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UniProtKB - Q9HC77 (CENPJ_HUMAN)

Entry version 166 (23 Feb 2022)
Sequence version 2 (26 Apr 2005)
Previous versions | rss
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Protein

Centromere protein J

Gene

CENPJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387).

Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797).

Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124).

Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).

May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797).

1 Publication6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HC77

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-8854518, AURKA Activation by TPX2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9HC77

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9HC77

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centromere protein J
Short name:
CENP-J
Alternative name(s):
Centrosomal P4.1-associated protein
LAG-3-associated protein
LYST-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CENPJ
Synonyms:CPAP, LAP, LIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17272, CENPJ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609279, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HC77

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151849

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly 6, primary, autosomal recessive (MCPH6)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0324331235E → V in MCPH6; reduced interaction with STIL. 2 PublicationsCorresponds to variant dbSNP:rs121434311EnsemblClinVar.1
Seckel syndrome 4 (SCKL4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi338F → A: Decreases interaction with alpha/beta-tubulin; when associated with A-339 and A-341. 1 Publication1
Mutagenesisi339E → A: Decreases interaction with alpha/beta-tubulin; when associated with A-338 and A-341. 1 Publication1
Mutagenesisi341Y → A: Decreases interaction with alpha/beta-tubulin; when associated with A-338 and A-339. 1 Publication1
Mutagenesisi343E → A: Slightly decreases interaction with alpha/beta-tubulin; causes overly long daughter centrioles and enhances ciliary length; when associated with A-344. 1 Publication1
Mutagenesisi344E → A: Slightly decreases interaction with alpha/beta-tubulin; causes overly long daughter centrioles and enhances ciliary length; when associated with A-343. 1 Publication1
Mutagenesisi375F → A: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with A-385. 1 Publication1
Mutagenesisi375F → A: Strongly decreases interaction with alpha/beta-tubulin; causes shorter centrioles and doublet microtubules in cilia. 1 Publication1
Mutagenesisi377K → E: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with E-378. 1 Publication1
Mutagenesisi378R → E: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with E-377. 1 Publication1
Mutagenesisi385F → A: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with A-375. 1 Publication1
Mutagenesisi589S → A: Abolishes phosphorylation by PLK2 and procentriole formation; when associated with A-595. 1 Publication1
Mutagenesisi595S → A: Abolishes phosphorylation by PLK2 and procentriole formation; when associated with A-589. 1 Publication1

Keywords - Diseasei

Disease variant, Dwarfism, Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNET

More...DisGeNETi		55835

MalaCards human disease database

More...MalaCardsi		CENPJ
MIMi608393, phenotype
613676, phenotype

Open Targets

More...OpenTargetsi		ENSG00000151849

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2512, Autosomal recessive primary microcephaly
808, Seckel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26403

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HC77, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CENPJ

Domain mapping of disease mutations (DMDM)

More...DMDMi		62899891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894801 – 1338Centromere protein JAdd BLAST1338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei260PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei589Phosphoserine; by PLK21 Publication1
Modified residuei595Phosphoserine; by PLK2 and PLK41 Publication1
Modified residuei759PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-589 and Ser-595 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-595 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HC77

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HC77

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HC77

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HC77

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HC77

PeptideAtlas

More...PeptideAtlasi		Q9HC77

PRoteomics IDEntifications database

More...PRIDEi		Q9HC77

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63008
81646 [Q9HC77-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HC77

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HC77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151849, Expressed in left lobe of thyroid gland and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HC77, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HC77, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151849, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers (PubMed:27219064). Associates with microtubules plus ends; binds to beta-tublin subunits exposed on microtubule outer surface at its distal tip; also associates with microtubule lattice (PubMed:19131341, PubMed:27219064, PubMed:27306797). Associated with the gamma-tubulin complex.

Interacts with the head domain of EPB41 (PubMed:11003675).

Interacts with LYST (PubMed:11984006).

Interacts with CEP152 (via C-terminus) (PubMed:20852615).

Interacts with STIL (PubMed:22020124, PubMed:25385835).

Forms a complex with STIL and SASS6 (PubMed:22020124).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120939, 173 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1159, CPAP-STIL complex

Database of interacting proteins

More...DIPi		DIP-49904N

Protein interaction database and analysis system

More...IntActi		Q9HC77, 138 interactors

Molecular INTeraction database

More...MINTi		Q9HC77

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000371308

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HC77, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9HC77

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HC77

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni190 – 211DisorderedSequence analysisAdd BLAST22
Regioni319 – 394Alpha/beta-tubulin binding1 PublicationAdd BLAST76
Regioni386 – 414DisorderedSequence analysisAdd BLAST29
Regioni436 – 479DisorderedSequence analysisAdd BLAST44
Regioni521 – 551DisorderedSequence analysisAdd BLAST31
Regioni611 – 789DisorderedSequence analysisAdd BLAST179
Regioni845 – 865DisorderedSequence analysisAdd BLAST21
Regioni895 – 1338Interaction with STIL2 PublicationsAdd BLAST444
Regioni1096 – 1153DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi397 – 414Polar residuesSequence analysisAdd BLAST18
Compositional biasi447 – 474Polar residuesSequence analysisAdd BLAST28
Compositional biasi618 – 632Polar residuesSequence analysisAdd BLAST15
Compositional biasi634 – 654Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi712 – 778Basic and acidic residuesSequence analysisAdd BLAST67

