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Entry version 135 (13 Feb 2019)
Sequence version 2 (18 May 2010)
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Protein

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Gene

PDE11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator. Weakly inhibited by Sildenafil (Viagra) and Tadalafil (Cialis); however, the fact that the protein is probably absent from testis, suggests that it is not biologically relevant and is not related with erectile dysfunction.4 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.0 µM for cAMP (isoform 1)3 Publications
  2. KM=1.4 µM for cGMP (isoform 1)3 Publications
  3. KM=3.0 µM for cAMP (isoform 2)3 Publications
  4. KM=1.5 µM for cGMP (isoform 2)3 Publications
  5. KM=3.3 µM for cAMP (isoform 3)3 Publications
  6. KM=3.7 µM for cGMP (isoform 3)3 Publications
  7. KM=1.04 µM for cAMP (isoform 4)3 Publications
  8. KM=0.52 µM for cGMP (isoform 4)3 Publications
  1. Vmax=3.6 pmol/min/µg enzyme with cAMP as substrate (isoform 4)3 Publications
  2. Vmax=3.9 pmol/min/µg enzyme with cGMP as substrate (isoform 4)3 Publications
  3. Vmax=270 pmol/min/µg enzyme with cAMP as substrate (isoform 1)3 Publications
  4. Vmax=120 pmol/min/µg enzyme with cGMP as substrate (isoform 1)3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei664Proton donorBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi668Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi704Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi705Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi705Divalent metal cation 2PROSITE-ProRule annotation1
Metal bindingi816Divalent metal cation 1PROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei869cAMP or cGMPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Hydrolase
LigandcAMP, cGMP, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.17 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC:3.1.4.35, EC:3.1.4.53)
Alternative name(s):
cAMP and cGMP phosphodiesterase 11A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDE11A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000128655.16

Human Gene Nomenclature Database

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HGNCi
HGNC:8773 PDE11A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604961 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCR9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Primary pigmented nodular adrenocortical disease 2 (PPNAD2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
See also OMIM:610475

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi355D → A: Induces a decrease in enzyme activity due to the inability of cGMP to bind and stimulate enzyme activity. 1 Publication1

Keywords - Diseasei

Cushing syndrome

Organism-specific databases

DisGeNET

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DisGeNETi
50940

MalaCards human disease database

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MalaCardsi
PDE11A
MIMi610475 phenotype

Open Targets

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OpenTargetsi
ENSG00000128655

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
189439 Primary pigmented nodular adrenocortical disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33121

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2717

Drug and drug target database

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DrugBanki
DB00201 Caffeine
DB00820 Tadalafil

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1311

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDE11A

Domain mapping of disease mutations (DMDM)

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DMDMi
296439264

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470401 – 933Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AAdd BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei162PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei239PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HCR9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9HCR9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9HCR9

PeptideAtlas

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PeptideAtlasi
Q9HCR9

PRoteomics IDEntifications database

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PRIDEi
Q9HCR9

ProteomicsDB human proteome resource

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ProteomicsDBi
81789
81790 [Q9HCR9-2]
81791 [Q9HCR9-3]
81792 [Q9HCR9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9HCR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9HCR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128655 Expressed in 118 organ(s), highest expression level in vastus lateralis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HCR9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HCR9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034560

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
9606.ENSP00000286063

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9HCR9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9HCR9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HCR9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini217 – 370GAF 1Add BLAST154
Domaini402 – 558GAF 2Add BLAST157
Domaini588 – 912PDEasePROSITE-ProRule annotationAdd BLAST325

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3689 Eukaryota
ENOG410XRI7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162151

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG101207

KEGG Orthology (KO)

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KOi
K13298

Identification of Orthologs from Complete Genome Data

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OMAi
KNHRDVF

Database of Orthologous Groups

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OrthoDBi
904682at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9HCR9

TreeFam database of animal gene trees

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TreeFami
TF316499

Family and domain databases

Conserved Domains Database

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CDDi
cd00077 HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1300.10, 1 hit
3.30.450.40, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00387 PDIESTERASE1

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCR9-1) [UniParc]FASTAAdd to basket
Also known as: PDE11A4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRLDFGE VETFLDRHPE LFEDYLMRKG KQEMVEKWLQ RHSQGQGALG
60 70 80 90 100
PRPSLAGTSS LAHSTCRGGS SVGGGTGPNG SAHSQPLPGG GDCGGVPLSP
110 120 130 140 150
SWAGGSRGDG NLQRRASQKE LRKSFARSKA IHVNRTYDEQ VTSRAQEPLS
160 170 180 190 200
SVRRRALLRK ASSLPPTTAH ILSALLESRV NLPRYPPTAI DYKCHLKKHN
210 220 230 240 250
ERQFFLELVK DISNDLDLTS LSYKILIFVC LMVDADRCSL FLVEGAAAGK
260 270 280 290 300
KTLVSKFFDV HAGTPLLPCS STENSNEVQV PWGKGIIGYV GEHGETVNIP
310 320 330 340 350
DAYQDRRFND EIDKLTGYKT KSLLCMPIRS SDGEIIGVAQ AINKIPEGAP
360 370 380 390 400
FTEDDEKVMQ MYLPFCGIAI SNAQLFAASR KEYERSRALL EVVNDLFEEQ
410 420 430 440 450
TDLEKIVKKI MHRAQTLLKC ERCSVLLLED IESPVVKFTK SFELMSPKCS
460 470 480 490 500
ADAENSFKES MEKSSYSDWL INNSIAELVA STGLPVNISD AYQDPRFDAE
510 520 530 540 550
ADQISGFHIR SVLCVPIWNS NHQIIGVAQV LNRLDGKPFD DADQRLFEAF
560 570 580 590 600
VIFCGLGINN TIMYDQVKKS WAKQSVALDV LSYHATCSKA EVDKFKAANI
610 620 630 640 650
PLVSELAIDD IHFDDFSLDV DAMITAALRM FMELGMVQKF KIDYETLCRW
660 670 680 690 700
LLTVRKNYRM VLYHNWRHAF NVCQLMFAML TTAGFQDILT EVEILAVIVG
710 720 730 740 750
CLCHDLDHRG TNNAFQAKSG SALAQLYGTS ATLEHHHFNH AVMILQSEGH
760 770 780 790 800
NIFANLSSKE YSDLMQLLKQ SILATDLTLY FERRTEFFEL VSKGEYDWNI
810 820 830 840 850
KNHRDIFRSM LMTACDLGAV TKPWEISRQV AELVTSEFFE QGDRERLELK
860 870 880 890 900
LTPSAIFDRN RKDELPRLQL EWIDSICMPL YQALVKVNVK LKPMLDSVAT
910 920 930
NRSKWEELHQ KRLLASTASS SPASVMVAKE DRN
Length:933
Mass (Da):104,752
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB725AE6963D6E799
GO
Isoform 2 (identifier: Q9HCR9-2) [UniParc]FASTAAdd to basket
Also known as: PDE11A3

The sequence of this isoform differs from the canonical sequence as follows:
     1-250: Missing.
     251-304: KTLVSKFFDV...ETVNIPDAYQ → MLKQARRPLF...FLIQRQTKTK

Show »
Length:683
Mass (Da):78,047
Checksum:i82DD9BB77C941A1C
GO
Isoform 3 (identifier: Q9HCR9-3) [UniParc]FASTAAdd to basket
Also known as: PDE11A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-358: Missing.

Show »
Length:575
Mass (Da):65,679
Checksum:iA1DDA7F4BAF43221
GO
Isoform 4 (identifier: Q9HCR9-4) [UniParc]FASTAAdd to basket
Also known as: PDE11A1

The sequence of this isoform differs from the canonical sequence as follows:
     1-444: Missing.

Show »
Length:489
Mass (Da):55,700
Checksum:i3E6ED2AAE9CBF03C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4D0H7C4D0_HUMAN
Phosphodiesterase
PDE11A
437Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6P9H0Y6P9_HUMAN
Dual 3',5'-cyclic-AMP and -GMP phos...
PDE11A
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDQ4F8WDQ4_HUMAN
Dual 3',5'-cyclic-AMP and -GMP phos...
PDE11A
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti184R → Q in BAB16371 (PubMed:10906126).Curated1
Sequence conflicti184R → Q in BAB62712 (PubMed:11121118).Curated1
Sequence conflicti184R → Q in AAI12394 (PubMed:15489334).Curated1
Sequence conflicti184R → Q in AAI14432 (PubMed:15489334).Curated1
Sequence conflicti921S → SS in BAB16371 (PubMed:10906126).Curated1
Sequence conflicti921S → SS in BAB16372 (PubMed:10906126).Curated1
Sequence conflicti921S → SS in CAB82573 (PubMed:10725373).Curated1
Sequence conflicti921S → SS in AAG32023 (PubMed:11050148).Curated1
Sequence conflicti921S → SS in CAC15567 (PubMed:11050148).Curated1
Sequence conflicti921S → SS in BAB62712 (PubMed:11121118).Curated1
Sequence conflicti921S → SS in BAB62713 (PubMed:11121118).Curated1
Sequence conflicti921S → SS in BAB62714 (PubMed:11121118).Curated1
Sequence conflicti921S → SS in AAI12394 (PubMed:15489334).Curated1
Sequence conflicti921S → SS in AAI14432 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027056804R → H1 PublicationCorresponds to variant dbSNP:rs75127279Ensembl.1
Natural variantiVAR_027057867R → G1 PublicationCorresponds to variant dbSNP:rs61306957Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0198981 – 444Missing in isoform 4. 1 PublicationAdd BLAST444
Alternative sequenceiVSP_0198991 – 358Missing in isoform 3. 1 PublicationAdd BLAST358
Alternative sequenceiVSP_0199001 – 250Missing in isoform 2. 2 PublicationsAdd BLAST250
Alternative sequenceiVSP_019901251 – 304KTLVS…PDAYQ → MLKQARRPLFRNVLSATQWK KVKITRLVQISGASLAEKQE KHQDFLIQRQTKTK in isoform 2. 2 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB036704 mRNA Translation: BAB16371.1
AB038041 mRNA Translation: BAB16372.1
AJ251509 mRNA Translation: CAB82573.1
AF281865 mRNA Translation: AAG32023.1
AJ278682 mRNA Translation: CAC15567.1
AB048423 Genomic DNA Translation: BAB62712.1
AB048423 Genomic DNA Translation: BAB62713.2
AB048423 Genomic DNA Translation: BAB62714.1
AC073834 Genomic DNA No translation available.
AC073892 Genomic DNA No translation available.
AC083824 Genomic DNA No translation available.
AC011998 Genomic DNA No translation available.
AC012499 Genomic DNA Translation: AAY14803.1
BC112393 mRNA Translation: AAI12394.1
BC114431 mRNA Translation: AAI14432.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33334.1 [Q9HCR9-1]
CCDS42785.1 [Q9HCR9-2]
CCDS42786.1 [Q9HCR9-4]
CCDS46459.1 [Q9HCR9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001070664.1, NM_001077196.1 [Q9HCR9-4]
NP_001070665.1, NM_001077197.1 [Q9HCR9-2]
NP_001070826.1, NM_001077358.1 [Q9HCR9-3]
NP_058649.3, NM_016953.3 [Q9HCR9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.570273

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286063; ENSP00000286063; ENSG00000128655 [Q9HCR9-1]
ENST00000389683; ENSP00000374333; ENSG00000128655 [Q9HCR9-4]
ENST00000409504; ENSP00000386539; ENSG00000128655 [Q9HCR9-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50940

