UniProtKB - Q9HCE1 (MOV10_HUMAN)

>sp|Q9HCE1|MOV10_HUMAN Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2
MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYG
MKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIFYDRAEYLHG
KHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFY
NEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIARFLAA
VAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRL
RQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDL
ESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKV
ELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRD
VPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQ
VVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDA
KKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIA
GLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGY
DPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHG
VMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKI
RYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK
NPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQN
LLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEWRNEL

Entry version 175 (02 Dec 2020)
Sequence version 2 (01 Nov 2002)
Previous versions | rss

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Protein

Helicase MOV-10

Gene

MOV10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568).By similarity8 Publications

(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.1 Publication

Catalytic activityⁱ

ATP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
ADP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
phosphate
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.20
  "MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs."
  Gregersen L.H., Schueler M., Munschauer M., Mastrobuoni G., Chen W., Kempa S., Dieterich C., Landthaler M.
  Mol. Cell 54:573-585(2014) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF LYS-530 AND ASP-645, SUBCELLULAR LOCATION, RNA-BINDING, INTERACTION WITH AGO2; TNRC6B AND UPF1.
EC:
3.6.4.13
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.20
  "MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs."
  Gregersen L.H., Schueler M., Munschauer M., Mastrobuoni G., Chen W., Kempa S., Dieterich C., Landthaler M.
  Mol. Cell 54:573-585(2014) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF LYS-530 AND ASP-645, SUBCELLULAR LOCATION, RNA-BINDING, INTERACTION WITH AGO2; TNRC6B AND UPF1.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
H₂O
=
ADP
+
H⁺
+
phosphate
zoom

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	524 – 531	ATPBy similarity		8

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, RNA-binding
Biological process	Host-virus interaction, RNA-mediated gene silencing, Transcription, Transcription regulation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q9HCE1
Reactomeⁱ	R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559585, Oncogene Induced Senescence R-HSA-4086398, Ca2+ pathway R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8934593, Regulation of RUNX1 Expression and Activity R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8943723, Regulation of PTEN mRNA translation R-HSA-8948700, Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
SIGNORⁱ	Q9HCE1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Helicase MOV-10Curated (EC:3.6.4.131 Publication) Alternative name(s): Armitage homolog1 Publication Moloney leukemia virus 10 protein
Gene namesⁱ	Name:MOV10Imported Synonyms:KIAA1631
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155363.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7200, MOV10
MIMⁱ	610742, gene
neXtProtⁱ	NX_Q9HCE1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	530	K → A: Abolishes 5' to 3' directional unwinding activity. Abolishes inhibition of RNA chaperonne activity of LIRE1. No effect on interaction with UPF1. 2 Publications		1
Mutagenesisⁱ	645	D → N: Abolishes 5' to 3' directional unwinding activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4343
Open Targets More...OpenTargetsⁱ	ENSG00000155363
PharmGKBⁱ	PA30908

Miscellaneous databases

Pharosⁱ	Q9HCE1, Tbio

Pharosⁱ

Q9HCE1, Tbio

Polymorphism and mutation databases

BioMutaⁱ	MOV10
DMDMⁱ	24638063

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080704	1 – 1003	Helicase MOV-10Add BLAST		1003

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	148	N6-acetyllysineCombined sources	1
Modified residueⁱ	160	PhosphothreonineCombined sources	1
Modified residueⁱ	254	PhosphothreonineCombined sources	1
Modified residueⁱ	432	PhosphoserineCombined sources	1
Modified residueⁱ	969	PhosphoserineCombined sources	1
Modified residueⁱ	977	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9HCE1
jPOSTⁱ	Q9HCE1
MassIVEⁱ	Q9HCE1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HCE1
PaxDbⁱ	Q9HCE1
PeptideAtlas More...PeptideAtlasⁱ	Q9HCE1
PRIDEⁱ	Q9HCE1
ProteomicsDBⁱ	81683 [Q9HCE1-1] 81684 [Q9HCE1-2] 81685 [Q9HCE1-3]

PTM databases

CarbonylDBⁱ	Q9HCE1
iPTMnetⁱ	Q9HCE1
MetOSiteⁱ	Q9HCE1
PhosphoSitePlusⁱ	Q9HCE1
SwissPalmⁱ	Q9HCE1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000155363, Expressed in prostate gland and 204 other tissues
ExpressionAtlasⁱ	Q9HCE1, baseline and differential
Genevisibleⁱ	Q9HCE1, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000155363, Low tissue specificity

HPAⁱ

ENSG00000155363, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

Interacts with APOBEC3G in an RNA-dependent manner.

Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).

Interacts with both protein products of LIRE1, ORF1p and ORF2p (PubMed:23093941).

Interacts with TUT4 and, to a lesser extent, TUT7; the interactions are RNA-dependent (PubMed:30122351).

Interacts with AGO2, TNRC6B and UPF1; the interactions are direct and RNA-dependent (PubMed:24726324).

Interacts with FMR1; this interaction is direct, occurs in an RNA-dependent manner on polysomes and induces association of MOV10 with RNAs (PubMed:25464849).

Interacts with SHFL; the interaction increases in presence of RNA (PubMed:27974568).

9 Publications

(Microbial infection) Interacts with the human hepatitis delta virus (HDV) antigen HDAg.

1 Publication

Binary interactionsⁱ

Hide details

Q9HCE1

With	#Exp.	IntAct
BMI1 [P35226]	2	EBI-1055820,EBI-2341576
CBX6 [O95503]	2	EBI-1055820,EBI-3951758
CBX7 [O95931]	5	EBI-1055820,EBI-3923843
CBX8 [Q9HC52]	5	EBI-1055820,EBI-712912
EIF2AK2 [P19525]	2	EBI-1055820,EBI-640775
PCGF2 [P35227]	2	EBI-1055820,EBI-2129767
Cbx7 [Q8VDS3] from Mus musculus.	4	EBI-1055820,EBI-1216533
P0C6L3 from Hepatitis delta virus genotype I (isolate D380).	2	EBI-1055820,EBI-15709810

Protein-protein interaction databases

BioGRIDⁱ	110484, 1069 interactors
CORUMⁱ	Q9HCE1
Database of interacting proteins More...DIPⁱ	DIP-44158N
IntActⁱ	Q9HCE1, 104 interactors
Molecular INTeraction database More...MINTⁱ	Q9HCE1
STRINGⁱ	9606.ENSP00000399797

Miscellaneous databases

RNActⁱ	Q9HCE1, protein

RNActⁱ

Q9HCE1, protein

Structureⁱ

3D structure databases

SMRⁱ	Q9HCE1
ModBaseⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	921 – 965	Interaction with AGO2 and APOBEC3G1 PublicationAdd BLAST		45

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	645 – 648	DEAG box		4

Sequence similaritiesⁱ

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1804, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156024
InParanoidⁱ	Q9HCE1
OMAⁱ	PLNPHIN
Database of Orthologous Groups More...OrthoDBⁱ	286011at2759
PhylomeDBⁱ	Q9HCE1
TreeFamⁱ	TF323999

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd18808, SF1_C_Upf1, 1 hit
InterProⁱ	View protein in InterPro IPR041679, DNA2/NAM7-like_C IPR026122, MOV-10 IPR027417, P-loop_NTPase
PANTHERⁱ	PTHR10887:SF419, PTHR10887:SF419, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13087, AAA_12, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9HCE1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP 
        60         70         80         90        100
APGFSSMLYG MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS 
       110        120        130        140        150
KHHKSLLAKI FYDRAEYLHG KHGVDVEVQG PHEARDGQLL IRLDLNRKEV 
       160        170        180        190        200
LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY NEDQELPCPL GPGECYELHV 
       210        220        230        240        250
HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA VAHSPLAAQL 
       260        270        280        290        300
KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL 
       310        320        330        340        350
RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ 
       360        370        380        390        400
MEHDIRHYDL ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL 
       410        420        430        440        450
LSSETHQEDP ITYKGFVHKV ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN 
       460        470        480        490        500
RQPLRVQHRA LELTGRWLLW PMLFPVAPRD VPLLPSDVKL KLYDRSLESN 
       510        520        530        540        550
PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI 
       560        570        580        590        600
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA 
       610        620        630        640        650
KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC 
       660        670        680        690        700
MEPESLVAIA GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY 
       710        720        730        740        750
SLLERLLTYN SLYKKGPDGY DPQFITKLLR NYRSHPTILD IPNQLYYEGE 
       760        770        780        790        800
LQACADVVDR ERFCRWAGLP RQGFPIIFHG VMGKDEREGN SPSFFNPEEA 
       810        820        830        840        850
ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDRE 
       860        870        880        890        900
LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK 
       910        920        930        940        950
NPKRFNVAVT RAKALLIIVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP 
       960        970        980        990       1000
AKLDLQQGQN LLQGLSKLSP STSGPHSHDY LPQEREGEGG LSLQVEPEWR 

