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UniProtKB - Q9HCE1 (MOV10_HUMAN)

Entry version 181 (25 May 2022)
Sequence version 2 (01 Nov 2002)
Previous versions | rss
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Protein

Helicase MOV-10

Gene

MOV10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324).

Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714).

In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849).

Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941).

Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351).

Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity).

May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324).

Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568).

By similarity8 Publications

(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi524 – 531ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processHost-virus interaction, RNA-mediated gene silencing, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HCE1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2559585, Oncogene Induced Senescence
R-HSA-4086398, Ca2+ pathway
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-8853884, Transcriptional Regulation by VENTX
R-HSA-8934593, Regulation of RUNX1 Expression and Activity
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8943723, Regulation of PTEN mRNA translation
R-HSA-8948700, Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-8986944, Transcriptional Regulation by MECP2
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9022692, Regulation of MECP2 expression and activity
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9HCE1

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9HCE1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase MOV-10Curated (EC:3.6.4.131 Publication)
Alternative name(s):
Armitage homolog1 Publication
Moloney leukemia virus 10 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOV10Imported
Synonyms:KIAA1631
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7200, MOV10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610742, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HCE1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000155363

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi530K → A: Abolishes 5' to 3' directional unwinding activity. Abolishes inhibition of RNA chaperonne activity of LIRE1. No effect on interaction with UPF1. 2 Publications1
Mutagenesisi645D → N: Abolishes 5' to 3' directional unwinding activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4343

Open Targets

More...OpenTargetsi		ENSG00000155363

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30908

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HCE1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MOV10

Domain mapping of disease mutations (DMDM)

More...DMDMi		24638063

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000807041 – 1003Helicase MOV-10Add BLAST1003

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148N6-acetyllysineCombined sources1
Modified residuei160PhosphothreonineCombined sources1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei969PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HCE1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HCE1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HCE1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HCE1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HCE1

PeptideAtlas

More...PeptideAtlasi		Q9HCE1

PRoteomics IDEntifications database

More...PRIDEi		Q9HCE1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81683 [Q9HCE1-1]
81684 [Q9HCE1-2]
81685 [Q9HCE1-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9HCE1

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9HCE1, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HCE1

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9HCE1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HCE1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9HCE1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155363, Expressed in prostate gland and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HCE1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HCE1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155363, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

Interacts with APOBEC3G in an RNA-dependent manner.

Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).

Interacts with both protein products of LIRE1, ORF1p and ORF2p (PubMed:23093941).

Interacts with TUT4 and, to a lesser extent, TUT7; the interactions are RNA-dependent (PubMed:30122351).

Interacts with AGO2, TNRC6B and UPF1; the interactions are direct and RNA-dependent (PubMed:24726324).

Interacts with FMR1; this interaction is direct, occurs in an RNA-dependent manner on polysomes and induces association of MOV10 with RNAs (PubMed:25464849).

Interacts with SHFL; the interaction increases in presence of RNA (PubMed:27974568).

Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).

10 Publications

(Microbial infection) Interacts with the human hepatitis delta virus (HDV) antigen HDAg.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110484, 1246 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9HCE1

Database of interacting proteins

More...DIPi		DIP-44158N

Protein interaction database and analysis system

More...IntActi		Q9HCE1, 131 interactors

Molecular INTeraction database

More...MINTi		Q9HCE1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000399797

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HCE1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9HCE1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HCE1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni921 – 965Interaction with AGO2 and APOBEC3G1 PublicationAdd BLAST45
Regioni966 – 1003DisorderedSequence analysisAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi645 – 648DEAG box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1804, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156024

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HCE1

Identification of Orthologs from Complete Genome Data

More...OMAi		RPYQGFI

Database of Orthologous Groups

More...OrthoDBi		286011at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HCE1

