ZFP14

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	172 – 194	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	200 – 222	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	228 – 250	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	256 – 278	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	284 – 306	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	312 – 334	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	340 – 362	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	368 – 390	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	396 – 418	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	424 – 446	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	452 – 474	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	480 – 502	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	508 – 530	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: GO_Central
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: GO_Central
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 14 homolog Short name: Zfp-14 Alternative name(s): Zinc finger protein 531
Gene namesⁱ	Name:ZFP14 Synonyms:KIAA1559, ZNF531
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142065.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29312 ZFP14
neXtProtⁱ	NX_Q9HCL3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000142065
PharmGKBⁱ	PA145147576

Polymorphism and mutation databases

BioMutaⁱ	ZFP14
DMDMⁱ	20140808

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047285	1 – 533	Zinc finger protein 14 homologAdd BLAST		533

Proteomic databases

EPDⁱ	Q9HCL3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HCL3
PaxDbⁱ	Q9HCL3
PeptideAtlas More...PeptideAtlasⁱ	Q9HCL3
PRIDEⁱ	Q9HCL3
ProteomicsDBⁱ	81753

PTM databases

iPTMnetⁱ	Q9HCL3
PhosphoSitePlusⁱ	Q9HCL3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000142065 Expressed in 152 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ZFP14
ExpressionAtlasⁱ	Q9HCL3 baseline and differential
Genevisibleⁱ	Q9HCL3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030637

HPAⁱ

HPA030637

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	121706, 1 interactor
IntActⁱ	Q9HCL3, 3 interactors
STRINGⁱ	9606.ENSP00000270001

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9HCL3
SMRⁱ	Q9HCL3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 78	KRABPROSITE-ProRule annotationAdd BLAST		73

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	172 – 194	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	200 – 222	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	228 – 250	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	256 – 278	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	284 – 306	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	312 – 334	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	340 – 362	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	368 – 390	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	396 – 418	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	424 – 446	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	452 – 474	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	480 – 502	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	508 – 530	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129704
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9HCL3
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	YKRHNFL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q9HCL3
TreeFamⁱ	TF341817

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9HCL3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAHGSVTFRD VAIDFSQEEW EFLDPAQRDL YRDVMWENYS NFISLGPSIS 
        60         70         80         90        100
KPDVITLLDE ERKEPGMVVR EGTRRYCPDL ESRYRTNTLS PEKDIYEIYS 
       110        120        130        140        150
FQWDIMERIK SYSLQGSIFR NDWECKSKIE GEKEQQEGYF GQVKITSEKM 
       160        170        180        190        200
TTYKRHNFLT EYQIVHNGEK VYECKECRKT FIRRSTLSQH LRIHTGEKPY 
       210        220        230        240        250
KCKECGQAFR QRAHLIRHHK LHTGEKPYEC KECGKAFTVL QELTQHQRLH 
       260        270        280        290        300
TGEKPYECKE CGKAFRVHQQ LARHQRIHTG EKPYECKDCG KTFRQCTHLT 
       310        320        330        340        350
RHQRLHTAEK LYECKECGKA FVCGPDLRVH QKIHFGEKPY ECKECGKAFR 
       360        370        380        390        400
ICQQLTVHQS IHTGEKPYEC KECGKTFRLR QQLVRHQRIH TREKPYECME 
       410        420        430        440        450
CWKTFSSYSQ LISHQSIHIG ERPYECEECG KAFRLLSQLT QHQSIHTGEK 
       460        470        480        490        500
PYECKECRKP FRLLSQLTQH QSIHTGEKPY ECKECGKAFR LYSFLTQHQR 
       510        520        530 
IHTGEKPYKC KECKKAFRQH SHLTQHQKIH NGI

Length:533

Mass (Da):63,463

Last modified:February 21, 2002 - v2

Checksum:ⁱE40EF5EC22A99F10

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7EM99	K7EM99_HUMAN		Zinc finger protein 14 homolog Zinc finger protein 14 homolog	ZFP14	81	Annotation score:

