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Protein

Mucin-5B

Gene

MUC5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I08.953

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-5B
Short name:
MUC-5B
Alternative name(s):
Cervical mucin
High molecular weight salivary mucin MG1
Mucin-5 subtype B, tracheobronchial
Sublingual gland mucin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC5B
Synonyms:MUC5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117983.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7516 MUC5B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600770 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HC84

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pulmonary fibrosis, idiopathic (IPF)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).1 Publication
Disease descriptionA lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.
See also OMIM:178500

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1790W → A: Poorly secreted. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
727897

MalaCards human disease database

More...
MalaCardsi
MUC5B
MIMi178500 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000117983

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
171700 Diffuse panbronchiolitis
2032 Idiopathic pulmonary fibrosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31321

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MUC5B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153579

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001928326 – 5762Mucin-5BAdd BLAST5737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi? ↔ 5741By similarity
Disulfide bondi99 ↔ 107By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi145N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi254N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi447 ↔ 455By similarity
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi805N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi929N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1340C-linked (Man) tryptophanCurated1
Glycosylationi1509C-linked (Man) tryptophanCurated1
Glycosylationi1556N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1774N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1790C-linked (Man) tryptophanCurated1
Glycosylationi2320C-linked (Man) tryptophanCurated1
Glycosylationi2749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2877C-linked (Man) tryptophanCurated1
Glycosylationi3449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3577C-linked (Man) tryptophanCurated1
Glycosylationi4006N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4134C-linked (Man) tryptophanCurated1
Glycosylationi4804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4960N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi5017N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi5024N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi5046N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi5096N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi5111N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi5215N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi5486N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5526N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5612N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5653 ↔ 5705By similarity
Glycosylationi5663N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5672 ↔ 5719By similarity
Glycosylationi5677N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5681 ↔ 5735By similarity
Disulfide bondi5685 ↔ 5737By similarity
Glycosylationi5721N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HC84

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HC84

PeptideAtlas

More...
PeptideAtlasi
Q9HC84

PRoteomics IDEntifications database

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PRIDEi
Q9HC84

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81649

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1520
376

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HC84

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HC84

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q9HC84

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117983 Expressed in 116 organ(s), highest expression level in trachea

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HC84 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HC84 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009396
HPA008246

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
608337, 15 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000436812

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9HC84

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HC84

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 277VWFD 1PROSITE-ProRule annotationAdd BLAST202
Domaini329 – 385TIL 1Add BLAST57
Domaini424 – 638VWFD 2PROSITE-ProRule annotationAdd BLAST215
Domaini695 – 752TIL 2Add BLAST58
Domaini805 – 855TIL 3Add BLAST51
Domaini855 – 927VWFC 1PROSITE-ProRule annotationAdd BLAST73
Domaini894 – 1099VWFD 3PROSITE-ProRule annotationAdd BLAST206
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1333 – 1432Cys-rich subdomain 1Add BLAST100
Repeati1503 – 1604Cys-rich subdomain 2Add BLAST102
Repeati1784 – 1885Cys-rich subdomain 3Add BLAST102
Repeati2313 – 2414Cys-rich subdomain 4Add BLAST102
Repeati2854 – 2886HAT 1Add BLAST33
Repeati2871 – 2971Cys-rich subdomain 5Add BLAST101
Repeati3554 – 3586HAT 2Add BLAST33
Repeati3571 – 3671Cys-rich subdomain 6Add BLAST101
Repeati4111 – 4143HAT 3Add BLAST33
Repeati4128 – 4228Cys-rich subdomain 7Add BLAST101
Domaini5074 – 5305VWFD 4PROSITE-ProRule annotationAdd BLAST232
Domaini5412 – 5484VWFC 2PROSITE-ProRule annotationAdd BLAST73
Domaini5521 – 5587VWFC 3PROSITE-ProRule annotationAdd BLAST67
Domaini5653 – 5742CTCKPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1333 – 42287 X Cys-rich subdomain repeatsAdd BLAST2896
Regioni1890 – 219911 X approximate tandem repeats, Ser/Thr-richAdd BLAST310
Regioni2419 – 275611 X approximate tandem repeats, Ser/Thr-richAdd BLAST338
Regioni2976 – 345617 X approximate tandem repeats, Ser/Thr-richAdd BLAST481
Regioni3676 – 401311 X approximate tandem repeats, Ser/Thr-richAdd BLAST338
Regioni4233 – 487923 X approximate tandem repeats, Ser/Thr-richAdd BLAST647

