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Protein

Post-GPI attachment to proteins factor 6

Gene

TMEM8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.N.2.1.6 the myoblast fusion complex (mfc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Post-GPI attachment to proteins factor 61 Publication (EC:3.1.1.41 Publication)
Alternative name(s):
GPI processing phospholipase A21 Publication
Short name:
GPI-PLA21 Publication
Protein M83
Transmembrane protein 6
Transmembrane protein 8
Transmembrane protein 8A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM8A
Synonyms:PGAP61 Publication, TMEM6, TMEM8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000129925.10

Human Gene Nomenclature Database

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HGNCi
HGNC:17205 TMEM8A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCN3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini35 – 545ExtracellularSequence analysisAdd BLAST511
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 568CytoplasmicSequence analysis2
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Topological domaini590 – 605ExtracellularSequence analysisAdd BLAST16
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21
Topological domaini627 – 629CytoplasmicSequence analysis3
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Topological domaini651 – 653ExtracellularSequence analysis3
Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Topological domaini675 – 690CytoplasmicSequence analysisAdd BLAST16
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 717ExtracellularSequence analysis6
Transmembranei718 – 738HelicalSequence analysisAdd BLAST21
Topological domaini739 – 771CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi584S → A: No effect. 1 Publication1
Mutagenesisi588H → A: Abolishes shedding of TDGF1. 1 Publication1
Mutagenesisi610D → A: Abolishes shedding of TDGF1. 1 Publication1
Mutagenesisi722H → A: Abolishes shedding of TDGF1. 1 Publication1
Mutagenesisi726H → A: Abolishes shedding of TDGF1. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000129925

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38211

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TMEM8A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453013

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002253935 – 771Post-GPI attachment to proteins factor 6Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 521PROSITE-ProRule annotation
Disulfide bondi523 ↔ 532PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HCN3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HCN3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9HCN3

PeptideAtlas

More...
PeptideAtlasi
Q9HCN3

PRoteomics IDEntifications database

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PRIDEi
Q9HCN3

ProteomicsDB human proteome resource

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ProteomicsDBi
81774

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1856

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCN3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed during activation of CD4+ and CD8+ T-lymphocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000129925 Expressed in 205 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

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CleanExi
HS_TMEM8

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HCN3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HCN3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051281
HPA064673

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121856, 10 interactors

Protein interaction database and analysis system

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IntActi
Q9HCN3, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000401338

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9HCN3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini497 – 533EGF-likePROSITE-ProRule annotationAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM8 family.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160060

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HCN3

Identification of Orthologs from Complete Genome Data

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OMAi
FAMSLQL

Database of Orthologous Groups

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OrthoDBi
EOG091G0KZA

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9HCN3

TreeFam database of animal gene trees

More...
TreeFami
TF331003

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR021910 NGX6/PGAP6/MYMK

The PANTHER Classification System

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PANTHERi
PTHR14319 PTHR14319, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12036 DUF3522, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9HCN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRAGTGTGG EAVAAVVAGP LLLLLLARPP PASAGYSGKS EVGLVSEHFS
60 70 80 90 100
QAPQRLSFYS WYGSARLFRF RVPPDAVLLR WLLQVSRESG AACTDAEITV
110 120 130 140 150
HFRSGAPPVI NPLGTSFPDD TAVQPSFQVG VPLSTTPRSN ASVNVSHPAP
160 170 180 190 200
GDWFVAAHLP PSSQKIELKG LAPTCAYVFQ PELLVTRVVE ISIMEPDVPL
210 220 230 240 250
PQTLLSHPSY LKVFVPDYTR ELLLELRDCV SNGSLGCPVR LTVGPVTLPS
260 270 280 290 300
NFQKVLTCTG APWPCRLLLP SPPWDRWLQV TAESLVGPLG TVAFSAVAAL
310 320 330 340 350
TACRPRSVTI QPLLQSSQNQ SFNASSGLLS PSPDHQDLGR SGRVDRSPFC
360 370 380 390 400
LTNYPVTRED MDVVSVHFQP LDRVSVRVCS DTPSVMRLRL NTGMDSGGSL
410 420 430 440 450
TISLRANKTE MRNETVVVAC VNAASPFLGF NTSLNCTTAF FQGYPLSLSA
460 470 480 490 500
WSRRANLIIP YPETDNWYLS LQLMCPENAE DCEQAVVHVE TTLYLVPCLN
510 520 530 540 550
DCGPYGQCLL LRRHSYLYAS CSCKAGWRGW SCTDNSTAQT VAQQRAATLL
560 570 580 590 600
LTLSNLMFLA PIAVSVRRFF LVEASVYAYT MFFSTFYHAC DQPGEAVLCI
610 620 630 640 650
LSYDTLQYCD FLGSGAAIWV TILCMARLKT VLKYVLFLLG TLVIAMSLQL
660 670 680 690 700
DRRGMWNMLG PCLFAFVIMA SMWAYRCGHR RQCYPTSWQR WAFYLLPGVS
710 720 730 740 750
MASVGIAIYT SMMTSDNYYY THSIWHILLA GSAALLLPPP DQPAEPWACS
760 770
QKFPCHYQIC KNDREELYAV T
Length:771
Mass (Da):84,761
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A21814C449724F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K4DI83K4DI83_HUMAN
Post-GPI attachment to proteins fac...
TMEM8A TMEM8, hCG_1984172
578Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1S0H7C1S0_HUMAN
Post-GPI attachment to proteins fac...
TMEM8A
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5B2H0Y5B2_HUMAN
Post-GPI attachment to proteins fac...
TMEM8A
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8D7C9J8D7_HUMAN
Post-GPI attachment to proteins fac...
TMEM8A
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14975 differs from that shown. Reason: Erroneous termination at position 750. Translated as Ser.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti460P → A in BAB14975 (PubMed:14702039).Curated1
Sequence conflicti654G → D in BAB16376 (PubMed:11006113).Curated1
Sequence conflicti687S → L in BAB14975 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025307136T → A3 PublicationsCorresponds to variant dbSNP:rs11248931Ensembl.1
Natural variantiVAR_025308310I → V3 PublicationsCorresponds to variant dbSNP:rs2071915Ensembl.1
Natural variantiVAR_057810567R → W1 PublicationCorresponds to variant dbSNP:rs3743887Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB045292 mRNA Translation: BAB16376.1
AE006463 Genomic DNA Translation: AAK61227.1
Z97634 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85824.1
CH471112 Genomic DNA Translation: EAW85825.1
BC021557 mRNA Translation: AAH21557.1
BC004276 mRNA Translation: AAH04276.1
AK024725 mRNA Translation: BAB14975.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS10407.1

Protein sequence database of the Protein Information Resource

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PIRi
JC7388

NCBI Reference Sequences

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RefSeqi
NP_067082.2, NM_021259.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.288940

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000431232; ENSP00000401338; ENSG00000129925

Database of genes from NCBI RefSeq genomes

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GeneIDi
58986

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:58986

UCSC genome browser

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UCSCi
uc002cgu.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045292 mRNA Translation: BAB16376.1
AE006463 Genomic DNA Translation: AAK61227.1
Z97634 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85824.1
CH471112 Genomic DNA Translation: EAW85825.1
BC021557 mRNA Translation: AAH21557.1
BC004276 mRNA Translation: AAH04276.1
AK024725 mRNA Translation: BAB14975.1 Sequence problems.
CCDSiCCDS10407.1
PIRiJC7388
RefSeqiNP_067082.2, NM_021259.2
UniGeneiHs.288940

3D structure databases

ProteinModelPortaliQ9HCN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121856, 10 interactors
IntActiQ9HCN3, 10 interactors
STRINGi9606.ENSP00000401338

Protein family/group databases

TCDBi1.N.2.1.6 the myoblast fusion complex (mfc) family

PTM databases

GlyConnecti1856
iPTMnetiQ9HCN3
PhosphoSitePlusiQ9HCN3

Polymorphism and mutation databases

BioMutaiTMEM8A
DMDMi296453013

Proteomic databases

EPDiQ9HCN3
MaxQBiQ9HCN3
PaxDbiQ9HCN3
PeptideAtlasiQ9HCN3
PRIDEiQ9HCN3
ProteomicsDBi81774

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
58986
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431232; ENSP00000401338; ENSG00000129925
GeneIDi58986
KEGGihsa:58986
UCSCiuc002cgu.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58986
EuPathDBiHostDB:ENSG00000129925.10

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM8A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0202255
HGNCiHGNC:17205 TMEM8A
HPAiHPA051281
HPA064673
neXtProtiNX_Q9HCN3
OpenTargetsiENSG00000129925
PharmGKBiPA38211

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA
GeneTreeiENSGT00940000160060
InParanoidiQ9HCN3
OMAiFAMSLQL
OrthoDBiEOG091G0KZA
PhylomeDBiQ9HCN3
TreeFamiTF331003

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM8A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58986

Protein Ontology

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PROi
PR:Q9HCN3

Gene expression databases

BgeeiENSG00000129925 Expressed in 205 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TMEM8
ExpressionAtlasiQ9HCN3 baseline and differential
GenevisibleiQ9HCN3 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR021910 NGX6/PGAP6/MYMK
PANTHERiPTHR14319 PTHR14319, 1 hit
PfamiView protein in Pfam
PF12036 DUF3522, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM8A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCN3
Secondary accession number(s): D3DU49
, Q4TT35, Q8WU24, Q96S25, Q9BR03, Q9BT97, Q9H7B9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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