UniProtKB - Q9HCP0 (KC1G1_HUMAN)
Protein
Casein kinase I isoform gamma-1
Gene
CSNK1G1
Organism
Homo sapiens (Human)
Status
Functioni
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.By similarity1 Publication
Catalytic activityi
Activity regulationi
Repressed by 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine (DB08325).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 73 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 164 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 50 – 58 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- endocytosis Source: GO_Central
- peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of canonical Wnt signaling pathway Source: GO_Central
- Wnt signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9HCP0 |
SignaLinki | Q9HCP0 |
SIGNORi | Q9HCP0 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CSNK1G1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2454, CSNK1G1 |
MIMi | 606274, gene |
neXtProti | NX_Q9HCP0 |
VEuPathDBi | HostDB:ENSG00000169118.16 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 169 | N → A: Loss of kinase activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 53944 |
OpenTargetsi | ENSG00000169118 |
PharmGKBi | PA26954 |
Miscellaneous databases
Pharosi | Q9HCP0, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2426 |
DrugBanki | DB08325, 2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol |
DrugCentrali | Q9HCP0 |
GuidetoPHARMACOLOGYi | 1999 |
Genetic variation databases
BioMutai | CSNK1G1 |
DMDMi | 18202957 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192839 | 1 – 422 | Casein kinase I isoform gamma-1Add BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 344 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Autophosphorylated.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9HCP0 |
jPOSTi | Q9HCP0 |
MassIVEi | Q9HCP0 |
MaxQBi | Q9HCP0 |
PaxDbi | Q9HCP0 |
PeptideAtlasi | Q9HCP0 |
PRIDEi | Q9HCP0 |
ProteomicsDBi | 81782 [Q9HCP0-1] 81783 [Q9HCP0-2] |
PTM databases
iPTMneti | Q9HCP0 |
PhosphoSitePlusi | Q9HCP0 |
SwissPalmi | Q9HCP0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169118, Expressed in secondary oocyte and 221 other tissues |
ExpressionAtlasi | Q9HCP0, baseline and differential |
Genevisiblei | Q9HCP0, HS |
Organism-specific databases
HPAi | ENSG00000169118, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
By similarityBinary interactionsi
Hide detailsQ9HCP0
With | #Exp. | IntAct |
---|---|---|
CEP76 [Q8TAP6] | 3 | EBI-1383814,EBI-742887 |
KRTAP10-7 [P60409] | 3 | EBI-1383814,EBI-10172290 |
Protein-protein interaction databases
BioGRIDi | 119824, 17 interactors |
IntActi | Q9HCP0, 13 interactors |
MINTi | Q9HCP0 |
STRINGi | 9606.ENSP00000305777 |
Chemistry databases
BindingDBi | Q9HCP0 |
Miscellaneous databases
RNActi | Q9HCP0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9HCP0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HCP0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 315 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 272 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
GeneTreei | ENSGT00940000155628 |
HOGENOMi | CLU_019279_2_0_1 |
InParanoidi | Q9HCP0 |
PhylomeDBi | Q9HCP0 |
TreeFami | TF313349 |
Family and domain databases
InterProi | View protein in InterPro IPR022247, Casein_kinase-1_gamma_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12605, CK1gamma_C, 2 hits PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1L (identifier: Q9HCP0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDHPSREKDE RQRTTKPMAQ RSAHCSRPSG SSSSSGVLMV GPNFRVGKKI
60 70 80 90 100
GCGNFGELRL GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG
110 120 130 140 150
LPQVYYFGPC GKYNAMVLEL LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS
160 170 180 190 200
RMEYVHSKNL IYRDVKPENF LIGRQGNKKE HVIHIIDFGL AKEYIDPETK
210 220 230 240 250
KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM FMYFLRGSLP
260 270 280 290 300
WQGLKADTLK ERYQKIGDTK RNTPIEALCE NFPEEMATYL RYVRRLDFFE
310 320 330 340 350
KPDYEYLRTL FTDLFEKKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT
360 370 380 390 400
RESHTHRDRP SQQQPLRNQV VSSTNGELNV DDPTGAHSNA PITAHAEVEV
410 420
VEEAKCCCFF KRKRKKTAQR HK
Isoform 1S (identifier: Q9HCP0-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
370-422: VVSSTNGELN...KRKKTAQRHK → SLRTVTAEHYDVNNSAIWHRGRGT
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IXA3 | Q8IXA3_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 hCG_2004507 | 438 | Annotation score: | ||
A0A0U1RQT7 | A0A0U1RQT7_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 430 | Annotation score: | ||
A0A0U1RR31 | A0A0U1RR31_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 158 | Annotation score: | ||
U3KQB3 | U3KQB3_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 475 | Annotation score: | ||
U3KQA5 | U3KQA5_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 422 | Annotation score: | ||
A0A0U1RQY7 | A0A0U1RQY7_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 459 | Annotation score: | ||
A0A0U1RQK6 | A0A0U1RQK6_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 204 | Annotation score: | ||
A0A0U1RQG9 | A0A0U1RQG9_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 173 | Annotation score: | ||
A0A0U1RQN5 | A0A0U1RQN5_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 67 | Annotation score: | ||
A0A0U1RQU4 | A0A0U1RQU4_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 36 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042084 | 206 | R → K1 PublicationCorresponds to variant dbSNP:rs55799101Ensembl. | 1 | |
Natural variantiVAR_078686 | 230 | R → W Probable disease-associated variant found in a patient with non-syndromic early-onset epilepsy associated with severe developmental delay and microcephaly. 1 PublicationCorresponds to variant dbSNP:rs587777544EnsemblClinVar. | 1 | |
Natural variantiVAR_042085 | 329 | V → I1 PublicationCorresponds to variant dbSNP:rs55699712Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004748 | 370 – 422 | VVSST…AQRHK → SLRTVTAEHYDVNNSAIWHR GRGT in isoform 1S. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042563 mRNA Translation: BAB17839.1 AB042562 mRNA Translation: BAB17838.1 AL832551 mRNA Translation: CAI46142.1 CH471082 Genomic DNA Translation: EAW77670.1 BC017236 mRNA Translation: AAH17236.2 BC130613 mRNA Translation: AAI30614.1 BC136504 mRNA Translation: AAI36505.1 |
CCDSi | CCDS10192.2 [Q9HCP0-1] |
RefSeqi | NP_001316535.1, NM_001329606.1 [Q9HCP0-1] NP_071331.2, NM_022048.4 [Q9HCP0-1] |
Genome annotation databases
Ensembli | ENST00000303052; ENSP00000305777; ENSG00000169118 [Q9HCP0-1] ENST00000606225; ENSP00000475325; ENSG00000169118 [Q9HCP0-2] |
GeneIDi | 53944 |
KEGGi | hsa:53944 |
UCSCi | uc002anf.4, human [Q9HCP0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042563 mRNA Translation: BAB17839.1 AB042562 mRNA Translation: BAB17838.1 AL832551 mRNA Translation: CAI46142.1 CH471082 Genomic DNA Translation: EAW77670.1 BC017236 mRNA Translation: AAH17236.2 BC130613 mRNA Translation: AAI30614.1 BC136504 mRNA Translation: AAI36505.1 |
CCDSi | CCDS10192.2 [Q9HCP0-1] |
RefSeqi | NP_001316535.1, NM_001329606.1 [Q9HCP0-1] NP_071331.2, NM_022048.4 [Q9HCP0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CMW | X-ray | 1.75 | A | 45-352 | [»] | |
SMRi | Q9HCP0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119824, 17 interactors |
IntActi | Q9HCP0, 13 interactors |
MINTi | Q9HCP0 |
STRINGi | 9606.ENSP00000305777 |
Chemistry databases
BindingDBi | Q9HCP0 |
ChEMBLi | CHEMBL2426 |
DrugBanki | DB08325, 2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol |
DrugCentrali | Q9HCP0 |
GuidetoPHARMACOLOGYi | 1999 |
PTM databases
iPTMneti | Q9HCP0 |
PhosphoSitePlusi | Q9HCP0 |
SwissPalmi | Q9HCP0 |
Genetic variation databases
BioMutai | CSNK1G1 |
DMDMi | 18202957 |
Proteomic databases
EPDi | Q9HCP0 |
jPOSTi | Q9HCP0 |
MassIVEi | Q9HCP0 |
MaxQBi | Q9HCP0 |
PaxDbi | Q9HCP0 |
PeptideAtlasi | Q9HCP0 |
PRIDEi | Q9HCP0 |
ProteomicsDBi | 81782 [Q9HCP0-1] 81783 [Q9HCP0-2] |
Protocols and materials databases
Antibodypediai | 13388, 395 antibodies |
DNASUi | 53944 |
Genome annotation databases
Ensembli | ENST00000303052; ENSP00000305777; ENSG00000169118 [Q9HCP0-1] ENST00000606225; ENSP00000475325; ENSG00000169118 [Q9HCP0-2] |
GeneIDi | 53944 |
KEGGi | hsa:53944 |
UCSCi | uc002anf.4, human [Q9HCP0-1] |
Organism-specific databases
CTDi | 53944 |
DisGeNETi | 53944 |
GeneCardsi | CSNK1G1 |
HGNCi | HGNC:2454, CSNK1G1 |
HPAi | ENSG00000169118, Low tissue specificity |
MIMi | 606274, gene |
neXtProti | NX_Q9HCP0 |
OpenTargetsi | ENSG00000169118 |
PharmGKBi | PA26954 |
VEuPathDBi | HostDB:ENSG00000169118.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
GeneTreei | ENSGT00940000155628 |
HOGENOMi | CLU_019279_2_0_1 |
InParanoidi | Q9HCP0 |
PhylomeDBi | Q9HCP0 |
TreeFami | TF313349 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9HCP0 |
SignaLinki | Q9HCP0 |
SIGNORi | Q9HCP0 |
Miscellaneous databases
BioGRID-ORCSi | 53944, 4 hits in 904 CRISPR screens |
ChiTaRSi | CSNK1G1, human |
EvolutionaryTracei | Q9HCP0 |
GenomeRNAii | 53944 |
Pharosi | Q9HCP0, Tchem |
PROi | PR:Q9HCP0 |
RNActi | Q9HCP0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169118, Expressed in secondary oocyte and 221 other tissues |
ExpressionAtlasi | Q9HCP0, baseline and differential |
Genevisiblei | Q9HCP0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR022247, Casein_kinase-1_gamma_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12605, CK1gamma_C, 2 hits PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KC1G1_HUMAN | |
Accessioni | Q9HCP0Primary (citable) accession number: Q9HCP0 Secondary accession number(s): Q5JPH1, Q96AE9, Q9HCP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human and mouse protein kinases
Human and mouse protein kinases: classification and index