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Protein

Transcription factor HES-4

Gene

HES4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-4
Short name:
hHES4
Alternative name(s):
Class B basic helix-loop-helix protein 42
Short name:
bHLHb42
Hairy and enhancer of split 4
bHLH factor Hes4
Gene namesi
Name:HES4
Synonyms:BHLHB42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188290.10
HGNCiHGNC:24149 HES4
MIMi608060 gene
neXtProtiNX_Q9HCC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57801
OpenTargetsiENSG00000188290
PharmGKBiPA134975318

Polymorphism and mutation databases

BioMutaiHES4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272111 – 221Transcription factor HES-4Add BLAST221

Proteomic databases

EPDiQ9HCC6
PeptideAtlasiQ9HCC6
PRIDEiQ9HCC6
ProteomicsDBi81667

2D gel databases

UCD-2DPAGEiQ9HCC6

PTM databases

iPTMnetiQ9HCC6
PhosphoSitePlusiQ9HCC6

Expressioni

Gene expression databases

BgeeiENSG00000188290 Expressed in 182 organ(s), highest expression level in heart left ventricle
CleanExiHS_HES4
ExpressionAtlasiQ9HCC6 baseline and differential
GenevisibleiQ9HCC6 HS

Organism-specific databases

HPAiHPA062465

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121772, 7 interactors
IntActiQ9HCC6, 10 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9HCC6
SMRiQ9HCC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 91bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini110 – 143OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi216 – 219WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 218Pro-richAdd BLAST67

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).By similarity
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiQ9HCC6
KOiK09089
PhylomeDBiQ9HCC6

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9HCC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKSSKP VMEKRRRARI
60 70 80 90 100
NESLAQLKTL ILDALRKESS RHSKLEKADI LEMTVRHLRS LRRVQVTAAL
110 120 130 140 150
SADPAVLGKY RAGFHECLAE VNRFLAGCEG VPADVRSRLL GHLAACLRQL
160 170 180 190 200
GPSRRPASLS PAAPAEAPAP EVYAGRPLLP SLGGPFPLLA PPLLPGLTRA
210 220
LPAAPRAGPQ GPGGPWRPWL R
Length:221
Mass (Da):23,523
Last modified:March 1, 2001 - v1
Checksum:iADFAE485C36EEBC4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PB28E9PB28_HUMAN
Transcription factor HES-4
HES4
247Annotation score:
D6REB3D6REB3_HUMAN
Transcription factor HES-4
HES4
189Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048791 mRNA Translation: BAB13510.1
AL645608 Genomic DNA No translation available.
BC012351 mRNA Translation: AAH12351.1
CCDSiCCDS5.1
RefSeqiNP_001135939.1, NM_001142467.1
NP_066993.1, NM_021170.3
UniGeneiHs.154029

Genome annotation databases

EnsembliENST00000304952; ENSP00000304595; ENSG00000188290
GeneIDi57801
KEGGihsa:57801
UCSCiuc001aci.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048791 mRNA Translation: BAB13510.1
AL645608 Genomic DNA No translation available.
BC012351 mRNA Translation: AAH12351.1
CCDSiCCDS5.1
RefSeqiNP_001135939.1, NM_001142467.1
NP_066993.1, NM_021170.3
UniGeneiHs.154029

3D structure databases

ProteinModelPortaliQ9HCC6
SMRiQ9HCC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121772, 7 interactors
IntActiQ9HCC6, 10 interactors

PTM databases

iPTMnetiQ9HCC6
PhosphoSitePlusiQ9HCC6

Polymorphism and mutation databases

BioMutaiHES4

2D gel databases

UCD-2DPAGEiQ9HCC6

Proteomic databases

EPDiQ9HCC6
PeptideAtlasiQ9HCC6
PRIDEiQ9HCC6
ProteomicsDBi81667

Protocols and materials databases

DNASUi57801
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304952; ENSP00000304595; ENSG00000188290
GeneIDi57801
KEGGihsa:57801
UCSCiuc001aci.3 human

Organism-specific databases

CTDi57801
DisGeNETi57801
EuPathDBiHostDB:ENSG00000188290.10
GeneCardsiHES4
HGNCiHGNC:24149 HES4
HPAiHPA062465
MIMi608060 gene
neXtProtiNX_Q9HCC6
OpenTargetsiENSG00000188290
PharmGKBiPA134975318
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiQ9HCC6
KOiK09089
PhylomeDBiQ9HCC6

Miscellaneous databases

GenomeRNAii57801
PROiPR:Q9HCC6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188290 Expressed in 182 organ(s), highest expression level in heart left ventricle
CleanExiHS_HES4
ExpressionAtlasiQ9HCC6 baseline and differential
GenevisibleiQ9HCC6 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHES4_HUMAN
AccessioniPrimary (citable) accession number: Q9HCC6
Secondary accession number(s): Q5SVA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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