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Entry version 137 (17 Jun 2020)
Sequence version 2 (11 Sep 2007)
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Protein

Zinc finger protein 532

Gene

ZNF532

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri616 – 635C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri754 – 779C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri783 – 805C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 865C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri870 – 893C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri905 – 927C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri936 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1025 – 1048C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1055 – 1078C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1085 – 1111C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1203 – 1226C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1264 – 1286C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 532
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF532
Synonyms:KIAA1629
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000074657.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30940 ZNF532

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCE3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55205

Open Targets

More...
OpenTargetsi
ENSG00000074657

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134901858

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HCE3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF532

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158564020

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995521 – 1301Zinc finger protein 532Add BLAST1301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei130PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei175N6-acetyllysineBy similarity1
Modified residuei205PhosphothreonineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki459Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki516Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki980Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1140PhosphoserineCombined sources1
Cross-linki1144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HCE3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9HCE3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9HCE3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HCE3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HCE3

PeptideAtlas

More...
PeptideAtlasi
Q9HCE3

PRoteomics IDEntifications database

More...
PRIDEi
Q9HCE3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81686

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074657 Expressed in corpus callosum and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HCE3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCE3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000074657 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120501, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HCE3, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9HCE3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338217

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HCE3 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri616 – 635C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri754 – 779C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri783 – 805C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 865C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri870 – 893C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri905 – 927C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri936 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1025 – 1048C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1055 – 1078C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1085 – 1111C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1203 – 1226C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1264 – 1286C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154437

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006283_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCE3

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPSHEDD

Database of Orthologous Groups

More...
OrthoDBi
180681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCE3

TreeFam database of animal gene trees

More...
TreeFami
TF329009

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041697 Znf-C2H2_11
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16622 zf-C2H2_11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

Q9HCE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMGDMKTPD FDDLLAAFDI PDMVDPKAAI ESGHDDHESH MKQNAHGEDD
60 70 80 90 100
SHAPSSSDVG VSVIVKNVRN IDSSEGGEKD GHNPTGNGLH NGFLTASSLD
110 120 130 140 150
SYSKDGAKSL KGDVPASEVT LKDSTFSQFS PISSAEEFDD DEKIEVDDPP
160 170 180 190 200
DKEDMRSSFR SNVLTGSAPQ QDYDKLKALG GENSSKTGLS TSGNVEKNKA
210 220 230 240 250
VKRETEASSI NLSVYEPFKV RKAEDKLKES SDKVLENRVL DGKLSSEKND
260 270 280 290 300
TSLPSVAPSK TKSSSKLSSC IAAIAALSAK KAASDSCKEP VANSRESSPL
310 320 330 340 350
PKEVNDSPRA ADKSPESQNL IDGTKKPSLK QPDSPRSISS ENSSKGSPSS
360 370 380 390 400
PAGSTPAIPK VRIKTIKTSS GEIKRTVTRV LPEVDLDSGK KPSEQTASVM
410 420 430 440 450
ASVTSLLSSP ASAAVLSSPP RAPLQSAVVT NAVSPAELTP KQVTIKPVAT
460 470 480 490 500
AFLPVSAVKT AGSQVINLKL ANNTTVKATV ISAASVQSAS SAIIKAANAI
510 520 530 540 550
QQQTVVVPAS SLANAKLVPK TVHLANLNLL PQGAQATSEL RQVLTKPQQQ
560 570 580 590 600
IKQAIINAAA SQPPKKVSRV QVVSSLQSSV VEAFNKVLSS VNPVPVYIPN
610 620 630 640 650
LSPPANAGIT LPTRGYKCLE CGDSFALEKS LTQHYDRRSV RIEVTCNHCT
660 670 680 690 700
KNLVFYNKCS LLSHARGHKE KGVVMQCSHL ILKPVPADQM IVSPSSNTST
710 720 730 740 750
STSTLQSPVG AGTHTVTKIQ SGITGTVISA PSSTPITPAM PLDEDPSKLC
760 770 780 790 800
RHSLKCLECN EVFQDETSLA THFQQAADTS GQKTCTICQM LLPNQCSYAS
810 820 830 840 850
HQRIHQHKSP YTCPECGAIC RSVHFQTHVT KNCLHYTRRV GFRCVHCNVV
860 870 880 890 900
YSDVAALKSH IQGSHCEVFY KCPICPMAFK SAPSTHSHAY TQHPGIKIGE
910 920 930 940 950
PKIIYKCSMC DTVFTLQTLL YRHFDQHIEN QKVSVFKCPD CSLLYAQKQL
960 970 980 990 1000
MMDHIKSMHG TLKSIEGPPN LGINLPLSIK PATQNSANQN KEDTKSMNGK
1010 1020 1030 1040 1050
EKLEKKSPSP VKKSMETKKV ASPGWTCWEC DCLFMQRDVY ISHVRKEHGK
1060 1070 1080 1090 1100
QMKKHPCRQC DKSFSSSHSL CRHNRIKHKG IRKVYACSHC PDSRRTFTKR
1110 1120 1130 1140 1150
LMLEKHVQLM HGIKDPDLKE MTDATNEEET EIKEDTKVPS PKRKLEEPVL
1160 1170 1180 1190 1200
EFRPPRGAIT QPLKKLKINV FKVHKCAVCG FTTENLLQFH EHIPQHKSDG
1210 1220 1230 1240 1250
SSYQCRECGL CYTSHVSLSR HLFIVHKLKE PQPVSKQNGA GEDNQQENKP
1260 1270 1280 1290 1300
SHEDESPDGA VSDRKCKVCA KTFETEAALN THMRTHGMAF IKSKRMSSAE

