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Protein

Ribonucleoprotein PTB-binding 2

Gene

RAVER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind single-stranded nucleic acids.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoprotein PTB-binding 2
Alternative name(s):
Protein raver-2
Gene namesi
Name:RAVER2
Synonyms:KIAA1579
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162437.14
HGNCiHGNC:25577 RAVER2
MIMi609953 gene
neXtProtiNX_Q9HCJ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162437
PharmGKBiPA144596391

Polymorphism and mutation databases

BioMutaiRAVER2
DMDMi67466983

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000814902 – 691Ribonucleoprotein PTB-binding 2Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9HCJ3
MaxQBiQ9HCJ3
PaxDbiQ9HCJ3
PeptideAtlasiQ9HCJ3
PRIDEiQ9HCJ3
ProteomicsDBi81738
81739 [Q9HCJ3-2]

PTM databases

iPTMnetiQ9HCJ3
PhosphoSitePlusiQ9HCJ3

Expressioni

Gene expression databases

BgeeiENSG00000162437 Expressed in 186 organ(s), highest expression level in colonic mucosa
CleanExiHS_RAVER2
ExpressionAtlasiQ9HCJ3 baseline and differential
GenevisibleiQ9HCJ3 HS

Organism-specific databases

HPAiHPA045785

Interactioni

Subunit structurei

Interacts with PTBP1 and RAVER1.By similarity

Protein-protein interaction databases

BioGridi120520, 4 interactors
IntActiQ9HCJ3, 2 interactors
STRINGi9606.ENSP00000360112

Structurei

Secondary structure

1691
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HCJ3
SMRiQ9HCJ3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCJ3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 140RRM 1PROSITE-ProRule annotationAdd BLAST72
Domaini142 – 220RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini231 – 309RRM 3PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 32Ala/Gly-richAdd BLAST31

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ9Q Eukaryota
ENOG410XSBX LUCA
GeneTreeiENSGT00390000006046
HOGENOMiHOG000253941
HOVERGENiHBG059515
InParanoidiQ9HCJ3
OMAiCGRAVKP
OrthoDBiEOG091G04CT
PhylomeDBiQ9HCJ3
TreeFamiTF331660

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034636 RAVER2
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23189:SF6 PTHR23189:SF6, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAGDGGG EGGAGLGSAA GLGPGPGLRG QGPSAEAHEG APDPMPAALH
60 70 80 90 100
PEEVAARLQR MQRELSNRRK ILVKNLPQDS NCQEVHDLLK DYDLKYCYVD
110 120 130 140 150
RNKRTAFVTL LNGEQAQNAI QMFHQYSFRG KDLIVQLQPT DALLCITNVP
160 170 180 190 200
ISFTSEEFEE LVRAYGNIER CFLVYSEVTG HSKGYGFVEY MKKDFAAKAR
210 220 230 240 250
LELLGRQLGA SALFAQWMDV NLLASELIHS KCLCIDKLPS DYRDSEELLQ
260 270 280 290 300
IFSSVHKPVF CQLAQDEGSY VGGFAVVEYS TAEQAEEVQQ AADGMTIKGS
310 320 330 340 350
KVQVSFCAPG APGRSTLAAL IAAQRVMHSN QKGLLPEPNP VQIMKSLNNP
360 370 380 390 400
AMLQVLLQPQ LCGRAVKPAV LGTPHSLPHL MNPSISPAFL HLNKAHQSSV
410 420 430 440 450
MGNTSNLFLQ NLSHIPLAQQ QLMKFENIHT NNKPGLLGEP PAVVLQTALG
460 470 480 490 500
IGSVLPLKKE LGHHHGEAHK TSSLIPTQTT ITAGMGMLPF FPNQHIAGQA
510 520 530 540 550
GPGHSNTQEK QPATVGMAEG NFSGSQPYLQ SFPNLAAGSL LVGHHKQQQS
560 570 580 590 600
QPKGTEISSG AASKNQTSLL GEPPKEIRLS KNPYLNLASV LPSVCLSSPA
610 620 630 640 650
SKTTLHKTGI ASSILDAISQ GSESQHALEK CIAYSPPFGD YAQVSSLRNE
660 670 680 690
KRGSSYLISA PEGGSVECVD QHSQGTGAYY METYLKKKRV Y
Length:691
Mass (Da):74,339
Last modified:May 10, 2005 - v2
Checksum:i03E287BAF9EE10F8
GO
Isoform 2 (identifier: Q9HCJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-409: Missing.