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1109 – 1261Cys-richAdd BLAST153
Compositional biasi1456 – 1502Thr-richAdd BLAST47
Compositional biasi1608 – 4932Thr-richAdd BLAST3325

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410XNSK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162219

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052535

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HC84

KEGG Orthology (KO)

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KOi
K13908

Identification of Orthologs from Complete Genome Data

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OMAi
STTGFHK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0006

TreeFam database of animal gene trees

More...
TreeFami
TF300299

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR025155 WxxW_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 4 hits
PF13330 Mucin2_WxxW, 7 hits
PF01826 TIL, 2 hits
PF00093 VWC, 1 hit
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00214 VWC, 5 hits
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9HC84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT
60 70 80 90 100
RRVSFVPPVT VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN
110 120 130 140 150
YVFSEHCRAA YEDFNVQLRR GLVGSRPVVT RVVIKAQGLV LEASNGSVLI
160 170 180 190 200
NGQREELPYS RTGLLVEQSG DYIKVSIRLV LTFLWNGEDS ALLELDPKYA
210 220 230 240 250
NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP TEQCPDPLPL
260 270 280 290 300
PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA
310 320 330 340 350
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ
360 370 380 390 400
RAQLCEDHCV DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF
410 420 430 440 450
NTTCSSCTCS GGLWQCQDLP CPGTCSVQGG AHISTYDEKL YDLHGDCSYV
460 470 480 490 500
LSKKCADSSF TVLAELRKCG LTDNENCLKA VTLSLDGGDT AIRVQADGGV
510 520 530 540 550
FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL VPLMQVFVRL
560 570 580 590 600
DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA
610 620 630 640 650
RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF
660 670 680 690 700
DTCNCERSED CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR
710 720 730 740 750
YAYVVDACQP TCRGLSEADV TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ
760 770 780 790 800
ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK LSCLGASLQK STGCAAPMVY
810 820 830 840 850
LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG LVSDGSGGCI
860 870 880 890 900
AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD
910 920 930 940 950
GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT
960 970 980 990 1000
CSKAIKLFVE SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM
1010 1020 1030 1040 1050
AVSWDRKTSV FIRLHQDYKG RVCGLCGNFD DNAINDFATR SRSVVGDALE
1060 1070 1080 1090 1100
FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG PTFAACRSQV
1110 1120 1130 1140 1150
DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG LCVSWRTPDT
1160 1170 1180 1190 1200
CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC
1210 1220 1230 1240 1250
PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI
1260 1270 1280 1290 1300
QCAHSLEACT CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV
1310 1320 1330 1340 1350
ACPGTPATTP FTFTTAWVPH STTSPALPVS TVCVREVCRW SSWYNGHRPE
1360 1370 1380 1390 1400
PGLGGGDFET FENLRQRGYQ VCPVLADIEC RAAQLPDMPL EELGQQVDCD
1410 1420 1430 1440 1450
RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT SPQPSLSAST
1460 1470 1480 1490 1500
EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT
1510 1520 1530 1540 1550
TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ
1560 1570 1580 1590 1600
AESFPNWTLA QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD
1610 1620 1630 1640 1650
DHCRGRATTP PPTTELETAT TTTTQALFST PQPTSSPGLT RAPPASTTAV
1660 1670 1680 1690 1700
PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS TEPTVPGVAT STLPTRSALP
1710 1720 1730 1740 1750
GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP LTTSLAPTLT
1760 1770 1780 1790 1800
SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT
1810 1820 1830 1840 1850
SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS
1860 1870 1880 1890 1900
