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Protein

Calpain-10

Gene

CAPN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1
Active sitei238By similarity1
Active sitei263By similarity1

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: BHF-UCL
  • cytoskeletal protein binding Source: BHF-UCL
  • SNARE binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B30 2681
ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
SIGNORiQ9HC96

Protein family/group databases

MEROPSiC02.018

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-10 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 10
Short name:
CANP 10
Gene namesi
Name:CAPN10
Synonyms:KIAA1845
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000142330.19
HGNCiHGNC:1477 CAPN10
MIMi605286 gene
neXtProtiNX_Q9HC96

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:601283

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNETi11132
MalaCardsiCAPN10
MIMi601283 phenotype
OpenTargetsiENSG00000142330
PharmGKBiPA26058

Polymorphism and mutation databases

BioMutaiCAPN10
DMDMi317373329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077251 – 672Calpain-10Add BLAST672

Proteomic databases

PaxDbiQ9HC96
PeptideAtlasiQ9HC96
PRIDEiQ9HC96
ProteomicsDBi81650
81651 [Q9HC96-2]
81652 [Q9HC96-3]
81653 [Q9HC96-4]
81654 [Q9HC96-5]
81655 [Q9HC96-6]
81656 [Q9HC96-7]
81657 [Q9HC96-8]

PTM databases

iPTMnetiQ9HC96
PhosphoSitePlusiQ9HC96

Expressioni

Tissue specificityi

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000142330 Expressed in 152 organ(s), highest expression level in spleen
ExpressionAtlasiQ9HC96 baseline and differential
GenevisibleiQ9HC96 HS

Organism-specific databases

HPAiHPA004170
HPA056098

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116305, 5 interactors
IntActiQ9HC96, 5 interactors
STRINGi9606.ENSP00000375844

Structurei

3D structure databases

ProteinModelPortaliQ9HC96
SMRiQ9HC96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 321Calpain catalyticPROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni322 – 494Domain III 1Add BLAST173
Regioni513 – 654Domain III 2Add BLAST142

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
HOVERGENiHBG050787
InParanoidiQ9HC96
KOiK08579
OMAiYEQLWAG
OrthoDBiEOG091G02O4
PhylomeDBiQ9HC96
TreeFamiTF314748

Family and domain databases

CDDicd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF30 PTHR10183:SF30, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9HC96-1) [UniParc]FASTAAdd to basket
Also known as: CAPN10a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC
60 70 80 90 100
ATPRLFPDDP REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW
110 120 130 140 150
ADQEYRGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL
160 170 180 190 200
LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWNLKGV AGSGGQQDRP
210 220 230 240 250
GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF IVSDLRELQG
260 270 280 290 300
QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE
310 320 330 340 350
FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ
360 370 380 390 400
SAGGCRNNSG FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV
410 420 430 440 450
GDSHTSWSPA SIPGKHYQAV GLHLWKVEKR RVNLPRVLSM PPVAGTACHA
460 470 480 490 500
YDREVHLRCE LSPGYYLAVP STFLKDAPGE FLLRVFSTGR VSLSAIRAVA
510 520 530 540 550
KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT NPCFPFSVPE
560 570 580 590 600
GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL
610 620 630 640 650
LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS
660 670
IHSQEMLGQF LQEVSIMAVM KT
Length:672
Mass (Da):74,952
Last modified:January 11, 2011 - v2
Checksum:i74A48D879E896C71
GO
Isoform B (identifier: Q9HC96-2) [UniParc]FASTAAdd to basket
Also known as: CAPN10b

The sequence of this isoform differs from the canonical sequence as follows:
     494-544: SAIRAVAKNT...FASYPTNPCF → RALAPAASAS...HPHCCCRSRC
     545-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:544
Mass (Da):60,657
Checksum:i17CE7B881A20855E
GO
Isoform C (identifier: Q9HC96-3) [UniParc]FASTAAdd to basket
Also known as: CAPN10c

The sequence of this isoform differs from the canonical sequence as follows:
     428-582: Missing.

Show »
Length:517
Mass (Da):57,999
Checksum:i8D81A0FA44993180
GO
Isoform D (identifier: Q9HC96-4) [UniParc]FASTAAdd to basket
Also known as: CAPN10d

The sequence of this isoform differs from the canonical sequence as follows:
     494-513: SAIRAVAKNTTPGAALPAGE → RSQRVEGARTHPHCCCRSRC
     514-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:513
Mass (Da):57,816
Checksum:iC66DC853F87AEC9C
GO
Isoform E (identifier: Q9HC96-5) [UniParc]FASTAAdd to basket
Also known as: CAPN10e

The sequence of this isoform differs from the canonical sequence as follows:
     427-444: VEKRRVNLPRVLSMPPVA → GVTLGTTLFPVPSWMWPT
     445-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:444
Mass (Da):49,994
Checksum:i32E4706B7D06D58E
GO
Isoform F (identifier: Q9HC96-6) [UniParc]FASTAAdd to basket
Also known as: CAPN10f

The sequence of this isoform differs from the canonical sequence as follows:
     154-274: VYAKVHGSYE...WGRRCWQGLW → GPWVLRAPVG...VLAGALERGG
     275-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:274
Mass (Da):29,453
Checksum:i570C2A6CB9B6B903
GO
Isoform G (identifier: Q9HC96-7) [UniParc]FASTAAdd to basket
Also known as: CAPN10g

The sequence of this isoform differs from the canonical sequence as follows:
     93-139: IPPGQPSWAD...CLAGRLCFSR → SCPVQLPADW...PDSATWGSWK
     140-672: Missing.

Show »
Length:139
Mass (Da):15,583
Checksum:iC934A0FD16963EC6
GO
Isoform H (identifier: Q9HC96-8) [UniParc]FASTAAdd to basket
Also known as: CAPN10h

The sequence of this isoform differs from the canonical sequence as follows:
     48-581: Missing.

Show »
Length:138
Mass (Da):15,275
Checksum:i28589100F645B66B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WPF5B7WPF5_HUMAN
Calpain-10
CAPN10
653Annotation score:
H7C2P1H7C2P1_HUMAN
Calpain-10
CAPN10
85Annotation score:
H7C251H7C251_HUMAN
Calpain-10
CAPN10
46Annotation score:

Sequence cautioni

The sequence BAB47474 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195G → S in BAC11220 (PubMed:14702039).Curated1
Sequence conflicti373E → K in AAG17969 (PubMed:11017071).Curated1
Sequence conflicti373E → K in AAG17971 (PubMed:11017071).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014437200P → T1 PublicationCorresponds to variant dbSNP:rs3792268Ensembl.1
Natural variantiVAR_014438202R → H1 PublicationCorresponds to variant dbSNP:rs768407925Ensembl.1
Natural variantiVAR_036049276E → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_014439341A → V1 PublicationCorresponds to variant dbSNP:rs776848131Ensembl.1
Natural variantiVAR_014440504T → A2 PublicationsCorresponds to variant dbSNP:rs7607759Ensembl.1
Natural variantiVAR_014441529A → S1 Publication1
Natural variantiVAR_014442613S → N1 PublicationCorresponds to variant dbSNP:rs146148004Ensembl.1
Natural variantiVAR_014443666I → V4 PublicationsCorresponds to variant dbSNP:rs2975766Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00524348 – 581Missing in isoform H. CuratedAdd BLAST534
Alternative sequenceiVSP_00524193 – 139IPPGQ…LCFSR → SCPVQLPADWTCKVQPVWLE FPCLPISCRLRVSSDTSPDS ATWGSWK in isoform G. CuratedAdd BLAST47
Alternative sequenceiVSP_005242140 – 672Missing in isoform G. CuratedAdd BLAST533
Alternative sequenceiVSP_005239154 – 274VYAKV…WQGLW → GPWVLRAPVGRAGGGCPGGP DRRPGRKMEPEGRSRKRRPA GQARPLGAQDLSAAAPPEGP VSDQLLRAQPQSRCPGAGGV PCLHCLGPAGAPGSGGPVHP AAADPEPLGPAVLAGALERG G in isoform F. CuratedAdd BLAST121
Alternative sequenceiVSP_005240275 – 672Missing in isoform F. CuratedAdd BLAST398
Alternative sequenceiVSP_005237427 – 444VEKRR…MPPVA → GVTLGTTLFPVPSWMWPT in isoform E. CuratedAdd BLAST18
Alternative sequenceiVSP_005234428 – 582Missing in isoform C. CuratedAdd BLAST155
Alternative sequenceiVSP_005238445 – 672Missing in isoform E. CuratedAdd BLAST228
Alternative sequenceiVSP_005232494 – 544SAIRA…TNPCF → RALAPAASASLCISTAGPVT PSSTPSASISSRSQRVEGAR THPHCCCRSRC in isoform B. CuratedAdd BLAST51
Alternative sequenceiVSP_005235494 – 513SAIRA…LPAGE → RSQRVEGARTHPHCCCRSRC in isoform D. CuratedAdd BLAST20
Alternative sequenceiVSP_005236514 – 672Missing in isoform D. CuratedAdd BLAST159
Alternative sequenceiVSP_005233545 – 672Missing in isoform B. CuratedAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089088 mRNA Translation: AAG17966.1
AF089090 mRNA Translation: AAG17968.1
AF089091 mRNA Translation: AAG17969.1
AF089092 mRNA Translation: AAG17970.1
AF089093 mRNA Translation: AAG17971.1
AF089094 mRNA Translation: AAG17972.1
AF089095 mRNA Translation: AAG17973.1
AF089096 mRNA Translation: AAG17974.1
AB058748 mRNA Translation: BAB47474.1 Different initiation.
AK074807 mRNA Translation: BAC11220.1
AC124862 Genomic DNA Translation: AAX88944.1
BC004260 mRNA Translation: AAH04260.1
BC007553 mRNA Translation: AAH07553.2
CCDSiCCDS33420.1 [Q9HC96-3]
CCDS42838.1 [Q9HC96-1]
RefSeqiNP_075571.1, NM_023083.3
NP_075573.2, NM_023085.3
UniGeneiHs.728234

Genome annotation databases

EnsembliENST00000270361; ENSP00000270361; ENSG00000142330 [Q9HC96-6]
ENST00000270364; ENSP00000270364; ENSG00000142330 [Q9HC96-7]
ENST00000352879; ENSP00000289381; ENSG00000142330 [Q9HC96-8]
ENST00000354082; ENSP00000270362; ENSG00000142330 [Q9HC96-3]
ENST00000357048; ENSP00000349556; ENSG00000142330 [Q9HC96-4]
ENST00000391983; ENSP00000375843; ENSG00000142330 [Q9HC96-2]
ENST00000391984; ENSP00000375844; ENSG00000142330 [Q9HC96-1]
ENST00000416591; ENSP00000400144; ENSG00000142330 [Q9HC96-5]
GeneIDi11132
KEGGihsa:11132
UCSCiuc002vzk.2 human [Q9HC96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089088 mRNA Translation: AAG17966.1
AF089090 mRNA Translation: AAG17968.1
AF089091 mRNA Translation: AAG17969.1
AF089092 mRNA Translation: AAG17970.1
AF089093 mRNA Translation: AAG17971.1
AF089094 mRNA Translation: AAG17972.1
AF089095 mRNA Translation: AAG17973.1
AF089096 mRNA Translation: AAG17974.1
AB058748 mRNA Translation: BAB47474.1 Different initiation.
AK074807 mRNA Translation: BAC11220.1
AC124862 Genomic DNA Translation: AAX88944.1
BC004260 mRNA Translation: AAH04260.1
BC007553 mRNA Translation: AAH07553.2
CCDSiCCDS33420.1 [Q9HC96-3]
CCDS42838.1 [Q9HC96-1]
RefSeqiNP_075571.1, NM_023083.3
NP_075573.2, NM_023085.3
UniGeneiHs.728234

3D structure databases

ProteinModelPortaliQ9HC96
SMRiQ9HC96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116305, 5 interactors
IntActiQ9HC96, 5 interactors
STRINGi9606.ENSP00000375844

Protein family/group databases

MEROPSiC02.018

PTM databases

iPTMnetiQ9HC96
PhosphoSitePlusiQ9HC96

Polymorphism and mutation databases

BioMutaiCAPN10
DMDMi317373329

Proteomic databases

PaxDbiQ9HC96
PeptideAtlasiQ9HC96
PRIDEiQ9HC96
ProteomicsDBi81650
81651 [Q9HC96-2]
81652 [Q9HC96-3]
81653 [Q9HC96-4]
81654 [Q9HC96-5]
81655 [Q9HC96-6]
81656 [Q9HC96-7]
81657 [Q9HC96-8]

Protocols and materials databases

DNASUi11132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270361; ENSP00000270361; ENSG00000142330 [Q9HC96-6]
ENST00000270364; ENSP00000270364; ENSG00000142330 [Q9HC96-7]
ENST00000352879; ENSP00000289381; ENSG00000142330 [Q9HC96-8]
ENST00000354082; ENSP00000270362; ENSG00000142330 [Q9HC96-3]
ENST00000357048; ENSP00000349556; ENSG00000142330 [Q9HC96-4]
ENST00000391983; ENSP00000375843; ENSG00000142330 [Q9HC96-2]
ENST00000391984; ENSP00000375844; ENSG00000142330 [Q9HC96-1]
ENST00000416591; ENSP00000400144; ENSG00000142330 [Q9HC96-5]
GeneIDi11132
KEGGihsa:11132
UCSCiuc002vzk.2 human [Q9HC96-1]

Organism-specific databases

CTDi11132
DisGeNETi11132
EuPathDBiHostDB:ENSG00000142330.19
GeneCardsiCAPN10
HGNCiHGNC:1477 CAPN10
HPAiHPA004170
HPA056098
MalaCardsiCAPN10
MIMi601283 phenotype
605286 gene
neXtProtiNX_Q9HC96
OpenTargetsiENSG00000142330
PharmGKBiPA26058
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
HOVERGENiHBG050787
InParanoidiQ9HC96
KOiK08579
OMAiYEQLWAG
OrthoDBiEOG091G02O4
PhylomeDBiQ9HC96
TreeFamiTF314748

Enzyme and pathway databases

BRENDAi3.4.22.B30 2681
ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
SIGNORiQ9HC96

Miscellaneous databases

ChiTaRSiCAPN10 human
GeneWikiiCAPN10
GenomeRNAii11132
PROiPR:Q9HC96
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142330 Expressed in 152 organ(s), highest expression level in spleen
ExpressionAtlasiQ9HC96 baseline and differential
GenevisibleiQ9HC96 HS

Family and domain databases

CDDicd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF30 PTHR10183:SF30, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAN10_HUMAN
AccessioniPrimary (citable) accession number: Q9HC96
Secondary accession number(s): A8MVS7
, Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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