UniProtKB - Q9HCI5 (MAGE1_HUMAN)
Protein
Melanoma-associated antigen E1
Gene
MAGEE1
Organism
Homo sapiens (Human)
Status
Functioni
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication
Keywordsi
Molecular function | Tumor antigen |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9HCI5 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma-associated antigen E1Alternative name(s): Alpha-dystrobrevin-associated MAGE Protein Short name: DAMAGE Hepatocellular carcinoma-associated protein 1 MAGE-E1 antigen |
Gene namesi | Name:MAGEE1 Synonyms:HCA1, KIAA1587 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24934, MAGEE1 |
MIMi | 300759, gene |
neXtProti | NX_Q9HCI5 |
VEuPathDBi | HostDB:ENSG00000198934.4 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Nucleus
- Nucleus By similarity
Other locations
- perinuclear region By similarity
Note: In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity).By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
- postsynaptic membrane Source: UniProtKB
Other locations
- dendrite Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57692 |
OpenTargetsi | ENSG00000198934 |
PharmGKBi | PA164741999 |
Miscellaneous databases
Pharosi | Q9HCI5, Tbio |
Genetic variation databases
BioMutai | MAGEE1 |
DMDMi | 50428953 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156729 | 1 – 957 | Melanoma-associated antigen E1Add BLAST | 957 |
Proteomic databases
jPOSTi | Q9HCI5 |
MassIVEi | Q9HCI5 |
PaxDbi | Q9HCI5 |
PeptideAtlasi | Q9HCI5 |
PRIDEi | Q9HCI5 |
ProteomicsDBi | 81730 |
PTM databases
iPTMneti | Q9HCI5 |
PhosphoSitePlusi | Q9HCI5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198934, Expressed in endothelial cell and 203 other tissues |
Genevisiblei | Q9HCI5, HS |
Organism-specific databases
HPAi | ENSG00000198934, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with DTNA (By similarity).
Interacts with TRIM28.
By similarity1 PublicationBinary interactionsi
Hide detailsQ9HCI5
With | #Exp. | IntAct |
---|---|---|
EID2B [Q96D98] | 4 | EBI-949966,EBI-724968 |
MCC [P23508] | 3 | EBI-949966,EBI-307531 |
TRIM28 [Q13263] | 2 | EBI-949966,EBI-78139 |
Protein-protein interaction databases
BioGRIDi | 121718, 18 interactors |
IntActi | Q9HCI5, 15 interactors |
STRINGi | 9606.ENSP00000354912 |
Miscellaneous databases
RNActi | Q9HCI5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 491 – 690 | MAGE 1PROSITE-ProRule annotationAdd BLAST | 200 | |
Domaini | 745 – 936 | MAGE 2PROSITE-ProRule annotationAdd BLAST | 192 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 743 – 957 | Interaction with DTNABy similarityAdd BLAST | 215 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 14 | Poly-Arg | 6 | |
Compositional biasi | 141 – 412 | Pro-richAdd BLAST | 272 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000163182 |
HOGENOMi | CLU_012911_0_0_1 |
InParanoidi | Q9HCI5 |
OMAi | YRPITDC |
OrthoDBi | 1195799at2759 |
PhylomeDBi | Q9HCI5 |
TreeFami | TF328505 |
Family and domain databases
Gene3Di | 1.10.10.1200, 2 hits 1.10.10.1210, 2 hits |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 5 hits |
Pfami | View protein in Pfam PF01454, MAGE, 2 hits |
SMARTi | View protein in SMART SM01373, MAGE, 2 hits |
PROSITEi | View protein in PROSITE PS50838, MAGE, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9HCI5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLVSQNSRR RRRRVAKATA HNSSWGEMQA PNAPGLPADV PGSDVPQGPS
60 70 80 90 100
DSQILQGLCA SEGPSTSVLP TSAEGPSTFV PPTISEASSA SGQPTISEGP
110 120 130 140 150
GTSVLPTPSE GLSTSGPPTI SKGLCTSVTL AASEGRNTSR PPTSSEEPST
160 170 180 190 200
SVPPTASEVP STSLPPTPGE GTSTSVPPTA YEGPSTSVVP TPDEGPSTSV
210 220 230 240 250
LPTPGEGPGT SVPLAATEGL STSVQATPDE GPSTSVPPTA TEGLSTPVPP
260 270 280 290 300
TRDEGPSTSV PATPGEGPST SVLPAASDGQ SISLVPTRGK GSSTSVPPTA
310 320 330 340 350
TEGLSTSVQP TAGEGSSTSV PPTPGGGLST SVPPTATEEL STSVPPTPGE
360 370 380 390 400
GPSTSVLPIP GEGLSTSVPP TASDGSDTSV PPTPGEGAST LVQPTAPDGP
410 420 430 440 450
GSSVLPNPGE GPSTLFSSSA SVDRNPSKCS LVLPSPRVTK ASVDSDSEGP
460 470 480 490 500
KGAEGPIEFE VLRDCESPNS ISIMGLNTSR VAITLKPQDP MEQNVAELLQ
510 520 530 540 550
FLLVKDQSKY PIRESEMREY IVKEYRNQFP EILRRAAAHL ECIFRFELRE
560 570 580 590 600
LDPEAHTYIL LNKLGPVPFE GLEESPNGPK MGLLMMILGQ IFLNGNQAKE
610 620 630 640 650
AEIWEMLWRM GVQRERRLSI FGNPKRLLSV EFVWQRYLDY RPVTDCKPVE
660 670 680 690 700
YEFFWGPRSH LETTKMKILK FMAKIYNKDP MDWPEKYNEA LEEDAARAFA
710 720 730 740 750
EGWQALPHFR RPFFEEAAAE VPSPDSEVSS YSSKYAPHSW PESRLESKAR
760 770 780 790 800
KLVQLFLLMD STKLPIPKKG ILYYIGRECS KVFPDLLNRA ARTLNHVYGT
810 820 830 840 850
ELVVLDPRNH SYTLYNRREM EETEEIVDSP NRPGNNFLMQ VLSFIFIMGN
860 870 880 890 900
HARESAVWAF LRGLGVQAGR KHVITCRYLS QRYIDSLRVP DSDPVQYEFV
910 920 930 940 950
WGPRARLETS KMKALRYVAR IHRKEPQDWP QQYREAMEDE ANRADVGHRQ
IFVHNFR
Sequence cautioni
The sequence BAB13413 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076263 | 305 | S → C1 PublicationCorresponds to variant dbSNP:rs142080557Ensembl. | 1 | |
Natural variantiVAR_060071 | 339 | E → D1 PublicationCorresponds to variant dbSNP:rs7051260Ensembl. | 1 | |
Natural variantiVAR_036585 | 640 | Y → F in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_036586 | 664 | T → N in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF490507 mRNA Translation: AAM08354.1 AB046807 mRNA Translation: BAB13413.1 Different initiation. AK291270 mRNA Translation: BAF83959.1 AL096827 Genomic DNA Translation: CAI42970.1 CH471104 Genomic DNA Translation: EAW98620.1 BC050588 mRNA Translation: AAH50588.1 AF320909 mRNA Translation: AAG38605.1 |
CCDSi | CCDS14433.1 |
RefSeqi | NP_065983.1, NM_020932.2 |
Genome annotation databases
Ensembli | ENST00000361470; ENSP00000354912; ENSG00000198934 |
GeneIDi | 57692 |
KEGGi | hsa:57692 |
UCSCi | uc004ecm.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF490507 mRNA Translation: AAM08354.1 AB046807 mRNA Translation: BAB13413.1 Different initiation. AK291270 mRNA Translation: BAF83959.1 AL096827 Genomic DNA Translation: CAI42970.1 CH471104 Genomic DNA Translation: EAW98620.1 BC050588 mRNA Translation: AAH50588.1 AF320909 mRNA Translation: AAG38605.1 |
CCDSi | CCDS14433.1 |
RefSeqi | NP_065983.1, NM_020932.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2H5T | model | - | A | 678-897 | [»] | |
SMRi | Q9HCI5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121718, 18 interactors |
IntActi | Q9HCI5, 15 interactors |
STRINGi | 9606.ENSP00000354912 |
PTM databases
iPTMneti | Q9HCI5 |
PhosphoSitePlusi | Q9HCI5 |
Genetic variation databases
BioMutai | MAGEE1 |
DMDMi | 50428953 |
Proteomic databases
jPOSTi | Q9HCI5 |
MassIVEi | Q9HCI5 |
PaxDbi | Q9HCI5 |
PeptideAtlasi | Q9HCI5 |
PRIDEi | Q9HCI5 |
ProteomicsDBi | 81730 |
Protocols and materials databases
Antibodypediai | 560, 61 antibodies |
Genome annotation databases
Ensembli | ENST00000361470; ENSP00000354912; ENSG00000198934 |
GeneIDi | 57692 |
KEGGi | hsa:57692 |
UCSCi | uc004ecm.3, human |
Organism-specific databases
CTDi | 57692 |
DisGeNETi | 57692 |
GeneCardsi | MAGEE1 |
HGNCi | HGNC:24934, MAGEE1 |
HPAi | ENSG00000198934, Tissue enhanced (brain) |
MIMi | 300759, gene |
neXtProti | NX_Q9HCI5 |
OpenTargetsi | ENSG00000198934 |
PharmGKBi | PA164741999 |
VEuPathDBi | HostDB:ENSG00000198934.4 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000163182 |
HOGENOMi | CLU_012911_0_0_1 |
InParanoidi | Q9HCI5 |
OMAi | YRPITDC |
OrthoDBi | 1195799at2759 |
PhylomeDBi | Q9HCI5 |
TreeFami | TF328505 |
Enzyme and pathway databases
PathwayCommonsi | Q9HCI5 |
Miscellaneous databases
BioGRID-ORCSi | 57692, 5 hits in 506 CRISPR screens |
GenomeRNAii | 57692 |
Pharosi | Q9HCI5, Tbio |
PROi | PR:Q9HCI5 |
RNActi | Q9HCI5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198934, Expressed in endothelial cell and 203 other tissues |
Genevisiblei | Q9HCI5, HS |
Family and domain databases
Gene3Di | 1.10.10.1200, 2 hits 1.10.10.1210, 2 hits |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 5 hits |
Pfami | View protein in Pfam PF01454, MAGE, 2 hits |
SMARTi | View protein in SMART SM01373, MAGE, 2 hits |
PROSITEi | View protein in PROSITE PS50838, MAGE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGE1_HUMAN | |
Accessioni | Q9HCI5Primary (citable) accession number: Q9HCI5 Secondary accession number(s): Q5JXC7 Q9H216 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants