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Protein

Band 4.1-like protein 5

Gene

EPB41L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Band 4.1-like protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPB41L5
Synonyms:KIAA1548
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000115109.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19819 EPB41L5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611730 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCM4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57669

Open Targets

More...
OpenTargetsi
ENSG00000115109

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134862834

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EPB41L5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187608883

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194061 – 733Band 4.1-like protein 5Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HCM4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HCM4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HCM4

PeptideAtlas

More...
PeptideAtlasi
Q9HCM4

PRoteomics IDEntifications database

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PRIDEi
Q9HCM4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81763
81764 [Q9HCM4-2]
81765 [Q9HCM4-3]
81766 [Q9HCM4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115109 Expressed in 184 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_EPB41L5

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCM4 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA037563
HPA037564

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MPP5, CRB2 and CRB3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121701, 69 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HCM4, 24 interactors

Molecular INTeraction database

More...
MINTi
Q9HCM4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263713

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HCM4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HCM4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 327FERMPROSITE-ProRule annotationAdd BLAST285

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FERM domain binds to CRB1.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ60 Eukaryota
ENOG410XRFC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156332

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231632

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051434

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCM4

Identification of Orthologs from Complete Genome Data

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OMAi
HNVKNAG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G032O

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCM4

TreeFam database of animal gene trees

More...
TreeFami
TF319780

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030694 Band4.1-like5
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

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PANTHERi
PTHR23280:SF15 PTHR23280:SF15, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935 BAND41
PR00661 ERMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HCM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSFFRRTLG RRSMRKHAEK ERLREAQRAA THIPAAGDSK SIITCRVSLL
60 70 80 90 100
DGTDVSVDLP KKAKGQELFD QIMYHLDLIE SDYFGLRFMD SAQVAHWLDG
110 120 130 140 150
TKSIKKQVKI GSPYCLHLRV KFYSSEPNNL REELTRYLFV LQLKQDILSG
160 170 180 190 200
KLDCPFDTAV QLAAYNLQAE LGDYDLAEHS PELVSEFRFV PIQTEEMELA
210 220 230 240 250
IFEKWKEYRG QTPAQAETNY LNKAKWLEMY GVDMHVVKAR DGNDYSLGLT
260 270 280 290 300
PTGVLVFEGD TKIGLFFWPK ITRLDFKKNK LTLVVVEDDD QGKEQEHTFV
310 320 330 340 350
FRLDHPKACK HLWKCAVEHH AFFRLRGPVQ KSSHRSGFIR LGSRFRYSGK
360 370 380 390 400
TEYQTTKTNK ARRSTSFERR PSKRYSRRTL QMKACATKPE ELSVHNNVST
410 420 430 440 450
QSNGSQQAWG MRSALPVSPS ISSAPVPVEI ENLPQSPGTD QHDRKCIPLN
460 470 480 490 500
IDLLNSPDLL EATIGDVIGA SDTMETSQAL NDVNVATRLP GLGEPEVEYE
510 520 530 540 550
TLKDTSEKLK QLEMENSPLL SPRSNIDVNI NSQEEVVKLT EKCLNNVIES
560 570 580 590 600
PGLNVMRVPP DFKSNILKAQ VEAVHKVTKE DSLLSHKNAN VQDAATNSAV
610 620 630 640 650
LNENNVPLPK ESLETLMLIT PADSGSVLKE ATDELDALLA SLTENLIDHT
660 670 680 690 700
VAPQVSSTSM ITPRWIVPQS GAMSNGLAGC EMLLTGKEGH GNKDGISLIS
710 720 730
PPAPFLVDAV TSSGPILAEE AVLKQKCLLT TEL
Length:733
Mass (Da):81,856
Last modified:April 29, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3712B5927C9C199
GO
Isoform 2 (identifier: Q9HCM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-505: CIPLNIDLLN...EVEYETLKDT → WLSAASDCCQ...FPGHTAMTEI
     506-733: Missing.

Show »
Length:505
Mass (Da):57,886
Checksum:iD481C3DD2A16B630
GO
Isoform 3 (identifier: Q9HCM4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-669: PQ → P

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):81,728
Checksum:i1DA5B2DC1599E331
GO
Isoform 4 (identifier: Q9HCM4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     669-687: QSGAMSNGLAGCEMLLTGK → LWSHFGRRSCPEAEVFTDH
     688-733: Missing.

Show »
Length:687
Mass (Da):77,520
Checksum:iC91D55CAC3D5C19D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048357334H → Y. Corresponds to variant dbSNP:rs28930677Ensembl.1
Natural variantiVAR_042699462A → T2 PublicationsCorresponds to variant dbSNP:rs1034489Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033034446 – 505CIPLN…TLKDT → WLSAASDCCQRGGNQWNTRA LPPPQTAHRNYTDFVHEHNV KNAGIRHDVHFPGHTAMTEI in isoform 2. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_033035506 – 733Missing in isoform 2. 2 PublicationsAdd BLAST228
Alternative sequenceiVSP_033036668 – 669PQ → P in isoform 3. 1 Publication2
Alternative sequenceiVSP_033037669 – 687QSGAM…LLTGK → LWSHFGRRSCPEAEVFTDH in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_033038688 – 733Missing in isoform 4. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023019 mRNA Translation: BAB14360.1
AK290895 mRNA Translation: BAF83584.1
CH471103 Genomic DNA Translation: EAW95234.1
BC032822 mRNA Translation: AAH32822.1
BC054508 mRNA Translation: AAH54508.1
AB046768 mRNA Translation: BAB13374.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2130.1 [Q9HCM4-1]
CCDS54392.1 [Q9HCM4-2]
CCDS54393.1 [Q9HCM4-4]
CCDS82506.1 [Q9HCM4-3]

