UniProtKB - Q9HCH5 (SYTL2_HUMAN)
Synaptotagmin-like protein 2
SYTL2
Functioni
GO - Molecular functioni
- neurexin family protein binding Source: UniProtKB
- phosphatase binding Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- phosphatidylserine binding Source: UniProtKB
- Rab GTPase binding Source: InterPro
GO - Biological processi
- exocytosis Source: UniProtKB
- intracellular protein transport Source: InterPro
- negative regulation of phosphatase activity Source: UniProtKB
- positive regulation of mucus secretion Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- vesicle docking involved in exocytosis Source: UniProtKB
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Biological process | Exocytosis |
Enzyme and pathway databases
PathwayCommonsi | Q9HCH5 |
Protein family/group databases
TCDBi | 9.A.57.1.4, the extended-synaptotagmin (e-syt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-like protein 2Alternative name(s): Breast cancer-associated antigen SGA-72M Exophilin-4 |
Gene namesi | Name:SYTL2 Synonyms:KIAA1597, SGA72M, SLP2, SLP2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137501.17 |
HGNCi | HGNC:15585, SYTL2 |
MIMi | 612880, gene |
neXtProti | NX_Q9HCH5 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Other locations
- Cytoplasm 1 Publication
Note: Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.1 Publication
Plasma membrane
- Cell membrane 1 Publication
Note: In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.1 Publication
Plasma Membrane
- extrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- exocytic vesicle Source: UniProtKB
- melanosome Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 11 | E → A: Abolishes interaction with RAB27A. 1 Publication | 1 | |
Mutagenesisi | 32 | R → A: Abolishes interaction with RAB27A. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 54843 |
OpenTargetsi | ENSG00000137501 |
PharmGKBi | PA37985 |
Miscellaneous databases
Pharosi | Q9HCH5, Tbio |
Polymorphism and mutation databases
BioMutai | SYTL2 |
DMDMi | 257051068 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190213 | 1 – 934 | Synaptotagmin-like protein 2Add BLAST | 934 |
Post-translational modificationi
Proteomic databases
jPOSTi | Q9HCH5 |
MassIVEi | Q9HCH5 |
MaxQBi | Q9HCH5 |
PaxDbi | Q9HCH5 |
PeptideAtlasi | Q9HCH5 |
PRIDEi | Q9HCH5 |
ProteomicsDBi | 81718 [Q9HCH5-1] 81719 [Q9HCH5-11] 81720 [Q9HCH5-12] 81721 [Q9HCH5-13] 81722 [Q9HCH5-14] 81723 [Q9HCH5-15] 81724 [Q9HCH5-2] 81725 [Q9HCH5-4] 81726 [Q9HCH5-6] 81727 [Q9HCH5-7] 81728 [Q9HCH5-8] 81729 [Q9HCH5-9] |
PTM databases
iPTMneti | Q9HCH5 |
PhosphoSitePlusi | Q9HCH5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000137501, Expressed in stomach and 214 other tissues |
ExpressionAtlasi | Q9HCH5, baseline and differential |
Genevisiblei | Q9HCH5, HS |
Organism-specific databases
HPAi | ENSG00000137501, Tissue enhanced (stomach) |
Interactioni
Subunit structurei
Monomer. Binds NRXN1.
Interacts with RAB27B (By similarity). Binds RAB27A that has been activated by GTP-binding.
By similarity2 PublicationsBinary interactionsi
Hide detailsQ9HCH5
With | #Exp. | IntAct |
---|---|---|
PPP1CA [P62136] | 2 | EBI-2690103,EBI-357253 |
Rab27a [Q9ERI2] from Mus musculus. | 4 | EBI-2690103,EBI-398172 |
Isoform 10 [Q9HCH5-13]
With | #Exp. | IntAct |
---|---|---|
LNX1 [Q8TBB1] | 3 | EBI-14291493,EBI-739832 |
MORN4 [Q8NDC4] | 3 | EBI-14291493,EBI-10269566 |
YIF1A [O95070] | 3 | EBI-14291493,EBI-2799703 |
GO - Molecular functioni
- neurexin family protein binding Source: UniProtKB
- phosphatase binding Source: UniProtKB
- Rab GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 120194, 13 interactors |
ELMi | Q9HCH5 |
IntActi | Q9HCH5, 9 interactors |
MINTi | Q9HCH5 |
STRINGi | 9606.ENSP00000318803 |
Miscellaneous databases
RNActi | Q9HCH5, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9HCH5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HCH5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 57 | RabBDPROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 628 – 753 | C2 1PROSITE-ProRule annotationAdd BLAST | 126 | |
Domaini | 768 – 897 | C2 2PROSITE-ProRule annotationAdd BLAST | 130 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 579 – 619 | Ser-richAdd BLAST | 41 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000155843 |
HOGENOMi | CLU_002711_2_0_1 |
InParanoidi | Q9HCH5 |
OrthoDBi | 916843at2759 |
PhylomeDBi | Q9HCH5 |
TreeFami | TF341184 |
Family and domain databases
CDDi | cd04020, C2B_SLP_1-2-3-4, 1 hit |
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR041282, FYVE_2 IPR010911, Rab_BD IPR043567, SYTL1-5_C2B IPR027006, SYTL2 IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45716:SF5, PTHR45716:SF5, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF02318, FYVE_2, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50916, RABBD, 1 hit |
s (12+)i Sequence
Sequence statusi: Complete.
