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Entry version 151 (13 Feb 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Leucine-rich repeat-containing protein 4C

Gene

LRRC4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May promote neurite outgrowth of developing thalamic neurons.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cell adhesion molecule binding Source: SynGO-UCL
  • cell-cell adhesion mediator activity Source: SynGO-UCL

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HCJ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 4C
Alternative name(s):
Netrin-G1 ligand
Short name:
NGL-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC4C
Synonyms:KIAA1580, NGL1
ORF Names:UNQ292/PRO331
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148948.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29317 LRRC4C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608817 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCJ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei528 – 548HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57689

Open Targets

More...
OpenTargetsi
ENSG00000148948

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671534

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC4C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
57012973

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 44Sequence analysisAdd BLAST44
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001510845 – 640Leucine-rich repeat-containing protein 4CAdd BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi375 ↔ 426PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei631PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HCJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HCJ2

PeptideAtlas

More...
PeptideAtlasi
Q9HCJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9HCJ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81737

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148948 Expressed in 170 organ(s), highest expression level in Brodmann (1909) area 46

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HCJ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCJ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051335
HPA054800

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NTNG1 and WHRN.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121715, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HCJ2, 16 interactors

Molecular INTeraction database

More...
MINTi
Q9HCJ2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278198

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1640
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZYJX-ray3.25A/C44-444[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HCJ2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HCJ2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 76LRRNTAdd BLAST32
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 98LRR 1Add BLAST22
Repeati101 – 122LRR 2Add BLAST22
Repeati125 – 146LRR 3Add BLAST22
Repeati149 – 170LRR 4Add BLAST22
Repeati173 – 195LRR 5Add BLAST23
Repeati198 – 219LRR 6Add BLAST22
Repeati220 – 241LRR 7Add BLAST22
Repeati244 – 265LRR 8Add BLAST22
Repeati268 – 289LRR 9Add BLAST22
Domaini301 – 353LRRCTAdd BLAST53
Domaini354 – 442Ig-like C2-typeAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LRR region is both necessary and sufficient for the interaction with NTNG1.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157405

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252924

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052359

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCJ2

KEGG Orthology (KO)

More...
KOi
K07523

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMTHGAY

Database of Orthologous Groups

More...
OrthoDBi
282791at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCJ2

TreeFam database of animal gene trees

More...
TreeFami
TF324303

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR026878 LRRC4C
IPR000372 LRRNT

The PANTHER Classification System

More...
PANTHERi
PTHR24369:SF8 PTHR24369:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 1 hit
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00406 IGv, 1 hit
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9HCJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNKMTLHPQ QIMIGPRFNR ALFDPLLVVL LALQLLVVAG LVRAQTCPSV
60 70 80 90 100
CSCSNQFSKV ICVRKNLREV PDGISTNTRL LNLHENQIQI IKVNSFKHLR
110 120 130 140 150
HLEILQLSRN HIRTIEIGAF NGLANLNTLE LFDNRLTTIP NGAFVYLSKL
160 170 180 190 200
KELWLRNNPI ESIPSYAFNR IPSLRRLDLG ELKRLSYISE GAFEGLSNLR
210 220 230 240 250
YLNLAMCNLR EIPNLTPLIK LDELDLSGNH LSAIRPGSFQ GLMHLQKLWM
260 270 280 290 300
IQSQIQVIER NAFDNLQSLV EINLAHNNLT LLPHDLFTPL HHLERIHLHH
310 320 330 340 350
NPWNCNCDIL WLSWWIKDMA PSNTACCARC NTPPNLKGRY IGELDQNYFT
360 370 380 390 400
CYAPVIVEPP ADLNVTEGMA AELKCRASTS LTSVSWITPN GTVMTHGAYK
410 420 430 440 450
VRIAVLSDGT LNFTNVTVQD TGMYTCMVSN SVGNTTASAT LNVTAATTTP
460 470 480 490 500
FSYFSTVTVE TMEPSQDEAR TTDNNVGPTP VVDWETTNVT TSLTPQSTRS
510 520 530 540 550
TEKTFTIPVT DINSGIPGID EVMKTTKIII GCFVAITLMA AVMLVIFYKM
560 570 580 590 600
RKQHHRQNHH APTRTVEIIN VDDEITGDTP MESHLPMPAI EHEHLNHYNS
610 620 630 640
YKSPFNHTTT VNTINSIHSS VHEPLLIRMN SKDNVQETQI
Length:640
Mass (Da):71,950
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6058974872636838
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLP4E9PLP4_HUMAN
Leucine-rich repeat-containing prot...
LRRC4C
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046800 mRNA Translation: BAB13406.1
AY358293 mRNA Translation: AAQ88660.1
AK289646 mRNA Translation: BAF82335.1
CH471064 Genomic DNA Translation: EAW68107.1
BC041374 mRNA Translation: AAH41374.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31464.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245348.1, NM_001258419.1
NP_065980.1, NM_020929.2
XP_011518540.1, XM_011520238.2
XP_011518541.1, XM_011520239.2
XP_011518542.1, XM_011520240.2
XP_011518543.1, XM_011520241.2
XP_011518544.1, XM_011520242.2
XP_011518545.1, XM_011520243.2
XP_011518546.1, XM_011520244.2
XP_016873559.1, XM_017018070.1
XP_016873560.1, XM_017018071.1
XP_016873561.1, XM_017018072.1
XP_016873562.1, XM_017018073.1
XP_016873563.1, XM_017018074.1
XP_016873564.1, XM_017018075.1
XP_016873565.1, XM_017018076.1
XP_016873566.1, XM_017018077.1
XP_016873567.1, XM_017018078.1
XP_016873568.1, XM_017018079.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.745123

