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UniProtKB - Q9HCH5 (SYTL2_HUMAN)

Entry version 173 (02 Dec 2020)
Sequence version 3 (01 Sep 2009)
Previous versions | rss
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Protein

Synaptotagmin-like protein 2

Gene

SYTL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca2+ while binding to PIP2 is Ca2+ insensitive.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HCH5

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.57.1.4, the extended-synaptotagmin (e-syt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-like protein 2
Alternative name(s):
Breast cancer-associated antigen SGA-72M
Exophilin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYTL2
Synonyms:KIAA1597, SGA72M, SLP2, SLP2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000137501.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:15585, SYTL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612880, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HCH5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11E → A: Abolishes interaction with RAB27A. 1 Publication1
Mutagenesisi32R → A: Abolishes interaction with RAB27A. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54843

Open Targets

More...OpenTargetsi		ENSG00000137501

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37985

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HCH5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYTL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		257051068

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902131 – 934Synaptotagmin-like protein 2Add BLAST934

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HCH5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HCH5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HCH5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HCH5

PeptideAtlas

More...PeptideAtlasi		Q9HCH5

PRoteomics IDEntifications database

More...PRIDEi		Q9HCH5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81718 [Q9HCH5-1]
81719 [Q9HCH5-11]
81720 [Q9HCH5-12]
81721 [Q9HCH5-13]
81722 [Q9HCH5-14]
81723 [Q9HCH5-15]
81724 [Q9HCH5-2]
81725 [Q9HCH5-4]
81726 [Q9HCH5-6]
81727 [Q9HCH5-7]
81728 [Q9HCH5-8]
81729 [Q9HCH5-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HCH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HCH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137501, Expressed in stomach and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HCH5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HCH5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137501, Tissue enhanced (stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Binds NRXN1.

Interacts with RAB27B (By similarity). Binds RAB27A that has been activated by GTP-binding.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120194, 13 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9HCH5

Protein interaction database and analysis system

More...IntActi		Q9HCH5, 9 interactors

Molecular INTeraction database

More...MINTi		Q9HCH5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000318803

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HCH5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1934
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HCH5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9HCH5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 57RabBDPROSITE-ProRule annotationAdd BLAST57
Domaini628 – 753C2 1PROSITE-ProRule annotationAdd BLAST126
Domaini768 – 897C2 2PROSITE-ProRule annotationAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi579 – 619Ser-richAdd BLAST41

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL).
The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2) and localization to the cell membrane.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002711_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HCH5

Database of Orthologous Groups

More...OrthoDBi		916843at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HCH5

TreeFam database of animal gene trees

More...TreeFami		TF341184

Family and domain databases

Conserved Domains Database

More...CDDi		cd04020, C2B_SLP_1-2-3-4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR010911, Rab_BD
IPR043567, SYTL1-5_C2B
IPR027006, SYTL2
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR45716:SF5, PTHR45716:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCH5-1) [UniParc]FASTAAdd to basket
Also known as: Hematopoietic form of Slp2a, Slp2a-hem

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIDLSFLTEE EQEAIMKVLQ RDAALKRAEE ERVRHLPEKI KDDQQLKNMS 
        60         70         80         90        100
GQWFYEAKAK RHRDKIHGAD IIRASMRKKR PQIAAEQSKD RENGAKESWV 
       110        120        130        140        150
NNVNKDAFLP PELAGVVEEP EEDAAPASPS SSVVNPASSV IDMSQENTRK 
       160        170        180        190        200
PNVSPEKRKN PFNSSKLPEG HSSQQTKNEQ SKNGRTGLFQ TSKEDELSES 
       210        220        230        240        250
KEKSTVADTS IQKLEKSKQT LPGLSNGSQI KAPIPKARKM IYKSTDLNKD 
       260        270        280        290        300
DNQSFPRQRT DSLKARGAPR GILKRNSSSS STDSETLRYN HNFEPKSKIV 
       310        320        330        340        350
SPGLTIHERI SEKEHSLEDN SSPNSLEPLK HVRFSAVKDE LPQSPGLIHG 
       360        370        380        390        400
REVGEFSVLE SDRLKNGMED AGDTEEFQSD PKPSQYRKPS LFHQSTSSPY 
       410        420        430        440        450
VSKSETHQPM TSGSFPINGL HSHSEVLTAR PQSMENSPTI NEPKDKSSEL 
       460        470        480        490        500
TRLESVLPRS PADELSHCVE PEPSQVPGGS SRDRQQGSEE EPSPVLKTLE 
       510        520        530        540        550
RSAARKMPSK SLEDISSDSS NQAKVDNQPE ELVRSAEDVS TVPTQPDNPF 
       560        570        580        590        600
SHPDKLKRMS KSVPAFLQDE SDDRETDTAS ESSYQLSRHK KSPSSLTNLS 
       610        620        630        640        650
SSSGMTSLSS VSGSVMSVYS GDFGNLEVKG NIQFAIEYVE SLKELHVFVA 
       660        670        680        690        700
QCKDLAAADV KKQRSDPYVK AYLLPDKGKM GKKKTLVVKK TLNPVYNEIL 
       710        720        730        740        750
RYKIEKQILK TQKLNLSIWH RDTFKRNSFL GEVELDLETW DWDNKQNKQL 
       760        770        780        790        800
RWYPLKRKTA PVALEAENRG EMKLALQYVP EPVPGKKLPT TGEVHIWVKE 
       810        820        830        840        850
CLDLPLLRGS HLNSFVKCTI LPDTSRKSRQ KTRAVGKTTN PIFNHTMVYD 
       860        870        880        890        900
GFRPEDLMEA CVELTVWDHY KLTNQFLGGL RIGFGTGKSY GTEVDWMDST 
       910        920        930 
SEEVALWEKM VNSPNTWIEA TLPLRMLLIA KISK
Length:934
Mass (Da):104,930
Last modified:September 1, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4531F9CDD02F25DE
GO
Isoform 2 (identifier: Q9HCH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-558: Missing.

Show »
Length:376
Mass (Da):42,736
Checksum:i8A243E20BAC2ADDF
GO
Isoform 3 (identifier: Q9HCH5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-558: Missing.
     571-610: Missing.

Show »
Length:336
Mass (Da):38,502
Checksum:iAF9104112AA3250D
GO
Isoform 4 (identifier: Q9HCH5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-539: V → DEKPDQKPVTNECVPRI
     571-610: Missing.

Show »
Length:910
Mass (Da):102,547
Checksum:i9A2F59AAD94B2463
GO
Isoform 5 (identifier: Q9HCH5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MDEPNAEQVY...NAESWRNPSS

Show »
Length:1,256
Mass (Da):139,871
Checksum:i6B22ECDEDF3A1785
GO
Isoform 6 (identifier: Q9HCH5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MDEPNAEQVY...NAESWRNPSS
     539-539: V → DEKPDQKPVTNECVPRI

Show »
Length:1,272
Mass (Da):141,722
Checksum:iD3568DB4C36D95B2
GO
Isoform 7 (identifier: Q9HCH5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-569: Missing.
     570-570: E → M

Show »
Length:365
Mass (Da):41,534
Checksum:i248C5AD2B497C9EE
GO
Isoform 8 (identifier: Q9HCH5-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MDEPNAEQVY...NAESWRNPSS
     539-539: V → DEKPDQKPVTNECVPRI
     571-610: Missing.

Show »
Length:1,232
Mass (Da):137,488
Checksum:i68C8C0CB131F520E
GO
Isoform 9 (identifier: Q9HCH5-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MLFPQDAHLV...NAESWRNPSS

Show »
Length:893
Mass (Da):99,439
Checksum:i0AA2D3F2198806D5
GO
Isoform 10 (identifier: Q9HCH5-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: K → KQ

Show »
Length:935
Mass (Da):105,058
Checksum:i56E05093B491746B
GO
Isoform 11 (identifier: Q9HCH5-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     539-539: V → DEKPDQKPVTNECVPRI

Show »
Length:902
Mass (Da):101,062
Checksum:iBDDC40D39014A87A
GO
Isoform 12 (identifier: Q9HCH5-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.
     571-610: Missing.

Show »
Length:752
Mass (Da):84,651
Checksum:iB224984F9D70523F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RR07A0A0U1RR07_HUMAN
Synaptotagmin-like protein 2
SYTL2
2,223Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS29E9PS29_HUMAN
Synaptotagmin-like protein 2
SYTL2
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQP0A0A0U1RQP0_HUMAN
Synaptotagmin-like protein 2
SYTL2
1,276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRW5E9PRW5_HUMAN
Synaptotagmin-like protein 2
SYTL2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQH1A0A0U1RQH1_HUMAN
Synaptotagmin-like protein 2
SYTL2
651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK22E9PK22_HUMAN
Synaptotagmin-like protein 2
SYTL2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS39E9PS39_HUMAN
Synaptotagmin-like protein 2
SYTL2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRJ3A0A0U1RRJ3_HUMAN
Synaptotagmin-like protein 2
SYTL2
866Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPL3E9PPL3_HUMAN
Synaptotagmin-like protein 2
SYTL2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQL8E9PQL8_HUMAN
Synaptotagmin-like protein 2
SYTL2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR25619 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA90989 differs from that shown. Probable cloning artifact.Curated
The sequence BAB13423 differs from that shown. Sequencing errors.Curated
The sequence BAB13423 differs from that shown. Reason: Frameshift.Curated
The sequence BAB13423 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD18516 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti603S → P in ABV82746 (PubMed:18812475).Curated1
Sequence conflicti658A → V in BAD18516 (PubMed:14702039).Curated1
Sequence conflicti682K → M in AAI44116 (PubMed:15489334).Curated1
Sequence conflicti718I → V in BAB15030 (PubMed:14702039).Curated1
Sequence conflicti860A → V in BAB13423 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 9 (identifier: Q9HCH5-12)
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0829066D → GCuratedCorresponds to variant dbSNP:rs556669Ensembl.1
Natural variantiVAR_08290720T → MCuratedCorresponds to variant dbSNP:rs641393Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0378961 – 569Missing in isoform 7. 1 PublicationAdd BLAST569
Alternative sequenceiVSP_0078851 – 558Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST558
Alternative sequenceiVSP_0379001 – 487MIDLS…DRQQG → MDEPNAEQVYNPSQFENLRK FWDLEANSNSKDNDKNITTT SQKNSAPFNRQKHKEFSDIK LSGKNTHEAEVLLSPKKVMA REEMEKLNSKGILQVLPDEI TFPLSPLRKYTYQLPGNESS KENVEKNTEGIVTPVFKEEK DYSEQEIQESIIKTNVLSKD CKDTFNDSLQKLLSETSTPA IQPSGGKVHGKQVLEPSVSE NRTWPQKTDFADTEEEVKGP EKIINEHVDKTVVHPKVKRN SLTASLDKLLKEATGTSPSP LQAKLAPVITGTNSKLEEGR FFGKGIEQSHNTSADKREIL APFPVRDETFGNTALLKKAE SGECQLSTQNLIQMAAEDSH PLDPTSQLSRKGSFGDVASP PQDMLFPQDAHLVPQARVHP SQTEISETVEKVILPPRPVL NDVSAALQKLCGEVWLSYPA GREVGPGEVNPEFPEAVQPV CSPLNPPGVISPWATMDTIV PDRKDFYSSNVVPDKTHEVG SYLAAQMSPSDQTLSSFASI VAQYGKGLPQEVEEIVRETI VQPKSEFLEFSAGLEKLLKE ETETFPSKYESDTGNLSPSK LIGSTEEPRRATSECHPEEL KETVEKAEAPLITESAFDAG FEKLLKEITEAPPYQPQVSV REETHEKESSQSEQTRFLGT VPHFYRAASQTSEMKDKSNG LESQVNQCDKMLGGDALVTD LLVDFCGSRSGVEIPRTPQL YVAHEIGTIKTVTPPEDRDS ESGVAGGQGTLQEPGFGEAS EAISVSRNRQPIPLLMNKEN STKTSKVELTLASPYMKQEK EEEKEGFSESDFSDGNTSSN AESWRNPSS in isoform 5, isoform 6 and isoform 8. 2 PublicationsAdd BLAST487
Alternative sequenceiVSP_0378991 – 487MIDLS…DRQQG → MLFPQDAHLVPQARVHPSQT EISETVEKVILPPRPVLNDV SAALQKLCGEVWLSYPAGRE VGPGEVNPEFPEAVQPVCSP LNPPGVISPWATMDTIVPDR KDFYSSNVVPDKTHEVGSYL AAQMSPSDQTLSSFASIVAQ YGKGLPQEVEEIVRETIVQP KSEFLEFSAGLEKLLKEETE TFPSKYESDTGNLSPSKLIG STEEPRRATSECHPEELKET VEKAEAPLITESAFDAGFEK LLKEITEAPPYQPQVSVREE THEKESSQSEQTRFLGTVPH FYRAASQTSEMKDKSNGLES QVNQCDKMLGGDALVTDLLV DFCGSRSGVEIPRTPQLYVA HEIGTIKTVTPPEDRDSESG VAGGQGTLQEPGFGEASEAI SVSRNRQPIPLLMNKENSTK TSKVELTLASPYMKQEKEEE KEGFSESDFSDGNTSSNAES WRNPSS in isoform 9. 1 PublicationAdd BLAST487
Alternative sequenceiVSP_0379011 – 142Missing in isoform 12. 1 PublicationAdd BLAST142
Alternative sequenceiVSP_0379021 – 48Missing in isoform 11. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_037904157K → KQ in isoform 10. 1 Publication1
Alternative sequenceiVSP_037905539V → DEKPDQKPVTNECVPRI in isoform 4, isoform 6, isoform 8 and isoform 11. 2 Publications1
Alternative sequenceiVSP_037906570E → M in isoform 7. 1 Publication1
Alternative sequenceiVSP_019004571 – 610Missing in isoform 3, isoform 4, isoform 8 and isoform 12. 3 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EU035829 mRNA Translation: ABV82746.1
AY386362 mRNA Translation: AAR25619.1 Different initiation.
AB046817 mRNA Translation: BAB13423.1 Sequence problems.
AK000170 mRNA Translation: BAA90989.1 Sequence problems.
AK024872 mRNA Translation: BAB15030.1
AK074737 mRNA Translation: BAC11170.1
AK092121 mRNA Translation: BAG52485.1
AK124754 mRNA Translation: BAC85937.1
AK127504 mRNA No translation available.
AK131365 mRNA Translation: BAD18516.1 Different initiation.
AK296224 mRNA Translation: BAG58947.1
AK296740 mRNA Translation: BAG59325.1
AK298604 mRNA Translation: BAG60788.1
AP000642 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75110.1
BC015540 mRNA Translation: AAH15540.2
BC110315 mRNA Translation: AAI10316.1
BC136450 mRNA Translation: AAI36451.1
BC144114 mRNA Translation: AAI44115.1
BC144115 mRNA Translation: AAI44116.1
AL834422 mRNA Translation: CAD39083.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31649.1 [Q9HCH5-6]
CCDS31652.1 [Q9HCH5-2]
CCDS41698.1 [Q9HCH5-9]
CCDS53687.1 [Q9HCH5-4]
CCDS53688.1 [Q9HCH5-1]
CCDS53689.1 [Q9HCH5-13]
CCDS76461.1 [Q9HCH5-14]

NCBI Reference Sequences

More...RefSeqi		NP_001156423.1, NM_001162951.2 [Q9HCH5-1]
NP_001156424.1, NM_001162952.2 [Q9HCH5-4]
NP_001156425.1, NM_001162953.2 [Q9HCH5-13]
NP_001276537.1, NM_001289608.1 [Q9HCH5-14]
NP_001276538.1, NM_001289609.1
NP_001276539.1, NM_001289610.1 [Q9HCH5-4]
NP_116561.1, NM_032943.4 [Q9HCH5-6]
NP_996812.1, NM_206929.3 [Q9HCH5-2]
NP_996813.1, NM_206930.3 [Q9HCH5-9]
XP_005274124.1, XM_005274067.4
XP_011543416.1, XM_011545114.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316356; ENSP00000318803; ENSG00000137501 [Q9HCH5-13]
ENST00000359152; ENSP00000352065; ENSG00000137501 [Q9HCH5-13]
ENST00000389958; ENSP00000374608; ENSG00000137501 [Q9HCH5-9]
ENST00000389960; ENSP00000374610; ENSG00000137501 [Q9HCH5-6]
ENST00000524452; ENSP00000435238; ENSG00000137501 [Q9HCH5-6]
ENST00000525702; ENSP00000432996; ENSG00000137501 [Q9HCH5-2]
ENST00000527523; ENSP00000434010; ENSG00000137501 [Q9HCH5-14]
ENST00000528231; ENSP00000431701; ENSG00000137501 [Q9HCH5-1]
ENST00000529581; ENSP00000435855; ENSG00000137501 [Q9HCH5-2]
ENST00000533892; ENSP00000432144; ENSG00000137501 [Q9HCH5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54843

UCSC genome browser

More...UCSCi		uc001pav.5, human [Q9HCH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU035829 mRNA Translation: ABV82746.1
AY386362 mRNA Translation: AAR25619.1 Different initiation.
AB046817 mRNA Translation: BAB13423.1 Sequence problems.
AK000170 mRNA Translation: BAA90989.1 Sequence problems.
AK024872 mRNA Translation: BAB15030.1
AK074737 mRNA Translation: BAC11170.1
AK092121 mRNA Translation: BAG52485.1
AK124754 mRNA Translation: BAC85937.1
AK127504 mRNA No translation available.
AK131365 mRNA Translation: BAD18516.1 Different initiation.
AK296224 mRNA Translation: BAG58947.1
AK296740 mRNA Translation: BAG59325.1
AK298604 mRNA Translation: BAG60788.1
AP000642 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75110.1
BC015540 mRNA Translation: AAH15540.2
BC110315 mRNA Translation: AAI10316.1
BC136450 mRNA Translation: AAI36451.1
BC144114 mRNA Translation: AAI44115.1
BC144115 mRNA Translation: AAI44116.1
AL834422 mRNA Translation: CAD39083.1
CCDSiCCDS31649.1 [Q9HCH5-6]
CCDS31652.1 [Q9HCH5-2]
CCDS41698.1 [Q9HCH5-9]
CCDS53687.1 [Q9HCH5-4]
CCDS53688.1 [Q9HCH5-1]
CCDS53689.1 [Q9HCH5-13]
CCDS76461.1 [Q9HCH5-14]
RefSeqiNP_001156423.1, NM_001162951.2 [Q9HCH5-1]
NP_001156424.1, NM_001162952.2 [Q9HCH5-4]
NP_001156425.1, NM_001162953.2 [Q9HCH5-13]
NP_001276537.1, NM_001289608.1 [Q9HCH5-14]
NP_001276538.1, NM_001289609.1
NP_001276539.1, NM_001289610.1 [Q9HCH5-4]
NP_116561.1, NM_032943.4 [Q9HCH5-6]
NP_996812.1, NM_206929.3 [Q9HCH5-2]
NP_996813.1, NM_206930.3 [Q9HCH5-9]
XP_005274124.1, XM_005274067.4
XP_011543416.1, XM_011545114.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BC1X-ray1.80B/F10-62[»]
SMRiQ9HCH5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120194, 13 interactors
ELMiQ9HCH5
IntActiQ9HCH5, 9 interactors
MINTiQ9HCH5
STRINGi9606.ENSP00000318803

Protein family/group databases

TCDBi9.A.57.1.4, the extended-synaptotagmin (e-syt) family

PTM databases

iPTMnetiQ9HCH5
PhosphoSitePlusiQ9HCH5

Polymorphism and mutation databases

BioMutaiSYTL2
DMDMi257051068

Proteomic databases

jPOSTiQ9HCH5
MassIVEiQ9HCH5
MaxQBiQ9HCH5
PaxDbiQ9HCH5
PeptideAtlasiQ9HCH5
PRIDEiQ9HCH5
ProteomicsDBi81718 [Q9HCH5-1]
81719 [Q9HCH5-11]
81720 [Q9HCH5-12]
81721 [Q9HCH5-13]
81722 [Q9HCH5-14]
81723 [Q9HCH5-15]
81724 [Q9HCH5-2]
81725 [Q9HCH5-4]
81726 [Q9HCH5-6]
81727 [Q9HCH5-7]
81728 [Q9HCH5-8]
81729 [Q9HCH5-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49544, 72 antibodies

The DNASU plasmid repository

More...DNASUi		54843

Genome annotation databases

EnsembliENST00000316356; ENSP00000318803; ENSG00000137501 [Q9HCH5-13]
ENST00000359152; ENSP00000352065; ENSG00000137501 [Q9HCH5-13]
ENST00000389958; ENSP00000374608; ENSG00000137501 [Q9HCH5-9]
ENST00000389960; ENSP00000374610; ENSG00000137501 [Q9HCH5-6]
ENST00000524452; ENSP00000435238; ENSG00000137501 [Q9HCH5-6]
ENST00000525702; ENSP00000432996; ENSG00000137501 [Q9HCH5-2]
ENST00000527523; ENSP00000434010; ENSG00000137501 [Q9HCH5-14]
ENST00000528231; ENSP00000431701; ENSG00000137501 [Q9HCH5-1]
ENST00000529581; ENSP00000435855; ENSG00000137501 [Q9HCH5-2]
ENST00000533892; ENSP00000432144; ENSG00000137501 [Q9HCH5-4]
GeneIDi54843
KEGGihsa:54843
UCSCiuc001pav.5, human [Q9HCH5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54843
DisGeNETi54843
EuPathDBiHostDB:ENSG00000137501.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYTL2
HGNCiHGNC:15585, SYTL2
HPAiENSG00000137501, Tissue enhanced (stomach)
MIMi612880, gene
neXtProtiNX_Q9HCH5
OpenTargetsiENSG00000137501
PharmGKBiPA37985

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000155843
HOGENOMiCLU_002711_2_0_1
InParanoidiQ9HCH5
OrthoDBi916843at2759
PhylomeDBiQ9HCH5
TreeFamiTF341184

Enzyme and pathway databases

PathwayCommonsiQ9HCH5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54843, 4 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYTL2, human
EvolutionaryTraceiQ9HCH5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SYTL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54843
PharosiQ9HCH5, Tbio

Protein Ontology

More...PROi		PR:Q9HCH5
RNActiQ9HCH5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137501, Expressed in stomach and 214 other tissues
ExpressionAtlasiQ9HCH5, baseline and differential
GenevisibleiQ9HCH5, HS

Family and domain databases

CDDicd04020, C2B_SLP_1-2-3-4, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR010911, Rab_BD
IPR043567, SYTL1-5_C2B
IPR027006, SYTL2
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45716:SF5, PTHR45716:SF5, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
SMARTiView protein in SMART
SM00239, C2, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYTL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCH5
Secondary accession number(s): B3KRS3
, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9NXM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: September 1, 2009
Last modified: December 2, 2020
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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