UniProtKB - Q9HCD5 (NCOA5_HUMAN)
Protein
Nuclear receptor coactivator 5
Gene
NCOA5
Organism
Homo sapiens (Human)
Status
Functioni
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).1 Publication
GO - Molecular functioni
- chromatin binding Source: Ensembl
- RNA binding Source: UniProtKB
- transcription corepressor activity Source: ARUK-UCL
GO - Biological processi
- glucose homeostasis Source: Ensembl
- negative regulation of insulin receptor signaling pathway Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9HCD5 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivator 5Short name: NCoA-5 Alternative name(s): Coactivator independent of AF-2 Short name: CIA |
Gene namesi | Name:NCOA5 Synonyms:KIAA1637 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15909, NCOA5 |
neXtProti | NX_Q9HCD5 |
VEuPathDBi | HostDB:ENSG00000124160.11 |
Subcellular locationi
Nucleus
Cytoskeleton
- actin cytoskeleton Source: HPA
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 342 | I → A: Abolishes E2-inducible strong interaction with ESR1, but not basal interaction. 1 Publication | 1 | |
Mutagenesisi | 348 – 349 | LL → AA: Abolishes interaction with ESR1. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 57727 |
OpenTargetsi | ENSG00000124160 |
PharmGKBi | PA31474 |
Miscellaneous databases
Pharosi | Q9HCD5, Tbio |
Chemistry databases
DrugBanki | DB07702, 17alpha-Estriol |
Genetic variation databases
BioMutai | NCOA5 |
DMDMi | 28380083 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094411 | 1 – 579 | Nuclear receptor coactivator 5Add BLAST | 579 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 3 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 9 | PhosphoserineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Modified residuei | 34 | PhosphoserineCombined sources | 1 | |
Modified residuei | 96 | PhosphoserineCombined sources | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Modified residuei | 126 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 151 | PhosphoserineCombined sources | 1 | |
Modified residuei | 274 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 378 | PhosphoserineCombined sources | 1 | |
Modified residuei | 379 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 381 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9HCD5 |
jPOSTi | Q9HCD5 |
MassIVEi | Q9HCD5 |
MaxQBi | Q9HCD5 |
PaxDbi | Q9HCD5 |
PeptideAtlasi | Q9HCD5 |
PRIDEi | Q9HCD5 |
ProteomicsDBi | 81676 |
PTM databases
GlyGeni | Q9HCD5, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q9HCD5 |
MetOSitei | Q9HCD5 |
PhosphoSitePlusi | Q9HCD5 |
Expressioni
Tissue specificityi
Widely expressed.
Gene expression databases
Bgeei | ENSG00000124160, Expressed in female gonad and 196 other tissues |
ExpressionAtlasi | Q9HCD5, baseline and differential |
Genevisiblei | Q9HCD5, HS |
Organism-specific databases
HPAi | ENSG00000124160, Low tissue specificity |
Interactioni
Subunit structurei
Binds HTATIP2/TIP30.
Interacts with YLPM1.
Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.
3 PublicationsBinary interactionsi
Q9HCD5
With | #Exp. | IntAct |
---|---|---|
Nr1d2 [Q60674] from Mus musculus. | 2 | EBI-2863498,EBI-5326205 |
Protein-protein interaction databases
BioGRIDi | 121747, 72 interactors |
IntActi | Q9HCD5, 39 interactors |
MINTi | Q9HCD5 |
STRINGi | 9606.ENSP00000290231 |
Miscellaneous databases
RNActi | Q9HCD5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9HCD5 |
SMRi | Q9HCD5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HCD5 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 158 | Transcription repressionAdd BLAST | 158 | |
Regioni | 458 – 579 | Transcription activationAdd BLAST | 122 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 345 – 349 | LXXLL motif | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 150 | Arg/Asp-rich (mixed charge)Add BLAST | 144 |
Domaini
Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.
Phylogenomic databases
eggNOGi | KOG0845, Eukaryota |
GeneTreei | ENSGT00530000064134 |
HOGENOMi | CLU_030807_1_1_1 |
InParanoidi | Q9HCD5 |
OMAi | DMRDHRD |
OrthoDBi | 994112at2759 |
PhylomeDBi | Q9HCD5 |
TreeFami | TF324704 |
Family and domain databases
Gene3Di | 3.40.50.800, 1 hit |
InterProi | View protein in InterPro IPR036621, Anticodon-bd_dom_sf |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9HCD5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTAPSRPSP TRRDPYGFGD SRDSRRDRSP IRGSPRREPR DGRNGRDARD
60 70 80 90 100
SRDIRDPRDL RDHRHSRDLR DHRDSRSVRD VRDVRDLRDF RDLRDSRDFR
110 120 130 140 150
DQRDPMYDRY RDMRDSRDPM YRREGSYDRY LRMDDYCRRK DDSYFDRYRD
160 170 180 190 200
SFDGRGPPGP ESQSRAKERL KREERRREEL YRQYFEEIQR RFDAERPVDC
210 220 230 240 250
SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS
260 270 280 290 300
PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKNE
310 320 330 340 350
CREKEREEIA RQAAKMADEA ILQERERGGP EEGVRGGHPP AIQSLINLLA
360 370 380 390 400
DNRYLTAEET DKIINYLRER KERLMRSSTD SLPGPISRQP LGATSGASLK
410 420 430 440 450
TQPSSQPLQS GQVLPSATPT PSAPPTSQQE LQAKILSLFN SGTVTANSSS
460 470 480 490 500
ASPSVAAGNT PNQNFSTAAN SQPQQRSQAS GNQPPSILGQ GGSAQNMGPR
510 520 530 540 550
PGAPSQGLFG QPSSRLAPAS NMTSQRPVSS TGINFDNPSV QKALDTLIQS
560 570
GPALSHLVSQ TTAQMGQPQA PMGSYQRHY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JY17 | Q5JY17_HUMAN | Nuclear receptor coactivator 5 | NCOA5 | 104 | Annotation score: |
Sequence cautioni
The sequence AAG36793 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053530 | 326 | E → G. Corresponds to variant dbSNP:rs11549557Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230533 mRNA Translation: AAG36793.1 Different initiation. AF470686 mRNA Translation: AAO33457.1 AL035662 Genomic DNA No translation available. AL162458 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75765.1 CH471077 Genomic DNA Translation: EAW75769.1 BC140836 mRNA Translation: AAI40837.1 BC151133 mRNA Translation: AAI51134.1 AB046857 mRNA Translation: BAB13463.1 |
CCDSi | CCDS13392.1 |
RefSeqi | NP_066018.1, NM_020967.2 |
Genome annotation databases
Ensembli | ENST00000290231; ENSP00000290231; ENSG00000124160 |
GeneIDi | 57727 |
KEGGi | hsa:57727 |
UCSCi | uc002xre.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230533 mRNA Translation: AAG36793.1 Different initiation. AF470686 mRNA Translation: AAO33457.1 AL035662 Genomic DNA No translation available. AL162458 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75765.1 CH471077 Genomic DNA Translation: EAW75769.1 BC140836 mRNA Translation: AAI40837.1 BC151133 mRNA Translation: AAI51134.1 AB046857 mRNA Translation: BAB13463.1 |
CCDSi | CCDS13392.1 |
RefSeqi | NP_066018.1, NM_020967.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1V95 | NMR | - | A | 197-313 | [»] | |
2J7X | X-ray | 2.10 | B | 338-354 | [»] | |
2J7Y | X-ray | 1.80 | B | 338-354 | [»] | |
4ZI1 | X-ray | 2.10 | B | 341-352 | [»] | |
BMRBi | Q9HCD5 | |||||
SMRi | Q9HCD5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121747, 72 interactors |
IntActi | Q9HCD5, 39 interactors |
MINTi | Q9HCD5 |
STRINGi | 9606.ENSP00000290231 |
Chemistry databases
DrugBanki | DB07702, 17alpha-Estriol |
PTM databases
GlyGeni | Q9HCD5, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q9HCD5 |
MetOSitei | Q9HCD5 |
PhosphoSitePlusi | Q9HCD5 |
Genetic variation databases
BioMutai | NCOA5 |
DMDMi | 28380083 |
Proteomic databases
EPDi | Q9HCD5 |
jPOSTi | Q9HCD5 |
MassIVEi | Q9HCD5 |
MaxQBi | Q9HCD5 |
PaxDbi | Q9HCD5 |
PeptideAtlasi | Q9HCD5 |
PRIDEi | Q9HCD5 |
ProteomicsDBi | 81676 |
Protocols and materials databases
Antibodypediai | 27960, 125 antibodies |
Genome annotation databases
Ensembli | ENST00000290231; ENSP00000290231; ENSG00000124160 |
GeneIDi | 57727 |
KEGGi | hsa:57727 |
UCSCi | uc002xre.4, human |
Organism-specific databases
CTDi | 57727 |
DisGeNETi | 57727 |
GeneCardsi | NCOA5 |
HGNCi | HGNC:15909, NCOA5 |
HPAi | ENSG00000124160, Low tissue specificity |
neXtProti | NX_Q9HCD5 |
OpenTargetsi | ENSG00000124160 |
PharmGKBi | PA31474 |
VEuPathDBi | HostDB:ENSG00000124160.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0845, Eukaryota |
GeneTreei | ENSGT00530000064134 |
HOGENOMi | CLU_030807_1_1_1 |
InParanoidi | Q9HCD5 |
OMAi | DMRDHRD |
OrthoDBi | 994112at2759 |
PhylomeDBi | Q9HCD5 |
TreeFami | TF324704 |
Enzyme and pathway databases
PathwayCommonsi | Q9HCD5 |
Miscellaneous databases
BioGRID-ORCSi | 57727, 40 hits in 879 CRISPR screens |
ChiTaRSi | NCOA5, human |
EvolutionaryTracei | Q9HCD5 |
GeneWikii | NCOA5 |
GenomeRNAii | 57727 |
Pharosi | Q9HCD5, Tbio |
PROi | PR:Q9HCD5 |
RNActi | Q9HCD5, protein |
Gene expression databases
Bgeei | ENSG00000124160, Expressed in female gonad and 196 other tissues |
ExpressionAtlasi | Q9HCD5, baseline and differential |
Genevisiblei | Q9HCD5, HS |
Family and domain databases
Gene3Di | 3.40.50.800, 1 hit |
InterProi | View protein in InterPro IPR036621, Anticodon-bd_dom_sf |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOA5_HUMAN | |
Accessioni | Q9HCD5Primary (citable) accession number: Q9HCD5 Secondary accession number(s): B2RTV9 Q9H4Y9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | February 12, 2003 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references