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Entry version 177 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

CELSR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G protein-coupled receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9HCU4

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2Curated
Alternative name(s):
Cadherin family member 10
Epidermal growth factor-like protein 2
Short name:
EGF-like protein 2
Flamingo homolog 3
Multiple epidermal growth factor-like domains protein 3
Short name:
Multiple EGF-like domains protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELSR2Imported
Synonyms:CDHF10, EGFL2, KIAA0279, MEGF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:3231 CELSR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604265 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCU4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 2380ExtracellularSequence analysisAdd BLAST2349
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2381 – 2401Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2402 – 2416CytoplasmicSequence analysisAdd BLAST15
Transmembranei2417 – 2437Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2438ExtracellularSequence analysis1
Transmembranei2439 – 2459Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2460 – 2480CytoplasmicSequence analysisAdd BLAST21
Transmembranei2481 – 2501Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2502 – 2519ExtracellularSequence analysisAdd BLAST18
Transmembranei2520 – 2540Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2541 – 2560CytoplasmicSequence analysisAdd BLAST20
Transmembranei2561 – 2581Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2582 – 2591ExtracellularSequence analysis10
Transmembranei2592 – 2612Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2613 – 2923CytoplasmicSequence analysisAdd BLAST311

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1952

Open Targets

More...
OpenTargetsi
ENSG00000143126

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26394

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HCU4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CELSR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22095550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291632 – 2923Cadherin EGF LAG seven-pass G-type receptor 2Add BLAST2892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1036N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1076N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1232 ↔ 1243By similarity
Disulfide bondi1237 ↔ 1274By similarity
Disulfide bondi1276 ↔ 1285By similarity
Disulfide bondi1292 ↔ 1303By similarity
Disulfide bondi1297 ↔ 1312By similarity
Disulfide bondi1314 ↔ 1323By similarity
Disulfide bondi1332 ↔ 1343By similarity
Disulfide bondi1337 ↔ 1353By similarity
Disulfide bondi1355 ↔ 1365By similarity
Glycosylationi1501N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1545 ↔ 1571By similarity
Glycosylationi1565N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1578 ↔ 1589By similarity
Disulfide bondi1583 ↔ 1598By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1591(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi1600 ↔ 1609By similarity
Glycosylationi1741N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1761 ↔ 1791By similarity
Disulfide bondi1797 ↔ 1808By similarity
Disulfide bondi1802 ↔ 1817By similarity
Modified residuei1810(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi1819 ↔ 1828By similarity
Glycosylationi1827N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1832 ↔ 1843By similarity
Disulfide bondi1837 ↔ 1855By similarity
Disulfide bondi1857 ↔ 1866By similarity
Disulfide bondi1887 ↔ 1899By similarity
Disulfide bondi1889 ↔ 1906By similarity
Glycosylationi1900N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1908 ↔ 1921By similarity
Disulfide bondi1924 ↔ 1936By similarity
Disulfide bondi1926 ↔ 1943By similarity
Disulfide bondi1945 ↔ 1954By similarity
Disulfide bondi1957 ↔ 1969By similarity
Glycosylationi2024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2043N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2061N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2345N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HCU4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9HCU4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9HCU4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HCU4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9HCU4

PeptideAtlas

More...
PeptideAtlasi
Q9HCU4

PRoteomics IDEntifications database

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PRIDEi
Q9HCU4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
81800

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1055

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCU4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCU4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in brain and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143126 Expressed in 186 organ(s), highest expression level in vagina

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HCU4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013952

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108272, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HCU4, 29 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271332

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HCU4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 289Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini290 – 399Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini400 – 505Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini506 – 610Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini611 – 712Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini713 – 815Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini816 – 921Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini922 – 1023Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1028 – 1146Cadherin 9PROSITE-ProRule annotationAdd BLAST119
Domaini1228 – 1286EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1288 – 1324EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1328 – 1366EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1367 – 1571Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1574 – 1610EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1614 – 1791Laminin G-like 2PROSITE-ProRule annotationAdd BLAST178
Domaini1793 – 1828EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1829 – 1867EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1883 – 1922EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1924 – 1971Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2316 – 2368GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2743 – 2752Poly-Glu10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157493

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231346

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HCU4

KEGG Orthology (KO)

