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UniProtKB - Q9HCG1 (ZN160_HUMAN)

Protein

Zinc finger protein 160

Gene

ZNF160

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri761 – 783C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri789 – 811C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • hemopoiesis Source: UniProtKB
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 160
Alternative name(s):
Zinc finger protein HZF5
Zinc finger protein Kr18
Short name:
HKr18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF160
Synonyms:KIAA1611
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000170949.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:12948 ZNF160

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600398 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HCG1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		90338

Open Targets

More...OpenTargetsi		ENSG00000170949

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37531

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF160

Domain mapping of disease mutations (DMDM)

More...DMDMi		296453072

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474331 – 818Zinc finger protein 160Add BLAST818

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HCG1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HCG1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HCG1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HCG1

PeptideAtlas

More...PeptideAtlasi		Q9HCG1

PRoteomics IDEntifications database

More...PRIDEi		Q9HCG1

ProteomicsDB human proteome resource

More...ProteomicsDBi		81708

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HCG1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HCG1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170949 Expressed in 245 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

More...CleanExi		HS_ZNF160

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HCG1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HCG1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA023599

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		124698, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q9HCG1, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000406201

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9HCG1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HCG1

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri761 – 783C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri789 – 811C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162609

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HCG1

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		ASHHRMH

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HCG1

TreeFam database of animal gene trees

More...TreeFami		TF341892

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 20 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 20 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 20 hits
PS50157 ZINC_FINGER_C2H2_2, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC 
        60         70         80         90        100
HFDMNIISML EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD 
       110        120        130        140        150
LLPKEKSSTE AVFHTVVLER HESPDIEDFS FKEPQKNVHD FECQWRDDTG 
       160        170        180        190        200
NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ LGVSFHSHLP ELQLFQGEGK 
       210        220        230        240        250
MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH FSLLTQRRKA 
       260        270        280        290        300
NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL 
       310        320        330        340        350
TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF 
       360        370        380        390        400
RGHSNLTTHQ LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN 
       410        420        430        440        450
ECGKAFSVRS SLAIHQTIHT GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE 
       460        470        480        490        500
KPYKCNECGK AFSMHSNLAT HQVIHTGTKP FKCNECSKVF TQNSQLANHR 
       510        520        530        540        550
RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI ECGKSFTQKS 
       560        570        580        590        600
HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR 
       610        620        630        640        650
AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK 
       660        670        680        690        700
CNECGKAFSM HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT 
       710        720        730        740        750
GEKPYRCNEC GKAFSVRSSL TTHQAIHTGK KPYKCNECGK VFTQNAHLAN 
       760        770        780        790        800
HRRIHTGEKP YRCTECGKAF RVRSSLTTHM AIHTGEKRYK CNECGKVFRQ 
       810 
SSNLASHHRM HTGEKPYK
Length:818
Mass (Da):94,112
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C5BE5E3E74B76B
GO
Isoform 2 (identifier: Q9HCG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-147: IPPKCTIKDL...VHDFECQWRD → LLRRWKHWLL...VCDKRVGSIF
     148-818: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):17,112
Checksum:i83D6F9CBB03F4735
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZI7M0QZI7_HUMAN
Zinc finger protein 160, isoform CR...
ZNF160 hCG_19658
782Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXU9M0QXU9_HUMAN
Zinc finger protein 160
ZNF160
556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ49M0QZ49_HUMAN
Zinc finger protein 160
ZNF160
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R285M0R285_HUMAN
Zinc finger protein 160
ZNF160
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA55528 differs from that shown. Dubious alternative splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0574007R → Q. Corresponds to variant dbSNP:rs329709Ensembl.1
Natural variantiVAR_06027482P → R2 PublicationsCorresponds to variant dbSNP:rs8105668Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05594092 – 147IPPKC…CQWRD → LLRRWKHWLLLLGICCPKPH GRVSSRLRLSRSLGHFFHSA FATFMGVCDKRVGSIF in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_055941148 – 818Missing in isoform 2. 1 PublicationAdd BLAST671

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC010328 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72110.1
BC000807 mRNA Translation: AAH00807.1
BC094880 mRNA Translation: AAH94880.1
AF277623 mRNA Translation: AAK61306.1
AB046831 mRNA Translation: BAB13437.1
AK024442 mRNA Translation: BAB15732.1
X78928 mRNA Translation: CAA55528.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12859.1 [Q9HCG1-1]
CCDS82392.1 [Q9HCG1-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S47066

NCBI Reference Sequences

More...RefSeqi		NP_001096073.1, NM_001102603.1 [Q9HCG1-1]
NP_001309054.1, NM_001322125.1 [Q9HCG1-2]
NP_001309055.1, NM_001322126.1 [Q9HCG1-2]
NP_001309057.1, NM_001322128.1 [Q9HCG1-1]
NP_001309058.1, NM_001322129.1 [Q9HCG1-1]
NP_001309059.1, NM_001322130.1 [Q9HCG1-1]
NP_001309060.1, NM_001322131.1 [Q9HCG1-1]
NP_001309061.1, NM_001322132.1 [Q9HCG1-1]
NP_001309062.1, NM_001322133.1 [Q9HCG1-1]
NP_001309063.1, NM_001322134.1 [Q9HCG1-1]
NP_001309064.1, NM_001322135.1 [Q9HCG1-1]
NP_001309065.1, NM_001322136.1 [Q9HCG1-1]
NP_150630.2, NM_033288.3 [Q9HCG1-1]
NP_942596.1, NM_198893.2 [Q9HCG1-1]
XP_016882935.1, XM_017027446.1
XP_016882937.1, XM_017027448.1 [Q9HCG1-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.655967

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355147; ENSP00000347273; ENSG00000170949 [Q9HCG1-2]
ENST00000418871; ENSP00000409597; ENSG00000170949 [Q9HCG1-1]
ENST00000429604; ENSP00000406201; ENSG00000170949 [Q9HCG1-1]
ENST00000599056; ENSP00000470961; ENSG00000170949 [Q9HCG1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90338

UCSC genome browser

More...UCSCi		uc002qaq.5 human [Q9HCG1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010328 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72110.1
BC000807 mRNA Translation: AAH00807.1
BC094880 mRNA Translation: AAH94880.1
AF277623 mRNA Translation: AAK61306.1
AB046831 mRNA Translation: BAB13437.1
AK024442 mRNA Translation: BAB15732.1
X78928 mRNA Translation: CAA55528.1 Sequence problems.
CCDSiCCDS12859.1 [Q9HCG1-1]
CCDS82392.1 [Q9HCG1-2]
PIRiS47066
RefSeqiNP_001096073.1, NM_001102603.1 [Q9HCG1-1]
NP_001309054.1, NM_001322125.1 [Q9HCG1-2]
NP_001309055.1, NM_001322126.1 [Q9HCG1-2]
NP_001309057.1, NM_001322128.1 [Q9HCG1-1]
NP_001309058.1, NM_001322129.1 [Q9HCG1-1]
NP_001309059.1, NM_001322130.1 [Q9HCG1-1]
NP_001309060.1, NM_001322131.1 [Q9HCG1-1]
NP_001309061.1, NM_001322132.1 [Q9HCG1-1]
NP_001309062.1, NM_001322133.1 [Q9HCG1-1]
NP_001309063.1, NM_001322134.1 [Q9HCG1-1]
NP_001309064.1, NM_001322135.1 [Q9HCG1-1]
NP_001309065.1, NM_001322136.1 [Q9HCG1-1]
NP_150630.2, NM_033288.3 [Q9HCG1-1]
NP_942596.1, NM_198893.2 [Q9HCG1-1]
XP_016882935.1, XM_017027446.1
XP_016882937.1, XM_017027448.1 [Q9HCG1-2]
UniGeneiHs.655967

3D structure databases

ProteinModelPortaliQ9HCG1
SMRiQ9HCG1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124698, 2 interactors
IntActiQ9HCG1, 5 interactors
STRINGi9606.ENSP00000406201

PTM databases

iPTMnetiQ9HCG1
PhosphoSitePlusiQ9HCG1

Polymorphism and mutation databases

BioMutaiZNF160
DMDMi296453072

Proteomic databases

EPDiQ9HCG1
jPOSTiQ9HCG1
MaxQBiQ9HCG1
PaxDbiQ9HCG1
PeptideAtlasiQ9HCG1
PRIDEiQ9HCG1
ProteomicsDBi81708

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355147; ENSP00000347273; ENSG00000170949 [Q9HCG1-2]
ENST00000418871; ENSP00000409597; ENSG00000170949 [Q9HCG1-1]
ENST00000429604; ENSP00000406201; ENSG00000170949 [Q9HCG1-1]
ENST00000599056; ENSP00000470961; ENSG00000170949 [Q9HCG1-1]
GeneIDi90338
KEGGihsa:90338
UCSCiuc002qaq.5 human [Q9HCG1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90338
DisGeNETi90338
EuPathDBiHostDB:ENSG00000170949.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF160
HGNCiHGNC:12948 ZNF160
HPAiHPA023599
MIMi600398 gene
neXtProtiNX_Q9HCG1
OpenTargetsiENSG00000170949
PharmGKBiPA37531

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162609
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9HCG1
KOiK09228
OMAiASHHRMH
OrthoDBi1318335at2759
PhylomeDBiQ9HCG1
TreeFamiTF341892

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF160 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZNF160

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90338

Protein Ontology

More...PROi		PR:Q9HCG1

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170949 Expressed in 245 organ(s), highest expression level in cerebellum
CleanExiHS_ZNF160
ExpressionAtlasiQ9HCG1 baseline and differential
GenevisibleiQ9HCG1 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 20 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 20 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 20 hits
PS50157 ZINC_FINGER_C2H2_2, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN160_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCG1
Secondary accession number(s): Q14589
, Q504Q8, Q96JC5, Q9BVY9, Q9H7N6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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