TreeFam database of animal gene trees

More...TreeFami		TF323999

Family and domain databases

Conserved Domains Database

More...CDDi		cd18808, SF1_C_Upf1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045055, DNA2/NAM7-like
IPR041679, DNA2/NAM7-like_C
IPR026122, MOV-10
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR10887, PTHR10887, 1 hit
PTHR10887:SF322, PTHR10887:SF322, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13087, AAA_12, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP 
        60         70         80         90        100
APGFSSMLYG MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS 
       110        120        130        140        150
KHHKSLLAKI FYDRAEYLHG KHGVDVEVQG PHEARDGQLL IRLDLNRKEV 
       160        170        180        190        200
LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY NEDQELPCPL GPGECYELHV 
       210        220        230        240        250
HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA VAHSPLAAQL 
       260        270        280        290        300
KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL 
       310        320        330        340        350
RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ 
       360        370        380        390        400
MEHDIRHYDL ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL 
       410        420        430        440        450
LSSETHQEDP ITYKGFVHKV ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN 
       460        470        480        490        500
RQPLRVQHRA LELTGRWLLW PMLFPVAPRD VPLLPSDVKL KLYDRSLESN 
       510        520        530        540        550
PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI 
       560        570        580        590        600
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA 
       610        620        630        640        650
KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC 
       660        670        680        690        700
MEPESLVAIA GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY 
       710        720        730        740        750
SLLERLLTYN SLYKKGPDGY DPQFITKLLR NYRSHPTILD IPNQLYYEGE 
       760        770        780        790        800
LQACADVVDR ERFCRWAGLP RQGFPIIFHG VMGKDEREGN SPSFFNPEEA 
       810        820        830        840        850
ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDRE 
       860        870        880        890        900
LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK 
       910        920        930        940        950
NPKRFNVAVT RAKALLIIVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP 
       960        970        980        990       1000
AKLDLQQGQN LLQGLSKLSP STSGPHSHDY LPQEREGEGG LSLQVEPEWR 

NEL
Length:1,003
Mass (Da):113,671
Last modified:November 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28A8B3BF9B5B54FC
GO
Isoform 2 (identifier: Q9HCE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-900: EKIRYCITKL...DLDFNLGFLK → RSSVTSKGGA...PGLLPGSLLH
     901-1003: Missing.

Show »
Length:900
Mass (Da):101,598
Checksum:i0CF3733285C48342
GO
Isoform 3 (identifier: Q9HCE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-56: FGTPAPGFSS → LASSKSILQS
     57-1003: Missing.

Show »
Length:56
Mass (Da):6,546
Checksum:i5FAEB3C0DC2A00F6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JR04Q5JR04_HUMAN
RNA helicase
MOV10 hCG_38463
947Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KXC3A0A8I5KXC3_HUMAN
Helicase MOV-10
MOV10
1,023Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KZ07A0A8I5KZ07_HUMAN
Helicase MOV-10
MOV10
937Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5QKW4A0A8I5QKW4_HUMAN
Helicase MOV-10
MOV10
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13457 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAB85000 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98D → N in AL833353 (PubMed:17974005).Curated1
Sequence conflicti248A → T in AL833353 (PubMed:17974005).Curated1
Sequence conflicti814S → T in AL833353 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03730547 – 56FGTPAPGFSS → LASSKSILQS in isoform 3. 1 Publication10
Alternative sequenceiVSP_03730657 – 1003Missing in isoform 3. 1 PublicationAdd BLAST947
Alternative sequenceiVSP_010943838 – 900EKIRY…LGFLK → RSSVTSKGGAPPPDGTSLIS RPLGRGSRSLGLCWLRISEE HQGQLPPPFVPQLPGLLPGS LLH in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_010944901 – 1003Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB046851 mRNA Translation: BAB13457.1 Sequence problems.
AK074174 mRNA Translation: BAB85000.1 Different initiation.
AL833353 mRNA No translation available.
AL603832 Genomic DNA No translation available.
BC002548 mRNA Translation: AAH02548.1
BC004499 mRNA Translation: AAH04499.2
BC009312 mRNA Translation: AAH09312.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS853.1 [Q9HCE1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001123551.1, NM_001130079.2 [Q9HCE1-1]
NP_001273001.1, NM_001286072.1
NP_001308253.1, NM_001321324.1 [Q9HCE1-1]
NP_066014.1, NM_020963.4 [Q9HCE1-1]
XP_005270926.1, XM_005270869.4
XP_005270927.1, XM_005270870.4
XP_016856807.1, XM_017001318.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357443.2; ENSP00000350028.2; ENSG00000155363.19
ENST00000369645.6; ENSP00000358659.1; ENSG00000155363.19
ENST00000413052.6; ENSP00000399797.2; ENSG00000155363.19

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4343

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4343

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000369645.6; ENSP00000358659.1; NM_001321324.2; NP_001308253.1

UCSC genome browser

More...UCSCi		uc001ecn.5, human [Q9HCE1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046851 mRNA Translation: BAB13457.1 Sequence problems.
AK074174 mRNA Translation: BAB85000.1 Different initiation.
AL833353 mRNA No translation available.
AL603832 Genomic DNA No translation available.
BC002548 mRNA Translation: AAH02548.1
BC004499 mRNA Translation: AAH04499.2
BC009312 mRNA Translation: AAH09312.1
CCDSiCCDS853.1 [Q9HCE1-1]
RefSeqiNP_001123551.1, NM_001130079.2 [Q9HCE1-1]
NP_001273001.1, NM_001286072.1
NP_001308253.1, NM_001321324.1 [Q9HCE1-1]
NP_066014.1, NM_020963.4 [Q9HCE1-1]
XP_005270926.1, XM_005270869.4
XP_005270927.1, XM_005270870.4
XP_016856807.1, XM_017001318.1

3D structure databases

AlphaFoldDBiQ9HCE1
SMRiQ9HCE1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110484, 1246 interactors
CORUMiQ9HCE1
DIPiDIP-44158N
IntActiQ9HCE1, 131 interactors
MINTiQ9HCE1
STRINGi9606.ENSP00000399797

PTM databases

CarbonylDBiQ9HCE1
GlyGeniQ9HCE1, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9HCE1
MetOSiteiQ9HCE1
PhosphoSitePlusiQ9HCE1
SwissPalmiQ9HCE1

Genetic variation databases

BioMutaiMOV10
DMDMi24638063

Proteomic databases

EPDiQ9HCE1
jPOSTiQ9HCE1
MassIVEiQ9HCE1
MaxQBiQ9HCE1
PaxDbiQ9HCE1
PeptideAtlasiQ9HCE1
PRIDEiQ9HCE1
ProteomicsDBi81683 [Q9HCE1-1]
81684 [Q9HCE1-2]
81685 [Q9HCE1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20136, 168 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		4343

Genome annotation databases

EnsembliENST00000357443.2; ENSP00000350028.2; ENSG00000155363.19
ENST00000369645.6; ENSP00000358659.1; ENSG00000155363.19
ENST00000413052.6; ENSP00000399797.2; ENSG00000155363.19
GeneIDi4343
KEGGihsa:4343
MANE-SelectiENST00000369645.6; ENSP00000358659.1; NM_001321324.2; NP_001308253.1
UCSCiuc001ecn.5, human [Q9HCE1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4343
DisGeNETi4343

GeneCards: human genes, protein and diseases

More...GeneCardsi		MOV10
HGNCiHGNC:7200, MOV10
HPAiENSG00000155363, Low tissue specificity
MIMi610742, gene
neXtProtiNX_Q9HCE1
OpenTargetsiENSG00000155363
PharmGKBiPA30908
VEuPathDBiHostDB:ENSG00000155363

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1804, Eukaryota
GeneTreeiENSGT00940000156024
InParanoidiQ9HCE1
OMAiRPYQGFI
OrthoDBi286011at2759
PhylomeDBiQ9HCE1
TreeFamiTF323999

Enzyme and pathway databases

PathwayCommonsiQ9HCE1
ReactomeiR-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2559585, Oncogene Induced Senescence
R-HSA-4086398, Ca2+ pathway
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-8853884, Transcriptional Regulation by VENTX
R-HSA-8934593, Regulation of RUNX1 Expression and Activity
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8943723, Regulation of PTEN mRNA translation
R-HSA-8948700, Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-8986944, Transcriptional Regulation by MECP2
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9022692, Regulation of MECP2 expression and activity
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
SignaLinkiQ9HCE1
SIGNORiQ9HCE1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4343, 15 hits in 1090 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MOV10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MOV10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4343
PharosiQ9HCE1, Tbio

Protein Ontology

More...PROi		PR:Q9HCE1
RNActiQ9HCE1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155363, Expressed in prostate gland and 205 other tissues
ExpressionAtlasiQ9HCE1, baseline and differential
GenevisibleiQ9HCE1, HS

Family and domain databases

CDDicd18808, SF1_C_Upf1, 1 hit
Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR045055, DNA2/NAM7-like
IPR041679, DNA2/NAM7-like_C
IPR026122, MOV-10
IPR027417, P-loop_NTPase
PANTHERiPTHR10887, PTHR10887, 1 hit
PTHR10887:SF322, PTHR10887:SF322, 1 hit
PfamiView protein in Pfam
PF13087, AAA_12, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOV10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCE1
Secondary accession number(s): Q5JR03
, Q8TEF0, Q9BSY3, Q9BUJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: May 25, 2022
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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