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Protein

Nuclear receptor coactivator 5

Gene

NCOA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 5
Short name:
NCoA-5
Alternative name(s):
Coactivator independent of AF-2
Short name:
CIA
Gene namesi
Name:NCOA5
Synonyms:KIAA1637
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124160.11
HGNCiHGNC:15909 NCOA5
neXtProtiNX_Q9HCD5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi342I → A: Abolishes E2-inducible strong interaction with ESR1, but not basal interaction. 1 Publication1
Mutagenesisi348 – 349LL → AA: Abolishes interaction with ESR1. 1 Publication2

Organism-specific databases

DisGeNETi57727
OpenTargetsiENSG00000124160
PharmGKBiPA31474

Polymorphism and mutation databases

BioMutaiNCOA5
DMDMi28380083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944111 – 579Nuclear receptor coactivator 5Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphothreonineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei274PhosphothreonineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei379PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HCD5
MaxQBiQ9HCD5
PaxDbiQ9HCD5
PeptideAtlasiQ9HCD5
PRIDEiQ9HCD5
ProteomicsDBi81676

PTM databases

iPTMnetiQ9HCD5
PhosphoSitePlusiQ9HCD5

Miscellaneous databases

PMAP-CutDBiQ9HCD5

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000124160 Expressed in 181 organ(s), highest expression level in female gonad
CleanExiHS_NCOA5
ExpressionAtlasiQ9HCD5 baseline and differential
GenevisibleiQ9HCD5 HS

Organism-specific databases

HPAiHPA050231

Interactioni

Subunit structurei

Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr1d2Q606742EBI-2863498,EBI-5326205From Mus musculus.

Protein-protein interaction databases

BioGridi121747, 49 interactors
IntActiQ9HCD5, 24 interactors
MINTiQ9HCD5
STRINGi9606.ENSP00000290231

Structurei

Secondary structure

1579
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HCD5
SMRiQ9HCD5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCD5

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 158Transcription repressionAdd BLAST158
Regioni458 – 579Transcription activationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi345 – 349LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 150Arg/Asp-rich (mixed charge)Add BLAST144

Domaini

Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.

Phylogenomic databases

eggNOGiKOG0845 Eukaryota
ENOG410XPV4 LUCA
GeneTreeiENSGT00530000064134
HOVERGENiHBG052585
InParanoidiQ9HCD5
OMAiRDHRDPM
OrthoDBiEOG091G09XU
PhylomeDBiQ9HCD5
TreeFamiTF324704

Family and domain databases

Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR036621 Anticodon-bd_dom_sf

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9HCD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTAPSRPSP TRRDPYGFGD SRDSRRDRSP IRGSPRREPR DGRNGRDARD
60 70 80 90 100
SRDIRDPRDL RDHRHSRDLR DHRDSRSVRD VRDVRDLRDF RDLRDSRDFR
110 120 130 140 150
DQRDPMYDRY RDMRDSRDPM YRREGSYDRY LRMDDYCRRK DDSYFDRYRD
160 170 180 190 200
SFDGRGPPGP ESQSRAKERL KREERRREEL YRQYFEEIQR RFDAERPVDC
210 220 230 240 250
SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS
260 270 280 290 300
PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKNE
310 320 330 340 350
CREKEREEIA RQAAKMADEA ILQERERGGP EEGVRGGHPP AIQSLINLLA
360 370 380 390 400
DNRYLTAEET DKIINYLRER KERLMRSSTD SLPGPISRQP LGATSGASLK
410 420 430 440 450
TQPSSQPLQS GQVLPSATPT PSAPPTSQQE LQAKILSLFN SGTVTANSSS
460 470 480 490 500
ASPSVAAGNT PNQNFSTAAN SQPQQRSQAS GNQPPSILGQ GGSAQNMGPR
510 520 530 540 550
PGAPSQGLFG QPSSRLAPAS NMTSQRPVSS TGINFDNPSV QKALDTLIQS
560 570
GPALSHLVSQ TTAQMGQPQA PMGSYQRHY
Length:579
Mass (Da):65,536
Last modified:February 12, 2003 - v2
Checksum:iD2ADCCEBEE566A91
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JY17Q5JY17_HUMAN
Nuclear receptor coactivator 5
NCOA5
104Annotation score:

Sequence cautioni

The sequence AAG36793 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053530326E → G. Corresponds to variant dbSNP:rs11549557Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230533 mRNA Translation: AAG36793.1 Different initiation.
AF470686 mRNA Translation: AAO33457.1
AL035662 Genomic DNA No translation available.
AL162458 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75765.1
CH471077 Genomic DNA Translation: EAW75769.1
BC140836 mRNA Translation: AAI40837.1
BC151133 mRNA Translation: AAI51134.1
AB046857 mRNA Translation: BAB13463.1
CCDSiCCDS13392.1
RefSeqiNP_066018.1, NM_020967.2
UniGeneiHs.654991

Genome annotation databases

EnsembliENST00000290231; ENSP00000290231; ENSG00000124160
GeneIDi57727
KEGGihsa:57727
UCSCiuc002xre.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230533 mRNA Translation: AAG36793.1 Different initiation.
AF470686 mRNA Translation: AAO33457.1
AL035662 Genomic DNA No translation available.
AL162458 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75765.1
CH471077 Genomic DNA Translation: EAW75769.1
BC140836 mRNA Translation: AAI40837.1
BC151133 mRNA Translation: AAI51134.1
AB046857 mRNA Translation: BAB13463.1
CCDSiCCDS13392.1
RefSeqiNP_066018.1, NM_020967.2
UniGeneiHs.654991

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V95NMR-A197-313[»]
2J7XX-ray2.10B338-354[»]
2J7YX-ray1.80B338-354[»]
4ZI1X-ray2.10B341-352[»]
ProteinModelPortaliQ9HCD5
SMRiQ9HCD5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121747, 49 interactors
IntActiQ9HCD5, 24 interactors
MINTiQ9HCD5
STRINGi9606.ENSP00000290231

PTM databases

iPTMnetiQ9HCD5
PhosphoSitePlusiQ9HCD5

Polymorphism and mutation databases

BioMutaiNCOA5
DMDMi28380083

Proteomic databases

EPDiQ9HCD5
MaxQBiQ9HCD5
PaxDbiQ9HCD5
PeptideAtlasiQ9HCD5
PRIDEiQ9HCD5
ProteomicsDBi81676

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290231; ENSP00000290231; ENSG00000124160
GeneIDi57727
KEGGihsa:57727
UCSCiuc002xre.4 human

Organism-specific databases

CTDi57727
DisGeNETi57727
EuPathDBiHostDB:ENSG00000124160.11
GeneCardsiNCOA5
HGNCiHGNC:15909 NCOA5
HPAiHPA050231
neXtProtiNX_Q9HCD5
OpenTargetsiENSG00000124160
PharmGKBiPA31474
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0845 Eukaryota
ENOG410XPV4 LUCA
GeneTreeiENSGT00530000064134
HOVERGENiHBG052585
InParanoidiQ9HCD5
OMAiRDHRDPM
OrthoDBiEOG091G09XU
PhylomeDBiQ9HCD5
TreeFamiTF324704

Miscellaneous databases

ChiTaRSiNCOA5 human
EvolutionaryTraceiQ9HCD5
GeneWikiiNCOA5
GenomeRNAii57727
PMAP-CutDBiQ9HCD5
PROiPR:Q9HCD5

Gene expression databases

BgeeiENSG00000124160 Expressed in 181 organ(s), highest expression level in female gonad
CleanExiHS_NCOA5
ExpressionAtlasiQ9HCD5 baseline and differential
GenevisibleiQ9HCD5 HS

Family and domain databases

Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR036621 Anticodon-bd_dom_sf
ProtoNetiSearch...

Entry informationi

Entry nameiNCOA5_HUMAN
AccessioniPrimary (citable) accession number: Q9HCD5
Secondary accession number(s): B2RTV9
, E1P5R0, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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