LETGLTCKNE DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST
1910 1920 1930 1940 1950
PGTTWILTKP TTTATTTAST GSTATPTSTL RTAPPPKVLT TTATTPTVTS
1960 1970 1980 1990 2000
SKATPSSSPG TATALPALRS TATTPTATSV TPIPSSSLGT TWTRLSQTTT
2010 2020 2030 2040 2050
PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS STPGTAHTTK
2060 2070 2080 2090 2100
VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH
2110 2120 2130 2140 2150
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS
2160 2170 2180 2190 2200
STPGTTPIPP VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR
2210 2220 2230 2240 2250
SLPPSSPHTV RTAWTSATSG ILGTTHITEP STVTSHTLAA TTGTTQHSTP
2260 2270 2280 2290 2300
ALSSPHPSSR TTESPPSPGT TTPGHTTATS RTTATATPSK TRTSTLLPSS
2310 2320 2330 2340 2350
PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA
2360 2370 2380 2390 2400
VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF
2410 2420 2430 2440 2450
NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG
2460 2470 2480 2490 2500
STATPSSTPG TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA
2510 2520 2530 2540 2550
TTPTVTSSKA TPFSSPGTAT ALPALRSTAT TPTATSFTAI PSSSLGTTWT
2560 2570 2580 2590 2600
RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTATTTGAT GSVATPSSTP
2610 2620 2630 2640 2650
GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP TTRGSTVTPS
2660 2670 2680 2690 2700
SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT
2710 2720 2730 2740 2750
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT
2760 2770 2780 2790 2800
TATTHGRSLS PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG
2810 2820 2830 2840 2850
TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRATSRTT ATATPSKTRT
2860 2870 2880 2890 2900
STLLPSSPTS APITTVVTMG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN
2910 2920 2930 2940 2950
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV
2960 2970 2980 2990 3000
GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA
3010 3020 3030 3040 3050
TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT
3060 3070 3080 3090 3100
LPVLTSTATK STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP
3110 3120 3130 3140 3150
ETTHTSTVLT TKATTTRATS SMSTPSSTPG TTWILTELTT AATTTAATGP
3160 3170 3180 3190 3200
TATPSSTPGT TWILTEPSTT ATVTVPTGST ATASSTRATA GTLKVLTSTA
3210 3220 3230 3240 3250
TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI PSSSLGTAWT
3260 3270 3280 3290 3300
RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP
3310 3320 3330 3340 3350
GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS
3360 3370 3380 3390 3400
SIPGTTHTAT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT
3410 3420 3430 3440 3450
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT
3460 3470 3480 3490 3500
TATTHGRSLP PSSPHTVRTA WTSATSGILG TTHITEPSTV TSHTPAATTS
3510 3520 3530 3540 3550
TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT ATATPSKTRT
3560 3570 3580 3590 3600
STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN
3610 3620 3630 3640 3650
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV
3660 3670 3680 3690 3700
GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA
3710 3720 3730 3740 3750
TTTESTGSTA TPSSTPGTTW ILTEPSTTAT VTVPTGSTAT ASSTQATAGT
3760 3770 3780 3790 3800
PHVSTTATTP TVTSSKATPF SSPGTATALP ALRSTATTPT ATSFTAIPSS
3810 3820 3830 3840 3850
SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT ATTTRATGSV
3860 3870 3880 3890 3900
ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS
3910 3920 3930 3940 3950
GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT
3960 3970 3980 3990 4000
ATTITATGST TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH
4010 4020 4030 4040 4050
TPPVPNTTAT THGRSLSPSS PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH
4060 4070 4080 4090 4100
TPAATTGTTQ HSTPALSSPH PSSRTTESPP SPGTTTPGHT TATSRTTATA
4110 4120 4130 4140 4150
TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY SYPMPGPSGG
4160 4170 4180 4190 4200
DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV
4210 4220 4230 4240 4250
CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL
4260 4270 4280 4290 4300
TELTTTATTT ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS
4310 4320 4330 4340 4350
SPRTATTLPV LTSTATKSTA TSVTPIPSST LGTTGTLPEQ TTTPVATMST
4360 4370 4380 4390 4400
IHPSSTPETT HTSTVLTTKA TTTRATSSTS TPSSTPGTTW ILTELTTAAT
4410 4420 4430 4440 4450
TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP SSTPGTTWIL
4460 4470 4480 4490 4500
TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS
4510 4520 4530 4540 4550
PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA
4560 4570 4580 4590 4600
TPSSTPETVH TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG
4610 4620 4630 4640 4650
FTATPSSSPG TALTPPVWIS TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR
4660 4670 4680 4690 4700
VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP
4710 4720 4730 4740 4750
GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS TATKSTATSF
4760 4770 4780 4790 4800
TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT
4810 4820 4830 4840 4850
RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE
4860 4870 4880 4890 4900
PSTIATVMVP TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV
4910 4920 4930 4940 4950
GTTRTPAVLP SSLPTFSVST VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ
4960 4970 4980 4990 5000
FFSPGEVIYN KTDRAGCHFY AVCNQHCDID RFQGACPTSP PPVSSAPLSS
5010 5020 5030 5040 5050
PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD PKPVANVTCV
5060 5070 5080 5090 5100
NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV
5110 5120 5130 5140 5150
LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT
5160 5170 5180 5190 5200
MVHGKEEGLI LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN
5210 5220 5230 5240 5250
GQVFQARLPY SLFHNNTEGQ CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW
5260 5270 5280 5290 5300
LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP TPTPCPPQPL CDLMLSQVFA
5310 5320 5330 5340 5350
ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA RGVCSDWRGA
5360 5370 5380 5390 5400
TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL
5410 5420 5430 5440 5450
FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP
5460 5470 5480 5490 5500
CDAQGQPPPC NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG
5510 5520 5530 5540 5550
QESICTQEEG DCCPTFRCRP QLCSYNGTFY GVGATFPGAL PCHMCTCLSG
5560 5570 5580 5590 5600
DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG QCCGECVQTA CLTPDGQPVQ
5610 5620 5630 5640 5650
LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC RGSLRKTGCC
5660 5670 5680 5690 5700
YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH
5710 5720 5730 5740 5750
QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH
5760
TRGFPAQEAT AV
Length:5,762
Mass (Da):596,340
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FEC7CDCD0ADA81C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDX8H0YDX8_HUMAN
Mucin-5B
MUC5B
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA06167 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95 – 100FPGLCN → LPCLCK in AAC67545 (PubMed:9790959).Curated6
Sequence conflicti104S → C in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti142E → K in AAG33673 (PubMed:11713095).Curated1
Sequence conflicti225R → S in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti330 – 331PL → T in AAC67545 (PubMed:9790959).Curated2
Sequence conflicti337E → N in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti356E → K in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti362G → R in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti368G → GS in AAG33673 (PubMed:11713095).Curated1
Sequence conflicti373D → N in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti392 – 393RT → TR in AAC67545 (PubMed:9790959).Curated2
Sequence conflicti467 – 468RK → GR in AAC67545 (PubMed:9790959).Curated2
Sequence conflicti511L → P in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti584 – 586GAA → AH in CAA06167 (PubMed:9804771).Curated3
Sequence conflicti600A → S in CAA06167 (PubMed:9804771).Curated1
Sequence conflicti627 – 628DP → RS in AAC67545 (PubMed:9790959).Curated2
Sequence conflicti632F → L in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti675A → P in CAA06167 (PubMed:9804771).Curated1
Sequence conflicti700R → P in CAA06167 (PubMed:9804771).Curated1
