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Protein

Protocadherin-18

Gene

PCDH18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB
  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-18
Gene namesi
Name:PCDH18
Synonyms:KIAA1562
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000189184.11
HGNCiHGNC:14268 PCDH18
MIMi608287 gene
neXtProtiNX_Q9HCL0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 699ExtracellularSequence analysisAdd BLAST672
Transmembranei700 – 720HelicalSequence analysisAdd BLAST21
Topological domaini721 – 1135CytoplasmicSequence analysisAdd BLAST415

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189184
PharmGKBiPA33002

Polymorphism and mutation databases

BioMutaiPCDH18
DMDMi212276496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000400228 – 1135Protocadherin-18Add BLAST1108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi641N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9HCL0
PaxDbiQ9HCL0
PeptideAtlasiQ9HCL0
PRIDEiQ9HCL0
ProteomicsDBi81750
81751 [Q9HCL0-2]

PTM databases

iPTMnetiQ9HCL0
PhosphoSitePlusiQ9HCL0

Expressioni

Tissue specificityi

Expressed in all tissues, with highest expression in lung and ovary.1 Publication

Gene expression databases

BgeeiENSG00000189184 Expressed in 195 organ(s), highest expression level in metanephros
CleanExiHS_PCDH18
ExpressionAtlasiQ9HCL0 baseline and differential
GenevisibleiQ9HCL0 HS

Organism-specific databases

HPAiHPA017976

Interactioni

Subunit structurei

Interacts with DAB1.By similarity

Protein-protein interaction databases

BioGridi120005, 1 interactor
IntActiQ9HCL0, 4 interactors
MINTiQ9HCL0
STRINGi9606.ENSP00000355082

Structurei

3D structure databases

ProteinModelPortaliQ9HCL0
SMRiQ9HCL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 137Cadherin 1PROSITE-ProRule annotationAdd BLAST110
Domaini138 – 246Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini247 – 354Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini361 – 465Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini466 – 576Cadherin 5PROSITE-ProRule annotationAdd BLAST111
Domaini582 – 688Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni893 – 1135Interaction with DAB1By similarityAdd BLAST243

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220893
HOVERGENiHBG054878
InParanoidiQ9HCL0
KOiK16499
OMAiTHFQNPA
OrthoDBiEOG091G00QD
PhylomeDBiQ9HCL0
TreeFamiTF352008

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030714 Protocadherin-18
PANTHERiPTHR24028:SF9 PTHR24028:SF9, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHQMNAKMHF RFVFALLIVS FNHDVLGKNL KYRIYEEQRV GSVIARLSED
60 70 80 90 100
VADVLLKLPN PSTVRFRAMQ RGNSPLLVVN EDNGEISIGA TIDREQLCQK
110 120 130 140 150
NLNCSIEFDV ITLPTEHLQL FHIEVEVLDI NDNSPQFSRS LIPIEISESA
160 170 180 190 200
AVGTRIPLDS AFDPDVGENS LHTYSLSAND FFNIEVRTRT DGAKYAELIV
210 220 230 240 250
VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQQS
260 270 280 290 300
YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIMETFKID
310 320 330 340 350
SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN
360 370 380 390 400
KPEININLMS PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH
410 420 430 440 450
GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDR GTPSLSTVKH
460 470 480 490 500
FTVQINDIND NPPHFQRSRY EFVISENNSP GAYITTVTAT DPDLGENGQV
510 520 530 540 550
TYTILESFIL GSSITTYVTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG
560 570 580 590 600
GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEITI PKGAESGFHV
610 620 630 640 650
TRIRAIDRDS GVNAELSCAI VAGNEENIFI IDPRSCDIHT NVSMDSVPYT
660 670 680 690 700
EWELSVIIQD KGNPQLHTKV LLKCMIFEYA ESVTSTAMTS VSQASLDVSM
710 720 730 740 750
IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP
760 770 780 790 800
SRQIHKGDIT LVPTINGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ
810 820 830 840 850
SLNSLVTISS NHVPENFSLE LTHATPAVEQ VSQLLSMLHQ GQYQPRPSFR
860 870 880 890 900
GNKYSRSYRY ALQDMDKFSL KDSGRGDSEA GDSDYDLGRD SPIDRLLGEG
910 920 930 940 950
FSDLFLTDGR IPAAMRLCTE ECRVLGHSDQ CWMPPLPSPS SDYRSNMFIP
960 970 980 990 1000
GEEFPTQPQQ QHPHQSLEDD AQPADSGEKK KSFSTFGKDS PNDEDTGDTS
1010 1020 1030 1040 1050
TSSLLSEMSS VFQRLLPPSL DTYSECSEVD RSNSLERRKG PLPAKTVGYP
1060 1070 1080 1090 1100
QGVAAWAAST HFQNPTTNCG PPLGTHSSVQ PSSKWLPAME EIPENYEEDD
1110 1120 1130
FDNVLNHLND GKHELMDASE LVAEINKLLQ DVRQS
Length:1,135
Mass (Da):126,149
Last modified:November 4, 2008 - v3
Checksum:i7C268409AC3EEB7D
GO
Isoform 2 (identifier: Q9HCL0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     830-830: Missing.

Show »
Length:1,134
Mass (Da):126,021
Checksum:iC89C22F2A2D025AC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIG4D6RIG4_HUMAN
Protocadherin-18
PCDH18
914Annotation score:
B4DLR6B4DLR6_HUMAN
cDNA FLJ57393, highly similar to Pr...
PCDH18
315Annotation score:
B4DQ29B4DQ29_HUMAN
cDNA FLJ57555, highly similar to Pr...
PCDH18
346Annotation score:
A0A087WTW3A0A087WTW3_HUMAN
Protocadherin-18
PCDH18
96Annotation score:

Sequence cautioni

The sequence BAB13388 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035648830Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046782 mRNA Translation: BAB13388.1 Different initiation.
AK292018 mRNA Translation: BAF84707.1
AC142278 Genomic DNA No translation available.
AC144556 Genomic DNA No translation available.
BC093815 mRNA Translation: AAH93815.1
BC143361 mRNA Translation: AAI43362.1
CCDSiCCDS34064.1 [Q9HCL0-1]
CCDS75193.1 [Q9HCL0-2]
RefSeqiNP_001287757.1, NM_001300828.1 [Q9HCL0-2]
NP_061908.1, NM_019035.4 [Q9HCL0-1]
UniGeneiHs.591691
Hs.738416

Genome annotation databases

EnsembliENST00000344876; ENSP00000355082; ENSG00000189184 [Q9HCL0-1]
ENST00000412923; ENSP00000390688; ENSG00000189184 [Q9HCL0-2]
GeneIDi54510
KEGGihsa:54510
UCSCiuc003ihe.5 human [Q9HCL0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046782 mRNA Translation: BAB13388.1 Different initiation.
AK292018 mRNA Translation: BAF84707.1
AC142278 Genomic DNA No translation available.
AC144556 Genomic DNA No translation available.
BC093815 mRNA Translation: AAH93815.1
BC143361 mRNA Translation: AAI43362.1
CCDSiCCDS34064.1 [Q9HCL0-1]
CCDS75193.1 [Q9HCL0-2]
RefSeqiNP_001287757.1, NM_001300828.1 [Q9HCL0-2]
NP_061908.1, NM_019035.4 [Q9HCL0-1]
UniGeneiHs.591691
Hs.738416

3D structure databases

ProteinModelPortaliQ9HCL0
SMRiQ9HCL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120005, 1 interactor
IntActiQ9HCL0, 4 interactors
MINTiQ9HCL0
STRINGi9606.ENSP00000355082

PTM databases

iPTMnetiQ9HCL0
PhosphoSitePlusiQ9HCL0

Polymorphism and mutation databases

BioMutaiPCDH18
DMDMi212276496

Proteomic databases

EPDiQ9HCL0
PaxDbiQ9HCL0
PeptideAtlasiQ9HCL0
PRIDEiQ9HCL0
ProteomicsDBi81750
81751 [Q9HCL0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344876; ENSP00000355082; ENSG00000189184 [Q9HCL0-1]
ENST00000412923; ENSP00000390688; ENSG00000189184 [Q9HCL0-2]
GeneIDi54510
KEGGihsa:54510
UCSCiuc003ihe.5 human [Q9HCL0-1]

Organism-specific databases

CTDi54510
EuPathDBiHostDB:ENSG00000189184.11
GeneCardsiPCDH18
HGNCiHGNC:14268 PCDH18
HPAiHPA017976
MIMi608287 gene
neXtProtiNX_Q9HCL0
OpenTargetsiENSG00000189184
PharmGKBiPA33002
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220893
HOVERGENiHBG054878
InParanoidiQ9HCL0
KOiK16499
OMAiTHFQNPA
OrthoDBiEOG091G00QD
PhylomeDBiQ9HCL0
TreeFamiTF352008

Miscellaneous databases

GeneWikiiPCDH18
GenomeRNAii54510
PROiPR:Q9HCL0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189184 Expressed in 195 organ(s), highest expression level in metanephros
CleanExiHS_PCDH18
ExpressionAtlasiQ9HCL0 baseline and differential
GenevisibleiQ9HCL0 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030714 Protocadherin-18
PANTHERiPTHR24028:SF9 PTHR24028:SF9, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCD18_HUMAN
AccessioniPrimary (citable) accession number: Q9HCL0
Secondary accession number(s): A8K7K3, B7ZKT1, Q52LS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 4, 2008
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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