UniProtKB - Q9HCG1 (ZN160_HUMAN)
Protein
Zinc finger protein 160
Gene
ZNF160
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 257 – 279 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 649 – 671 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 677 – 699 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 705 – 727 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 733 – 755 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 761 – 783 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 789 – 811 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- hemopoiesis Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-212436 Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 160Alternative name(s): Zinc finger protein HZF5 Zinc finger protein Kr18 Short name: HKr18 |
Gene namesi | Name:ZNF160 Synonyms:KIAA1611 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12948 ZNF160 |
MIMi | 600398 gene |
neXtProti | NX_Q9HCG1 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 90338 |
OpenTargetsi | ENSG00000170949 |
PharmGKBi | PA37531 |
Miscellaneous databases
Pharosi | Q9HCG1 |
Polymorphism and mutation databases
BioMutai | ZNF160 |
DMDMi | 296453072 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047433 | 1 – 818 | Zinc finger protein 160Add BLAST | 818 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 249 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9HCG1 |
jPOSTi | Q9HCG1 |
MassIVEi | Q9HCG1 |
MaxQBi | Q9HCG1 |
PaxDbi | Q9HCG1 |
PeptideAtlasi | Q9HCG1 |
PRIDEi | Q9HCG1 |
ProteomicsDBi | 79244 81708 [Q9HCG1-1] |
PTM databases
iPTMneti | Q9HCG1 |
PhosphoSitePlusi | Q9HCG1 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000170949 Expressed in 245 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | Q9HCG1 baseline and differential |
Genevisiblei | Q9HCG1 HS |
Organism-specific databases
HPAi | HPA023599 |
Interactioni
Protein-protein interaction databases
BioGridi | 124698, 3 interactors |
IntActi | Q9HCG1, 5 interactors |
STRINGi | 9606.ENSP00000406201 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 79 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 257 – 279 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 649 – 671 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 677 – 699 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 705 – 727 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 733 – 755 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 761 – 783 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 789 – 811 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000162609 |
HOGENOMi | HOG000234617 |
InParanoidi | Q9HCG1 |
KOi | K09228 |
OMAi | QHDRRDI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9HCG1 |
TreeFami | TF341892 |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 20 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 20 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 12 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 20 hits PS50157 ZINC_FINGER_C2H2_2, 20 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9HCG1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC
60 70 80 90 100
HFDMNIISML EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD
110 120 130 140 150
LLPKEKSSTE AVFHTVVLER HESPDIEDFS FKEPQKNVHD FECQWRDDTG
160 170 180 190 200
NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ LGVSFHSHLP ELQLFQGEGK
210 220 230 240 250
MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH FSLLTQRRKA
260 270 280 290 300
NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL
310 320 330 340 350
TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF
360 370 380 390 400
RGHSNLTTHQ LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN
410 420 430 440 450
ECGKAFSVRS SLAIHQTIHT GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE
460 470 480 490 500
KPYKCNECGK AFSMHSNLAT HQVIHTGTKP FKCNECSKVF TQNSQLANHR
510 520 530 540 550
RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI ECGKSFTQKS
560 570 580 590 600
HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR
610 620 630 640 650
AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK
660 670 680 690 700
CNECGKAFSM HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT
710 720 730 740 750
GEKPYRCNEC GKAFSVRSSL TTHQAIHTGK KPYKCNECGK VFTQNAHLAN
760 770 780 790 800
HRRIHTGEKP YRCTECGKAF RVRSSLTTHM AIHTGEKRYK CNECGKVFRQ
810
SSNLASHHRM HTGEKPYK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZI7 | M0QZI7_HUMAN | Zinc finger protein 160, isoform CR... | ZNF160 hCG_19658 | 782 | Annotation score: | ||
M0QXU9 | M0QXU9_HUMAN | Zinc finger protein 160 | ZNF160 | 556 | Annotation score: | ||
M0QZ49 | M0QZ49_HUMAN | Zinc finger protein 160 | ZNF160 | 117 | Annotation score: | ||
M0R285 | M0R285_HUMAN | Zinc finger protein 160 | ZNF160 | 13 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057400 | 7 | R → Q. Corresponds to variant dbSNP:rs329709Ensembl. | 1 | |
Natural variantiVAR_060274 | 82 | P → R2 PublicationsCorresponds to variant dbSNP:rs8105668Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055940 | 92 – 147 | IPPKC…CQWRD → LLRRWKHWLLLLGICCPKPH GRVSSRLRLSRSLGHFFHSA FATFMGVCDKRVGSIF in isoform 2. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_055941 | 148 – 818 | Missing in isoform 2. 1 PublicationAdd BLAST | 671 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000355147; ENSP00000347273; ENSG00000170949 [Q9HCG1-2] ENST00000418871; ENSP00000409597; ENSG00000170949 [Q9HCG1-1] ENST00000429604; ENSP00000406201; ENSG00000170949 [Q9HCG1-1] ENST00000599056; ENSP00000470961; ENSG00000170949 [Q9HCG1-1] |
GeneIDi | 90338 |
KEGGi | hsa:90338 |
UCSCi | uc002qaq.5 human [Q9HCG1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q9HCG1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 124698, 3 interactors |
IntActi | Q9HCG1, 5 interactors |
STRINGi | 9606.ENSP00000406201 |
PTM databases
iPTMneti | Q9HCG1 |
PhosphoSitePlusi | Q9HCG1 |
Polymorphism and mutation databases
BioMutai | ZNF160 |
DMDMi | 296453072 |
Proteomic databases
EPDi | Q9HCG1 |
jPOSTi | Q9HCG1 |
MassIVEi | Q9HCG1 |
MaxQBi | Q9HCG1 |
PaxDbi | Q9HCG1 |
PeptideAtlasi | Q9HCG1 |
PRIDEi | Q9HCG1 |
ProteomicsDBi | 79244 81708 [Q9HCG1-1] |
Genome annotation databases
Ensembli | ENST00000355147; ENSP00000347273; ENSG00000170949 [Q9HCG1-2] ENST00000418871; ENSP00000409597; ENSG00000170949 [Q9HCG1-1] ENST00000429604; ENSP00000406201; ENSG00000170949 [Q9HCG1-1] ENST00000599056; ENSP00000470961; ENSG00000170949 [Q9HCG1-1] |
GeneIDi | 90338 |
KEGGi | hsa:90338 |
UCSCi | uc002qaq.5 human [Q9HCG1-1] |
Organism-specific databases
CTDi | 90338 |
DisGeNETi | 90338 |
GeneCardsi | ZNF160 |
HGNCi | HGNC:12948 ZNF160 |
HPAi | HPA023599 |
MIMi | 600398 gene |
neXtProti | NX_Q9HCG1 |
OpenTargetsi | ENSG00000170949 |
PharmGKBi | PA37531 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000162609 |
HOGENOMi | HOG000234617 |
InParanoidi | Q9HCG1 |
KOi | K09228 |
OMAi | QHDRRDI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9HCG1 |
TreeFami | TF341892 |
Enzyme and pathway databases
Reactomei | R-HSA-212436 Generic Transcription Pathway |
Miscellaneous databases
ChiTaRSi | ZNF160 human |
GeneWikii | ZNF160 |
GenomeRNAii | 90338 |
Pharosi | Q9HCG1 |
PROi | PR:Q9HCG1 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170949 Expressed in 245 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | Q9HCG1 baseline and differential |
Genevisiblei | Q9HCG1 HS |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 20 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 20 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 12 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 20 hits PS50157 ZINC_FINGER_C2H2_2, 20 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN160_HUMAN | |
Accessioni | Q9HCG1Primary (citable) accession number: Q9HCG1 Secondary accession number(s): Q14589 Q9H7N6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2002 |
Last sequence update: | May 18, 2010 | |
Last modified: | October 16, 2019 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot