401, Sds3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BRMS1_HUMAN | |
Accessioni | Q9HCU9Primary (citable) accession number: Q9HCU9 Secondary accession number(s): Q6IAI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families