UniProtKB - Q9HCU5 (PREB_HUMAN)

BLAST

>sp|Q9HCU5|PREB_HUMAN Prolactin regulatory element-binding protein OS=Homo sapiens OX=9606 GN=PREB PE=1 SV=2
MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSAS
LLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKG
AAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRV
WKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTF
SSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGH
EVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPE
LLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL

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History
Entry version 153 (07 Nov 2018)
Sequence version 2 (23 Nov 2004)
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Protein

Prolactin regulatory element-binding protein

Gene

PREB

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.By similarity

Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.By similarity

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
GTPase activator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
guanyl-nucleotide exchange factor activity Source: Reactome
Sar guanyl-nucleotide exchange factor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

COPII vesicle coating Source: UniProtKB
ER to Golgi vesicle-mediated transport Source: UniProtKB
IRE1-mediated unfolded protein response Source: Reactome
protein exit from endoplasmic reticulum
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25202031
protein secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of COPII vesicle coating
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	ER-Golgi transport, Protein transport, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-5694530 Cargo concentration in the ER
SignaLinkⁱ	Q9HCU5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prolactin regulatory element-binding protein Alternative name(s): Mammalian guanine nucleotide exchange factor mSec12
Gene namesⁱ	Name:PREB Synonyms:SEC12
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138073.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9356 PREB
MIMⁱ	606395 gene
neXtProtⁱ	NX_Q9HCU5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 388	CytoplasmicSequence analysisAdd BLAST	388
Transmembraneⁱ	389 – 409	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	410 – 417	LumenalSequence analysis	8

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000138073
PharmGKBⁱ	PA33727

Polymorphism and mutation databases

BioMutaⁱ	PREB
DMDMⁱ	55977881

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051154	1 – 417	Prolactin regulatory element-binding proteinAdd BLAST		417

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	10	Nitrated tyrosineBy similarity		1

Keywords - PTMⁱ

Nitration

Proteomic databases

EPDⁱ	Q9HCU5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HCU5
PaxDbⁱ	Q9HCU5
PeptideAtlas More...PeptideAtlasⁱ	Q9HCU5
PRIDEⁱ	Q9HCU5
ProteomicsDBⁱ	81801

PTM databases

iPTMnetⁱ	Q9HCU5
PhosphoSitePlusⁱ	Q9HCU5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000138073 Expressed in 217 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_PREB
ExpressionAtlasⁱ	Q9HCU5 baseline and differential
Genevisibleⁱ	Q9HCU5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA013582 HPA014133

HPAⁱ

HPA013582
HPA014133

Interactionⁱ

Subunit structureⁱ

GO - Molecular functionⁱ

GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
guanyl-nucleotide exchange factor activity Source: Reactome
Sar guanyl-nucleotide exchange factor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115419, 20 interactors
IntActⁱ	Q9HCU5, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q9HCU5
STRINGⁱ	9606.ENSP00000260643

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	16 – 22	Combined sources	7
Turnⁱ	23 – 26	Combined sources	4
Beta strandⁱ	27 – 33	Combined sources	7
Beta strandⁱ	38 – 40	Combined sources	3
Beta strandⁱ	42 – 52	Combined sources	11
Beta strandⁱ	57 – 66	Combined sources	10
Beta strandⁱ	72 – 78	Combined sources	7
Beta strandⁱ	81 – 86	Combined sources	6
Beta strandⁱ	89 – 97	Combined sources	9
Beta strandⁱ	139 – 148	Combined sources	10
Beta strandⁱ	152 – 154	Combined sources	3
Beta strandⁱ	157 – 162	Combined sources	6
Beta strandⁱ	166 – 173	Combined sources	8
Beta strandⁱ	177 – 182	Combined sources	6
Turnⁱ	183 – 185	Combined sources	3
Beta strandⁱ	188 – 193	Combined sources	6
Beta strandⁱ	199 – 204	Combined sources	6
Helixⁱ	206 – 208	Combined sources	3
Beta strandⁱ	210 – 214	Combined sources	5
Beta strandⁱ	219 – 223	Combined sources	5
Beta strandⁱ	226 – 231	Combined sources	6
Beta strandⁱ	245 – 254	Combined sources	10
Beta strandⁱ	262 – 272	Combined sources	11
Beta strandⁱ	281 – 286	Combined sources	6
Turnⁱ	287 – 289	Combined sources	3
Beta strandⁱ	292 – 297	Combined sources	6
Beta strandⁱ	303 – 308	Combined sources	6
Beta strandⁱ	312 – 319	Combined sources	8
Beta strandⁱ	324 – 328	Combined sources	5
Turnⁱ	329 – 332	Combined sources	4
Beta strandⁱ	333 – 338	Combined sources	6
Beta strandⁱ	341 – 344	Combined sources	4
Beta strandⁱ	346 – 351	Combined sources	6
Helixⁱ	358 – 362	Combined sources	5
Beta strandⁱ	368 – 373	Combined sources	6
Beta strandⁱ	376 – 382	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9HCU5
SMRⁱ	Q9HCU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 50	WD 1Add BLAST	47
Repeatⁱ	58 – 97	WD 2Add BLAST	40
Repeatⁱ	127 – 183	WD 3Add BLAST	57
Repeatⁱ	187 – 224	WD 4Add BLAST	38
Repeatⁱ	230 – 287	WD 5Add BLAST	58
Repeatⁱ	291 – 329	WD 6Add BLAST	39
Repeatⁱ	334 – 385	WD 7Add BLAST	52