K
Length:1,301
Mass (Da):141,696
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i434E9519D144904A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQN0K7EQN0_HUMAN
Zinc finger protein 532
ZNF532
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELB7K7ELB7_HUMAN
Zinc finger protein 532
ZNF532
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMF9K7EMF9_HUMAN
Zinc finger protein 532
ZNF532
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES47K7ES47_HUMAN
Zinc finger protein 532
ZNF532
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKV7K7EKV7_HUMAN
Zinc finger protein 532
ZNF532
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP49K7EP49_HUMAN
Zinc finger protein 532
ZNF532
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPI7K7EPI7_HUMAN
Zinc finger protein 532
ZNF532
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER18K7ER18_HUMAN
Zinc finger protein 532
ZNF532
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJM2K7EJM2_HUMAN
Zinc finger protein 532
ZNF532
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL14K7EL14_HUMAN
Zinc finger protein 532
ZNF532
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36366 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91755 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB13455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti972G → S in AAH36366 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034846761E → D. Corresponds to variant dbSNP:rs3737506Ensembl.1
Natural variantiVAR_035585822S → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs771503724Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY039256 mRNA Translation: AAK72122.1
AB046849 mRNA Translation: BAB13455.1 Different initiation.
BC036366 mRNA Translation: AAH36366.1 Frameshift.
BC130618 mRNA Translation: AAI30619.1
BC130620 mRNA Translation: AAI30621.1
AK001559 mRNA Translation: BAA91755.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11969.1

NCBI Reference Sequences

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RefSeqi
NP_001305655.1, NM_001318726.1
NP_001305656.1, NM_001318727.1
NP_001305657.1, NM_001318728.1
NP_060651.2, NM_018181.5
XP_016881301.1, XM_017025812.1
XP_016881302.1, XM_017025813.1
XP_016881303.1, XM_017025814.1
XP_016881304.1, XM_017025815.1
XP_016881305.1, XM_017025816.1
XP_016881306.1, XM_017025817.1
XP_016881307.1, XM_017025818.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336078; ENSP00000338217; ENSG00000074657
ENST00000589288; ENSP00000466007; ENSG00000074657
ENST00000591083; ENSP00000468532; ENSG00000074657
ENST00000591230; ENSP00000465709; ENSG00000074657
ENST00000591808; ENSP00000468238; ENSG00000074657

Database of genes from NCBI RefSeq genomes

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GeneIDi
55205

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55205

UCSC genome browser

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UCSCi
uc002lho.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039256 mRNA Translation: AAK72122.1
AB046849 mRNA Translation: BAB13455.1 Different initiation.
BC036366 mRNA Translation: AAH36366.1 Frameshift.
BC130618 mRNA Translation: AAI30619.1
BC130620 mRNA Translation: AAI30621.1
AK001559 mRNA Translation: BAA91755.1 Different initiation.
CCDSiCCDS11969.1
RefSeqiNP_001305655.1, NM_001318726.1
NP_001305656.1, NM_001318727.1
NP_001305657.1, NM_001318728.1
NP_060651.2, NM_018181.5
XP_016881301.1, XM_017025812.1
XP_016881302.1, XM_017025813.1
XP_016881303.1, XM_017025814.1
XP_016881304.1, XM_017025815.1
XP_016881305.1, XM_017025816.1
XP_016881306.1, XM_017025817.1
XP_016881307.1, XM_017025818.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120501, 6 interactors
IntActiQ9HCE3, 7 interactors
MINTiQ9HCE3
STRINGi9606.ENSP00000338217

PTM databases

iPTMnetiQ9HCE3
PhosphoSitePlusiQ9HCE3

Polymorphism and mutation databases

BioMutaiZNF532
DMDMi158564020

Proteomic databases

EPDiQ9HCE3
jPOSTiQ9HCE3
MassIVEiQ9HCE3
MaxQBiQ9HCE3
PaxDbiQ9HCE3
PeptideAtlasiQ9HCE3
PRIDEiQ9HCE3
ProteomicsDBi81686

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
9795 44 antibodies

Genome annotation databases

EnsembliENST00000336078; ENSP00000338217; ENSG00000074657
ENST00000589288; ENSP00000466007; ENSG00000074657
ENST00000591083; ENSP00000468532; ENSG00000074657
ENST00000591230; ENSP00000465709; ENSG00000074657
ENST00000591808; ENSP00000468238; ENSG00000074657
GeneIDi55205
KEGGihsa:55205
UCSCiuc002lho.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55205
DisGeNETi55205
EuPathDBiHostDB:ENSG00000074657.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF532
HGNCiHGNC:30940 ZNF532
HPAiENSG00000074657 Low tissue specificity
neXtProtiNX_Q9HCE3
OpenTargetsiENSG00000074657
PharmGKBiPA134901858

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000154437
HOGENOMiCLU_006283_0_0_1
InParanoidiQ9HCE3
OMAiKPSHEDD
OrthoDBi180681at2759
PhylomeDBiQ9HCE3
TreeFamiTF329009

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55205 10 hits in 809 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF532 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55205
PharosiQ9HCE3 Tdark

Protein Ontology

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PROi
PR:Q9HCE3
RNActiQ9HCE3 protein

Gene expression databases

BgeeiENSG00000074657 Expressed in corpus callosum and 228 other tissues
ExpressionAtlasiQ9HCE3 baseline and differential
GenevisibleiQ9HCE3 HS

Family and domain databases

InterProiView protein in InterPro
IPR041697 Znf-C2H2_11
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF16622 zf-C2H2_11, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN532_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCE3
Secondary accession number(s): Q4G0V6
, Q7L7Z7, Q96QR7, Q9NVJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 17, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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