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UniProtKB - Q9HCM9 (TRI39_HUMAN)

Entry version 193 (02 Jun 2021)
Sequence version 2 (07 Dec 2004)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase TRIM39

Gene

TRIM39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase (PubMed:22529100).

May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100).

Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).

Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).

3 Publications

Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).

Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).

Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi107ZincPROSITE-ProRule annotation1
Metal bindingi110ZincPROSITE-ProRule annotation1
Metal bindingi129ZincPROSITE-ProRule annotation1
Metal bindingi135ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processApoptosis, Cell cycle, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HCM9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM39 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 23
RING-type E3 ubiquitin transferase TRIM39Curated
Testis-abundant finger protein
Tripartite motif-containing protein 39
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM39
Synonyms:RNF23, TFP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10065, TRIM39

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605700, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HCM9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204599.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56658

Open Targets

More...OpenTargetsi		ENSG00000204599

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35535

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HCM9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM39

Domain mapping of disease mutations (DMDM)

More...DMDMi		56405385

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562571 – 518E3 ubiquitin-protein ligase TRIM39Add BLAST518

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HCM9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HCM9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HCM9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HCM9

PeptideAtlas

More...PeptideAtlasi		Q9HCM9

PRoteomics IDEntifications database

More...PRIDEi		Q9HCM9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81768 [Q9HCM9-1]
81769 [Q9HCM9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HCM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HCM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204599, Expressed in testis and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HCM9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HCM9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204599, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with MOAP1 (PubMed:19100260). Isoform 1 and isoform 2 interact with CDKN1A (PubMed:23213251). Isoform 2 interacts (via domain B box-type) with CACTIN (PubMed:26363554).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9HCM9
With#Exp.IntAct
CCNC [P24863]4EBI-739510,EBI-395261
DC-UbP [B2R886]3EBI-739510,EBI-10175550
DCUN1D1 [Q96GG9]4EBI-739510,EBI-740086
DIP2A - isoform 6 [Q14689-6]3EBI-739510,EBI-10233719
EIF4A2 [Q14240]4EBI-739510,EBI-73473
EIF4A2 - isoform 2 [Q14240-2]3EBI-739510,EBI-10232522
EPHB6 - isoform 2 [O15197-2]3EBI-739510,EBI-10182490
LNX1 [Q8TBB1]3EBI-739510,EBI-739832
LXN [Q9BS40]3EBI-739510,EBI-1044504
MED18 [Q9BUE0]3EBI-739510,EBI-394640
NCK1 [P16333]2EBI-739510,EBI-389883
POLI [Q9UNA4]4EBI-739510,EBI-741774
PRPF3 [O43395]4EBI-739510,EBI-744322
PSMA6 [P60900]3EBI-739510,EBI-357793
PSMD9 [O00233]4EBI-739510,EBI-750973
RECK [Q6P9E2]3EBI-739510,EBI-10253121
SMCO3 [A2RU48]3EBI-739510,EBI-10173195
TRIM17 [Q9Y577]8EBI-739510,EBI-743894
TRIM21 [P19474]4EBI-739510,EBI-81290
itself6EBI-739510,EBI-739510
TTC32 [Q5I0X7]3EBI-739510,EBI-8636434
UBAC1 [Q9BSL1]3EBI-739510,EBI-749370
UBE2D1 [P51668]6EBI-739510,EBI-743540
UBE2D3 [P61077]6EBI-739510,EBI-348268
UBE2D4 [Q9Y2X8]5EBI-739510,EBI-745527
UBE2E2 [Q96LR5]6EBI-739510,EBI-2129763
UBE2E3 [Q969T4]5EBI-739510,EBI-348496
UBE2K [P61086]3EBI-739510,EBI-473850
UBTD1 [Q9HAC8]4EBI-739510,EBI-745871
UBXN1 [Q04323]3EBI-739510,EBI-1058647
UBXN6 [Q9BZV1]5EBI-739510,EBI-1993899
WDFY3 - isoform 2 [Q8IZQ1-2]3EBI-739510,EBI-10264625
ZKSCAN4 [Q969J2]3EBI-739510,EBI-2818641
ZNF26 [P17031]4EBI-739510,EBI-2841331
A8K2R33EBI-739510,EBI-9977437
TRIM39 - isoform 2 [Q9HCM9-2]
With#Exp.IntAct
DCUN1D1 [Q96GG9]7EBI-11523450,EBI-740086
EPHB6 - isoform 2 [O15197-2]5EBI-11523450,EBI-10182490
GAMT [Q14353]5EBI-11523450,EBI-3909086
LNX1 [Q8TBB1]3EBI-11523450,EBI-739832
MED18 [Q9BUE0]3EBI-11523450,EBI-394640
MTURN [Q8N3F0]3EBI-11523450,EBI-11980301
PRPF3 [O43395]8EBI-11523450,EBI-744322
PSMA6 [P60900]5EBI-11523450,EBI-357793
PSMB1 [P20618]3EBI-11523450,EBI-372273
RAD23A [P54725]3EBI-11523450,EBI-746453
RNF11 [Q9Y3C5]3EBI-11523450,EBI-396669
TRIM21 [P19474]3EBI-11523450,EBI-81290
itself3EBI-11523450,EBI-11523450
UBE2D1 [P51668]5EBI-11523450,EBI-743540
UBE2D2 [P62837]5EBI-11523450,EBI-347677
UBE2D3 [P61077]5EBI-11523450,EBI-348268
UBE2D4 [Q9Y2X8]7EBI-11523450,EBI-745527
UBE2E2 [Q96LR5]8EBI-11523450,EBI-2129763
UBE2E3 [Q969T4]3EBI-11523450,EBI-348496
UBE2K [P61086]8EBI-11523450,EBI-473850
UBL5 [Q9BZL1]3EBI-11523450,EBI-607755
UBTD1 [Q9HAC8]5EBI-11523450,EBI-745871
UBXN6 [Q9BZV1]3EBI-11523450,EBI-1993899
UBXN7 [O94888]3EBI-11523450,EBI-1993627

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121170, 102 interactors

Protein interaction database and analysis system

More...IntActi		Q9HCM9, 78 interactors

Molecular INTeraction database

More...MINTi		Q9HCM9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365844

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HCM9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1518
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9HCM9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HCM9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9HCM9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 514B30.2/SPRYPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni268 – 337Interaction with CDKN1A1 PublicationAdd BLAST70
Regioni389 – 518Interaction with CDKN1A1 PublicationAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili181 – 250Sequence analysisAdd BLAST70

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154126

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013137_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HCM9

Identification of Orthologs from Complete Genome Data

More...OMAi		WAVGVCQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HCM9

TreeFam database of animal gene trees

More...TreeFami		TF342569

Family and domain databases

Conserved Domains Database

More...CDDi		cd13745, SPRY_PRY_TRIM39, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR035033, PRY/SPRY_TRIM39
IPR003877, SPRY_dom
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCM9-1) [UniParc]FASTAAdd to basket
Also known as: TIM39alpha1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK 
        60         70         80         90        100
ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK 
       110        120        130        140        150
IRDESLCPQH HEALSLFCYE DQEAVCLICA ISHTHRAHTV VPLDDATQEY 
       160        170        180        190        200
KEKLQKCLEP LEQKLQEITR CKSSEEKKPG ELKRLVESRR QQILREFEEL 
       210        220        230        240        250
HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL AHLAAEVEGK 
       260        270        280        290        300
CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE 
       310        320        330        340        350
KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL 
       360        370        380        390        400
VLSEDRKSVK FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG 
       410        420        430        440        450
DKTHWAVGVC RDSVSRKGEL TPLPETGYWR VRLWNGDKYA ATTTPFTPLH 
       460        470        480        490        500
IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI YTFTDTFTEK LWPLFYPGIR 
       510 
AGRKNAAPLT IRPPTDWE
Length:518
Mass (Da):59,690
Last modified:December 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F946F518B217153
GO
Isoform 2 (identifier: Q9HCM9-2) [UniParc]FASTAAdd to basket
Also known as: TIM39beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     269-298: Missing.