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50940

UCSC genome browser

More...
UCSCi
uc002ulp.4 human [Q9HCR9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036704 mRNA Translation: BAB16371.1
AB038041 mRNA Translation: BAB16372.1
AJ251509 mRNA Translation: CAB82573.1
AF281865 mRNA Translation: AAG32023.1
AJ278682 mRNA Translation: CAC15567.1
AB048423 Genomic DNA Translation: BAB62712.1
AB048423 Genomic DNA Translation: BAB62713.2
AB048423 Genomic DNA Translation: BAB62714.1
AC073834 Genomic DNA No translation available.
AC073892 Genomic DNA No translation available.
AC083824 Genomic DNA No translation available.
AC011998 Genomic DNA No translation available.
AC012499 Genomic DNA Translation: AAY14803.1
BC112393 mRNA Translation: AAI12394.1
BC114431 mRNA Translation: AAI14432.1
CCDSiCCDS33334.1 [Q9HCR9-1]
CCDS42785.1 [Q9HCR9-2]
CCDS42786.1 [Q9HCR9-4]
CCDS46459.1 [Q9HCR9-3]
RefSeqiNP_001070664.1, NM_001077196.1 [Q9HCR9-4]
NP_001070665.1, NM_001077197.1 [Q9HCR9-2]
NP_001070826.1, NM_001077358.1 [Q9HCR9-3]
NP_058649.3, NM_016953.3 [Q9HCR9-1]
UniGeneiHs.570273

3D structure databases

ProteinModelPortaliQ9HCR9
SMRiQ9HCR9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000286063

Chemistry databases

BindingDBiQ9HCR9
ChEMBLiCHEMBL2717
DrugBankiDB00201 Caffeine
DB00820 Tadalafil
GuidetoPHARMACOLOGYi1311

PTM databases

iPTMnetiQ9HCR9
PhosphoSitePlusiQ9HCR9

Polymorphism and mutation databases

BioMutaiPDE11A
DMDMi296439264

Proteomic databases

EPDiQ9HCR9
jPOSTiQ9HCR9
PaxDbiQ9HCR9
PeptideAtlasiQ9HCR9
PRIDEiQ9HCR9
ProteomicsDBi81789
81790 [Q9HCR9-2]
81791 [Q9HCR9-3]
81792 [Q9HCR9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286063; ENSP00000286063; ENSG00000128655 [Q9HCR9-1]
ENST00000389683; ENSP00000374333; ENSG00000128655 [Q9HCR9-4]
ENST00000409504; ENSP00000386539; ENSG00000128655 [Q9HCR9-3]
GeneIDi50940
KEGGihsa:50940
UCSCiuc002ulp.4 human [Q9HCR9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50940
DisGeNETi50940
EuPathDBiHostDB:ENSG00000128655.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDE11A
HGNCiHGNC:8773 PDE11A
HPAiHPA034560
MalaCardsiPDE11A
MIMi604961 gene
610475 phenotype
neXtProtiNX_Q9HCR9
OpenTargetsiENSG00000128655
Orphaneti189439 Primary pigmented nodular adrenocortical disease
PharmGKBiPA33121

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00940000162151
HOVERGENiHBG101207
KOiK13298
OMAiKNHRDVF
OrthoDBi904682at2759
PhylomeDBiQ9HCR9
TreeFamiTF316499

Enzyme and pathway databases

BRENDAi3.1.4.17 2681
ReactomeiR-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PDE11A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PDE11A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50940

Protein Ontology

More...
PROi
PR:Q9HCR9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128655 Expressed in 118 organ(s), highest expression level in vastus lateralis
ExpressionAtlasiQ9HCR9 baseline and differential
GenevisibleiQ9HCR9 HS

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 2 hits
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCR9
Secondary accession number(s): Q14CD1
, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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