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Protein

Spondin-1

Gene

SPON1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi325CalciumCombined sources1 Publication1
Metal bindingi354CalciumCombined sources1 Publication1
Metal bindingi358Calcium; via carbonyl oxygenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandMetal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spondin-1
Alternative name(s):
F-spondin
Vascular smooth muscle cell growth-promoting factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPON1
Synonyms:KIAA0762, VSGP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000262655.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11252 SPON1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604989 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCB6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10418

Open Targets

More...
OpenTargetsi
ENSG00000262655

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36082

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPON1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52783472

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003586529 – 807Spondin-1Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 128Combined sources2 Publications
Disulfide bondi156 ↔ 182Combined sources2 Publications
Disulfide bondi199 ↔ 336Combined sources1 Publication
Disulfide bondi200 ↔ 340Combined sources1 Publication
Disulfide bondi202 ↔ 415Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi214N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi443 ↔ 480PROSITE-ProRule annotation
Glycosylationi448C-linked (Man) tryptophan1 Publication1
Glycosylationi451C-linked (Man) tryptophan; partial1 Publication1
Disulfide bondi454 ↔ 489PROSITE-ProRule annotation
Disulfide bondi459 ↔ 494PROSITE-ProRule annotation
Disulfide bondi502 ↔ 538PROSITE-ProRule annotation
Glycosylationi507C-linked (Man) tryptophan1 Publication1
Glycosylationi510C-linked (Man) tryptophan; partial1 Publication1
Disulfide bondi513 ↔ 517PROSITE-ProRule annotation
Disulfide bondi548 ↔ 554PROSITE-ProRule annotation
Disulfide bondi559 ↔ 595PROSITE-ProRule annotation
Glycosylationi564C-linked (Man) tryptophan1 Publication1
Disulfide bondi570 ↔ 574PROSITE-ProRule annotation
Disulfide bondi605 ↔ 610PROSITE-ProRule annotation
Disulfide bondi615 ↔ 650PROSITE-ProRule annotation
Glycosylationi620C-linked (Man) tryptophan; partial1 Publication1
Glycosylationi623C-linked (Man) tryptophan1 Publication1
Disulfide bondi626 ↔ 630PROSITE-ProRule annotation
Disulfide bondi660 ↔ 665PROSITE-ProRule annotation
Glycosylationi674C-linked (Man) tryptophan1 Publication1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HCB6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HCB6

PeptideAtlas

More...
PeptideAtlasi
Q9HCB6

PRoteomics IDEntifications database

More...
PRIDEi
Q9HCB6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81664

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1768

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000262655 Expressed in 225 organ(s), highest expression level in female reproductive system

CleanEx database of gene expression profiles

More...
CleanExi
HS_SPON1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCB6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038584
HPA077546

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPP05067-43EBI-2431846,EBI-302641

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115687, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HCB6, 7 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1807
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZOTX-ray2.70A/B/C/D29-198[»]
2ZOUX-ray1.45A/B40-186[»]
3COOX-ray2.00A/B29-194[»]
3Q13X-ray1.95A191-434[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HCB6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HCB6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9HCB6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 194ReelinPROSITE-ProRule annotationAdd BLAST166
Domaini195 – 388SpondinPROSITE-ProRule annotationAdd BLAST194
Domaini442 – 495TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini501 – 555TSP type-1 2PROSITE-ProRule annotationAdd BLAST55
Domaini558 – 611TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini614 – 666TSP type-1 4PROSITE-ProRule annotationAdd BLAST53
Domaini668 – 721TSP type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini754 – 806TSP type-1 6PROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154910

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000124667

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052920

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCB6

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRQQSDE

Database of Orthologous Groups

More...
OrthoDBi
517669at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCB6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544 Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 6 hits
2.60.40.2130, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002861 Reeler_dom
IPR009465 Spondin_N
IPR038678 Spondin_N_sf
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02014 Reeler, 1 hit
PF06468 Spond_N, 1 hit
PF00090 TSP_1, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209 TSP1, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51019 REELIN, 1 hit
PS51020 SPONDIN, 1 hit
PS50092 TSP1, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSPAPLKL SRTPALLALA LPLAAALAFS DETLDKVPKS EGYCSRILRA
60 70 80 90 100
QGTRREGYTE FSLRVEGDPD FYKPGTSYRV TLSAAPPSYF RGFTLIALRE
110 120 130 140 150
NREGDKEEDH AGTFQIIDEE ETQFMSNCPV AVTESTPRRR TRIQVFWIAP
160 170 180 190 200
PAGTGCVILK ASIVQKRIIY FQDEGSLTKK LCEQDSTFDG VTDKPILDCC
210 220 230 240 250
ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS KNYVLWEYGG
260 270 280 290 300
YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP AWQPLNVRAA
310 320 330 340 350
PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL
360 370 380 390 400
IPWDAGTDSG VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV
410 420 430 440 450
ARVVIERIAR KGEQCNIVPD NVDDIVADLA PEEKDEDDTP ETCIYSNWSP
460 470 480 490 500
WSACSSSTCD KGKRMRQRML KAQLDLSVPC PDTQDFQPCM GPGCSDEDGS
510 520 530 540 550
TCTMSEWITW SPCSISCGMG MRSRERYVKQ FPEDGSVCTL PTEETEKCTV
560 570 580 590 600
NEECSPSSCL MTEWGEWDEC SATCGMGMKK RHRMIKMNPA DGSMCKAETS
610 620 630 640 650
QAEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC
660 670 680 690 700
NEDLEQVEKC MLPECPIDCE LTEWSQWSEC NKSCGKGHVI RTRMIQMEPQ
710 720 730 740 750
FGGAPCPETV QRKKCRIRKC LRNPSIQKLR WREARESRRS EQLKEESEGE
760 770 780 790 800
QFPGCRMRPW TAWSECTKLC GGGIQERYMT VKKRFKSSQF TSCKDKKEIR