Sequence cautionⁱ

The sequence BAB13385 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB046779 mRNA Translation: BAB13385.1 Different initiation. BC152446 mRNA Translation: AAI52447.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33002.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065968.1, NM_020917.2 XP_016882527.1, XM_017027038.1
UniGeneⁱ	Hs.35524

Genome annotation databases

Ensemblⁱ	ENST00000270001; ENSP00000270001; ENSG00000142065
GeneIDⁱ	57677
KEGGⁱ	hsa:57677
UCSC genome browser More...UCSCⁱ	uc010eex.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HCL3	Uncharacterized protein		PROCO		534	UniRef90_Q9HCL3
ZFP14 isoform 1		PANTR		533
Uncharacterized protein		RHIRO		533
cDNA FLJ75848, highly similar to Homo sapiens mouse zinc finger protein 14-like, mRNA		HUMAN		533
zinc finger protein 14 homolog isoform X3		PHYCD		533
+68

Protein	Similar proteins		Species	Score	Length	Source
Q9HCL3	Zinc finger protein 571		HUMAN		609	UniRef50_Q7Z3V5
Zinc finger protein 571		PONAB		608
Uncharacterized protein		CERAT		609
Uncharacterized protein		COLAP		609
Uncharacterized protein		RHIRO		609
+234

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB046779 mRNA Translation: BAB13385.1 Different initiation. BC152446 mRNA Translation: AAI52447.1
CCDSⁱ	CCDS33002.1
RefSeqⁱ	NP_065968.1, NM_020917.2 XP_016882527.1, XM_017027038.1
UniGeneⁱ	Hs.35524

3D structure databases

ProteinModelPortalⁱ	Q9HCL3
SMRⁱ	Q9HCL3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121706, 1 interactor
IntActⁱ	Q9HCL3, 3 interactors
STRINGⁱ	9606.ENSP00000270001

PTM databases

iPTMnetⁱ	Q9HCL3
PhosphoSitePlusⁱ	Q9HCL3

Polymorphism and mutation databases

BioMutaⁱ	ZFP14
DMDMⁱ	20140808

Proteomic databases

EPDⁱ	Q9HCL3
MaxQBⁱ	Q9HCL3
PaxDbⁱ	Q9HCL3
PeptideAtlasⁱ	Q9HCL3
PRIDEⁱ	Q9HCL3
ProteomicsDBⁱ	81753

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000270001; ENSP00000270001; ENSG00000142065
GeneIDⁱ	57677
KEGGⁱ	hsa:57677
UCSCⁱ	uc010eex.3 human

Organism-specific databases

CTDⁱ	57677
EuPathDBⁱ	HostDB:ENSG00000142065.13
GeneCardsⁱ	ZFP14
HGNCⁱ	HGNC:29312 ZFP14
HPAⁱ	HPA030637
neXtProtⁱ	NX_Q9HCL3
OpenTargetsⁱ	ENSG00000142065
PharmGKBⁱ	PA145147576
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00840000129704
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9HCL3
KOⁱ	K09228
OMAⁱ	YKRHNFL
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q9HCL3
TreeFamⁱ	TF341817

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZFP14 human
GenomeRNAiⁱ	57677
Protein Ontology More...PROⁱ	PR:Q9HCL3

Gene expression databases

Bgeeⁱ	ENSG00000142065 Expressed in 152 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ZFP14
ExpressionAtlasⁱ	Q9HCL3 baseline and differential
Genevisibleⁱ	Q9HCL3 HS

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFP14_HUMAN
Accessionⁱ	Q9HCL3Primary (citable) accession number: Q9HCL3 Secondary accession number(s): A7MD23
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
	Last sequence update:	February 21, 2002
	Last modified:	October 10, 2018
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9HCL3 (ZFP14_HUMAN)

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Zinc finger protein 14 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