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0771 Eukaryota ENOG410XRQK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018031
HOGENOMⁱ	HOG000045302
HOVERGENⁱ	HBG002027
InParanoidⁱ	Q9HCU5
KEGG Orthology (KO) More...KOⁱ	K14003
OMAⁱ	AHSMFVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06TN
PhylomeDBⁱ	Q9HCU5
TreeFamⁱ	TF314383

Family and domain databases

InterProⁱ	View protein in InterPro IPR011047 Quinoprotein_ADH-like_supfam IPR001680 WD40_repeat IPR017986 WD40_repeat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 4 hits
SUPFAMⁱ	SSF50998 SSF50998, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q9HCU5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL 
        60         70         80         90        100
ELINGRLSAS LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ 
       110        120        130        140        150
QGNKAEKAGS KEQGPRQRKG AAPAEKKCGA ETQHEGLELR VENLQAVQTD 
       160        170        180        190        200
FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV WKVPSLEKVL EFKAHEGEIE 
       210        220        230        240        250
DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF SSTPYRYQAC 
       260        270        280        290        300
RFGQVPDQPA GLRLFTVQIP HKRLRQPPPC YLTAWDGSNF LPLRTKSCGH 
       310        320        330        340        350
EVVSCLDVSE SGTFLGLGTV TGSVAIYIAF SLQCLYYVRE AHGIVVTDVA 
       360        370        380        390        400
FLPEKGRGPE LLGSHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG 
       410 
LIIVTILLLQ SAFPGFL

Length:417

Mass (Da):45,468

Last modified:November 23, 2004 - v2

Checksum:ⁱ7FD490A641202D19

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B5MC98	B5MC98_HUMAN	Prolactin regulatory element-bindin... Prolactin regulatory element-binding protein	PREB	359	Annotation score:
H7C2N7	H7C2N7_HUMAN	Prolactin regulatory element-bindin... Prolactin regulatory element-binding protein	PREB	106	Annotation score:
H7C0W3	H7C0W3_HUMAN	Prolactin regulatory element-bindin... Prolactin regulatory element-binding protein	PREB	176	Annotation score:
F8WCS5	F8WCS5_HUMAN	Prolactin regulatory element-bindin... Prolactin regulatory element-binding protein	PREB	50	Annotation score:
H7BZX0	H7BZX0_HUMAN	Prolactin regulatory element-bindin... Prolactin regulatory element-binding protein	PREB	22	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	L → F in AAG01692 (PubMed:10920239).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF226684 mRNA Translation: AAG01692.1 AF203687 mRNA Translation: AAF19192.1 AF227166 Genomic DNA Translation: AAF74572.1 AK023064 mRNA Translation: BAB14385.1 AC013403 Genomic DNA Translation: AAX93170.1 CH471053 Genomic DNA Translation: EAX00627.1 BC002765 mRNA Translation: AAH02765.1 BC012890 mRNA Translation: AAH12890.1 BC016472 mRNA Translation: AAH16472.1 BC041032 mRNA Translation: AAH41032.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1738.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001317414.1, NM_001330485.1 NP_001317415.1, NM_001330486.1 NP_037520.1, NM_013388.5
UniGeneⁱ	Hs.279784

Genome annotation databases

Ensemblⁱ	ENST00000260643; ENSP00000260643; ENSG00000138073
GeneIDⁱ	10113
KEGGⁱ	hsa:10113
UCSC genome browser More...UCSCⁱ	uc002rix.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HCU5	PREB protein		HUMAN		345	UniRef100_Q9HCU5

Protein	Similar proteins		Species	Score	Length	Source
Q9HCU5	PREB protein		HUMAN		345	UniRef90_Q9HCU5
Prolactin regulatory element binding		CALJA		420
Prolactin regulatory element binding		SAIBB		420
Uncharacterized protein		Cebus capucinus imitator		420
Uncharacterized protein		AOTNA		420
+101

Protein	Similar proteins		Species	Score	Length	Source
Q9HCU5	PREB protein		HUMAN		345	UniRef50_Q9HCU5
Uncharacterized protein		Cebus capucinus imitator		420
Prolactin regulatory element-binding protein		CALJA		420
Uncharacterized protein		AOTNA		420
Prolactin regulatory element binding		AILME		420
+112

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF226684 mRNA Translation: AAG01692.1 AF203687 mRNA Translation: AAF19192.1 AF227166 Genomic DNA Translation: AAF74572.1 AK023064 mRNA Translation: BAB14385.1 AC013403 Genomic DNA Translation: AAX93170.1 CH471053 Genomic DNA Translation: EAX00627.1 BC002765 mRNA Translation: AAH02765.1 BC012890 mRNA Translation: AAH12890.1 BC016472 mRNA Translation: AAH16472.1 BC041032 mRNA Translation: AAH41032.1
CCDSⁱ	CCDS1738.1
RefSeqⁱ	NP_001317414.1, NM_001330485.1 NP_001317415.1, NM_001330486.1 NP_037520.1, NM_013388.5
UniGeneⁱ	Hs.279784

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5TF2	X-ray	2.80	A	1-389	[»]
ProteinModelPortalⁱ	Q9HCU5
SMRⁱ	Q9HCU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115419, 20 interactors
IntActⁱ	Q9HCU5, 21 interactors
MINTⁱ	Q9HCU5
STRINGⁱ	9606.ENSP00000260643

PTM databases

iPTMnetⁱ	Q9HCU5
PhosphoSitePlusⁱ	Q9HCU5

Polymorphism and mutation databases

BioMutaⁱ	PREB
DMDMⁱ	55977881

Proteomic databases

EPDⁱ	Q9HCU5
MaxQBⁱ	Q9HCU5
PaxDbⁱ	Q9HCU5
PeptideAtlasⁱ	Q9HCU5
PRIDEⁱ	Q9HCU5
ProteomicsDBⁱ	81801

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10113
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000260643; ENSP00000260643; ENSG00000138073
GeneIDⁱ	10113
KEGGⁱ	hsa:10113
UCSCⁱ	uc002rix.3 human

Organism-specific databases

CTDⁱ	10113
EuPathDBⁱ	HostDB:ENSG00000138073.13
GeneCardsⁱ	PREB
HGNCⁱ	HGNC:9356 PREB
HPAⁱ	HPA013582 HPA014133
MIMⁱ	606395 gene
neXtProtⁱ	NX_Q9HCU5
OpenTargetsⁱ	ENSG00000138073
PharmGKBⁱ	PA33727
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0771 Eukaryota ENOG410XRQK LUCA
GeneTreeⁱ	ENSGT00390000018031
HOGENOMⁱ	HOG000045302
HOVERGENⁱ	HBG002027
InParanoidⁱ	Q9HCU5
KOⁱ	K14003
OMAⁱ	AHSMFVT
OrthoDBⁱ	EOG091G06TN
PhylomeDBⁱ	Q9HCU5
TreeFamⁱ	TF314383

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-5694530 Cargo concentration in the ER
SignaLinkⁱ	Q9HCU5

Miscellaneous databases

ChiTaRSⁱ	PREB human
GeneWikiⁱ	PREB
GenomeRNAiⁱ	10113
Protein Ontology More...PROⁱ	PR:Q9HCU5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000138073 Expressed in 217 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_PREB
ExpressionAtlasⁱ	Q9HCU5 baseline and differential
Genevisibleⁱ	Q9HCU5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011047 Quinoprotein_ADH-like_supfam IPR001680 WD40_repeat IPR017986 WD40_repeat_dom
Pfamⁱ	View protein in Pfam PF00400 WD40, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 4 hits
SUPFAMⁱ	SSF50998 SSF50998, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PREB_HUMAN
Accessionⁱ	Q9HCU5Primary (citable) accession number: Q9HCU5 Secondary accession number(s): Q53SZ8, Q9UH94
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
	Last sequence update:	November 23, 2004
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - Q9HCU5 (PREB_HUMAN)

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Prolactin regulatory element-binding protein

PREB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Nucleus

Endoplasmic reticulum

Golgi apparatus

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