UniProtKB - Q9HCK4 (ROBO2_HUMAN)
Protein
Roundabout homolog 2
Gene
ROBO2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
GO - Molecular functioni
- axon guidance receptor activity Source: UniProtKB
- identical protein binding Source: UniProtKB
GO - Biological processi
- aorta development Source: BHF-UCL
- aortic valve morphogenesis Source: BHF-UCL
- apoptotic process involved in luteolysis Source: UniProtKB
- axon guidance Source: UniProtKB
- axon midline choice point recognition Source: UniProtKB
- brain development Source: UniProtKB
- cellular response to hormone stimulus Source: UniProtKB
- central nervous system development Source: UniProtKB
- endocardial cushion formation Source: BHF-UCL
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- metanephros development Source: UniProtKB
- negative regulation of negative chemotaxis Source: UniProtKB
- negative regulation of synapse assembly Source: UniProtKB
- olfactory bulb interneuron development Source: UniProtKB
- outflow tract septum morphogenesis Source: BHF-UCL
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of Notch signaling pathway involved in heart induction Source: BHF-UCL
- pulmonary valve morphogenesis Source: BHF-UCL
- retinal ganglion cell axon guidance Source: UniProtKB
- ureteric bud development Source: UniProtKB
- ventricular septum morphogenesis Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein |
Biological process | Chemotaxis, Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9HCK4 |
Reactomei | R-HSA-376176, Signaling by ROBO receptors R-HSA-428542, Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-8985801, Regulation of cortical dendrite branching R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9010642, ROBO receptors bind AKAP5 |
Names & Taxonomyi
Protein namesi | Recommended name: Roundabout homolog 2 |
Gene namesi | Name:ROBO2 Synonyms:KIAA1568 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10250, ROBO2 |
MIMi | 602431, gene |
neXtProti | NX_Q9HCK4 |
VEuPathDBi | HostDB:ENSG00000185008.17 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- axolemma Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 859 | ExtracellularSequence analysisAdd BLAST | 838 | |
Transmembranei | 860 – 880 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 881 – 1378 | CytoplasmicSequence analysisAdd BLAST | 498 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Vesicoureteral reflux 2 (VUR2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032960 | 945 | I → T in VUR2. 1 PublicationCorresponds to variant dbSNP:rs267607014Ensembl. | 1 | |
Natural variantiVAR_032961 | 1236 | A → T in VUR2. 1 PublicationCorresponds to variant dbSNP:rs267607015Ensembl. | 1 |
A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6092 |
MalaCardsi | ROBO2 |
MIMi | 610878, phenotype |
OpenTargetsi | ENSG00000185008 |
Orphaneti | 289365, Familial vesicoureteral reflux |
PharmGKBi | PA34621 |
Miscellaneous databases
Pharosi | Q9HCK4, Tbio |
Genetic variation databases
BioMutai | ROBO2 |
DMDMi | 49036496 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000031036 | 22 – 1378 | Roundabout homolog 2Add BLAST | 1357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 52 ↔ 110 | PROSITE-ProRule annotation | ||
Glycosylationi | 123 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 154 ↔ 203 | PROSITE-ProRule annotation | ||
Disulfide bondi | 246 ↔ 293 | PROSITE-ProRule annotation | ||
Disulfide bondi | 335 ↔ 391 | PROSITE-ProRule annotation | ||
Glycosylationi | 426 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 439 ↔ 488 | PROSITE-ProRule annotation | ||
Glycosylationi | 752 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 782 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 789 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 845 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1154 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1156 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9HCK4 |
jPOSTi | Q9HCK4 |
MassIVEi | Q9HCK4 |
MaxQBi | Q9HCK4 |
PaxDbi | Q9HCK4 |
PeptideAtlasi | Q9HCK4 |
PRIDEi | Q9HCK4 |
ProteomicsDBi | 81744 [Q9HCK4-1] 81745 [Q9HCK4-2] 81746 [Q9HCK4-3] |
PTM databases
GlyGeni | Q9HCK4, 6 sites |
iPTMneti | Q9HCK4 |
PhosphoSitePlusi | Q9HCK4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185008, Expressed in subventricular zone (outer) (primate) and 170 other tissues |
ExpressionAtlasi | Q9HCK4, baseline and differential |
Genevisiblei | Q9HCK4, HS |
Organism-specific databases
HPAi | ENSG00000185008, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with SLIT2.
2 PublicationsBinary interactionsi
Hide detailsQ9HCK4
With | #Exp. | IntAct |
---|---|---|
GPR152 [Q8TDT2] | 3 | EBI-399800,EBI-13345167 |
TMEM237 - isoform 2 [Q96Q45-2] | 5 | EBI-399800,EBI-10982110 |
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112019, 28 interactors |
IntActi | Q9HCK4, 28 interactors |
MINTi | Q9HCK4 |
STRINGi | 9606.ENSP00000417335 |
Miscellaneous databases
RNActi | Q9HCK4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9HCK4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HCK4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 127 | Ig-like C2-type 1Add BLAST | 97 | |
Domaini | 133 – 220 | Ig-like C2-type 2Add BLAST | 88 | |
Domaini | 225 – 309 | Ig-like C2-type 3Add BLAST | 85 | |
Domaini | 314 – 409 | Ig-like C2-type 4Add BLAST | 96 | |
Domaini | 418 – 504 | Ig-like C2-type 5Add BLAST | 87 | |
Domaini | 524 – 618 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 637 – 735 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 739 – 836 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 98 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4222, Eukaryota |
GeneTreei | ENSGT00940000156324 |
InParanoidi | Q9HCK4 |
OMAi | ATSAWQN |
OrthoDBi | 45439at2759 |
PhylomeDBi | Q9HCK4 |
TreeFami | TF351053 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 4 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9HCK4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLLMFTQLL LCGFLYVRVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL
60 70 80 90 100
NCKAEGRPTP TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR
110 120 130 140 150
SKPDEGSYVC VARNYLGEAV SRNASLEVAL LRDDFRQNPT DVVVAAGEPA
160 170 180 190 200
ILECQPPRGH PEPTIYWKKD KVRIDDKEER ISIRGGKLMI SNTRKSDAGM
210 220 230 240 250
YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE AVEFRCQVQG
260 270 280 290 300
DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKTMSTDEGT YMCIAENRVG
310 320 330 340 350
KMEASATLTV RAPPQFVVRP RDQIVAQGRT VTFPCETKGN PQPAVFWQKE
360 370 380 390 400
GSQNLLFPNQ PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI
410 420 430 440 450
LAKAQLEVTD VLTDRPPPII LQGPANQTLA VDGTALLKCK ATGDPLPVIS
460 470 480 490 500
WLKEGFTFPG RDPRATIQEQ GTLQIKNLRI SDTGTYTCVA TSSSGETSWS
510 520 530 540 550
AVLDVTESGA TISKNYDLSD LPGPPSKPQV TDVTKNSVTL SWQPGTPGTL
560 570 580 590 600
PASAYIIEAF SQSVSNSWQT VANHVKTTLY TVRGLRPNTI YLFMVRAINP
610 620 630 640 650
QGLSDPSPMS DPVRTQDISP PAQGVDHRQV QKELGDVLVR LHNPVVLTPT
660 670 680 690 700
TVQVTWTVDR QPQFIQGYRV MYRQTSGLQA TSSWQNLDAK VPTERSAVLV
710 720 730 740 750
NLKKGVTYEI KVRPYFNEFQ GMDSESKTVR TTEEAPSAPP QSVTVLTVGS
760 770 780 790 800
YNSTSISVSW DPPPPDHQNG IIQEYKIWCL GNETRFHINK TVDAAIRSVI
810 820 830 840 850
IGGLFPGIQY RVEVAASTSA GVGVKSEPQP IIIGRRNEVV ITENNNSITE
860 870 880 890 900
QITDVVKQPA FIAGIGGACW VILMGFSIWL YWRRKKRKGL SNYAVTFQRG
910 920 930 940 950
DGGLMSNGSR PGLLNAGDPS YPWLADSWPA TSLPVNNSNS GPNEIGNFGR
960 970 980 990 1000
GDVLPPVPGQ GDKTATMLSD GAIYSSIDFT TKTSYNSSSQ ITQATPYATT
1010 1020 1030 1040 1050
QILHSNSIHE LAVDLPDPQW KSSIQQKTDL MGFGYSLPDQ NKGNNGGKGG
1060 1070 1080 1090 1100
KKKKNKNSSK PQKNNGSTWA NVPLPPPPVQ PLPGTELEHY AVEQQENGYD
1110 1120 1130 1140 1150
SDSWCPPLPV QTYLHQGLED ELEEDDDRVP TPPVRGVASS PAISFGQQST
1160 1170 1180 1190 1200
ATLTPSPREE MQPMLQAHLD ELTRAYQFDI AKQTWHIQSN NQPPQPPVPP
1210 1220 1230 1240 1250
LGYVSGALIS DLETDVADDD ADDEEEALEI PRPLRALDQT PGSSMDNLDS
1260 1270 1280 1290 1300
SVTGKAFTSS QRPRPTSPFS TDSNTSAALS QSQRPRPTKK HKGGRMDQQP
1310 1320 1330 1340 1350
ALPHRREGMT DEEALVPYSK PSFPSPGGHS SSGTASSKGS TGPRKTEVLR
1360 1370
AGHQRNASDL LDIGYMGSNS QGQFTGEL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W703 | F8W703_HUMAN | Roundabout homolog 2 | ROBO2 | 1,439 | Annotation score: | ||
R4GMM8 | R4GMM8_HUMAN | Roundabout homolog 2 | ROBO2 | 1,070 | Annotation score: | ||
A0A087WWM5 | A0A087WWM5_HUMAN | Roundabout homolog 2 | ROBO2 | 1,250 | Annotation score: | ||
F8WBR3 | F8WBR3_HUMAN | Roundabout homolog 2 | ROBO2 | 564 | Annotation score: | ||
H7C4V8 | H7C4V8_HUMAN | Roundabout homolog 2 | ROBO2 | 342 | Annotation score: | ||
H7C4J7 | H7C4J7_HUMAN | Roundabout homolog 2 | ROBO2 | 198 | Annotation score: | ||
H7C4W9 | H7C4W9_HUMAN | Roundabout homolog 2 | ROBO2 | 208 | Annotation score: | ||
H7C4U9 | H7C4U9_HUMAN | Roundabout homolog 2 | ROBO2 | 214 | Annotation score: |
Sequence cautioni
The sequence AAC39576 differs from that shown. Reason: Frameshift.Curated
The sequence BAB13394 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 497 | T → A (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032960 | 945 | I → T in VUR2. 1 PublicationCorresponds to variant dbSNP:rs267607014Ensembl. | 1 | |
Natural variantiVAR_032961 | 1236 | A → T in VUR2. 1 PublicationCorresponds to variant dbSNP:rs267607015Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043394 | 1 – 20 | MSLLM…YVRVD → MARRHERVTRRMWTWAPGLL MMTVVFWGHQGNGQGQ in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_010647 | 1186 – 1378 | Missing in isoform 2. 1 PublicationAdd BLAST | 193 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ533874 mRNA Translation: ABF83431.1 AB046788 mRNA Translation: BAB13394.1 Different initiation. DQ533873 mRNA Translation: ABF83430.1 AC016942 Genomic DNA No translation available. AC016952 Genomic DNA No translation available. AC024256 Genomic DNA No translation available. AC026877 Genomic DNA No translation available. AC067717 Genomic DNA No translation available. AC117514 Genomic DNA No translation available. AC117515 Genomic DNA No translation available. AC117516 Genomic DNA No translation available. AC126467 Genomic DNA No translation available. AC130004 Genomic DNA No translation available. AC131005 Genomic DNA No translation available. AC131154 Genomic DNA No translation available. AC133040 Genomic DNA No translation available. AC138974 Genomic DNA No translation available. BC064374 mRNA Translation: AAH64374.1 BC146772 mRNA Translation: AAI46773.1 AF040991 mRNA Translation: AAC39576.1 Frameshift. |
CCDSi | CCDS43109.1 [Q9HCK4-1] CCDS54609.1 [Q9HCK4-3] |
RefSeqi | NP_001122401.1, NM_001128929.3 [Q9HCK4-3] NP_001276968.1, NM_001290039.1 NP_001276969.1, NM_001290040.1 NP_001276994.1, NM_001290065.1 NP_002933.1, NM_002942.4 [Q9HCK4-1] |
Genome annotation databases
Ensembli | ENST00000461745; ENSP00000417164; ENSG00000185008 [Q9HCK4-1] ENST00000487694; ENSP00000417335; ENSG00000185008 [Q9HCK4-3] |
GeneIDi | 6092 |
KEGGi | hsa:6092 |
UCSCi | uc003dpy.5, human [Q9HCK4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ533874 mRNA Translation: ABF83431.1 AB046788 mRNA Translation: BAB13394.1 Different initiation. DQ533873 mRNA Translation: ABF83430.1 AC016942 Genomic DNA No translation available. AC016952 Genomic DNA No translation available. AC024256 Genomic DNA No translation available. AC026877 Genomic DNA No translation available. AC067717 Genomic DNA No translation available. AC117514 Genomic DNA No translation available. AC117515 Genomic DNA No translation available. AC117516 Genomic DNA No translation available. AC126467 Genomic DNA No translation available. AC130004 Genomic DNA No translation available. AC131005 Genomic DNA No translation available. AC131154 Genomic DNA No translation available. AC133040 Genomic DNA No translation available. AC138974 Genomic DNA No translation available. BC064374 mRNA Translation: AAH64374.1 BC146772 mRNA Translation: AAI46773.1 AF040991 mRNA Translation: AAC39576.1 Frameshift. |
CCDSi | CCDS43109.1 [Q9HCK4-1] CCDS54609.1 [Q9HCK4-3] |
RefSeqi | NP_001122401.1, NM_001128929.3 [Q9HCK4-3] NP_001276968.1, NM_001290039.1 NP_001276969.1, NM_001290040.1 NP_001276994.1, NM_001290065.1 NP_002933.1, NM_002942.4 [Q9HCK4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UEM | NMR | - | A | 514-617 | [»] | |
1UJT | NMR | - | A | 628-734 | [»] | |
2EDJ | NMR | - | A | 417-509 | [»] | |
5NOI | X-ray | 2.40 | A | 311-509 | [»] | |
6I9S | X-ray | 2.48 | A/B | 126-312 | [»] | |
6IAA | X-ray | 3.60 | A/B/C | 22-859 | [»] | |
SMRi | Q9HCK4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112019, 28 interactors |
IntActi | Q9HCK4, 28 interactors |
MINTi | Q9HCK4 |
STRINGi | 9606.ENSP00000417335 |
PTM databases
GlyGeni | Q9HCK4, 6 sites |
iPTMneti | Q9HCK4 |
PhosphoSitePlusi | Q9HCK4 |
Genetic variation databases
BioMutai | ROBO2 |
DMDMi | 49036496 |
Proteomic databases
EPDi | Q9HCK4 |
jPOSTi | Q9HCK4 |
MassIVEi | Q9HCK4 |
MaxQBi | Q9HCK4 |
PaxDbi | Q9HCK4 |
PeptideAtlasi | Q9HCK4 |
PRIDEi | Q9HCK4 |
ProteomicsDBi | 81744 [Q9HCK4-1] 81745 [Q9HCK4-2] 81746 [Q9HCK4-3] |
Protocols and materials databases
Antibodypediai | 2693, 248 antibodies |
Genome annotation databases
Ensembli | ENST00000461745; ENSP00000417164; ENSG00000185008 [Q9HCK4-1] ENST00000487694; ENSP00000417335; ENSG00000185008 [Q9HCK4-3] |
GeneIDi | 6092 |
KEGGi | hsa:6092 |
UCSCi | uc003dpy.5, human [Q9HCK4-1] |
Organism-specific databases
CTDi | 6092 |
DisGeNETi | 6092 |
GeneCardsi | ROBO2 |
HGNCi | HGNC:10250, ROBO2 |
HPAi | ENSG00000185008, Tissue enhanced (brain) |
MalaCardsi | ROBO2 |
MIMi | 602431, gene 610878, phenotype |
neXtProti | NX_Q9HCK4 |
OpenTargetsi | ENSG00000185008 |
Orphaneti | 289365, Familial vesicoureteral reflux |
PharmGKBi | PA34621 |
VEuPathDBi | HostDB:ENSG00000185008.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4222, Eukaryota |
GeneTreei | ENSGT00940000156324 |
InParanoidi | Q9HCK4 |
OMAi | ATSAWQN |
OrthoDBi | 45439at2759 |
PhylomeDBi | Q9HCK4 |
TreeFami | TF351053 |
Enzyme and pathway databases
PathwayCommonsi | Q9HCK4 |
Reactomei | R-HSA-376176, Signaling by ROBO receptors R-HSA-428542, Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-8985801, Regulation of cortical dendrite branching R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9010642, ROBO receptors bind AKAP5 |
Miscellaneous databases
BioGRID-ORCSi | 6092, 5 hits in 978 CRISPR screens |
ChiTaRSi | ROBO2, human |
EvolutionaryTracei | Q9HCK4 |
GeneWikii | ROBO2 |
GenomeRNAii | 6092 |
Pharosi | Q9HCK4, Tbio |
PROi | PR:Q9HCK4 |
RNActi | Q9HCK4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185008, Expressed in subventricular zone (outer) (primate) and 170 other tissues |
ExpressionAtlasi | Q9HCK4, baseline and differential |
Genevisiblei | Q9HCK4, HS |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 4 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROBO2_HUMAN | |
Accessioni | Q9HCK4Primary (citable) accession number: Q9HCK4 Secondary accession number(s): O43608, Q19AB4, Q19AB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | June 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families