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UniProtKB - Q9HCD5 (NCOA5_HUMAN)

Entry version 166 (25 May 2022)
Sequence version 2 (12 Feb 2003)
Previous versions | rss
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Protein

Nuclear receptor coactivator 5

Gene

NCOA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HCD5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9HCD5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 5
Short name:
NCoA-5
Alternative name(s):
Coactivator independent of AF-2
Short name:
CIA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOA5
Synonyms:KIAA1637
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15909, NCOA5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HCD5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124160

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi342I → A: Abolishes E2-inducible strong interaction with ESR1, but not basal interaction. 1 Publication1
Mutagenesisi348 – 349LL → AA: Abolishes interaction with ESR1. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		57727

Open Targets

More...OpenTargetsi		ENSG00000124160

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31474

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HCD5, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB07702, 17alpha-Estriol

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NCOA5

Domain mapping of disease mutations (DMDM)

More...DMDMi		28380083

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944111 – 579Nuclear receptor coactivator 5Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphothreonineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei274PhosphothreonineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei379PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HCD5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HCD5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HCD5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HCD5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HCD5

PeptideAtlas

More...PeptideAtlasi		Q9HCD5

PRoteomics IDEntifications database

More...PRIDEi		Q9HCD5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81676

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9HCD5, 15 sites, 2 O-linked glycans (15 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HCD5

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9HCD5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HCD5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124160, Expressed in female gonad and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HCD5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HCD5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124160, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds HTATIP2/TIP30.

Interacts with YLPM1.

Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121747, 111 interactors

Protein interaction database and analysis system

More...IntActi		Q9HCD5, 42 interactors

Molecular INTeraction database

More...MINTi		Q9HCD5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000290231

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HCD5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1579
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9HCD5

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9HCD5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HCD5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9HCD5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 158Transcription repressionAdd BLAST158
Regioni1 – 78DisorderedSequence analysisAdd BLAST78
Regioni148 – 173DisorderedSequence analysisAdd BLAST26
Regioni375 – 428DisorderedSequence analysisAdd BLAST54
Regioni444 – 537DisorderedSequence analysisAdd BLAST94
Regioni458 – 579Transcription activationAdd BLAST122
Regioni560 – 579DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi345 – 349LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 78Basic and acidic residuesSequence analysisAdd BLAST63
Compositional biasi391 – 428Polar residuesSequence analysisAdd BLAST38
Compositional biasi444 – 493Polar residuesSequence analysisAdd BLAST50
Compositional biasi507 – 537Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0845, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064134

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030807_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HCD5

Identification of Orthologs from Complete Genome Data

More...OMAi		ERRNMNK

Database of Orthologous Groups

More...OrthoDBi		994112at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HCD5

TreeFam database of animal gene trees

More...TreeFami		TF324704

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.800, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036621, Anticodon-bd_dom_sf

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9HCD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTAPSRPSP TRRDPYGFGD SRDSRRDRSP IRGSPRREPR DGRNGRDARD 
        60         70         80         90        100
SRDIRDPRDL RDHRHSRDLR DHRDSRSVRD VRDVRDLRDF RDLRDSRDFR 
       110        120        130        140        150
DQRDPMYDRY RDMRDSRDPM YRREGSYDRY LRMDDYCRRK DDSYFDRYRD 
       160        170        180        190        200
SFDGRGPPGP ESQSRAKERL KREERRREEL YRQYFEEIQR RFDAERPVDC 
       210        220        230        240        250
SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS 
       260        270        280        290        300
PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKNE 
       310        320        330        340        350
CREKEREEIA RQAAKMADEA ILQERERGGP EEGVRGGHPP AIQSLINLLA 
       360        370        380        390        400
DNRYLTAEET DKIINYLRER KERLMRSSTD SLPGPISRQP LGATSGASLK 
       410        420        430        440        450
TQPSSQPLQS GQVLPSATPT PSAPPTSQQE LQAKILSLFN SGTVTANSSS 
       460        470        480        490        500
ASPSVAAGNT PNQNFSTAAN SQPQQRSQAS GNQPPSILGQ GGSAQNMGPR 
       510        520        530        540        550
PGAPSQGLFG QPSSRLAPAS NMTSQRPVSS TGINFDNPSV QKALDTLIQS 
       560        570 
GPALSHLVSQ TTAQMGQPQA PMGSYQRHY
Length:579
Mass (Da):65,536
Last modified:February 12, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2ADCCEBEE566A91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JY17Q5JY17_HUMAN
Nuclear receptor coactivator 5
NCOA5
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG36793 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053530326E → G. Corresponds to variant dbSNP:rs11549557Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF230533 mRNA Translation: AAG36793.1 Different initiation.
AF470686 mRNA Translation: AAO33457.1
AL035662 Genomic DNA No translation available.
AL162458 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75765.1
CH471077 Genomic DNA Translation: EAW75769.1
BC140836 mRNA Translation: AAI40837.1
BC151133 mRNA Translation: AAI51134.1
AB046857 mRNA Translation: BAB13463.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13392.1

NCBI Reference Sequences

More...RefSeqi		NP_066018.1, NM_020967.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000290231.11; ENSP00000290231.6; ENSG00000124160.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57727

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57727

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000290231.11; ENSP00000290231.6; NM_020967.3; NP_066018.1

UCSC genome browser

More...UCSCi		uc002xre.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230533 mRNA Translation: AAG36793.1 Different initiation.
AF470686 mRNA Translation: AAO33457.1
AL035662 Genomic DNA No translation available.
AL162458 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75765.1
CH471077 Genomic DNA Translation: EAW75769.1
BC140836 mRNA Translation: AAI40837.1
BC151133 mRNA Translation: AAI51134.1
AB046857 mRNA Translation: BAB13463.1
CCDSiCCDS13392.1
RefSeqiNP_066018.1, NM_020967.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V95NMR-A197-313[»]
2J7XX-ray2.10B338-354[»]
2J7YX-ray1.80B338-354[»]
4ZI1X-ray2.10B341-352[»]
AlphaFoldDBiQ9HCD5
BMRBiQ9HCD5
SMRiQ9HCD5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121747, 111 interactors
IntActiQ9HCD5, 42 interactors
MINTiQ9HCD5
STRINGi9606.ENSP00000290231

Chemistry databases

DrugBankiDB07702, 17alpha-Estriol

PTM databases

GlyGeniQ9HCD5, 15 sites, 2 O-linked glycans (15 sites)
iPTMnetiQ9HCD5
MetOSiteiQ9HCD5
PhosphoSitePlusiQ9HCD5

Genetic variation databases

BioMutaiNCOA5
DMDMi28380083

Proteomic databases

EPDiQ9HCD5
jPOSTiQ9HCD5
MassIVEiQ9HCD5
MaxQBiQ9HCD5
PaxDbiQ9HCD5
PeptideAtlasiQ9HCD5
PRIDEiQ9HCD5
ProteomicsDBi81676

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27960, 139 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		57727

Genome annotation databases

EnsembliENST00000290231.11; ENSP00000290231.6; ENSG00000124160.12
GeneIDi57727
KEGGihsa:57727
MANE-SelectiENST00000290231.11; ENSP00000290231.6; NM_020967.3; NP_066018.1
UCSCiuc002xre.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57727
DisGeNETi57727

GeneCards: human genes, protein and diseases

More...GeneCardsi		NCOA5
HGNCiHGNC:15909, NCOA5
HPAiENSG00000124160, Low tissue specificity
neXtProtiNX_Q9HCD5
OpenTargetsiENSG00000124160
PharmGKBiPA31474
VEuPathDBiHostDB:ENSG00000124160

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0845, Eukaryota
GeneTreeiENSGT00530000064134
HOGENOMiCLU_030807_1_1_1
InParanoidiQ9HCD5
OMAiERRNMNK
OrthoDBi994112at2759
PhylomeDBiQ9HCD5
TreeFamiTF324704

Enzyme and pathway databases

PathwayCommonsiQ9HCD5
SignaLinkiQ9HCD5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57727, 49 hits in 1086 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NCOA5, human
EvolutionaryTraceiQ9HCD5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NCOA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57727
PharosiQ9HCD5, Tbio

Protein Ontology

More...PROi		PR:Q9HCD5
RNActiQ9HCD5, protein

Gene expression databases

BgeeiENSG00000124160, Expressed in female gonad and 197 other tissues
ExpressionAtlasiQ9HCD5, baseline and differential
GenevisibleiQ9HCD5, HS

Family and domain databases

Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR036621, Anticodon-bd_dom_sf

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCD5
Secondary accession number(s): B2RTV9
, E1P5R0, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: May 25, 2022
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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