This entry describes 12 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 12 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIDLSFLTEE EQEAIMKVLQ RDAALKRAEE ERVRHLPEKI KDDQQLKNMS
60 70 80 90 100
GQWFYEAKAK RHRDKIHGAD IIRASMRKKR PQIAAEQSKD RENGAKESWV
110 120 130 140 150
NNVNKDAFLP PELAGVVEEP EEDAAPASPS SSVVNPASSV IDMSQENTRK
160 170 180 190 200
PNVSPEKRKN PFNSSKLPEG HSSQQTKNEQ SKNGRTGLFQ TSKEDELSES
210 220 230 240 250
KEKSTVADTS IQKLEKSKQT LPGLSNGSQI KAPIPKARKM IYKSTDLNKD
260 270 280 290 300
DNQSFPRQRT DSLKARGAPR GILKRNSSSS STDSETLRYN HNFEPKSKIV
310 320 330 340 350
SPGLTIHERI SEKEHSLEDN SSPNSLEPLK HVRFSAVKDE LPQSPGLIHG
360 370 380 390 400
REVGEFSVLE SDRLKNGMED AGDTEEFQSD PKPSQYRKPS LFHQSTSSPY
410 420 430 440 450
VSKSETHQPM TSGSFPINGL HSHSEVLTAR PQSMENSPTI NEPKDKSSEL
460 470 480 490 500
TRLESVLPRS PADELSHCVE PEPSQVPGGS SRDRQQGSEE EPSPVLKTLE
510 520 530 540 550
RSAARKMPSK SLEDISSDSS NQAKVDNQPE ELVRSAEDVS TVPTQPDNPF
560 570 580 590 600
SHPDKLKRMS KSVPAFLQDE SDDRETDTAS ESSYQLSRHK KSPSSLTNLS
610 620 630 640 650
SSSGMTSLSS VSGSVMSVYS GDFGNLEVKG NIQFAIEYVE SLKELHVFVA
660 670 680 690 700
QCKDLAAADV KKQRSDPYVK AYLLPDKGKM GKKKTLVVKK TLNPVYNEIL
710 720 730 740 750
RYKIEKQILK TQKLNLSIWH RDTFKRNSFL GEVELDLETW DWDNKQNKQL
760 770 780 790 800
RWYPLKRKTA PVALEAENRG EMKLALQYVP EPVPGKKLPT TGEVHIWVKE
810 820 830 840 850
CLDLPLLRGS HLNSFVKCTI LPDTSRKSRQ KTRAVGKTTN PIFNHTMVYD
860 870 880 890 900
GFRPEDLMEA CVELTVWDHY KLTNQFLGGL RIGFGTGKSY GTEVDWMDST
910 920 930
SEEVALWEKM VNSPNTWIEA TLPLRMLLIA KISK
The sequence of this isoform differs from the canonical sequence as follows:
157-157: K → KQ
The sequence of this isoform differs from the canonical sequence as follows:
1-48: Missing.
539-539: V → DEKPDQKPVTNECVPRI
The sequence of this isoform differs from the canonical sequence as follows:
1-142: Missing.
571-610: Missing.
