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UniProtKB - Q9HCU5 (PREB_HUMAN)

Entry version 171 (23 Feb 2022)
Sequence version 2 (23 Nov 2004)
Previous versions | rss
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Protein

Prolactin regulatory element-binding protein

Gene

PREB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.

By similarity

Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processER-Golgi transport, Protein transport, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HCU5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005, COPII-mediated vesicle transport
R-HSA-381038, XBP1(S) activates chaperone genes
R-HSA-5694530, Cargo concentration in the ER

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9HCU5

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.92.1.10, the g-protein AlphaBetaGama complex (gpc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolactin regulatory element-binding protein
Alternative name(s):
Mammalian guanine nucleotide exchange factor mSec12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PREB
Synonyms:SEC12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9356, PREB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606395, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HCU5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000138073

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 388CytoplasmicSequence analysisAdd BLAST388
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 417LumenalSequence analysis8

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10113

Open Targets

More...OpenTargetsi		ENSG00000138073

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33727

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HCU5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PREB

Domain mapping of disease mutations (DMDM)

More...DMDMi		55977881

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000511541 – 417Prolactin regulatory element-binding proteinAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei103'-nitrotyrosineBy similarity1

Keywords - PTMi

Nitration

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HCU5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HCU5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HCU5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HCU5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HCU5

PeptideAtlas

More...PeptideAtlasi		Q9HCU5

PRoteomics IDEntifications database

More...PRIDEi		Q9HCU5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81801

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HCU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HCU5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9HCU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138073, Expressed in right lobe of liver and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HCU5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HCU5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138073, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SAR1B (GDP-bound form) (By similarity).

Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites (PubMed:25202031, PubMed:27170179).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115419, 133 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9HCU5

Protein interaction database and analysis system

More...IntActi		Q9HCU5, 31 interactors

Molecular INTeraction database

More...MINTi		Q9HCU5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000260643

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HCU5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HCU5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 50WD 1Add BLAST47
Repeati58 – 97WD 2Add BLAST40
Repeati127 – 183WD 3Add BLAST57
Repeati187 – 224WD 4Add BLAST38
Repeati230 – 287WD 5Add BLAST58
Repeati291 – 329WD 6Add BLAST39
Repeati334 – 385WD 7Add BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni101 – 130DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 130Basic and acidic residuesSequence analysisAdd BLAST22

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0771, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018031

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_054579_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HCU5

Identification of Orthologs from Complete Genome Data

More...OMAi		AHCQMYY

Database of Orthologous Groups

More...OrthoDBi		828247at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HCU5

TreeFam database of animal gene trees

More...TreeFami		TF314383

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011047, Quinoprotein_ADH-like_supfam
IPR045260, Sec12-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23284, PTHR23284, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00400, WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320, WD40, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50998, SSF50998, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9HCU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL 
        60         70         80         90        100
ELINGRLSAS LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ 
       110        120        130        140        150
QGNKAEKAGS KEQGPRQRKG AAPAEKKCGA ETQHEGLELR VENLQAVQTD 
       160        170        180        190        200
FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV WKVPSLEKVL EFKAHEGEIE 
       210        220        230        240        250
DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF SSTPYRYQAC 
       260        270        280        290        300
RFGQVPDQPA GLRLFTVQIP HKRLRQPPPC YLTAWDGSNF LPLRTKSCGH 
       310        320        330        340        350
EVVSCLDVSE SGTFLGLGTV TGSVAIYIAF SLQCLYYVRE AHGIVVTDVA 
       360        370        380        390        400
FLPEKGRGPE LLGSHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG 
       410 
LIIVTILLLQ SAFPGFL
Length:417
Mass (Da):45,468
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FD490A641202D19
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MC98B5MC98_HUMAN
Prolactin regulatory element-bindin...
PREB
359Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2N7H7C2N7_HUMAN
Prolactin regulatory element-bindin...
PREB
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0W3H7C0W3_HUMAN
Prolactin regulatory element-bindin...
PREB
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCS5F8WCS5_HUMAN
Prolactin regulatory element-bindin...
PREB
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZX0H7BZX0_HUMAN
Prolactin regulatory element-bindin...
PREB
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19L → F in AAG01692 (PubMed:10920239).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF226684 mRNA Translation: AAG01692.1
AF203687 mRNA Translation: AAF19192.1
AF227166 Genomic DNA Translation: AAF74572.1
AK023064 mRNA Translation: BAB14385.1
AC013403 Genomic DNA Translation: AAX93170.1
CH471053 Genomic DNA Translation: EAX00627.1
BC002765 mRNA Translation: AAH02765.1
BC012890 mRNA Translation: AAH12890.1
BC016472 mRNA Translation: AAH16472.1
BC041032 mRNA Translation: AAH41032.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1738.1

NCBI Reference Sequences

More...RefSeqi		NP_001317414.1, NM_001330485.1
NP_001317415.1, NM_001330486.1
NP_037520.1, NM_013388.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000260643; ENSP00000260643; ENSG00000138073

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10113

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000260643.7; ENSP00000260643.2; NM_013388.6; NP_037520.1

UCSC genome browser

More...UCSCi		uc002rix.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226684 mRNA Translation: AAG01692.1
AF203687 mRNA Translation: AAF19192.1
AF227166 Genomic DNA Translation: AAF74572.1
AK023064 mRNA Translation: BAB14385.1
AC013403 Genomic DNA Translation: AAX93170.1
CH471053 Genomic DNA Translation: EAX00627.1
BC002765 mRNA Translation: AAH02765.1
BC012890 mRNA Translation: AAH12890.1
BC016472 mRNA Translation: AAH16472.1
BC041032 mRNA Translation: AAH41032.1
CCDSiCCDS1738.1
RefSeqiNP_001317414.1, NM_001330485.1
NP_001317415.1, NM_001330486.1
NP_037520.1, NM_013388.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TF2X-ray2.80A1-389[»]
SMRiQ9HCU5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115419, 133 interactors
CORUMiQ9HCU5
IntActiQ9HCU5, 31 interactors
MINTiQ9HCU5
STRINGi9606.ENSP00000260643

Protein family/group databases

TCDBi8.A.92.1.10, the g-protein AlphaBetaGama complex (gpc) family

PTM databases

iPTMnetiQ9HCU5
PhosphoSitePlusiQ9HCU5
SwissPalmiQ9HCU5

Genetic variation databases

BioMutaiPREB
DMDMi55977881

Proteomic databases

EPDiQ9HCU5
jPOSTiQ9HCU5
MassIVEiQ9HCU5
MaxQBiQ9HCU5
PaxDbiQ9HCU5
PeptideAtlasiQ9HCU5
PRIDEiQ9HCU5
ProteomicsDBi81801

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3012, 115 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		10113

Genome annotation databases

EnsembliENST00000260643; ENSP00000260643; ENSG00000138073
GeneIDi10113
KEGGihsa:10113
MANE-SelectiENST00000260643.7; ENSP00000260643.2; NM_013388.6; NP_037520.1
UCSCiuc002rix.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10113
DisGeNETi10113

GeneCards: human genes, protein and diseases

More...GeneCardsi		PREB
HGNCiHGNC:9356, PREB
HPAiENSG00000138073, Low tissue specificity
MIMi606395, gene
neXtProtiNX_Q9HCU5
OpenTargetsiENSG00000138073
PharmGKBiPA33727
VEuPathDBiHostDB:ENSG00000138073

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0771, Eukaryota
GeneTreeiENSGT00390000018031
HOGENOMiCLU_054579_1_0_1
InParanoidiQ9HCU5
OMAiAHCQMYY
OrthoDBi828247at2759
PhylomeDBiQ9HCU5
TreeFamiTF314383

Enzyme and pathway databases

PathwayCommonsiQ9HCU5
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-381038, XBP1(S) activates chaperone genes
R-HSA-5694530, Cargo concentration in the ER
SignaLinkiQ9HCU5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10113, 718 hits in 1048 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PREB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PREB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10113
PharosiQ9HCU5, Tbio

Protein Ontology

More...PROi		PR:Q9HCU5
RNActiQ9HCU5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138073, Expressed in right lobe of liver and 231 other tissues
ExpressionAtlasiQ9HCU5, baseline and differential
GenevisibleiQ9HCU5, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011047, Quinoprotein_ADH-like_supfam
IPR045260, Sec12-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
PANTHERiPTHR23284, PTHR23284, 1 hit
PfamiView protein in Pfam
PF00400, WD40, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 4 hits
SUPFAMiSSF50998, SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPREB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCU5
Secondary accession number(s): Q53SZ8, Q9UH94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: November 23, 2004
Last modified: February 23, 2022
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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