NEL

Length:1,003

Mass (Da):113,671

Last modified:November 1, 2002 - v2

Checksum:ⁱ28A8B3BF9B5B54FC

Isoform 2 (identifier: Q9HCE1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
838-900: EKIRYCITKL...DLDFNLGFLK → RSSVTSKGGA...PGLLPGSLLH
901-1003: Missing.

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        10         20         30         40         50
MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP 
        60         70         80         90        100
APGFSSMLYG MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS 
       110        120        130        140        150
KHHKSLLAKI FYDRAEYLHG KHGVDVEVQG PHEARDGQLL IRLDLNRKEV 
       160        170        180        190        200
LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY NEDQELPCPL GPGECYELHV 
       210        220        230        240        250
HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA VAHSPLAAQL 
       260        270        280        290        300
KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL 
       310        320        330        340        350
RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ 
       360        370        380        390        400
MEHDIRHYDL ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL 
       410        420        430        440        450
LSSETHQEDP ITYKGFVHKV ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN 
       460        470        480        490        500
RQPLRVQHRA LELTGRWLLW PMLFPVAPRD VPLLPSDVKL KLYDRSLESN 
       510        520        530        540        550
PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI 
       560        570        580        590        600
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA 
       610        620        630        640        650
KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC 
       660        670        680        690        700
MEPESLVAIA GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY 
       710        720        730        740        750
SLLERLLTYN SLYKKGPDGY DPQFITKLLR NYRSHPTILD IPNQLYYEGE 
       760        770        780        790        800
LQACADVVDR ERFCRWAGLP RQGFPIIFHG VMGKDEREGN SPSFFNPEEA 
       810        820        830        840        850
ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVRSS VTSKGGAPPP 
       860        870        880        890        900
DGTSLISRPL GRGSRSLGLC WLRISEEHQG QLPPPFVPQL PGLLPGSLLH

Show »

Length:900

Mass (Da):101,598

Checksum:ⁱ0CF3733285C48342

Isoform 3 (identifier: Q9HCE1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
47-56: FGTPAPGFSS → LASSKSILQS
57-1003: Missing.

« Hide

        10         20         30         40         50
MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISLASS 

KSILQS

Show »

Length:56

Mass (Da):6,546

Checksum:ⁱ5FAEB3C0DC2A00F6

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5JR04	Q5JR04_HUMAN		RNA helicase RNA helicase, EC 3.6.4.13	MOV10 hCG_38463	947	Annotation score:

Sequence cautionⁱ

The sequence BAB13457 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

The sequence BAB85000 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	98	D → N in AL833353 (PubMed:17974005).Curated	1
Sequence conflictⁱ	248	A → T in AL833353 (PubMed:17974005).Curated	1
Sequence conflictⁱ	814	S → T in AL833353 (PubMed:17974005).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_037305	47 – 56	FGTPAPGFSS → LASSKSILQS in isoform 3. 1 Publication	10
Alternative sequenceⁱVSP_037306	57 – 1003	Missing in isoform 3. 1 PublicationAdd BLAST	947
Alternative sequenceⁱVSP_010943	838 – 900	EKIRY…LGFLK → RSSVTSKGGAPPPDGTSLIS RPLGRGSRSLGLCWLRISEE HQGQLPPPFVPQLPGLLPGS LLH in isoform 2. 1 PublicationAdd BLAST	63
Alternative sequenceⁱVSP_010944	901 – 1003	Missing in isoform 2. 1 PublicationAdd BLAST	103

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB046851 mRNA Translation: BAB13457.1 Sequence problems. AK074174 mRNA Translation: BAB85000.1 Different initiation. AL833353 mRNA No translation available. AL603832 Genomic DNA No translation available. BC002548 mRNA Translation: AAH02548.1 BC004499 mRNA Translation: AAH04499.2 BC009312 mRNA Translation: AAH09312.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS853.1 [Q9HCE1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001123551.1, NM_001130079.2 [Q9HCE1-1] NP_001273001.1, NM_001286072.1 NP_001308253.1, NM_001321324.1 [Q9HCE1-1] NP_066014.1, NM_020963.4 [Q9HCE1-1] XP_005270926.1, XM_005270869.4 XP_005270927.1, XM_005270870.4 XP_016856807.1, XM_017001318.1

Genome annotation databases

Ensemblⁱ	ENST00000357443; ENSP00000350028; ENSG00000155363 [Q9HCE1-1] ENST00000369645; ENSP00000358659; ENSG00000155363 [Q9HCE1-1] ENST00000413052; ENSP00000399797; ENSG00000155363 [Q9HCE1-1]
GeneIDⁱ	4343
KEGGⁱ	hsa:4343
UCSC genome browser More...UCSCⁱ	uc001ecn.5, human [Q9HCE1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HCE1	RNA helicase		PANTR		1003	UniRef100_Q9HCE1
RNA helicase		GORGO		1003
RNA helicase		PANPA		957
RNA helicase		HUMAN		947
RNA helicase		PANTR		1003
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9HCE1	RNA helicase		PANTR		1003	UniRef90_Q9HCE1
RNA helicase		GORGO		1003
RNA helicase		PANPA		957
RNA helicase		HUMAN		947
RNA helicase		MARMO		1093
+89
Q9HCE1-2	RNA helicase		CHRAS		1004	UniRef90_Q9HCE1-2
RNA helicase (Fragment)		CAMFR		944
RNA helicase		SURSU		936
RNA helicase		URSMA		932
RNA helicase		PIG		927
+21

Protein	Similar proteins		Species	Score	Length	Source
Q9HCE1	Putative helicase MOV-10		BOVIN		1003	UniRef50_Q9HCE1
Putative helicase MOV-10		MOUSE		1004
RNA helicase		PANTR		1003
RNA helicase		GORGO		1003
RNA helicase		PANPA		957
+419
Q9HCE1-3	Uncharacterized protein (Fragment)		GULGU		54	UniRef50_Q9HCE1-3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB046851 mRNA Translation: BAB13457.1 Sequence problems. AK074174 mRNA Translation: BAB85000.1 Different initiation. AL833353 mRNA No translation available. AL603832 Genomic DNA No translation available. BC002548 mRNA Translation: AAH02548.1 BC004499 mRNA Translation: AAH04499.2 BC009312 mRNA Translation: AAH09312.1
CCDSⁱ	CCDS853.1 [Q9HCE1-1]
RefSeqⁱ	NP_001123551.1, NM_001130079.2 [Q9HCE1-1] NP_001273001.1, NM_001286072.1 NP_001308253.1, NM_001321324.1 [Q9HCE1-1] NP_066014.1, NM_020963.4 [Q9HCE1-1] XP_005270926.1, XM_005270869.4 XP_005270927.1, XM_005270870.4 XP_016856807.1, XM_017001318.1

3D structure databases

SMRⁱ	Q9HCE1
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	110484, 1069 interactors
CORUMⁱ	Q9HCE1
DIPⁱ	DIP-44158N
IntActⁱ	Q9HCE1, 104 interactors
MINTⁱ	Q9HCE1
STRINGⁱ	9606.ENSP00000399797