Sequence conflicti751E → K in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti811P → L in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti816 – 817LR → DG in AAC67545 (PubMed:9790959).Curated2
Sequence conflicti859 – 860HN → NK in AAC67545 (PubMed:9790959).Curated2
Sequence conflicti866P → L in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti872V → F in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti883R → T in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti889R → G in CAA06167 (PubMed:9804771).Curated1
Sequence conflicti1020G → A in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti1082Q → E in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti1144S → C in CAA06167 (PubMed:9804771).Curated1
Sequence conflicti1195G → R in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti1207Missing in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti1291S → T in CAA06167 (PubMed:9804771).Curated1
Sequence conflicti1317Missing in AAC67545 (PubMed:9790959).Curated1
Sequence conflicti1675 – 1677TTP → RQS in CAA96577 (PubMed:9013550).Curated3
Sequence conflicti1926 – 1927PT → AS in CAA96577 (PubMed:9013550).Curated2
Sequence conflicti1930 – 1931LR → QA in CAA96577 (PubMed:9013550).Curated2
Sequence conflicti1934 – 1940PPPKVLT → GTPHVS in CAA96577 (PubMed:9013550).Curated7
Sequence conflicti1956S → F in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti1980 – 1982VTP → FTA in CAA96577 (PubMed:9013550).Curated3
Sequence conflicti2002T → M in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2017A → V in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2052P → L in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2069 – 2073TALTP → RARTL in CAA96577 (PubMed:9013550).Curated5
Sequence conflicti2102A → P in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2174N → S in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2203P → S in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2211R → C in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2233V → G in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2300S → Q in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2333P → S in AAB61398 (PubMed:9147051).Curated1
Sequence conflicti2456 – 2497SSTPG…TPHVS → TSTLRTAPPPKVLT in CAA96577 (PubMed:9013550).CuratedAdd BLAST42
Sequence conflicti2461 – 2462TT → DD in AAB61398 (PubMed:9147051).Curated2
Sequence conflicti2468 – 3695Missing in AAB61398 (PubMed:9147051).CuratedAdd BLAST1228
Sequence conflicti2513F → S in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2537 – 2539FTA → VTP in CAA96577 (PubMed:9013550).Curated3
Sequence conflicti2574V → A in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2582T → A in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2609L → P in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2628 – 2630RTL → LTP in CAA96577 (PubMed:9013550).Curated3
Sequence conflicti2659P → A in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2713T → R in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti2834R → T in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3028T → Q in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3080 – 3086LPEQTTT → SQNRPPH in CAA96577 (PubMed:9013550).Curated7
Sequence conflicti3148 – 3152TGPTA → LPHG in CAA96577 (PubMed:9013550).Curated5
Sequence conflicti3289Missing in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3490V → G in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3500S → G in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3504H → P in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3716 – 3747PGTTW…STQAT → QGPP in CAA96577 (PubMed:9013550).CuratedAdd BLAST32
Sequence conflicti3811Q → P in AAB61398 (PubMed:9147051).Curated1
Sequence conflicti3831A → V in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3845R → G in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3909V → I in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti3924 – 3925TT → QP in CAA96577 (PubMed:9013550).Curated2
Sequence conflicti3975V → E in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti4060 – 4061QH → TT in CAA96577 (PubMed:9013550).Curated2