Show »
Length:678
Mass (Da):72,959
Checksum:i9E91312CD90DD981
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PE10E9PE10_HUMAN
Ribonucleoprotein PTB-binding 2
RAVER2
166Annotation score:

Sequence cautioni

The sequence BAB13405 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013676397 – 409Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046799 mRNA Translation: BAB13405.1 Different initiation.
BC065303 mRNA Translation: AAH65303.1
AL359613 mRNA Translation: CAB94883.1
CCDSiCCDS41345.1 [Q9HCJ3-2]
PIRiT50631
RefSeqiNP_060681.2, NM_018211.3 [Q9HCJ3-2]
XP_006710801.2, XM_006710738.3 [Q9HCJ3-1]
UniGeneiHs.591443

Genome annotation databases

EnsembliENST00000294428; ENSP00000294428; ENSG00000162437 [Q9HCJ3-1]
ENST00000371072; ENSP00000360112; ENSG00000162437 [Q9HCJ3-2]
GeneIDi55225
KEGGihsa:55225
UCSCiuc001dbs.3 human [Q9HCJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046799 mRNA Translation: BAB13405.1 Different initiation.
BC065303 mRNA Translation: AAH65303.1
AL359613 mRNA Translation: CAB94883.1
CCDSiCCDS41345.1 [Q9HCJ3-2]
PIRiT50631
RefSeqiNP_060681.2, NM_018211.3 [Q9HCJ3-2]
XP_006710801.2, XM_006710738.3 [Q9HCJ3-1]
UniGeneiHs.591443

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WG1NMR-A71-145[»]
ProteinModelPortaliQ9HCJ3
SMRiQ9HCJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120520, 4 interactors
IntActiQ9HCJ3, 2 interactors
STRINGi9606.ENSP00000360112

PTM databases

iPTMnetiQ9HCJ3
PhosphoSitePlusiQ9HCJ3

Polymorphism and mutation databases

BioMutaiRAVER2
DMDMi67466983

Proteomic databases

EPDiQ9HCJ3
MaxQBiQ9HCJ3
PaxDbiQ9HCJ3
PeptideAtlasiQ9HCJ3
PRIDEiQ9HCJ3
ProteomicsDBi81738
81739 [Q9HCJ3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294428; ENSP00000294428; ENSG00000162437 [Q9HCJ3-1]
ENST00000371072; ENSP00000360112; ENSG00000162437 [Q9HCJ3-2]
GeneIDi55225
KEGGihsa:55225
UCSCiuc001dbs.3 human [Q9HCJ3-1]

Organism-specific databases

CTDi55225
EuPathDBiHostDB:ENSG00000162437.14
GeneCardsiRAVER2
HGNCiHGNC:25577 RAVER2
HPAiHPA045785
MIMi609953 gene
neXtProtiNX_Q9HCJ3
OpenTargetsiENSG00000162437
PharmGKBiPA144596391
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9Q Eukaryota
ENOG410XSBX LUCA
GeneTreeiENSGT00390000006046
HOGENOMiHOG000253941
HOVERGENiHBG059515
InParanoidiQ9HCJ3
OMAiCGRAVKP
OrthoDBiEOG091G04CT
PhylomeDBiQ9HCJ3
TreeFamiTF331660

Miscellaneous databases

ChiTaRSiRAVER2 human
EvolutionaryTraceiQ9HCJ3
GenomeRNAii55225
PROiPR:Q9HCJ3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162437 Expressed in 186 organ(s), highest expression level in colonic mucosa
CleanExiHS_RAVER2
ExpressionAtlasiQ9HCJ3 baseline and differential
GenevisibleiQ9HCJ3 HS

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034636 RAVER2
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23189:SF6 PTHR23189:SF6, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRAVR2_HUMAN
AccessioniPrimary (citable) accession number: Q9HCJ3
Secondary accession number(s): Q6P141, Q9NPV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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