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KOi
K04601

Identification of Orthologs from Complete Genome Data

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OMAi
GCPTKKN

Database of Orthologous Groups

More...
OrthoDBi
23882at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCU4

TreeFam database of animal gene trees

More...
TreeFami
TF323983

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF12661 hEGF, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSPATGVPL PTPPPPLLLL LLLLLPPPLL GDQVGPCRSL GSRGRGSSGA
60 70 80 90 100
CAPMGWLCPS SASNLWLYTS RCRDAGTELT GHLVPHHDGL RVWCPESEAH
110 120 130 140 150
IPLPPAPEGC PWSCRLLGIG GHLSPQGKLT LPEEHPCLKA PRLRCQSCKL
160 170 180 190 200
AQAPGLRAGE RSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTPV
210 220 230 240 250
ASLRAIDPDE GEAGRLEYTM DALFDSRSNQ FFSLDPVTGA VTTAEELDRE
260 270 280 290 300
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE
310 320 330 340 350
NLEVGYEVLT VRATDGDAPP NANILYRLLE GSGGSPSEVF EIDPRSGVIR
360 370 380 390 400
TRGPVDREEV ESYQLTVEAS DQGRDPGPRS TTAAVFLSVE DDNDNAPQFS
410 420 430 440 450
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NAVVHYSIMS GNARGQFYLD
460 470 480 490 500
AQTGALDVVS PLDYETTKEY TLRVRAQDGG RPPLSNVSGL VTVQVLDIND
510 520 530 540 550
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYRLAGVGHD
560 570 580 590 600
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTV
610 620 630 640 650
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG
660 670 680 690 700
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV
710 720 730 740 750
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF
760 770 780 790 800
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY
810 820 830 840 850
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV
860 870 880 890 900
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP
910 920 930 940 950
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE
960 970 980 990 1000
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS
1010 1020 1030 1040 1050
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP
1060 1070 1080 1090 1100
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELKLSRALDN NRPLEAIMSV
1110 1120 1130 1140 1150
LVSDGVHSVT AQCALRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI
1160 1170 1180 1190 1200
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL
1210 1220 1230 1240 1250
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD
1260 1270 1280 1290 1300
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH
1310 1320 1330 1340 1350
GRCRSREGGY TCLCRDGYTG EHCEVSARSG RCTPGVCKNG GTCVNLLVGG
1360 1370 1380 1390 1400
FKCDCPSGDF EKPYCQVTTR SFPAHSFITF RGLRQRFHFT LALSFATKER
1410 1420 1430 1440 1450
DGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG
1460 1470 1480 1490 1500
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVTVDGCDTG VALRFGSVLG
1510 1520 1530 1540 1550
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR QFVGCMRNLQ
1560 1570 1580 1590 1600
VDSRHIDMAD FIANNGTVPG CPAKKNVCDS NTCHNGGTCV NQWDAFSCEC
1610 1620 1630 1640 1650
PLGFGGKSCA QEMANPQHFL GSSLVAWHGL SLPISQPWYL SLMFRTRQAD
1660 1670 1680 1690 1700
GVLLQAITRG RSTITLQLRE GHVMLSVEGT GLQASSLRLE PGRANDGDWH
1710 1720 1730 1740 1750
HAQLALGASG GPGHAILSFD YGQQRAEGNL GPRLHGLHLS NITVGGIPGP
1760 1770 1780 1790 1800
AGGVARGFRG CLQGVRVSDT PEGVNSLDPS HGESINVEQG CSLPDPCDSN
1810 1820 1830 1840 1850
PCPANSYCSN DWDSYSCSCD PGYYGDNCTN VCDLNPCEHQ SVCTRKPSAP
1860 1870 1880 1890 1900
HGYTCECPPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN
1910 1920 1930 1940 1950
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI
1960 1970 1980 1990 2000
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP
2010 2020 2030 2040 2050
KGSFGTAVRH CDEHRGWLPP NLFNCTSITF SELKGFAERL QRNESGLDSG
2060 2070 2080 2090 2100
RSQQLALLLR NATQHTAGYF GSDVKVAYQL ATRLLAHEST QRGFGLSATQ
2110 2120 2130 2140 2150
DVHFTENLLR VGSALLDTAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ
2160 2170 2180 2190 2200
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GAKLPRYEAL RGEQPPDLET
2210 2220 2230 2240 2250
TVILPESVFR ETPPVVRPAG PGEAQEPEEL ARRQRRHPEL SQGEAVASVI
2260 2270 2280 2290 2300
IYRTLAGLLP HNYDPDKRSL RVPKRPIINT PVVSISVHDD EELLPRALDK
2310 2320 2330 2340 2350
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS
2360 2370 2380 2390 2400
CQCNHMTSFA VLMDVSRREN GEILPLKTLT YVALGVTLAA LLLTFFFLTL
2410 2420 2430 2440 2450
LRILRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY
2460 2470 2480 2490 2500
LCTFSWALLE ALHLYRALTE VRDVNTGPMR FYYMLGWGVP AFITGLAVGL
2510 2520 2530 2540 2550
DPEGYGNPDF CWLSIYDTLI WSFAGPVAFA VSMSVFLYIL AARASCAAQR
2560 2570 2580 2590 2600
QGFEKKGPVS GLQPSFAVLL LLSATWLLAL LSVNSDTLLF HYLFATCNCI
2610 2620 2630 2640 2650
QGPFIFLSYV VLSKEVRKAL KLACSRKPSP DPALTTKSTL TSSYNCPSPY
2660 2670 2680 2690 2700
ADGRLYQPYG DSAGSLHSTS RSGKSQPSYI PFLLREESAL NPGQGPPGLG
2710 2720 2730 2740 2750
DPGSLFLEGQ DQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEEE
2760 2770 2780 2790 2800
EEAAFPGEQG WDSLLGPGAE RLPLHSTPKD GGPGPGKAPW PGDFGTTAKE
2810 2820 2830 2840 2850
SSGNGAPEER LRENGDALSR EGSLGPLPGS SAQPHKGILK KKCLPTISEK
2860 2870 2880 2890 2900
SSLLRLPLEQ CTGSSRGSSA SEGSRGGPPP RPPPRQSLQE QLNGVMPIAM
2910 2920
SIKAGTVDED SSGSEFLFFN FLH
Length:2,923
Mass (Da):317,453
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i382757D315158ED8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0494741066R → Q. Corresponds to variant dbSNP:rs12083590Ensembl.1
Natural variantiVAR_0244811639Y → H1 PublicationCorresponds to variant dbSNP:rs653635Ensembl.1
Natural variantiVAR_0494751992G → R. Corresponds to variant dbSNP:rs12567377Ensembl.1
Natural variantiVAR_0494762387T → A. Corresponds to variant dbSNP:rs17035649Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF234887 mRNA Translation: AAG00080.1
AB065955 Genomic DNA Translation: BAC06168.1
AL390252 Genomic DNA No translation available.
D87469 mRNA Translation: BAA13407.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS796.1

NCBI Reference Sequences

More...
RefSeqi
NP_001399.1, NM_001408.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271332; ENSP00000271332; ENSG00000143126

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1952

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1952

UCSC genome browser

More...
UCSCi
uc001dxa.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234887 mRNA Translation: AAG00080.1
AB065955 Genomic DNA Translation: BAC06168.1
AL390252 Genomic DNA No translation available.
D87469 mRNA Translation: BAA13407.2
CCDSiCCDS796.1
RefSeqiNP_001399.1, NM_001408.2

3D structure databases

SMRiQ9HCU4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108272, 36 interactors
IntActiQ9HCU4, 29 interactors
STRINGi9606.ENSP00000271332

Protein family/group databases

MEROPSiP02.006

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyConnecti1055
iPTMnetiQ9HCU4
PhosphoSitePlusiQ9HCU4

Polymorphism and mutation databases

BioMutaiCELSR2
DMDMi22095550

Proteomic databases

EPDiQ9HCU4
jPOSTiQ9HCU4
MassIVEiQ9HCU4
MaxQBiQ9HCU4
PaxDbiQ9HCU4
PeptideAtlasiQ9HCU4
PRIDEiQ9HCU4
ProteomicsDBi81800

Genome annotation databases

EnsembliENST00000271332; ENSP00000271332; ENSG00000143126
GeneIDi1952
KEGGihsa:1952
UCSCiuc001dxa.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1952
DisGeNETi1952

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CELSR2
HGNCiHGNC:3231 CELSR2
HPAiHPA013952
MIMi604265 gene
neXtProtiNX_Q9HCU4
OpenTargetsiENSG00000143126
PharmGKBiPA26394

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000157493
HOGENOMiHOG000231346
InParanoidiQ9HCU4
KOiK04601
OMAiGCPTKKN
OrthoDBi23882at2759
PhylomeDBiQ9HCU4
TreeFamiTF323983

Enzyme and pathway databases

SignaLinkiQ9HCU4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CELSR2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CELSR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1952
PharosiQ9HCU4

Protein Ontology

More...
PROi
PR:Q9HCU4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143126 Expressed in 186 organ(s), highest expression level in vagina
GenevisibleiQ9HCU4 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF12661 hEGF, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCU4
Secondary accession number(s): Q5T2Y7, Q92566
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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