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Entry version 164 (08 May 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Calpain-10

Gene

CAPN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei73By similarity1
Active sitei238By similarity1
Active sitei263By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.B30 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HC96

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.018

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-10 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 10
Short name:
CANP 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPN10
Synonyms:KIAA1845
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1477 CAPN10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605286 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HC96

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIM

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...
DisGeNETi
11132

MalaCards human disease database

More...
MalaCardsi
CAPN10
MIMi601283 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000142330

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26058

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAPN10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373329

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002077251 – 672Calpain-10Add BLAST672

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HC96

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HC96

PeptideAtlas

More...
PeptideAtlasi
Q9HC96

PRoteomics IDEntifications database

More...
PRIDEi
Q9HC96

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81650
81651 [Q9HC96-2]
81652 [Q9HC96-3]
81653 [Q9HC96-4]
81654 [Q9HC96-5]
81655 [Q9HC96-6]
81656 [Q9HC96-7]
81657 [Q9HC96-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HC96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HC96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142330 Expressed in 152 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HC96 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HC96 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004170
HPA056098

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116305, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HC96, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375844

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HC96

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 321Calpain catalyticPROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni322 – 494Domain III 1Add BLAST173
Regioni513 – 654Domain III 2Add BLAST142

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159706

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HC96

KEGG Orthology (KO)

More...
KOi
K08579

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEQLWAG

Database of Orthologous Groups

More...
OrthoDBi
704215at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HC96

TreeFam database of animal gene trees

More...
TreeFami
TF314748

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat

The PANTHER Classification System

More...
PANTHERi
PTHR10183:SF30 PTHR10183:SF30, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9HC96-1) [UniParc]FASTAAdd to basket
Also known as: CAPN10a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC
60 70 80 90 100
ATPRLFPDDP REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW
110 120 130 140 150
ADQEYRGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL
160 170 180 190 200
LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWNLKGV AGSGGQQDRP
210 220 230 240 250
GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF IVSDLRELQG
260 270 280 290 300
QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE
310 320 330 340 350
FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ
360 370 380 390 400
SAGGCRNNSG FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV
410 420 430 440 450
GDSHTSWSPA SIPGKHYQAV GLHLWKVEKR RVNLPRVLSM PPVAGTACHA
460 470 480 490 500
YDREVHLRCE LSPGYYLAVP STFLKDAPGE FLLRVFSTGR VSLSAIRAVA
510 520 530 540 550
KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT NPCFPFSVPE
560 570 580 590 600
GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL
610 620 630 640 650
LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS
660 670
IHSQEMLGQF LQEVSIMAVM KT
Length:672
Mass (Da):74,952
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74A48D879E896C71
GO
Isoform B (identifier: Q9HC96-2) [UniParc]FASTAAdd to basket
Also known as: CAPN10b

The sequence of this isoform differs from the canonical sequence as follows:
     494-544: SAIRAVAKNT...FASYPTNPCF → RALAPAASAS...HPHCCCRSRC
     545-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:544
Mass (Da):60,657
Checksum:i17CE7B881A20855E
GO
Isoform C (identifier: Q9HC96-3) [UniParc]FASTAAdd to basket
Also known as: CAPN10c

The sequence of this isoform differs from the canonical sequence as follows:
     428-582: Missing.

Show »
Length:517
Mass (Da):57,999
Checksum:i8D81A0FA44993180
GO
Isoform D (identifier: Q9HC96-4) [UniParc]FASTAAdd to basket
Also known as: CAPN10d

The sequence of this isoform differs from the canonical sequence as follows:
     494-513: SAIRAVAKNTTPGAALPAGE → RSQRVEGARTHPHCCCRSRC
     514-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:513
Mass (Da):57,816
Checksum:iC66DC853F87AEC9C
GO
Isoform E (identifier: Q9HC96-5) [UniParc]FASTAAdd to basket
Also known as: CAPN10e

The sequence of this isoform differs from the canonical sequence as follows:
     427-444: VEKRRVNLPRVLSMPPVA → GVTLGTTLFPVPSWMWPT
     445-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:444
Mass (Da):49,994
Checksum:i32E4706B7D06D58E
GO
Isoform F (identifier: Q9HC96-6) [UniParc]FASTAAdd to basket
Also known as: CAPN10f

The sequence of this isoform differs from the canonical sequence as follows:
     154-274: VYAKVHGSYE...WGRRCWQGLW → GPWVLRAPVG...VLAGALERGG
     275-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:274
Mass (Da):29,453
Checksum:i570C2A6CB9B6B903
GO
Isoform G (identifier: Q9HC96-7) [UniParc]FASTAAdd to basket
Also known as: CAPN10g

The sequence of this isoform differs from the canonical sequence as follows:
     93-139: IPPGQPSWAD...CLAGRLCFSR → SCPVQLPADW...PDSATWGSWK
     140-672: Missing.

Show »
Length:139
Mass (Da):15,583
Checksum:iC934A0FD16963EC6
GO
Isoform H (identifier: Q9HC96-8) [UniParc]FASTAAdd to basket
Also known as: CAPN10h

The sequence of this isoform differs from the canonical sequence as follows:
     48-581: Missing.

Show »
Length:138
Mass (Da):15,275
Checksum:i28589100F645B66B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WPF5B7WPF5_HUMAN
Calpain-10
CAPN10
653Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2P1H7C2P1_HUMAN
Calpain-10
CAPN10
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C251H7C251_HUMAN
Calpain-10
CAPN10
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47474 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195G → S in BAC11220 (PubMed:14702039).Curated1
Sequence conflicti373E → K in AAG17969 (PubMed:11017071).Curated1
Sequence conflicti373E → K in AAG17971 (PubMed:11017071).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014437200P → T1 PublicationCorresponds to variant dbSNP:rs3792268Ensembl.1
Natural variantiVAR_014438202R → H1 PublicationCorresponds to variant dbSNP:rs768407925Ensembl.1
Natural variantiVAR_036049276E → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_014439341A → V1 PublicationCorresponds to variant dbSNP:rs776848131Ensembl.1
Natural variantiVAR_014440504T → A2 PublicationsCorresponds to variant dbSNP:rs7607759Ensembl.1
Natural variantiVAR_014441529A → S1 Publication1
Natural variantiVAR_014442613S → N1 PublicationCorresponds to variant dbSNP:rs146148004Ensembl.1
Natural variantiVAR_014443666I → V4 PublicationsCorresponds to variant dbSNP:rs2975766Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00524348 – 581Missing in isoform H. CuratedAdd BLAST534
Alternative sequenceiVSP_00524193 – 139IPPGQ…LCFSR → SCPVQLPADWTCKVQPVWLE FPCLPISCRLRVSSDTSPDS ATWGSWK in isoform G. CuratedAdd BLAST47
Alternative sequenceiVSP_005242140 – 672Missing in isoform G. CuratedAdd BLAST533
Alternative sequenceiVSP_005239154 – 274VYAKV…WQGLW → GPWVLRAPVGRAGGGCPGGP DRRPGRKMEPEGRSRKRRPA GQARPLGAQDLSAAAPPEGP VSDQLLRAQPQSRCPGAGGV PCLHCLGPAGAPGSGGPVHP AAADPEPLGPAVLAGALERG G in isoform F. CuratedAdd BLAST121
Alternative sequenceiVSP_005240275 – 672Missing in isoform F. CuratedAdd BLAST398
Alternative sequenceiVSP_005237427 – 444VEKRR…MPPVA → GVTLGTTLFPVPSWMWPT in isoform E. CuratedAdd BLAST18
Alternative sequenceiVSP_005234428 – 582Missing in isoform C. CuratedAdd BLAST155
Alternative sequenceiVSP_005238445 – 672Missing in isoform E. CuratedAdd BLAST228
Alternative sequenceiVSP_005232494 – 544SAIRA…TNPCF → RALAPAASASLCISTAGPVT PSSTPSASISSRSQRVEGAR THPHCCCRSRC in isoform B. CuratedAdd BLAST51
Alternative sequenceiVSP_005235494 – 513SAIRA…LPAGE → RSQRVEGARTHPHCCCRSRC in isoform D. CuratedAdd BLAST20
Alternative sequenceiVSP_005236514 – 672Missing in isoform D. CuratedAdd BLAST159
Alternative sequenceiVSP_005233545 – 672Missing in isoform B. CuratedAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF089088 mRNA Translation: AAG17966.1
AF089090 mRNA Translation: AAG17968.1
AF089091 mRNA Translation: AAG17969.1
AF089092 mRNA Translation: AAG17970.1
AF089093 mRNA Translation: AAG17971.1
AF089094 mRNA Translation: AAG17972.1
AF089095 mRNA Translation: AAG17973.1
AF089096 mRNA Translation: AAG17974.1
AB058748 mRNA Translation: BAB47474.1 Different initiation.
AK074807 mRNA Translation: BAC11220.1
AC124862 Genomic DNA Translation: AAX88944.1
BC004260 mRNA Translation: AAH04260.1
BC007553 mRNA Translation: AAH07553.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS33420.1 [Q9HC96-3]
CCDS42838.1 [Q9HC96-1]

NCBI Reference Sequences

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RefSeqi
NP_075571.1, NM_023083.3 [Q9HC96-1]
NP_075573.2, NM_023085.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000270361; ENSP00000270361; ENSG00000142330 [Q9HC96-6]
ENST00000270364; ENSP00000270364; ENSG00000142330 [Q9HC96-7]
ENST00000352879; ENSP00000289381; ENSG00000142330 [Q9HC96-8]
ENST00000354082; ENSP00000270362; ENSG00000142330 [Q9HC96-3]
ENST00000357048; ENSP00000349556; ENSG00000142330 [Q9HC96-4]
ENST00000391983; ENSP00000375843; ENSG00000142330 [Q9HC96-2]
ENST00000391984; ENSP00000375844; ENSG00000142330 [Q9HC96-1]
ENST00000416591; ENSP00000400144; ENSG00000142330 [Q9HC96-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11132

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11132

UCSC genome browser

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UCSCi
uc002vzk.2 human [Q9HC96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089088 mRNA Translation: AAG17966.1
AF089090 mRNA Translation: AAG17968.1
AF089091 mRNA Translation: AAG17969.1
AF089092 mRNA Translation: AAG17970.1
AF089093 mRNA Translation: AAG17971.1
AF089094 mRNA Translation: AAG17972.1
AF089095 mRNA Translation: AAG17973.1
AF089096 mRNA Translation: AAG17974.1
AB058748 mRNA Translation: BAB47474.1 Different initiation.
AK074807 mRNA Translation: BAC11220.1
AC124862 Genomic DNA Translation: AAX88944.1
BC004260 mRNA Translation: AAH04260.1
BC007553 mRNA Translation: AAH07553.2
CCDSiCCDS33420.1 [Q9HC96-3]
CCDS42838.1 [Q9HC96-1]
RefSeqiNP_075571.1, NM_023083.3 [Q9HC96-1]
NP_075573.2, NM_023085.3

3D structure databases

SMRiQ9HC96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116305, 5 interactors
IntActiQ9HC96, 5 interactors
STRINGi9606.ENSP00000375844

Protein family/group databases

MEROPSiC02.018

PTM databases

iPTMnetiQ9HC96
PhosphoSitePlusiQ9HC96

Polymorphism and mutation databases

BioMutaiCAPN10
DMDMi317373329

Proteomic databases

jPOSTiQ9HC96
PaxDbiQ9HC96
PeptideAtlasiQ9HC96
PRIDEiQ9HC96
ProteomicsDBi81650
81651 [Q9HC96-2]
81652 [Q9HC96-3]
81653 [Q9HC96-4]
81654 [Q9HC96-5]
81655 [Q9HC96-6]
81656 [Q9HC96-7]
81657 [Q9HC96-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270361; ENSP00000270361; ENSG00000142330 [Q9HC96-6]
ENST00000270364; ENSP00000270364; ENSG00000142330 [Q9HC96-7]
ENST00000352879; ENSP00000289381; ENSG00000142330 [Q9HC96-8]
ENST00000354082; ENSP00000270362; ENSG00000142330 [Q9HC96-3]
ENST00000357048; ENSP00000349556; ENSG00000142330 [Q9HC96-4]
ENST00000391983; ENSP00000375843; ENSG00000142330 [Q9HC96-2]
ENST00000391984; ENSP00000375844; ENSG00000142330 [Q9HC96-1]
ENST00000416591; ENSP00000400144; ENSG00000142330 [Q9HC96-5]
GeneIDi11132
KEGGihsa:11132
UCSCiuc002vzk.2 human [Q9HC96-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11132
DisGeNETi11132

GeneCards: human genes, protein and diseases

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GeneCardsi
CAPN10
HGNCiHGNC:1477 CAPN10
HPAiHPA004170
HPA056098
MalaCardsiCAPN10
MIMi601283 phenotype
605286 gene
neXtProtiNX_Q9HC96
OpenTargetsiENSG00000142330
PharmGKBiPA26058

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00940000159706
InParanoidiQ9HC96
KOiK08579
OMAiYEQLWAG
OrthoDBi704215at2759
PhylomeDBiQ9HC96
TreeFamiTF314748

Enzyme and pathway databases

BRENDAi3.4.22.B30 2681
ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
SIGNORiQ9HC96

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CAPN10 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CAPN10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11132

Protein Ontology

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PROi
PR:Q9HC96

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142330 Expressed in 152 organ(s), highest expression level in spleen
ExpressionAtlasiQ9HC96 baseline and differential
GenevisibleiQ9HC96 HS

Family and domain databases

CDDicd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF30 PTHR10183:SF30, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAN10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC96
Secondary accession number(s): A8MVS7
, Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 11, 2011
Last modified: May 8, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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