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278198; ENSP00000278198; ENSG00000148948
ENST00000527150; ENSP00000436976; ENSG00000148948
ENST00000528697; ENSP00000437132; ENSG00000148948
ENST00000530763; ENSP00000434761; ENSG00000148948
ENST00000619527; ENSP00000480903; ENSG00000148948

Database of genes from NCBI RefSeq genomes

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GeneIDi
57689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57689

UCSC genome browser

More...
UCSCi
uc031pzt.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046800 mRNA Translation: BAB13406.1
AY358293 mRNA Translation: AAQ88660.1
AK289646 mRNA Translation: BAF82335.1
CH471064 Genomic DNA Translation: EAW68107.1
BC041374 mRNA Translation: AAH41374.3
CCDSiCCDS31464.1
RefSeqiNP_001245348.1, NM_001258419.1
NP_065980.1, NM_020929.2
XP_011518540.1, XM_011520238.2
XP_011518541.1, XM_011520239.2
XP_011518542.1, XM_011520240.2
XP_011518543.1, XM_011520241.2
XP_011518544.1, XM_011520242.2
XP_011518545.1, XM_011520243.2
XP_011518546.1, XM_011520244.2
XP_016873559.1, XM_017018070.1
XP_016873560.1, XM_017018071.1
XP_016873561.1, XM_017018072.1
XP_016873562.1, XM_017018073.1
XP_016873563.1, XM_017018074.1
XP_016873564.1, XM_017018075.1
XP_016873565.1, XM_017018076.1
XP_016873566.1, XM_017018077.1
XP_016873567.1, XM_017018078.1
XP_016873568.1, XM_017018079.1
UniGeneiHs.745123

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZYJX-ray3.25A/C44-444[»]
ProteinModelPortaliQ9HCJ2
SMRiQ9HCJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121715, 27 interactors
IntActiQ9HCJ2, 16 interactors
MINTiQ9HCJ2
STRINGi9606.ENSP00000278198

PTM databases

iPTMnetiQ9HCJ2
PhosphoSitePlusiQ9HCJ2

Polymorphism and mutation databases

BioMutaiLRRC4C
DMDMi57012973

Proteomic databases

jPOSTiQ9HCJ2
PaxDbiQ9HCJ2
PeptideAtlasiQ9HCJ2
PRIDEiQ9HCJ2
ProteomicsDBi81737

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278198; ENSP00000278198; ENSG00000148948
ENST00000527150; ENSP00000436976; ENSG00000148948
ENST00000528697; ENSP00000437132; ENSG00000148948
ENST00000530763; ENSP00000434761; ENSG00000148948
ENST00000619527; ENSP00000480903; ENSG00000148948
GeneIDi57689
KEGGihsa:57689
UCSCiuc031pzt.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57689
DisGeNETi57689
EuPathDBiHostDB:ENSG00000148948.7

GeneCards: human genes, protein and diseases

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GeneCardsi
LRRC4C
HGNCiHGNC:29317 LRRC4C
HPAiHPA051335
HPA054800
MIMi608817 gene
neXtProtiNX_Q9HCJ2
OpenTargetsiENSG00000148948
PharmGKBiPA142671534

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000157405
HOGENOMiHOG000252924
HOVERGENiHBG052359
InParanoidiQ9HCJ2
KOiK07523
OMAiIMTHGAY
OrthoDBi282791at2759
PhylomeDBiQ9HCJ2
TreeFamiTF324303

Enzyme and pathway databases

SIGNORiQ9HCJ2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRRC4C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57689

Protein Ontology

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PROi
PR:Q9HCJ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148948 Expressed in 170 organ(s), highest expression level in Brodmann (1909) area 46
ExpressionAtlasiQ9HCJ2 baseline and differential
GenevisibleiQ9HCJ2 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR026878 LRRC4C
IPR000372 LRRNT
PANTHERiPTHR24369:SF8 PTHR24369:SF8, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00406 IGv, 1 hit
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC4C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCJ2
Secondary accession number(s): A8K0T1, Q7L0N3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2001
Last modified: February 13, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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