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RR07 | A0A0U1RR07_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 2,223 | Annotation score: | ||
E9PS29 | E9PS29_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 155 | Annotation score: | ||
A0A0U1RQP0 | A0A0U1RQP0_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 1,276 | Annotation score: | ||
E9PRW5 | E9PRW5_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 103 | Annotation score: | ||
A0A0U1RQH1 | A0A0U1RQH1_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 651 | Annotation score: | ||
E9PK22 | E9PK22_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 69 | Annotation score: | ||
E9PS39 | E9PS39_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 63 | Annotation score: | ||
A0A0U1RRJ3 | A0A0U1RRJ3_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 866 | Annotation score: | ||
E9PPL3 | E9PPL3_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 160 | Annotation score: | ||
E9PQL8 | E9PQL8_HUMAN | Synaptotagmin-like protein 2 | SYTL2 | 124 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 603 | S → P in ABV82746 (PubMed:18812475).Curated | 1 | |
Sequence conflicti | 658 | A → V in BAD18516 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 682 | K → M in AAI44116 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 718 | I → V in BAB15030 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 860 | A → V in BAB13423 (PubMed:10997877).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 9 (identifier: Q9HCH5-12) | |||||
Natural variantiVAR_082906 | 6 | D → GCuratedCorresponds to variant dbSNP:rs556669Ensembl. | 1 | ||
Natural variantiVAR_082907 | 20 | T → MCuratedCorresponds to variant dbSNP:rs641393Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037896 | 1 – 569 | Missing in isoform 7. 1 PublicationAdd BLAST | 569 | |
Alternative sequenceiVSP_007885 | 1 – 558 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 558 | |
Alternative sequenceiVSP_037900 | 1 – 487 | MIDLS…DRQQG → MDEPNAEQVYNPSQFENLRK FWDLEANSNSKDNDKNITTT SQKNSAPFNRQKHKEFSDIK LSGKNTHEAEVLLSPKKVMA REEMEKLNSKGILQVLPDEI TFPLSPLRKYTYQLPGNESS KENVEKNTEGIVTPVFKEEK DYSEQEIQESIIKTNVLSKD CKDTFNDSLQKLLSETSTPA IQPSGGKVHGKQVLEPSVSE NRTWPQKTDFADTEEEVKGP EKIINEHVDKTVVHPKVKRN SLTASLDKLLKEATGTSPSP LQAKLAPVITGTNSKLEEGR FFGKGIEQSHNTSADKREIL APFPVRDETFGNTALLKKAE SGECQLSTQNLIQMAAEDSH PLDPTSQLSRKGSFGDVASP PQDMLFPQDAHLVPQARVHP SQTEISETVEKVILPPRPVL NDVSAALQKLCGEVWLSYPA GREVGPGEVNPEFPEAVQPV CSPLNPPGVISPWATMDTIV PDRKDFYSSNVVPDKTHEVG SYLAAQMSPSDQTLSSFASI VAQYGKGLPQEVEEIVRETI VQPKSEFLEFSAGLEKLLKE ETETFPSKYESDTGNLSPSK LIGSTEEPRRATSECHPEEL KETVEKAEAPLITESAFDAG FEKLLKEITEAPPYQPQVSV REETHEKESSQSEQTRFLGT VPHFYRAASQTSEMKDKSNG LESQVNQCDKMLGGDALVTD LLVDFCGSRSGVEIPRTPQL YVAHEIGTIKTVTPPEDRDS ESGVAGGQGTLQEPGFGEAS EAISVSRNRQPIPLLMNKEN STKTSKVELTLASPYMKQEK EEEKEGFSESDFSDGNTSSN AESWRNPSS in isoform 5, isoform 6 and isoform 8. 2 PublicationsAdd BLAST | 487 | |
Alternative sequenceiVSP_037899 | 1 – 487 | MIDLS…DRQQG → MLFPQDAHLVPQARVHPSQT EISETVEKVILPPRPVLNDV SAALQKLCGEVWLSYPAGRE VGPGEVNPEFPEAVQPVCSP LNPPGVISPWATMDTIVPDR KDFYSSNVVPDKTHEVGSYL AAQMSPSDQTLSSFASIVAQ YGKGLPQEVEEIVRETIVQP KSEFLEFSAGLEKLLKEETE TFPSKYESDTGNLSPSKLIG STEEPRRATSECHPEELKET VEKAEAPLITESAFDAGFEK LLKEITEAPPYQPQVSVREE THEKESSQSEQTRFLGTVPH FYRAASQTSEMKDKSNGLES QVNQCDKMLGGDALVTDLLV DFCGSRSGVEIPRTPQLYVA HEIGTIKTVTPPEDRDSESG VAGGQGTLQEPGFGEASEAI SVSRNRQPIPLLMNKENSTK TSKVELTLASPYMKQEKEEE KEGFSESDFSDGNTSSNAES WRNPSS in isoform 9. 1 PublicationAdd BLAST | 487 | |