PTM databases

CarbonylDBⁱ	Q9HCE1
iPTMnetⁱ	Q9HCE1
MetOSiteⁱ	Q9HCE1
PhosphoSitePlusⁱ	Q9HCE1
SwissPalmⁱ	Q9HCE1

Polymorphism and mutation databases

BioMutaⁱ	MOV10
DMDMⁱ	24638063

Proteomic databases

EPDⁱ	Q9HCE1
jPOSTⁱ	Q9HCE1
MassIVEⁱ	Q9HCE1
MaxQBⁱ	Q9HCE1
PaxDbⁱ	Q9HCE1
PeptideAtlasⁱ	Q9HCE1
PRIDEⁱ	Q9HCE1
ProteomicsDBⁱ	81683 [Q9HCE1-1] 81684 [Q9HCE1-2] 81685 [Q9HCE1-3]

Protocols and materials databases

Antibodypediaⁱ	20136, 159 antibodies
The DNASU plasmid repository More...DNASUⁱ	4343

Genome annotation databases

Ensemblⁱ	ENST00000357443; ENSP00000350028; ENSG00000155363 [Q9HCE1-1] ENST00000369645; ENSP00000358659; ENSG00000155363 [Q9HCE1-1] ENST00000413052; ENSP00000399797; ENSG00000155363 [Q9HCE1-1]
GeneIDⁱ	4343
KEGGⁱ	hsa:4343
UCSCⁱ	uc001ecn.5, human [Q9HCE1-1]

Organism-specific databases

CTDⁱ	4343
DisGeNETⁱ	4343
EuPathDBⁱ	HostDB:ENSG00000155363.18
GeneCardsⁱ	MOV10
HGNCⁱ	HGNC:7200, MOV10
HPAⁱ	ENSG00000155363, Low tissue specificity
MIMⁱ	610742, gene
neXtProtⁱ	NX_Q9HCE1
OpenTargetsⁱ	ENSG00000155363
PharmGKBⁱ	PA30908
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1804, Eukaryota
GeneTreeⁱ	ENSGT00940000156024
InParanoidⁱ	Q9HCE1
OMAⁱ	PLNPHIN
OrthoDBⁱ	286011at2759
PhylomeDBⁱ	Q9HCE1
TreeFamⁱ	TF323999

Enzyme and pathway databases

PathwayCommonsⁱ	Q9HCE1
Reactomeⁱ	R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559585, Oncogene Induced Senescence R-HSA-4086398, Ca2+ pathway R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8934593, Regulation of RUNX1 Expression and Activity R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8943723, Regulation of PTEN mRNA translation R-HSA-8948700, Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
SIGNORⁱ	Q9HCE1

Miscellaneous databases

BioGRID-ORCSⁱ	4343, 7 hits in 847 CRISPR screens
ChiTaRSⁱ	MOV10, human
GeneWikiⁱ	MOV10
GenomeRNAiⁱ	4343
Pharosⁱ	Q9HCE1, Tbio
Protein Ontology More...PROⁱ	PR:Q9HCE1
RNActⁱ	Q9HCE1, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000155363, Expressed in prostate gland and 204 other tissues
ExpressionAtlasⁱ	Q9HCE1, baseline and differential
Genevisibleⁱ	Q9HCE1, HS

Family and domain databases

CDDⁱ	cd18808, SF1_C_Upf1, 1 hit
InterProⁱ	View protein in InterPro IPR041679, DNA2/NAM7-like_C IPR026122, MOV-10 IPR027417, P-loop_NTPase
PANTHERⁱ	PTHR10887:SF419, PTHR10887:SF419, 1 hit
Pfamⁱ	View protein in Pfam PF13087, AAA_12, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MOV10_HUMAN
Accessionⁱ	Q9HCE1Primary (citable) accession number: Q9HCE1 Secondary accession number(s): Q5JR03 , Q8TEF0, Q9BSY3, Q9BUJ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
	Last sequence update:	November 1, 2002
	Last modified:	December 2, 2020
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM

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UniProtKB - Q9HCE1 (MOV10_HUMAN)

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Helicase MOV-10

MOV10

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Q9HCE1

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3D structure databases

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

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Keywords - Technical termⁱ