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Protein

Synaptic vesicle membrane protein VAT-1 homolog-like

Gene

VAT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog-like (EC:1.-.-.-)
Gene namesi
Name:VAT1L
Synonyms:KIAA1576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000171724.2
HGNCiHGNC:29315 VAT1L
neXtProtiNX_Q9HCJ6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171724
PharmGKBiPA164727497

Polymorphism and mutation databases

BioMutaiVAT1L
DMDMi52783098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001609221 – 419Synaptic vesicle membrane protein VAT-1 homolog-likeAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei392PhosphoserineBy similarity1
Modified residuei393PhosphothreonineBy similarity1
Modified residuei395PhosphothreonineBy similarity1
Modified residuei396PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCJ6
MaxQBiQ9HCJ6
PaxDbiQ9HCJ6
PeptideAtlasiQ9HCJ6
PRIDEiQ9HCJ6
ProteomicsDBi81741

PTM databases

iPTMnetiQ9HCJ6
PhosphoSitePlusiQ9HCJ6

Expressioni

Tissue specificityi

Detected in skin fibroblasts.1 Publication

Gene expression databases

BgeeiENSG00000171724 Expressed in 148 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_VAT1L
GenevisibleiQ9HCJ6 HS

Organism-specific databases

HPAiCAB046032
HPA044061

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBXN2BQ14CS03EBI-10234766,EBI-1993619

Protein-protein interaction databases

BioGridi121713, 8 interactors
IntActiQ9HCJ6, 2 interactors
STRINGi9606.ENSP00000303129

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HCJ6
SMRiQ9HCJ6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCJ6

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294681
HOVERGENiHBG002466
InParanoidiQ9HCJ6
OMAiARSWWQV
OrthoDBiEOG091G0EEJ
PhylomeDBiQ9HCJ6
TreeFamiTF314255

Family and domain databases

InterProiView protein in InterPro
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HCJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKEGVEKAE ETEQMIEKEA GKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF
60 70 80 90 100
GGLNKLRLFR KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL
110 120 130 140 150
VPGFECSGIV EALGDSVKGY EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP
160 170 180 190 200
DDMSFSEAAA FPMNFVTAYV MLFEVANLRE GMSVLVHSAG GGVGQAVAQL
210 220 230 240 250
CSTVPNVTVF GTASTFKHEA IKDSVTHLFD RNADYVQEVK RISAEGVDIV
260 270 280 290 300
LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK
310 320 330 340 350
VNPIKLYEEN KVIAGFSLLN LLFKQGRAGL IRGVVEKLIG LYNQKKIKPV
360 370 380 390 400
VDSLWALEEV KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE
410
EEEDHEGDSE NKERMPFIQ
Length:419
Mass (Da):45,899
Last modified:September 27, 2004 - v2
Checksum:iBA962924662987AC
GO

Sequence cautioni

The sequence BAB13402 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046796 mRNA Translation: BAB13402.1 Different initiation.
BC033537 mRNA Translation: AAH33537.1
CCDSiCCDS32492.1
RefSeqiNP_065978.1, NM_020927.2
UniGeneiHs.461405

Genome annotation databases

EnsembliENST00000302536; ENSP00000303129; ENSG00000171724
GeneIDi57687
KEGGihsa:57687
UCSCiuc002ffg.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046796 mRNA Translation: BAB13402.1 Different initiation.
BC033537 mRNA Translation: AAH33537.1
CCDSiCCDS32492.1
RefSeqiNP_065978.1, NM_020927.2
UniGeneiHs.461405

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A27X-ray2.10A/B41-387[»]
ProteinModelPortaliQ9HCJ6
SMRiQ9HCJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121713, 8 interactors
IntActiQ9HCJ6, 2 interactors
STRINGi9606.ENSP00000303129

PTM databases

iPTMnetiQ9HCJ6
PhosphoSitePlusiQ9HCJ6

Polymorphism and mutation databases

BioMutaiVAT1L
DMDMi52783098

Proteomic databases

EPDiQ9HCJ6
MaxQBiQ9HCJ6
PaxDbiQ9HCJ6
PeptideAtlasiQ9HCJ6
PRIDEiQ9HCJ6
ProteomicsDBi81741

Protocols and materials databases

DNASUi57687
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302536; ENSP00000303129; ENSG00000171724
GeneIDi57687
KEGGihsa:57687
UCSCiuc002ffg.2 human

Organism-specific databases

CTDi57687
EuPathDBiHostDB:ENSG00000171724.2
GeneCardsiVAT1L
HGNCiHGNC:29315 VAT1L
HPAiCAB046032
HPA044061
neXtProtiNX_Q9HCJ6
OpenTargetsiENSG00000171724
PharmGKBiPA164727497
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294681
HOVERGENiHBG002466
InParanoidiQ9HCJ6
OMAiARSWWQV
OrthoDBiEOG091G0EEJ
PhylomeDBiQ9HCJ6
TreeFamiTF314255

Miscellaneous databases

ChiTaRSiVAT1L human
EvolutionaryTraceiQ9HCJ6
GenomeRNAii57687
PROiPR:Q9HCJ6

Gene expression databases

BgeeiENSG00000171724 Expressed in 148 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_VAT1L
GenevisibleiQ9HCJ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAT1L_HUMAN
AccessioniPrimary (citable) accession number: Q9HCJ6
Secondary accession number(s): Q8IYW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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