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Protein

Casein kinase I isoform gamma-1

Gene

CSNK1G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Repressed by 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine (DB08325).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 58ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9HCP0
SIGNORiQ9HCP0

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-1 (EC:2.7.11.1)
Short name:
CKI-gamma 1
Gene namesi
Name:CSNK1G1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000169118.16
HGNCiHGNC:2454 CSNK1G1
MIMi606274 gene
neXtProtiNX_Q9HCP0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi169N → A: Loss of kinase activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

OpenTargetsiENSG00000169118
PharmGKBiPA26954

Chemistry databases

ChEMBLiCHEMBL2426
DrugBankiDB08325 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
GuidetoPHARMACOLOGYi1999

Polymorphism and mutation databases

BioMutaiCSNK1G1
DMDMi18202957

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928391 – 422Casein kinase I isoform gamma-1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei344PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCP0
MaxQBiQ9HCP0
PaxDbiQ9HCP0
PeptideAtlasiQ9HCP0
PRIDEiQ9HCP0
ProteomicsDBi81782
81783 [Q9HCP0-2]

PTM databases

iPTMnetiQ9HCP0
PhosphoSitePlusiQ9HCP0
SwissPalmiQ9HCP0

Expressioni

Gene expression databases

BgeeiENSG00000169118
CleanExiHS_CSNK1G1
ExpressionAtlasiQ9HCP0 baseline and differential
GenevisibleiQ9HCP0 HS

Organism-specific databases

HPAiHPA018209

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119824, 16 interactors
IntActiQ9HCP0, 9 interactors
MINTiQ9HCP0
STRINGi9606.ENSP00000305777

Chemistry databases

BindingDBiQ9HCP0

Structurei

Secondary structure

1422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi49 – 52Combined sources4
Beta strandi54 – 62Combined sources9
Turni64 – 66Combined sources3
Beta strandi69 – 76Combined sources8
Helixi84 – 94Combined sources11
Beta strandi104 – 110Combined sources7
Beta strandi113 – 119Combined sources7
Helixi125 – 131Combined sources7
Turni132 – 134Combined sources3
Helixi138 – 157Combined sources20
Helixi167 – 169Combined sources3
Beta strandi170 – 172Combined sources3
Turni175 – 178Combined sources4
Beta strandi183 – 185Combined sources3
Turni197 – 199Combined sources3
Turni215 – 217Combined sources3
Helixi220 – 223Combined sources4
Helixi230 – 246Combined sources17
Turni250 – 253Combined sources4
Helixi259 – 272Combined sources14
Helixi275 – 278Combined sources4
Turni279 – 281Combined sources3
Helixi284 – 295Combined sources12
Helixi304 – 317Combined sources14
Turni327 – 330Combined sources4

3D structure databases

ProteinModelPortaliQ9HCP0
SMRiQ9HCP0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCP0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 315Protein kinasePROSITE-ProRule annotationAdd BLAST272

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1165 Eukaryota
ENOG410XNXP LUCA
GeneTreeiENSGT00920000148988
HOGENOMiHOG000182054
HOVERGENiHBG000176
InParanoidiQ9HCP0
KOiK08958
PhylomeDBiQ9HCP0
TreeFamiTF313349

Family and domain databases

InterProiView protein in InterPro
IPR022247 Casein_kinase-1_gamma_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12605 CK1gamma_C, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1L (identifier: Q9HCP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHPSREKDE RQRTTKPMAQ RSAHCSRPSG SSSSSGVLMV GPNFRVGKKI
60 70 80 90 100
GCGNFGELRL GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG
110 120 130 140 150
LPQVYYFGPC GKYNAMVLEL LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS
160 170 180 190 200
RMEYVHSKNL IYRDVKPENF LIGRQGNKKE HVIHIIDFGL AKEYIDPETK
210 220 230 240 250
KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM FMYFLRGSLP
260 270 280 290 300
WQGLKADTLK ERYQKIGDTK RNTPIEALCE NFPEEMATYL RYVRRLDFFE
310 320 330 340 350
KPDYEYLRTL FTDLFEKKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT
360 370 380 390 400
RESHTHRDRP SQQQPLRNQV VSSTNGELNV DDPTGAHSNA PITAHAEVEV
410 420
VEEAKCCCFF KRKRKKTAQR HK
Length:422
Mass (Da):48,511
Last modified:March 1, 2001 - v1
Checksum:iB875922349B97645
GO
Isoform 1S (identifier: Q9HCP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-422: VVSSTNGELN...KRKKTAQRHK → SLRTVTAEHYDVNNSAIWHRGRGT

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:393
Mass (Da):45,414
Checksum:i2979A77D92F62261
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042084206R → K1 PublicationCorresponds to variant dbSNP:rs55799101Ensembl.1
Natural variantiVAR_078686230R → W Probable disease-associated mutation found in a patient with non-syndromic early-onset epilepsy associated with severe developmental delay and microcephaly. 1 PublicationCorresponds to variant dbSNP:rs587777544EnsemblClinVar.1
Natural variantiVAR_042085329V → I1 PublicationCorresponds to variant dbSNP:rs55699712Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004748370 – 422VVSST…AQRHK → SLRTVTAEHYDVNNSAIWHR GRGT in isoform 1S. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042563 mRNA Translation: BAB17839.1
AB042562 mRNA Translation: BAB17838.1
AL832551 mRNA Translation: CAI46142.1
CH471082 Genomic DNA Translation: EAW77670.1
BC017236 mRNA Translation: AAH17236.2
BC130613 mRNA Translation: AAI30614.1
BC136504 mRNA Translation: AAI36505.1
CCDSiCCDS10192.2 [Q9HCP0-1]
RefSeqiNP_001316535.1, NM_001329606.1
NP_071331.2, NM_022048.4 [Q9HCP0-1]
UniGeneiHs.646508

Genome annotation databases

EnsembliENST00000303052; ENSP00000305777; ENSG00000169118 [Q9HCP0-1]
ENST00000606225; ENSP00000475325; ENSG00000169118 [Q9HCP0-2]
GeneIDi53944
KEGGihsa:53944
UCSCiuc002anf.4 human [Q9HCP0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKC1G1_HUMAN
AccessioniPrimary (citable) accession number: Q9HCP0
Secondary accession number(s): Q5JPH1, Q96AE9, Q9HCP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

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