Sequence conflicti4114S → Q in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti4177Q → T in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti4313S → T in CAA52910 (PubMed:9013550).Curated1
Sequence conflicti4373Missing in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti4461 – 4463VPT → APP in CAA96577 (PubMed:9013550).Curated3
Sequence conflicti4567A → T in CAA96577 (PubMed:9013550).Curated1
Sequence conflicti4780T → P in AAC51344 (PubMed:9164870).Curated1
Sequence conflicti5134R → A in AAB65151 (PubMed:8554565).Curated1
Sequence conflicti5164Q → P in AAB65151 (PubMed:8554565).Curated1
Sequence conflicti5187R → A in AAC51344 (PubMed:9164870).Curated1
Sequence conflicti5187R → A in AAB65151 (PubMed:8554565).Curated1
Sequence conflicti5289P → L in AAB65151 (PubMed:8554565).Curated1
Sequence conflicti5304 – 5306NLV → TLL in AAB65151 (PubMed:8554565).Curated3
Sequence conflicti5333A → R in AAC51344 (PubMed:9164870).Curated1
Sequence conflicti5397D → N in AAC51343 (PubMed:9164870).Curated1
Sequence conflicti5397D → N in AAC51344 (PubMed:9164870).Curated1
Sequence conflicti5474E → R in CAA70926 (PubMed:9201995).Curated1
Sequence conflicti5475N → T in AAB65151 (PubMed:8554565).Curated1
Sequence conflicti5620A → S in AAB65151 (PubMed:8554565).Curated1
Sequence conflicti5632A → D in AAC51343 (PubMed:9164870).Curated1
Sequence conflicti5660V → C in AAB65151 (PubMed:8554565).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06361634E → G2 PublicationsCorresponds to variant dbSNP:rs2672785EnsemblClinVar.1
Natural variantiVAR_05658851R → W. Corresponds to variant dbSNP:rs2075853EnsemblClinVar.1
Natural variantiVAR_0595381360T → M. Corresponds to variant dbSNP:rs12363494Ensembl.1
Natural variantiVAR_0595391401R → H. Corresponds to variant dbSNP:rs10835639Ensembl.1
Natural variantiVAR_0636171805G → S1 PublicationCorresponds to variant dbSNP:rs1541314Ensembl.1
Natural variantiVAR_0636181889P → L1 PublicationCorresponds to variant dbSNP:rs2943510EnsemblClinVar.1
Natural variantiVAR_0636192025A → T1 PublicationCorresponds to variant dbSNP:rs34739266EnsemblClinVar.1
Natural variantiVAR_0595402027A → T. Corresponds to variant dbSNP:rs2943531EnsemblClinVar.1
Natural variantiVAR_0636202194M → T1 PublicationCorresponds to variant dbSNP:rs2943502EnsemblClinVar.1
Natural variantiVAR_0636212238L → P1 PublicationCorresponds to variant dbSNP:rs4963031EnsemblClinVar.1
Natural variantiVAR_0636222425M → T1 PublicationCorresponds to variant dbSNP:rs3965632Ensembl.1
Natural variantiVAR_0595412559T → M. Corresponds to variant dbSNP:rs60787297EnsemblClinVar.1
Natural variantiVAR_0636233072F → S1 PublicationCorresponds to variant dbSNP:rs55813014EnsemblClinVar.1
Natural variantiVAR_0636243284T → A1 PublicationCorresponds to variant dbSNP:rs2943531EnsemblClinVar.1
Natural variantiVAR_0636253468R → P1 PublicationCorresponds to variant dbSNP:rs2943529EnsemblClinVar.1
Natural variantiVAR_0636263816T → M1 PublicationCorresponds to variant dbSNP:rs201948297Ensembl.1
Natural variantiVAR_0636274404A → G1 PublicationCorresponds to variant dbSNP:rs2943517EnsemblClinVar.1
Natural variantiVAR_0636284440P → L1 PublicationCorresponds to variant dbSNP:rs2943516EnsemblClinVar.1
Natural variantiVAR_0636294706T → P1 PublicationCorresponds to variant dbSNP:rs2943512EnsemblClinVar.1
Natural variantiVAR_0636304712T → M1 PublicationCorresponds to variant dbSNP:rs2943511Ensembl.1
Natural variantiVAR_0636314867A → T1 PublicationCorresponds to variant dbSNP:rs3021155Ensembl.1
Natural variantiVAR_0636324882T → A1 PublicationCorresponds to variant dbSNP:rs3021156Ensembl.1
Natural variantiVAR_0141235196S → T1 PublicationCorresponds to variant dbSNP:rs2672788Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF107890 Genomic DNA Translation: AAG33673.1
AF086604 mRNA Translation: AAC67545.1
AJ004862 Genomic DNA Translation: CAA06167.1 Different initiation.
X74955 mRNA Translation: CAA52910.1
Z72496 Genomic DNA Translation: CAA96577.1
U63836 mRNA Translation: AAB61398.1
U78551 mRNA Translation: AAC51343.1
AH006676 Genomic DNA Translation: AAC51344.1
U95031 mRNA Translation: AAB65151.1
Y09788 Genomic DNA Translation: CAA70926.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44515.2