Show »
Length:488
Mass (Da):56,374
Checksum:i102AA8E5C8786A3E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AAZ6A2AAZ6_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y735H0Y735_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ5A2AAZ5_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ4A2AAZ4_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ3A2AAZ3_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ2A2AAZ2_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137A → P in BAB16374 (PubMed:11006080).Curated1
Sequence conflicti419E → K in BAD13703 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005755269 – 298Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB046381 mRNA Translation: BAB16374.1
BT007370 mRNA Translation: AAP36034.1
AB110937 Genomic DNA Translation: BAD13703.1
AK292512 mRNA Translation: BAF85201.1
AB110938 Genomic DNA Translation: BAD13704.1
AB202089 Genomic DNA Translation: BAE78608.1
AL662832 Genomic DNA No translation available.
AL662795 Genomic DNA No translation available.
AL773535 Genomic DNA No translation available.
BX248580 Genomic DNA No translation available.
CR759928 Genomic DNA No translation available.
BX927214 Genomic DNA No translation available.
CR759281 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03283.1
CH471081 Genomic DNA Translation: EAX03284.1
BC007661 mRNA Translation: AAH07661.1
BC034985 mRNA Translation: AAH34985.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34377.1 [Q9HCM9-1]
CCDS34378.1 [Q9HCM9-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JC7387

NCBI Reference Sequences

More...RefSeqi		NP_067076.2, NM_021253.3 [Q9HCM9-1]
NP_742013.1, NM_172016.2 [Q9HCM9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376656; ENSP00000365844; ENSG00000204599 [Q9HCM9-1]
ENST00000376659; ENSP00000365847; ENSG00000204599 [Q9HCM9-2]
ENST00000383601; ENSP00000373095; ENSG00000206495 [Q9HCM9-2]
ENST00000383602; ENSP00000373096; ENSG00000206495 [Q9HCM9-1]
ENST00000383603; ENSP00000373097; ENSG00000206495 [Q9HCM9-2]
ENST00000396547; ENSP00000379796; ENSG00000204599 [Q9HCM9-1]
ENST00000396548; ENSP00000379797; ENSG00000204599 [Q9HCM9-2]
ENST00000396551; ENSP00000379800; ENSG00000204599 [Q9HCM9-2]
ENST00000400644; ENSP00000383486; ENSG00000206495 [Q9HCM9-2]
ENST00000413715; ENSP00000411949; ENSG00000224994 [Q9HCM9-1]
ENST00000414015; ENSP00000401071; ENSG00000224994 [Q9HCM9-2]
ENST00000419790; ENSP00000401184; ENSG00000229929 [Q9HCM9-2]
ENST00000424575; ENSP00000409902; ENSG00000230308 [Q9HCM9-1]
ENST00000426469; ENSP00000397043; ENSG00000229929 [Q9HCM9-1]
ENST00000430502; ENSP00000398956; ENSG00000232839 [Q9HCM9-2]
ENST00000431272; ENSP00000396986; ENSG00000230308 [Q9HCM9-2]
ENST00000433900; ENSP00000389852; ENSG00000232839 [Q9HCM9-2]
ENST00000438076; ENSP00000389198; ENSG00000232839 [Q9HCM9-2]
ENST00000438859; ENSP00000411582; ENSG00000226437 [Q9HCM9-2]
ENST00000440117; ENSP00000392130; ENSG00000224994 [Q9HCM9-2]
ENST00000443109; ENSP00000414525; ENSG00000229929 [Q9HCM9-2]
ENST00000445206; ENSP00000391917; ENSG00000226437 [Q9HCM9-1]
ENST00000446397; ENSP00000412743; ENSG00000230308 [Q9HCM9-2]
ENST00000449318; ENSP00000404904; ENSG00000224994 [Q9HCM9-2]
ENST00000450778; ENSP00000387445; ENSG00000226437 [Q9HCM9-2]
ENST00000451132; ENSP00000394353; ENSG00000226437 [Q9HCM9-2]
ENST00000451715; ENSP00000398355; ENSG00000232839 [Q9HCM9-1]
ENST00000452705; ENSP00000415259; ENSG00000229929 [Q9HCM9-2]
ENST00000458607; ENSP00000404340; ENSG00000230308 [Q9HCM9-2]
ENST00000547030; ENSP00000449847; ENSG00000224994 [Q9HCM9-1]
ENST00000548002; ENSP00000447835; ENSG00000232839 [Q9HCM9-1]
ENST00000549841; ENSP00000448572; ENSG00000230308 [Q9HCM9-1]
ENST00000550282; ENSP00000449272; ENSG00000206495 [Q9HCM9-1]
ENST00000552337; ENSP00000450288; ENSG00000226437 [Q9HCM9-1]
ENST00000552520; ENSP00000448462; ENSG00000229929 [Q9HCM9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56658