NCBI Reference Sequences

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RefSeqi
NP_001171866.1, NM_001184937.1 [Q9HCM4-4]
NP_001171867.1, NM_001184938.3 [Q9HCM4-2]
NP_001171868.1, NM_001184939.2 [Q9HCM4-2]
NP_001317239.1, NM_001330310.1 [Q9HCM4-3]
NP_065960.2, NM_020909.3 [Q9HCM4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.369232
Hs.733250

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263713; ENSP00000263713; ENSG00000115109 [Q9HCM4-1]
ENST00000331393; ENSP00000329687; ENSG00000115109 [Q9HCM4-2]
ENST00000443124; ENSP00000393722; ENSG00000115109 [Q9HCM4-2]
ENST00000443902; ENSP00000393856; ENSG00000115109 [Q9HCM4-4]
ENST00000452780; ENSP00000390439; ENSG00000115109 [Q9HCM4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57669

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57669

UCSC genome browser

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UCSCi
uc002tmg.4 human [Q9HCM4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023019 mRNA Translation: BAB14360.1
AK290895 mRNA Translation: BAF83584.1
CH471103 Genomic DNA Translation: EAW95234.1
BC032822 mRNA Translation: AAH32822.1
BC054508 mRNA Translation: AAH54508.1
AB046768 mRNA Translation: BAB13374.1
CCDSiCCDS2130.1 [Q9HCM4-1]
CCDS54392.1 [Q9HCM4-2]
CCDS54393.1 [Q9HCM4-4]
CCDS82506.1 [Q9HCM4-3]
RefSeqiNP_001171866.1, NM_001184937.1 [Q9HCM4-4]
NP_001171867.1, NM_001184938.3 [Q9HCM4-2]
NP_001171868.1, NM_001184939.2 [Q9HCM4-2]
NP_001317239.1, NM_001330310.1 [Q9HCM4-3]
NP_065960.2, NM_020909.3 [Q9HCM4-1]
UniGeneiHs.369232
Hs.733250

3D structure databases

ProteinModelPortaliQ9HCM4
SMRiQ9HCM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121701, 69 interactors
IntActiQ9HCM4, 24 interactors
MINTiQ9HCM4
STRINGi9606.ENSP00000263713

PTM databases

iPTMnetiQ9HCM4
PhosphoSitePlusiQ9HCM4

Polymorphism and mutation databases

BioMutaiEPB41L5
DMDMi187608883

Proteomic databases

EPDiQ9HCM4
MaxQBiQ9HCM4
PaxDbiQ9HCM4
PeptideAtlasiQ9HCM4
PRIDEiQ9HCM4
ProteomicsDBi81763
81764 [Q9HCM4-2]
81765 [Q9HCM4-3]
81766 [Q9HCM4-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57669
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263713; ENSP00000263713; ENSG00000115109 [Q9HCM4-1]
ENST00000331393; ENSP00000329687; ENSG00000115109 [Q9HCM4-2]
ENST00000443124; ENSP00000393722; ENSG00000115109 [Q9HCM4-2]
ENST00000443902; ENSP00000393856; ENSG00000115109 [Q9HCM4-4]
ENST00000452780; ENSP00000390439; ENSG00000115109 [Q9HCM4-3]
GeneIDi57669
KEGGihsa:57669
UCSCiuc002tmg.4 human [Q9HCM4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57669
DisGeNETi57669
EuPathDBiHostDB:ENSG00000115109.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EPB41L5
HGNCiHGNC:19819 EPB41L5
HPAiHPA037563
HPA037564
MIMi611730 gene
neXtProtiNX_Q9HCM4
OpenTargetsiENSG00000115109
PharmGKBiPA134862834

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IQ60 Eukaryota
ENOG410XRFC LUCA
GeneTreeiENSGT00940000156332
HOGENOMiHOG000231632
HOVERGENiHBG051434
InParanoidiQ9HCM4
OMAiHNVKNAG
OrthoDBiEOG091G032O
PhylomeDBiQ9HCM4
TreeFamiTF319780

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EPB41L5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EPB41L5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57669

Protein Ontology

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PROi
PR:Q9HCM4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000115109 Expressed in 184 organ(s), highest expression level in oocyte
CleanExiHS_EPB41L5
GenevisibleiQ9HCM4 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030694 Band4.1-like5
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF15 PTHR23280:SF15, 1 hit
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE41L5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCM4
Secondary accession number(s): Q7Z5S1, Q8IZ12, Q9H975
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: April 29, 2008
Last modified: December 5, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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