Protein sequence database of the Protein Information Resource

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PIRi
A33811
T45025

NCBI Reference Sequences

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RefSeqi
NP_002449.2, NM_002458.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.523395

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000529681; ENSP00000436812; ENSG00000117983

Database of genes from NCBI RefSeq genomes

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GeneIDi
727897

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:727897

UCSC genome browser

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UCSCi
uc001lta.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107890 Genomic DNA Translation: AAG33673.1
AF086604 mRNA Translation: AAC67545.1
AJ004862 Genomic DNA Translation: CAA06167.1 Different initiation.
X74955 mRNA Translation: CAA52910.1
Z72496 Genomic DNA Translation: CAA96577.1
U63836 mRNA Translation: AAB61398.1
U78551 mRNA Translation: AAC51343.1
AH006676 Genomic DNA Translation: AAC51344.1
U95031 mRNA Translation: AAB65151.1
Y09788 Genomic DNA Translation: CAA70926.1
CCDSiCCDS44515.2
PIRiA33811
T45025
RefSeqiNP_002449.2, NM_002458.2
UniGeneiHs.523395

3D structure databases

ProteinModelPortaliQ9HC84
SMRiQ9HC84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608337, 15 interactors
STRINGi9606.ENSP00000436812

Protein family/group databases

MEROPSiI08.953

PTM databases

GlyConnecti1520
376
iPTMnetiQ9HC84
PhosphoSitePlusiQ9HC84
UniCarbKBiQ9HC84

Polymorphism and mutation databases

BioMutaiMUC5B
DMDMi308153579

Proteomic databases

MaxQBiQ9HC84
PaxDbiQ9HC84
PeptideAtlasiQ9HC84
PRIDEiQ9HC84
ProteomicsDBi81649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529681; ENSP00000436812; ENSG00000117983
GeneIDi727897
KEGGihsa:727897
UCSCiuc001lta.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
727897
DisGeNETi727897
EuPathDBiHostDB:ENSG00000117983.17

GeneCards: human genes, protein and diseases

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GeneCardsi
MUC5B

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0035863
HIX0171268
HIX0171346
HGNCiHGNC:7516 MUC5B
HPAiCAB009396
HPA008246
MalaCardsiMUC5B
MIMi178500 phenotype
600770 gene
neXtProtiNX_Q9HC84
OpenTargetsiENSG00000117983
Orphaneti171700 Diffuse panbronchiolitis
2032 Idiopathic pulmonary fibrosis
PharmGKBiPA31321

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XNSK LUCA
GeneTreeiENSGT00940000162219
HOVERGENiHBG052535
InParanoidiQ9HC84
KOiK13908
OMAiSTTGFHK
OrthoDBiEOG091G0006
TreeFamiTF300299

Enzyme and pathway databases

ReactomeiR-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MUC5B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MUC5B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
727897

Protein Ontology

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PROi
PR:Q9HC84

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117983 Expressed in 116 organ(s), highest expression level in trachea
ExpressionAtlasiQ9HC84 baseline and differential
GenevisibleiQ9HC84 HS

Family and domain databases

InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR025155 WxxW_domain
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF13330 Mucin2_WxxW, 7 hits
PF01826 TIL, 2 hits
PF00093 VWC, 1 hit
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00214 VWC, 5 hits
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SUPFAMiSSF57567 SSF57567, 4 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC5B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC84
Secondary accession number(s): O00447
, O00573, O14985, O15494, O95291, O95451, Q14881, Q7M4S5, Q99552, Q9UE28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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