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UniProtKB - Q9HCG1 (ZN160_HUMAN)

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Protein

Zinc finger protein 160

Gene

ZNF160

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri761 – 783C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri789 – 811C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • hemopoiesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 160
Alternative name(s):
Zinc finger protein HZF5
Zinc finger protein Kr18
Short name:
HKr18
Gene namesi
Name:ZNF160
Synonyms:KIAA1611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170949.17
HGNCiHGNC:12948 ZNF160
MIMi600398 gene
neXtProtiNX_Q9HCG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90338
OpenTargetsiENSG00000170949
PharmGKBiPA37531

Polymorphism and mutation databases

BioMutaiZNF160
DMDMi296453072

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474331 – 818Zinc finger protein 160Add BLAST818

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9HCG1
MaxQBiQ9HCG1
PaxDbiQ9HCG1
PeptideAtlasiQ9HCG1
PRIDEiQ9HCG1
ProteomicsDBi81708

PTM databases

iPTMnetiQ9HCG1
PhosphoSitePlusiQ9HCG1

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000170949
CleanExiHS_ZNF160
ExpressionAtlasiQ9HCG1 baseline and differential
GenevisibleiQ9HCG1 HS

Organism-specific databases

HPAiHPA023599

Interactioni

Protein-protein interaction databases

BioGridi124698, 2 interactors
IntActiQ9HCG1, 5 interactors
STRINGi9606.ENSP00000406201

Structurei

3D structure databases

ProteinModelPortaliQ9HCG1
SMRiQ9HCG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 727C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri733 – 755C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri761 – 783C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri789 – 811C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148973
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9HCG1
KOiK09228
OMAiNSCGKPY
OrthoDBiEOG091G02KC
PhylomeDBiQ9HCG1
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 20 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 20 hits
PS50157 ZINC_FINGER_C2H2_2, 20 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC 
        60         70         80         90        100
HFDMNIISML EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD 
       110        120        130        140        150
LLPKEKSSTE AVFHTVVLER HESPDIEDFS FKEPQKNVHD FECQWRDDTG 
       160        170        180        190        200
NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ LGVSFHSHLP ELQLFQGEGK 
       210        220        230        240        250
MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH FSLLTQRRKA 
       260        270        280        290        300
NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL 
       310        320        330        340        350
TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF 
       360        370        380        390        400
RGHSNLTTHQ LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN 
       410        420        430        440        450
ECGKAFSVRS SLAIHQTIHT GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE 
       460        470        480        490        500
KPYKCNECGK AFSMHSNLAT HQVIHTGTKP FKCNECSKVF TQNSQLANHR 
       510        520        530        540        550
RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI ECGKSFTQKS 
       560        570        580        590        600
HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR 
       610        620        630        640        650
AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK 
       660        670        680        690        700
CNECGKAFSM HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT 
       710        720        730        740        750
GEKPYRCNEC GKAFSVRSSL TTHQAIHTGK KPYKCNECGK VFTQNAHLAN 
       760        770        780        790        800
HRRIHTGEKP YRCTECGKAF RVRSSLTTHM AIHTGEKRYK CNECGKVFRQ 
       810 
SSNLASHHRM HTGEKPYK
Length:818
Mass (Da):94,112
Last modified:May 18, 2010 - v3
Checksum:i00C5BE5E3E74B76B
GO
Isoform 2 (identifier: Q9HCG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-147: IPPKCTIKDL...VHDFECQWRD → LLRRWKHWLL...VCDKRVGSIF
     148-818: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):17,112
Checksum:i83D6F9CBB03F4735
GO

Sequence cautioni

The sequence CAA55528 differs from that shown. Dubious alternative splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0574007R → Q. Corresponds to variant dbSNP:rs329709Ensembl.1
Natural variantiVAR_06027482P → R2 PublicationsCorresponds to variant dbSNP:rs8105668Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05594092 – 147IPPKC…CQWRD → LLRRWKHWLLLLGICCPKPH GRVSSRLRLSRSLGHFFHSA FATFMGVCDKRVGSIF in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_055941148 – 818Missing in isoform 2. 1 PublicationAdd BLAST671

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010328 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72110.1
BC000807 mRNA Translation: AAH00807.1
BC094880 mRNA Translation: AAH94880.1
AF277623 mRNA Translation: AAK61306.1
AB046831 mRNA Translation: BAB13437.1
AK024442 mRNA Translation: BAB15732.1
X78928 mRNA Translation: CAA55528.1 Sequence problems.
CCDSiCCDS12859.1 [Q9HCG1-1]
CCDS82392.1 [Q9HCG1-2]
PIRiS47066
RefSeqiNP_001096073.1, NM_001102603.1 [Q9HCG1-1]
NP_001309054.1, NM_001322125.1 [Q9HCG1-2]
NP_001309055.1, NM_001322126.1 [Q9HCG1-2]
NP_001309057.1, NM_001322128.1 [Q9HCG1-1]
NP_001309058.1, NM_001322129.1 [Q9HCG1-1]
NP_001309059.1, NM_001322130.1 [Q9HCG1-1]
NP_001309060.1, NM_001322131.1 [Q9HCG1-1]
NP_001309061.1, NM_001322132.1 [Q9HCG1-1]
NP_001309062.1, NM_001322133.1 [Q9HCG1-1]
NP_001309063.1, NM_001322134.1 [Q9HCG1-1]
NP_001309064.1, NM_001322135.1 [Q9HCG1-1]
NP_001309065.1, NM_001322136.1 [Q9HCG1-1]
NP_150630.2, NM_033288.3 [Q9HCG1-1]
NP_942596.1, NM_198893.2 [Q9HCG1-1]
XP_016882935.1, XM_017027446.1 [Q9HCG1-1]
XP_016882937.1, XM_017027448.1 [Q9HCG1-2]
UniGeneiHs.655967

Genome annotation databases

EnsembliENST00000355147; ENSP00000347273; ENSG00000170949 [Q9HCG1-2]
ENST00000418871; ENSP00000409597; ENSG00000170949 [Q9HCG1-1]
ENST00000429604; ENSP00000406201; ENSG00000170949 [Q9HCG1-1]
ENST00000599056; ENSP00000470961; ENSG00000170949 [Q9HCG1-1]
GeneIDi90338
KEGGihsa:90338
UCSCiuc002qaq.5 human [Q9HCG1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN160_HUMAN
AccessioniPrimary (citable) accession number: Q9HCG1
Secondary accession number(s): Q14589
, Q504Q8, Q96JC5, Q9BVY9, Q9H7N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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