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56658

UCSC genome browser

More...UCSCi		uc003nqb.4, human [Q9HCM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046381 mRNA Translation: BAB16374.1
BT007370 mRNA Translation: AAP36034.1
AB110937 Genomic DNA Translation: BAD13703.1
AK292512 mRNA Translation: BAF85201.1
AB110938 Genomic DNA Translation: BAD13704.1
AB202089 Genomic DNA Translation: BAE78608.1
AL662832 Genomic DNA No translation available.
AL662795 Genomic DNA No translation available.
AL773535 Genomic DNA No translation available.
BX248580 Genomic DNA No translation available.
CR759928 Genomic DNA No translation available.
BX927214 Genomic DNA No translation available.
CR759281 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03283.1
CH471081 Genomic DNA Translation: EAX03284.1
BC007661 mRNA Translation: AAH07661.1
BC034985 mRNA Translation: AAH34985.1
CCDSiCCDS34377.1 [Q9HCM9-1]
CCDS34378.1 [Q9HCM9-2]
PIRiJC7387
RefSeqiNP_067076.2, NM_021253.3 [Q9HCM9-1]
NP_742013.1, NM_172016.2 [Q9HCM9-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIDNMR-A104-143[»]
2DIFNMR-A104-143[»]
2ECJNMR-A19-69[»]
BMRBiQ9HCM9
SMRiQ9HCM9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121170, 102 interactors
IntActiQ9HCM9, 78 interactors
MINTiQ9HCM9
STRINGi9606.ENSP00000365844

PTM databases

iPTMnetiQ9HCM9
PhosphoSitePlusiQ9HCM9

Genetic variation databases

BioMutaiTRIM39
DMDMi56405385

Proteomic databases

jPOSTiQ9HCM9
MassIVEiQ9HCM9
MaxQBiQ9HCM9
PaxDbiQ9HCM9
PeptideAtlasiQ9HCM9
PRIDEiQ9HCM9
ProteomicsDBi81768 [Q9HCM9-1]
81769 [Q9HCM9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34966, 270 antibodies

The DNASU plasmid repository

More...DNASUi		56658

Genome annotation databases

EnsembliENST00000376656; ENSP00000365844; ENSG00000204599 [Q9HCM9-1]
ENST00000376659; ENSP00000365847; ENSG00000204599 [Q9HCM9-2]
ENST00000383601; ENSP00000373095; ENSG00000206495 [Q9HCM9-2]
ENST00000383602; ENSP00000373096; ENSG00000206495 [Q9HCM9-1]
ENST00000383603; ENSP00000373097; ENSG00000206495 [Q9HCM9-2]
ENST00000396547; ENSP00000379796; ENSG00000204599 [Q9HCM9-1]
ENST00000396548; ENSP00000379797; ENSG00000204599 [Q9HCM9-2]
ENST00000396551; ENSP00000379800; ENSG00000204599 [Q9HCM9-2]
ENST00000400644; ENSP00000383486; ENSG00000206495 [Q9HCM9-2]
ENST00000413715; ENSP00000411949; ENSG00000224994 [Q9HCM9-1]
ENST00000414015; ENSP00000401071; ENSG00000224994 [Q9HCM9-2]
ENST00000419790; ENSP00000401184; ENSG00000229929 [Q9HCM9-2]
ENST00000424575; ENSP00000409902; ENSG00000230308 [Q9HCM9-1]
ENST00000426469; ENSP00000397043; ENSG00000229929 [Q9HCM9-1]
ENST00000430502; ENSP00000398956; ENSG00000232839 [Q9HCM9-2]
ENST00000431272; ENSP00000396986; ENSG00000230308 [Q9HCM9-2]
ENST00000433900; ENSP00000389852; ENSG00000232839 [Q9HCM9-2]
ENST00000438076; ENSP00000389198; ENSG00000232839 [Q9HCM9-2]
ENST00000438859; ENSP00000411582; ENSG00000226437 [Q9HCM9-2]
ENST00000440117; ENSP00000392130; ENSG00000224994 [Q9HCM9-2]
ENST00000443109; ENSP00000414525; ENSG00000229929 [Q9HCM9-2]
ENST00000445206; ENSP00000391917; ENSG00000226437 [Q9HCM9-1]
ENST00000446397; ENSP00000412743; ENSG00000230308 [Q9HCM9-2]
ENST00000449318; ENSP00000404904; ENSG00000224994 [Q9HCM9-2]
ENST00000450778; ENSP00000387445; ENSG00000226437 [Q9HCM9-2]
ENST00000451132; ENSP00000394353; ENSG00000226437 [Q9HCM9-2]
ENST00000451715; ENSP00000398355; ENSG00000232839 [Q9HCM9-1]
ENST00000452705; ENSP00000415259; ENSG00000229929 [Q9HCM9-2]
ENST00000458607; ENSP00000404340; ENSG00000230308 [Q9HCM9-2]
ENST00000547030; ENSP00000449847; ENSG00000224994 [Q9HCM9-1]
ENST00000548002; ENSP00000447835; ENSG00000232839 [Q9HCM9-1]
ENST00000549841; ENSP00000448572; ENSG00000230308 [Q9HCM9-1]
ENST00000550282; ENSP00000449272; ENSG00000206495 [Q9HCM9-1]
ENST00000552337; ENSP00000450288; ENSG00000226437 [Q9HCM9-1]
ENST00000552520; ENSP00000448462; ENSG00000229929 [Q9HCM9-1]
GeneIDi56658
KEGGihsa:56658
UCSCiuc003nqb.4, human [Q9HCM9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56658
DisGeNETi56658

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM39
HGNCiHGNC:10065, TRIM39
HPAiENSG00000204599, Low tissue specificity
MIMi605700, gene
neXtProtiNX_Q9HCM9
OpenTargetsiENSG00000204599
PharmGKBiPA35535
VEuPathDBiHostDB:ENSG00000204599.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000154126
HOGENOMiCLU_013137_0_3_1
InParanoidiQ9HCM9
OMAiWAVGVCQ
PhylomeDBiQ9HCM9
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9HCM9
ReactomeiR-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56658, 3 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM39, human
EvolutionaryTraceiQ9HCM9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56658
PharosiQ9HCM9, Tbio

Protein Ontology

More...PROi		PR:Q9HCM9
RNActiQ9HCM9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204599, Expressed in testis and 206 other tissues
ExpressionAtlasiQ9HCM9, baseline and differential
GenevisibleiQ9HCM9, HS

Family and domain databases

CDDicd13745, SPRY_PRY_TRIM39, 1 hit
Gene3Di2.60.120.920, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR035033, PRY/SPRY_TRIM39
IPR003877, SPRY_dom
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PRINTSiPR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI39_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCM9
Secondary accession number(s): Q5STG3
, Q5STG4, Q76BL3, Q8IYT9, Q96IB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: December 7, 2004
Last modified: June 2, 2021
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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