ACNVHPC
Length:807
Mass (Da):90,973
Last modified:September 27, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEA84A83F206A5A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti500S → P in BAC11217 (PubMed:14702039).Curated1
Sequence conflicti545T → M in BAB18461 (PubMed:11368520).Curated1
Sequence conflicti570C → Y in BAC11217 (PubMed:14702039).Curated1
Sequence conflicti605C → R in BAC11217 (PubMed:14702039).Curated1
Sequence conflicti695I → T in AAH19825 (PubMed:15489334).Curated1
Sequence conflicti729L → P in BAB18461 (PubMed:11368520).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB051390 mRNA Translation: BAB18461.1
AK074803 mRNA Translation: BAC11217.1
AK291780 mRNA Translation: BAF84469.1
CH471064 Genomic DNA Translation: EAW68488.1
CH471064 Genomic DNA Translation: EAW68489.1
BC019825 mRNA Translation: AAH19825.1
BC136513 mRNA Translation: AAI36514.1
BC136563 mRNA Translation: AAI36564.1
AB018305 mRNA Translation: BAA34482.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73262.1

NCBI Reference Sequences

More...
RefSeqi
NP_006099.2, NM_006108.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.643864

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000576479; ENSP00000460236; ENSG00000262655

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10418

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10418

UCSC genome browser

More...
UCSCi
uc031xfv.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051390 mRNA Translation: BAB18461.1
AK074803 mRNA Translation: BAC11217.1
AK291780 mRNA Translation: BAF84469.1
CH471064 Genomic DNA Translation: EAW68488.1
CH471064 Genomic DNA Translation: EAW68489.1
BC019825 mRNA Translation: AAH19825.1
BC136513 mRNA Translation: AAI36514.1
BC136563 mRNA Translation: AAI36564.1
AB018305 mRNA Translation: BAA34482.2
CCDSiCCDS73262.1
RefSeqiNP_006099.2, NM_006108.3
UniGeneiHs.643864

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZOTX-ray2.70A/B/C/D29-198[»]
2ZOUX-ray1.45A/B40-186[»]
3COOX-ray2.00A/B29-194[»]
3Q13X-ray1.95A191-434[»]
ProteinModelPortaliQ9HCB6
SMRiQ9HCB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115687, 15 interactors
IntActiQ9HCB6, 7 interactors

PTM databases

GlyConnecti1768
iPTMnetiQ9HCB6
PhosphoSitePlusiQ9HCB6

Polymorphism and mutation databases

BioMutaiSPON1
DMDMi52783472

Proteomic databases

EPDiQ9HCB6
jPOSTiQ9HCB6
PeptideAtlasiQ9HCB6
PRIDEiQ9HCB6
ProteomicsDBi81664

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000576479; ENSP00000460236; ENSG00000262655
GeneIDi10418
KEGGihsa:10418
UCSCiuc031xfv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10418
DisGeNETi10418
EuPathDBiHostDB:ENSG00000262655.3

GeneCards: human genes, protein and diseases

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GeneCardsi
SPON1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0009464
HGNCiHGNC:11252 SPON1
HPAiHPA038584
HPA077546
MIMi604989 gene
neXtProtiNX_Q9HCB6
OpenTargetsiENSG00000262655
PharmGKBiPA36082

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000154910
HOGENOMiHOG000124667
HOVERGENiHBG052920
InParanoidiQ9HCB6
OMAiIRQQSDE
OrthoDBi517669at2759
PhylomeDBiQ9HCB6

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPON1 human
EvolutionaryTraceiQ9HCB6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Spondin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10418

Protein Ontology

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PROi
PR:Q9HCB6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000262655 Expressed in 225 organ(s), highest expression level in female reproductive system
CleanExiHS_SPON1
GenevisibleiQ9HCB6 HS

Family and domain databases

CDDicd08544 Reeler, 1 hit
Gene3Di2.20.100.10, 6 hits
2.60.40.2130, 2 hits
InterProiView protein in InterPro
IPR002861 Reeler_dom
IPR009465 Spondin_N
IPR038678 Spondin_N_sf
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF02014 Reeler, 1 hit
PF06468 Spond_N, 1 hit
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS51019 REELIN, 1 hit
PS51020 SPONDIN, 1 hit
PS50092 TSP1, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPON1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCB6
Secondary accession number(s): A8K6W5
, O94862, Q8NCD7, Q8WUR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: January 16, 2019
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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