Alternative sequenceiVSP_037901 | 1 – 142 | Missing in isoform 12. 1 PublicationAdd BLAST | 142 | |
Alternative sequenceiVSP_037902 | 1 – 48 | Missing in isoform 11. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_037904 | 157 | K → KQ in isoform 10. 1 Publication | 1 | |
Alternative sequenceiVSP_037905 | 539 | V → DEKPDQKPVTNECVPRI in isoform 4, isoform 6, isoform 8 and isoform 11. 2 Publications | 1 | |
Alternative sequenceiVSP_037906 | 570 | E → M in isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_019004 | 571 – 610 | Missing in isoform 3, isoform 4, isoform 8 and isoform 12. 3 PublicationsAdd BLAST | 40 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BC1 | X-ray | 1.80 | B/F | 10-62 | [»] | |
SMRi | Q9HCH5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120194, 13 interactors |
ELMi | Q9HCH5 |
IntActi | Q9HCH5, 9 interactors |
MINTi | Q9HCH5 |
STRINGi | 9606.ENSP00000318803 |
Protein family/group databases
TCDBi | 9.A.57.1.4, the extended-synaptotagmin (e-syt) family |
PTM databases
iPTMneti | Q9HCH5 |
PhosphoSitePlusi | Q9HCH5 |
Polymorphism and mutation databases
BioMutai | SYTL2 |
DMDMi | 257051068 |
Proteomic databases
jPOSTi | Q9HCH5 |
MassIVEi | Q9HCH5 |
MaxQBi | Q9HCH5 |
PaxDbi | Q9HCH5 |
PeptideAtlasi | Q9HCH5 |
PRIDEi | Q9HCH5 |
ProteomicsDBi | 81718 [Q9HCH5-1] 81719 [Q9HCH5-11] 81720 [Q9HCH5-12] 81721 [Q9HCH5-13] 81722 [Q9HCH5-14] 81723 [Q9HCH5-15] 81724 [Q9HCH5-2] 81725 [Q9HCH5-4] 81726 [Q9HCH5-6] 81727 [Q9HCH5-7] 81728 [Q9HCH5-8] 81729 [Q9HCH5-9] |
Protocols and materials databases
Antibodypediai | 49544, 72 antibodies |
DNASUi | 54843 |
Genome annotation databases
Organism-specific databases
CTDi | 54843 |
DisGeNETi | 54843 |
EuPathDBi | HostDB:ENSG00000137501.17 |
GeneCardsi | SYTL2 |
HGNCi | HGNC:15585, SYTL2 |
HPAi | ENSG00000137501, Tissue enhanced (stomach) |
MIMi | 612880, gene |
neXtProti | NX_Q9HCH5 |
OpenTargetsi | ENSG00000137501 |
PharmGKBi | PA37985 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000155843 |
HOGENOMi | CLU_002711_2_0_1 |
InParanoidi | Q9HCH5 |
OrthoDBi | 916843at2759 |
PhylomeDBi | Q9HCH5 |
TreeFami | TF341184 |
Enzyme and pathway databases
PathwayCommonsi | Q9HCH5 |
Miscellaneous databases
BioGRID-ORCSi | 54843, 4 hits in 849 CRISPR screens |
ChiTaRSi | SYTL2, human |
EvolutionaryTracei | Q9HCH5 |
GeneWikii | SYTL2 |
GenomeRNAii | 54843 |
Pharosi | Q9HCH5, Tbio |
PROi | PR:Q9HCH5 |
RNActi | Q9HCH5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137501, Expressed in stomach and 214 other tissues |
ExpressionAtlasi | Q9HCH5, baseline and differential |
Genevisiblei | Q9HCH5, HS |
Family and domain databases
CDDi | cd04020, C2B_SLP_1-2-3-4, 1 hit |
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR041282, FYVE_2 IPR010911, Rab_BD IPR043567, SYTL1-5_C2B IPR027006, SYTL2 IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45716:SF5, PTHR45716:SF5, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF02318, FYVE_2, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50916, RABBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYTL2_HUMAN | |
Accessioni | Q9HCH5Primary (citable) accession number: Q9HCH5 Secondary accession number(s): B3KRS3 Q9NXM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2003 |
Last sequence update: | September 1, 2009 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM