Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 122 (17 Jun 2020)
Sequence version 3 (17 Jun 2020)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Nck-associated protein 5-like

Gene

NCKAP5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • microtubule bundle formation Source: UniProtKB
  • microtubule depolymerization Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nck-associated protein 5-like
Short name:
NCKAP5-like
Alternative name(s):
Centrosomal protein of 169 kDa1 Publication
Short name:
Cep1691 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCKAP5L
Synonyms:CEP1691 Publication, KIAA1602
ORF Names:FP1193
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167566.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29321 NCKAP5L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615104 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCH0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi486 – 487IP → AA: No decrease in localization to microtubule plus ends. Loss of interaction with MAPRE1 and localization to microtubule plus ends; when associated with 818-A-A-819 and 928-A-A-929. 2 Publications2
Mutagenesisi818 – 819LP → AA: No decrease in localization to microtubule plus ends. Loss of interaction with MAPRE1 and localization to microtubule plus ends; when associated with 486-A-A-487 and 928-A-A-929. 2 Publications2
Mutagenesisi928 – 929LP → AA: Loss of interaction with MAPRE1 and significantly reduced localization to microtubule plus ends. Loss of interaction with MAPRE1 and localization to microtubule plus ends; when associated with 486-A-A-487 and 818-A-A-819. 2 Publications2

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165513124

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HCH0 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCKAP5L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156630840

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002884471 – 1334Nck-associated protein 5-likeAdd BLAST1334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei440Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei451Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei470Phosphoserine; by CDK11 Publication1
Modified residuei477Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei493PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei571Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei577Phosphoserine; by CDK11 Publication1
Modified residuei659PhosphothreonineCombined sources1
Modified residuei767Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei1194PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

CDK1/Cyclin B-dependent phosphorylation mediates its dissociation from centrosomes during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HCH0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HCH0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HCH0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HCH0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HCH0

PeptideAtlas

More...
PeptideAtlasi
Q9HCH0

PRoteomics IDEntifications database

More...
PRIDEi
Q9HCH0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81713 [Q9HCH0-1]
81714 [Q9HCH0-2]
81716 [Q9HCH0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCH0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167566 Expressed in prostate gland and 138 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HCH0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCH0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167566 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:26482847).

Interacts with CDK5RAP2 (PubMed:26485573).

Interacts with MAPRE1 (PubMed:26485573).

Interacts with beta-tubulin (PubMed:26482847).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121726, 64 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HCH0, 27 interactors

Molecular INTeraction database

More...
MINTi
Q9HCH0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337998

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HCH0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 139Mediates interaction with CDK5RAP2 and is required for homodimerization and microtubule bundle formation2 PublicationsAdd BLAST139
Regioni750 – 1146Mediates interaction with beta-tubulin and is required for microtubule bundle formation1 PublicationAdd BLAST397

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili28 – 106Sequence analysisAdd BLAST79
Coiled coili956 – 994Sequence analysisAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi484 – 487(S/T)X(I/L)P motif 12 Publications4
Motifi816 – 819(S/T)X(I/L)P motif 22 Publications4
Motifi926 – 929(S/T)X(I/L)P motif 3; required for interaction with MAPRE12 Publications4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi116 – 618Pro-richAdd BLAST503
Compositional biasi788 – 879Pro-richAdd BLAST92
Compositional biasi1046 – 1287Pro-richAdd BLAST242

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHBY Eukaryota
ENOG410XSUM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007601_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCH0

Database of Orthologous Groups

More...
OrthoDBi
29694at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCH0

TreeFam database of animal gene trees

More...
TreeFami
TF331208

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032769 NCKAP5_C
IPR026163 Nckap5l

The PANTHER Classification System

More...
PANTHERi
PTHR21740 PTHR21740, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15246 NCKAP5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEAMDQPAG GPGNPRPGEG DDGSMEPGTC QELLHRLREL EAENSALAQA
60 70 80 90 100
NENQRETYER CLDEVANHVV QALLNQKDLR EECIKLKKRV FDLERQNQML
110 120 130 140 150
SALFQQKLQL TTGSLPQIPL TPLQPPSEPP ASPSLSSTEG PAAPLPLGHC
160 170 180 190 200
AGQREVCWEQ QLRPGGPGPP AAPPPALDAL SPFLRKKAQI LEVLRALEET
210 220 230 240 250
DPLLLCSPAT PWRPPGQGPG SPEPINGELC GPPQPEPSPW APCLLLGPGN
260 270 280 290 300
LGGLLHWERL LGGLGGEEDT GRPWGPSRGP PQAQGTSSGP NCAPGSSSSS
310 320 330 340 350
SSDEAGDPNE APSPDTLLGA LARRQLNLGQ LLEDTESYLQ AFLAGAAGPL
360 370 380 390 400
NGDHPGPGQS SSPDQAPPQL SKSKGLPKSA WGGGTPEAHR PGFGATSEGQ
410 420 430 440 450
GPLPFLSMFM GAGDAPLGSR PGHPHSSSQV KSKLQIGPPS PGEAQGPLLP
460 470 480 490 500
SPARGLKFLK LPPTSEKSPS PGGPQLSPQL PRNSRIPCRN SGSDGSPSPL
510 520 530 540 550
LARRGLGGGE LSPEGAQGLP TSPSPCYTTP DSTQLRPPQS ALSTTLSPGP
560 570 580 590 600
VVSPCYENIL DLSRSTFRGP SPEPPPSPLQ VPTYPQLTLE VPQAPEVLRS
610 620 630 640 650
PGVPPSPCLP ESYPYGSPQE KSLDKAGSES PHPGRRTPGN SSKKPSQGSG
660 670 680 690 700
RRPGDPGSTP LRDRLAALGK LKTGPEGALG SEKNGVPARP GTEKTRGPGK
710 720 730 740 750
SGESAGDMVP SIHRPLEQLE AKGGIRGAVA LGTNSLKQQE PGLMGDPGAR
760 770 780 790 800
VYSSHSMGAR VDLEPVSPRS CLTKVELAKS RLAGALCPQV PRTPAKVPTS
810 820 830 840 850
APSLGKPNKS PHSSPTKLPS KSPTKVVPRP GAPLVTKESP KPDKGKGPPW
860 870 880 890 900
ADCGSTTAQS TPLVPGPTDP SQGPEGLAPH SAIEEKVMKG IEENVLRLQG
910 920 930 940 950
QERAPGAEVK HRNTSSIASW FGLKKSKLPA LNRRTEATKN KEGAGGGSPL
960 970 980 990 1000
RREVKMEARK LEAESLNISK LMAKAEDLRR ALEEEKAYLS SRARPRPGGP
1010 1020 1030 1040 1050
APGPNTGLGQ VQGQLAGMYQ GADTFMQQLL NRVDGKELPS KSWREPKPEY
1060 1070 1080 1090 1100
GDFQPVSSDP KSPWPACGPR NGLVGPLQGC GKPPGKPSSE PGRREETPSE
1110 1120 1130 1140 1150
DSLAEPVPTS HFTACGSLTR TLDSGIGTFP PPDHGSSGTP SKNLPKTKPP
1160 1170 1180 1190 1200
RLDPPPGVPP ARPPPLTKVP RRAHTLEREV PGIEELLVSG RHPSMPAFPA
1210 1220 1230 1240 1250
LLPAAPGHRG HETCPDDPCE DPGPTPPVQL AKNWTFPNTR AAGSSSDPLM
1260 1270 1280 1290 1300
CPPRQLEGLP RTPMALPVDR KRSQEPSRPS PTPQGPPFGG SRTPSTSDMA
1310 1320 1330
EEGRVASGGP PGLETSESLS DSLYDSLSSC GSQG
Length:1,334
Mass (Da):139,432
Last modified:June 17, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEF63BA074B7A4C8
GO
Isoform 2 (identifier: Q9HCH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1265-1334: ALPVDRKRSQ...DSLSSCGSQG → VRIAAEERERTREQEGVMWGDQFLQ

Note: Dubious isoform produced through intron retention.Curated
Show »
Length:1,289
Mass (Da):135,332
Checksum:iEE8A404A9CED0400
GO
Isoform 4 (identifier: Q9HCH0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-112: ANHVVQALLN...LFQQKLQLTT → CGSVVGLGGC...GTGVAEPEGE
     113-1334: Missing.

Note: Dubious isoform produced through intron retention.Curated
Show »
Length:112
Mass (Da):11,605
Checksum:iB3A055D92B61085F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1V4H7C1V4_HUMAN
Nck-associated protein 5-like
NCKAP5L
1,004Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07998 differs from that shown. Probable cloning artifact.Curated
The sequence AAQ15202 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1097T → M in AAH07998 (PubMed:15489334).Curated1
Sequence conflicti1097T → M in AAH33253 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03381866 – 112ANHVV…LQLTT → CGSVVGLGGCGSSAPGRSWG QLMALPRGFLSPGCQPCGTG VAEPEGE in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_033819113 – 1334Missing in isoform 4. 1 PublicationAdd BLAST1222
Alternative sequenceiVSP_0256781265 – 1334ALPVD…CGSQG → VRIAAEERERTREQEGVMWG DQFLQ in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC131157 Genomic DNA No translation available.
BC007998 mRNA Translation: AAH07998.1 Sequence problems.
BC033253 mRNA Translation: AAH33253.1
BC110599 mRNA Translation: AAI10600.1
AB046822 mRNA Translation: BAB13428.1
AF370366 mRNA Translation: AAQ15202.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
NP_001032895.2, NM_001037806.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335999; ENSP00000337998; ENSG00000167566

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57701

UCSC genome browser

More...
UCSCi
uc009zlk.2 human [Q9HCH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131157 Genomic DNA No translation available.
BC007998 mRNA Translation: AAH07998.1 Sequence problems.
BC033253 mRNA Translation: AAH33253.1
BC110599 mRNA Translation: AAI10600.1
AB046822 mRNA Translation: BAB13428.1
AF370366 mRNA Translation: AAQ15202.1 Frameshift.
RefSeqiNP_001032895.2, NM_001037806.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121726, 64 interactors
IntActiQ9HCH0, 27 interactors
MINTiQ9HCH0
STRINGi9606.ENSP00000337998

PTM databases

iPTMnetiQ9HCH0
PhosphoSitePlusiQ9HCH0

Polymorphism and mutation databases

BioMutaiNCKAP5L
DMDMi156630840

Proteomic databases

EPDiQ9HCH0
jPOSTiQ9HCH0
MassIVEiQ9HCH0
MaxQBiQ9HCH0
PaxDbiQ9HCH0
PeptideAtlasiQ9HCH0
PRIDEiQ9HCH0
ProteomicsDBi81713 [Q9HCH0-1]
81714 [Q9HCH0-2]
81716 [Q9HCH0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49270 16 antibodies

Genome annotation databases

EnsembliENST00000335999; ENSP00000337998; ENSG00000167566
GeneIDi57701
KEGGihsa:57701
UCSCiuc009zlk.2 human [Q9HCH0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57701
EuPathDBiHostDB:ENSG00000167566.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCKAP5L
HGNCiHGNC:29321 NCKAP5L
HPAiENSG00000167566 Low tissue specificity
MIMi615104 gene
neXtProtiNX_Q9HCH0
PharmGKBiPA165513124

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHBY Eukaryota
ENOG410XSUM LUCA
HOGENOMiCLU_007601_0_0_1
InParanoidiQ9HCH0
OrthoDBi29694at2759
PhylomeDBiQ9HCH0
TreeFamiTF331208

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57701 56 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCKAP5L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57701
PharosiQ9HCH0 Tdark

Protein Ontology

More...
PROi
PR:Q9HCH0
RNActiQ9HCH0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167566 Expressed in prostate gland and 138 other tissues
ExpressionAtlasiQ9HCH0 baseline and differential
GenevisibleiQ9HCH0 HS

Family and domain databases

InterProiView protein in InterPro
IPR032769 NCKAP5_C
IPR026163 Nckap5l
PANTHERiPTHR21740 PTHR21740, 1 hit
PfamiView protein in Pfam
PF15246 NCKAP5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCK5L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCH0
Secondary accession number(s): Q2TB26
, Q71RH1, Q8N4W1, Q96HX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 17, 2020
Last modified: June 17, 2020
This is version 122 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again