UniProtKB - Q9HCE1 (MOV10_HUMAN)
Helicase MOV-10
MOV10
Functioni
5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324).
Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714).
In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849).
Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941).
Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351).
Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity).
May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324).
Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568).
By similarity8 Publications(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
1 PublicationCatalytic activityi
- EC:3.6.4.131 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 524 – 531 | ATPBy similarity | 8 |
GO - Molecular functioni
- 5'-3' RNA helicase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: RHEA
- RNA binding Source: UniProtKB
GO - Biological processi
- 3'-UTR-mediated mRNA destabilization Source: UniProtKB
- defense response to virus Source: UniProtKB
- gene silencing by miRNA Source: UniProtKB
- miRNA-mediated gene silencing by mRNA destabilization Source: UniProtKB
- negative regulation of transposition, RNA-mediated Source: UniProtKB
- positive regulation of mRNA catabolic process Source: UniProtKB
- post-transcriptional gene silencing by RNA Source: GO_Central
- regulation of neuron projection arborization Source: UniProtKB
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | Host-virus interaction, RNA-mediated gene silencing, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9HCE1 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559585, Oncogene Induced Senescence R-HSA-4086398, Ca2+ pathway R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8934593, Regulation of RUNX1 Expression and Activity R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8943723, Regulation of PTEN mRNA translation R-HSA-8948700, Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
SignaLinki | Q9HCE1 |
SIGNORi | Q9HCE1 |
Names & Taxonomyi
Protein namesi | Recommended name: Helicase MOV-10Curated (EC:3.6.4.131 Publication)Alternative name(s): Armitage homolog1 Publication Moloney leukemia virus 10 protein |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7200, MOV10 |
MIMi | 610742, gene |
neXtProti | NX_Q9HCE1 |
VEuPathDBi | HostDB:ENSG00000155363 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Other locations
- P-body 4 Publications
- Cytoplasmic ribonucleoprotein granule 1 Publication
- Stress granule 1 Publication
Note: Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568).By similarity2 Publications
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasmic ribonucleoprotein granule Source: UniProtKB
- cytoplasmic stress granule Source: UniProtKB-SubCell
- P granule Source: GO_Central
- P-body Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 530 | K → A: Abolishes 5' to 3' directional unwinding activity. Abolishes inhibition of RNA chaperonne activity of LIRE1. No effect on interaction with UPF1. 2 Publications | 1 | |
Mutagenesisi | 645 | D → N: Abolishes 5' to 3' directional unwinding activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4343 |
OpenTargetsi | ENSG00000155363 |
PharmGKBi | PA30908 |
Miscellaneous databases
Pharosi | Q9HCE1, Tbio |
Genetic variation databases
BioMutai | MOV10 |
DMDMi | 24638063 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080704 | 1 – 1003 | Helicase MOV-10Add BLAST | 1003 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 148 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 160 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 254 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 969 | PhosphoserineCombined sources | 1 | |
Modified residuei | 977 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9HCE1 |
jPOSTi | Q9HCE1 |
MassIVEi | Q9HCE1 |
MaxQBi | Q9HCE1 |
PaxDbi | Q9HCE1 |
PeptideAtlasi | Q9HCE1 |
PRIDEi | Q9HCE1 |
ProteomicsDBi | 81683 [Q9HCE1-1] 81684 [Q9HCE1-2] 81685 [Q9HCE1-3] |
PTM databases
CarbonylDBi | Q9HCE1 |
GlyGeni | Q9HCE1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9HCE1 |
MetOSitei | Q9HCE1 |
PhosphoSitePlusi | Q9HCE1 |
SwissPalmi | Q9HCE1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000155363, Expressed in prostate gland and 205 other tissues |
ExpressionAtlasi | Q9HCE1, baseline and differential |
Genevisiblei | Q9HCE1, HS |
Organism-specific databases
HPAi | ENSG00000155363, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).
Interacts with APOBEC3G in an RNA-dependent manner.
Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).
Interacts with both protein products of LIRE1, ORF1p and ORF2p (PubMed:23093941).
Interacts with TUT4 and, to a lesser extent, TUT7; the interactions are RNA-dependent (PubMed:30122351).
Interacts with AGO2, TNRC6B and UPF1; the interactions are direct and RNA-dependent (PubMed:24726324).
Interacts with FMR1; this interaction is direct, occurs in an RNA-dependent manner on polysomes and induces association of MOV10 with RNAs (PubMed:25464849).
Interacts with SHFL; the interaction increases in presence of RNA (PubMed:27974568).
Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).
10 Publications(Microbial infection) Interacts with the human hepatitis delta virus (HDV) antigen HDAg.
1 PublicationBinary interactionsi
Q9HCE1
Protein-protein interaction databases
BioGRIDi | 110484, 1246 interactors |
CORUMi | Q9HCE1 |
DIPi | DIP-44158N |
IntActi | Q9HCE1, 131 interactors |
MINTi | Q9HCE1 |
STRINGi | 9606.ENSP00000399797 |
Miscellaneous databases
RNActi | Q9HCE1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 921 – 965 | Interaction with AGO2 and APOBEC3G1 PublicationAdd BLAST | 45 | |
Regioni | 966 – 1003 | DisorderedSequence analysisAdd BLAST | 38 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 645 – 648 | DEAG box | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1804, Eukaryota |
GeneTreei | ENSGT00940000156024 |
InParanoidi | Q9HCE1 |
OMAi | RPYQGFI |
OrthoDBi | 286011at2759 |
PhylomeDBi | Q9HCE1 |
TreeFami | TF323999 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR045055, DNA2/NAM7-like IPR041679, DNA2/NAM7-like_C IPR026122, MOV-10 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10887, PTHR10887, 1 hit PTHR10887:SF322, PTHR10887:SF322, 1 hit |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP
60 70 80 90 100
APGFSSMLYG MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS
110 120 130 140 150
KHHKSLLAKI FYDRAEYLHG KHGVDVEVQG PHEARDGQLL IRLDLNRKEV
160 170 180 190 200
LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY NEDQELPCPL GPGECYELHV
210 220 230 240 250
HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA VAHSPLAAQL
260 270 280 290 300
KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL
310 320 330 340 350
RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ
360 370 380 390 400
MEHDIRHYDL ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL
410 420 430 440 450
LSSETHQEDP ITYKGFVHKV ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN
460 470 480 490 500
RQPLRVQHRA LELTGRWLLW PMLFPVAPRD VPLLPSDVKL KLYDRSLESN
510 520 530 540 550
PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI
560 570 580 590 600
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA
610 620 630 640 650
KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC
660 670 680 690 700
MEPESLVAIA GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY
710 720 730 740 750
SLLERLLTYN SLYKKGPDGY DPQFITKLLR NYRSHPTILD IPNQLYYEGE
760 770 780 790 800
LQACADVVDR ERFCRWAGLP RQGFPIIFHG VMGKDEREGN SPSFFNPEEA
810 820 830 840 850
ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDRE
860 870 880 890 900
LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK
910 920 930 940 950
NPKRFNVAVT RAKALLIIVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP
960 970 980 990 1000
AKLDLQQGQN LLQGLSKLSP STSGPHSHDY LPQEREGEGG LSLQVEPEWR
NEL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JR04 | Q5JR04_HUMAN | RNA helicase | MOV10 hCG_38463 | 947 | Annotation score: | ||
A0A8I5KXC3 | A0A8I5KXC3_HUMAN | Helicase MOV-10 | MOV10 | 1,023 | Annotation score: | ||
A0A8I5KZ07 | A0A8I5KZ07_HUMAN | Helicase MOV-10 | MOV10 | 937 | Annotation score: | ||
A0A8I5QKW4 | A0A8I5QKW4_HUMAN | Helicase MOV-10 | MOV10 | 151 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 98 | D → N in AL833353 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 248 | A → T in AL833353 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 814 | S → T in AL833353 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037305 | 47 – 56 | FGTPAPGFSS → LASSKSILQS in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_037306 | 57 – 1003 | Missing in isoform 3. 1 PublicationAdd BLAST | 947 | |
Alternative sequenceiVSP_010943 | 838 – 900 | EKIRY…LGFLK → RSSVTSKGGAPPPDGTSLIS RPLGRGSRSLGLCWLRISEE HQGQLPPPFVPQLPGLLPGS LLH in isoform 2. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_010944 | 901 – 1003 | Missing in isoform 2. 1 PublicationAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046851 mRNA Translation: BAB13457.1 Sequence problems. AK074174 mRNA Translation: BAB85000.1 Different initiation. AL833353 mRNA No translation available. AL603832 Genomic DNA No translation available. BC002548 mRNA Translation: AAH02548.1 BC004499 mRNA Translation: AAH04499.2 BC009312 mRNA Translation: AAH09312.1 |
CCDSi | CCDS853.1 [Q9HCE1-1] |
RefSeqi | NP_001123551.1, NM_001130079.2 [Q9HCE1-1] NP_001273001.1, NM_001286072.1 NP_001308253.1, NM_001321324.1 [Q9HCE1-1] NP_066014.1, NM_020963.4 [Q9HCE1-1] XP_005270926.1, XM_005270869.4 XP_005270927.1, XM_005270870.4 XP_016856807.1, XM_017001318.1 |
Genome annotation databases
Ensembli | ENST00000357443.2; ENSP00000350028.2; ENSG00000155363.19 ENST00000369645.6; ENSP00000358659.1; ENSG00000155363.19 ENST00000413052.6; ENSP00000399797.2; ENSG00000155363.19 |
GeneIDi | 4343 |
KEGGi | hsa:4343 |
MANE-Selecti | ENST00000369645.6; ENSP00000358659.1; NM_001321324.2; NP_001308253.1 |
UCSCi | uc001ecn.5, human [Q9HCE1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046851 mRNA Translation: BAB13457.1 Sequence problems. AK074174 mRNA Translation: BAB85000.1 Different initiation. AL833353 mRNA No translation available. AL603832 Genomic DNA No translation available. BC002548 mRNA Translation: AAH02548.1 BC004499 mRNA Translation: AAH04499.2 BC009312 mRNA Translation: AAH09312.1 |
CCDSi | CCDS853.1 [Q9HCE1-1] |
RefSeqi | NP_001123551.1, NM_001130079.2 [Q9HCE1-1] NP_001273001.1, NM_001286072.1 NP_001308253.1, NM_001321324.1 [Q9HCE1-1] NP_066014.1, NM_020963.4 [Q9HCE1-1] XP_005270926.1, XM_005270869.4 XP_005270927.1, XM_005270870.4 XP_016856807.1, XM_017001318.1 |
3D structure databases
AlphaFoldDBi | Q9HCE1 |
SMRi | Q9HCE1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110484, 1246 interactors |
CORUMi | Q9HCE1 |
DIPi | DIP-44158N |
IntActi | Q9HCE1, 131 interactors |
MINTi | Q9HCE1 |
STRINGi | 9606.ENSP00000399797 |
PTM databases
CarbonylDBi | Q9HCE1 |
GlyGeni | Q9HCE1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9HCE1 |
MetOSitei | Q9HCE1 |
PhosphoSitePlusi | Q9HCE1 |
SwissPalmi | Q9HCE1 |
Genetic variation databases
BioMutai | MOV10 |
DMDMi | 24638063 |
Proteomic databases
EPDi | Q9HCE1 |
jPOSTi | Q9HCE1 |
MassIVEi | Q9HCE1 |
MaxQBi | Q9HCE1 |
PaxDbi | Q9HCE1 |
PeptideAtlasi | Q9HCE1 |
PRIDEi | Q9HCE1 |
ProteomicsDBi | 81683 [Q9HCE1-1] 81684 [Q9HCE1-2] 81685 [Q9HCE1-3] |
Protocols and materials databases
Antibodypediai | 20136, 168 antibodies from 25 providers |
DNASUi | 4343 |
Genome annotation databases
Ensembli | ENST00000357443.2; ENSP00000350028.2; ENSG00000155363.19 ENST00000369645.6; ENSP00000358659.1; ENSG00000155363.19 ENST00000413052.6; ENSP00000399797.2; ENSG00000155363.19 |
GeneIDi | 4343 |
KEGGi | hsa:4343 |
MANE-Selecti | ENST00000369645.6; ENSP00000358659.1; NM_001321324.2; NP_001308253.1 |
UCSCi | uc001ecn.5, human [Q9HCE1-1] |
Organism-specific databases
CTDi | 4343 |
DisGeNETi | 4343 |
GeneCardsi | MOV10 |
HGNCi | HGNC:7200, MOV10 |
HPAi | ENSG00000155363, Low tissue specificity |
MIMi | 610742, gene |
neXtProti | NX_Q9HCE1 |
OpenTargetsi | ENSG00000155363 |
PharmGKBi | PA30908 |
VEuPathDBi | HostDB:ENSG00000155363 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1804, Eukaryota |
GeneTreei | ENSGT00940000156024 |
InParanoidi | Q9HCE1 |
OMAi | RPYQGFI |
OrthoDBi | 286011at2759 |
PhylomeDBi | Q9HCE1 |
TreeFami | TF323999 |
Enzyme and pathway databases
PathwayCommonsi | Q9HCE1 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559585, Oncogene Induced Senescence R-HSA-4086398, Ca2+ pathway R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8934593, Regulation of RUNX1 Expression and Activity R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8943723, Regulation of PTEN mRNA translation R-HSA-8948700, Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
SignaLinki | Q9HCE1 |
SIGNORi | Q9HCE1 |
Miscellaneous databases
BioGRID-ORCSi | 4343, 15 hits in 1090 CRISPR screens |
ChiTaRSi | MOV10, human |
GeneWikii | MOV10 |
GenomeRNAii | 4343 |
Pharosi | Q9HCE1, Tbio |
PROi | PR:Q9HCE1 |
RNActi | Q9HCE1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155363, Expressed in prostate gland and 205 other tissues |
ExpressionAtlasi | Q9HCE1, baseline and differential |
Genevisiblei | Q9HCE1, HS |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR045055, DNA2/NAM7-like IPR041679, DNA2/NAM7-like_C IPR026122, MOV-10 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10887, PTHR10887, 1 hit PTHR10887:SF322, PTHR10887:SF322, 1 hit |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MOV10_HUMAN | |
Accessioni | Q9HCE1Primary (citable) accession number: Q9HCE1 Secondary accession number(s): Q5JR03 Q9BUJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | November 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families