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQR0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063927

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008072_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HC77

Identification of Orthologs from Complete Genome Data

More...OMAi		EPLNFPD

Database of Orthologous Groups

More...OrthoDBi		1249457at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HC77

TreeFam database of animal gene trees

More...TreeFami		TF343156

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033068, CENP-J
IPR009852, Tcp10_C_dom
IPR026581, TCP10_fam

The PANTHER Classification System

More...PANTHERi		PTHR10331, PTHR10331, 1 hit
PTHR10331:SF23, PTHR10331:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07202, Tcp10_C, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HC77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFLMPTSSEL NSGQNFLTQW MTNPSRAGVI LNRGFPILEA DKEKRAAVDI 
        60         70         80         90        100
STSFPIKGTH FSDSFSFINE EDSLLEEQKL ESNNPYKPQS DKSETHTAFP 
       110        120        130        140        150
CIKKGPQVAA CHSAPGHQEE NKNDFIPDLA SEFKEGAYKD PLFKKLEQLK 
       160        170        180        190        200
EVQQKKQEQL KRQQLEQLQR LMEEQEKLLT MVSGQCTLPG LSLLPDDQSQ 
       210        220        230        240        250
KHRSPGNTTT GERATCCFPS YVYPDPTQEE TYPSNILSHE QSNFCRTAHG 
       260        270        280        290        300
DFVLTSKRAS PNLFSEAQYQ EAPVEKNNLK EENRNHPTGE SILCWEKVTE 
       310        320        330        340        350
QIQEANDKNL QKHDDSSEVA NIEERPIKAA IGERKQTFED YLEEQIQLEE 
       360        370        380        390        400
QELKQKQLKE AEGPLPIKAK PKQPFLKRGE GLARFTNAKS KFQKGKESKL 
       410        420        430        440        450
VTNQSTSEDQ PLFKMDRQQL QRKTALKNKE LCADNPILKK DSKARTKSGS 
       460        470        480        490        500
VTLSQKPKML KCSNRKSLSP SGLKIQTGKK CDGQFRDQIK FENKVTSNNK 
       510        520        530        540        550
ENVTECPKPC DTGCTGWNKT QGKDRLPLST GPASRLAAKS PIRETMKESE 
       560        570        580        590        600
SSLDVSLQKK LETWEREKEK ENLELDEFLF LEQAADEISF SSNSSFVLKI 
       610        620        630        640        650
LERDQQICKG HRMSSTPVKA VPQKTNPADP ISHCNRSEDL DHTAREKESE 
       660        670        680        690        700
CEVAPKQLHS LSSADELREQ PCKIRKAVQK STSENQTEWN ARDDEGVPNS 
       710        720        730        740        750
DSSTDSEEQL DVTIKPSTED RERGISSRED SPQVCDDKGP FKDTRTQEDK 
       760        770        780        790        800
RRDVDLDLSD KDYSSDESIM ESIKHKVSEP SRSSSLSLSK MDFDDERTWT 
       810        820        830        840        850
DLEENLCNHD VVLGNESTYG TPQTCYPNNE IGILDKTIKR KIAPVKRGED 
       860        870        880        890        900
LSKSRRSRSP PTSELMMKFF PSLKPKPKSD SHLGNELKLN ISQDQPPGDN 
       910        920        930        940        950
ARSQVLREKI IELETEIEKF KAENASLAKL RIERESALEK LRKEIADFEQ 
       960        970        980        990       1000
QKAKELARIE EFKKEEMRKL QKERKVFEKY TTAARTFPDK KEREEIQTLK 
      1010       1020       1030       1040       1050
QQIADLREDL KRKETKWSST HSRLRSQIQM LVRENTDLRE EIKVMERFRL 
      1060       1070       1080       1090       1100
DAWKRAEAIE SSLEVEKKDK LANTSVRFQN SQISSGTQVE KYKKNYLPMQ 
      1110       1120       1130       1140       1150
GNPPRRSKSA PPRDLGNLDK GQAASPREPL EPLNFPDPEY KEEEEDQDIQ 
      1160       1170       1180       1190       1200
GEISHPDGKV EKVYKNGCRV ILFPNGTRKE VSADGKTITV TFFNGDVKQV 
      1210       1220       1230       1240       1250
MPDQRVIYYY AAAQTTHTTY PEGLEVLHFS SGQIEKHYPD GRKEITFPDQ 
      1260       1270       1280       1290       1300
TVKNLFPDGQ EESIFPDGTI VRVQRDGNKL IEFNNGQREL HTAQFKRREY 
      1310       1320       1330 
PDGTVKTVYA NGHQETKYRS GRIRVKDKEG NVLMDTEL
Length:1,338
Mass (Da):153,000
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4E6531B62A30F2D
GO
Isoform 2 (identifier: Q9HC77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1073-1086: NTSVRFQNSQISSG → AIHLEDPSLHLLVI
     1087-1338: Missing.

Show »
Length:1,086
Mass (Da):124,244
Checksum:i4AD0A29BE7DD1523
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VUX8F6VUX8_HUMAN
Centromere protein J
CENPJ
1,136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5L8H0Y5L8_HUMAN
Centromere protein J
CENPJ
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24209 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129L → R in AAG21074 (PubMed:11003675).Curated1
Sequence conflicti1142E → R in AAG49440 (PubMed:11984006).Curated1
Sequence conflicti1224L → W in AAG49440 (PubMed:11984006).Curated1
Sequence conflicti1333L → S in AAG21074 (PubMed:11003675).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03242721M → V. Corresponds to variant dbSNP:rs35498994EnsemblClinVar.1
Natural variantiVAR_03242855P → A. Corresponds to variant dbSNP:rs17081389EnsemblClinVar.1
Natural variantiVAR_03242963D → H. Corresponds to variant dbSNP:rs7336216EnsemblClinVar.1
Natural variantiVAR_03243085P → T. Corresponds to variant dbSNP:rs9511510EnsemblClinVar.1
Natural variantiVAR_032431151E → G. Corresponds to variant dbSNP:rs34177811EnsemblClinVar.1
Natural variantiVAR_032432879S → A. Corresponds to variant dbSNP:rs17402892EnsemblClinVar.1
Natural variantiVAR_0324331235E → V in MCPH6; reduced interaction with STIL. 2 PublicationsCorresponds to variant dbSNP:rs121434311EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0568311073 – 1086NTSVR…QISSG → AIHLEDPSLHLLVI in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0568321087 – 1338Missing in isoform 2. 1 PublicationAdd BLAST252

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF139625 mRNA Translation: AAG21074.1
AL833182 mRNA Translation: CAI46195.1
AL354798 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08354.1
BC024209 mRNA Translation: AAH24209.3 Different initiation.
BC113110 mRNA Translation: AAI13111.1
BC113662 mRNA Translation: AAI13663.1
BC113664 mRNA Translation: AAI13665.1
AJ303006 mRNA Translation: CAC80028.1
AF141337 mRNA Translation: AAG49440.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9310.1 [Q9HC77-1]

NCBI Reference Sequences

More...RefSeqi		NP_060921.3, NM_018451.4 [Q9HC77-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381884; ENSP00000371308; ENSG00000151849
ENST00000616936; ENSP00000477511; ENSG00000151849 [Q9HC77-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55835

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000381884.9; ENSP00000371308.4; NM_018451.5; NP_060921.3

UCSC genome browser

More...UCSCi		uc001upt.6, human [Q9HC77-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139625 mRNA Translation: AAG21074.1
AL833182 mRNA Translation: CAI46195.1
AL354798 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08354.1
BC024209 mRNA Translation: AAH24209.3 Different initiation.
BC113110 mRNA Translation: AAI13111.1
BC113662 mRNA Translation: AAI13663.1
BC113664 mRNA Translation: AAI13665.1
AJ303006 mRNA Translation: CAC80028.1
AF141337 mRNA Translation: AAG49440.1
CCDSiCCDS9310.1 [Q9HC77-1]
RefSeqiNP_060921.3, NM_018451.4 [Q9HC77-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EIBX-ray2.10F372-394[»]
5ITZX-ray2.20D311-422[»]
BMRBiQ9HC77
SMRiQ9HC77
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120939, 173 interactors
ComplexPortaliCPX-1159, CPAP-STIL complex
DIPiDIP-49904N
IntActiQ9HC77, 138 interactors
MINTiQ9HC77
STRINGi9606.ENSP00000371308

PTM databases

iPTMnetiQ9HC77
PhosphoSitePlusiQ9HC77

Genetic variation databases

BioMutaiCENPJ
DMDMi62899891

Proteomic databases

EPDiQ9HC77
jPOSTiQ9HC77
MassIVEiQ9HC77
MaxQBiQ9HC77
PaxDbiQ9HC77
PeptideAtlasiQ9HC77
PRIDEiQ9HC77
ProteomicsDBi63008
81646 [Q9HC77-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22520, 191 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		55835

Genome annotation databases

EnsembliENST00000381884; ENSP00000371308; ENSG00000151849
ENST00000616936; ENSP00000477511; ENSG00000151849 [Q9HC77-2]
GeneIDi55835
KEGGihsa:55835
MANE-SelectiENST00000381884.9; ENSP00000371308.4; NM_018451.5; NP_060921.3
UCSCiuc001upt.6, human [Q9HC77-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55835
DisGeNETi55835

GeneCards: human genes, protein and diseases

More...GeneCardsi		CENPJ
HGNCiHGNC:17272, CENPJ
HPAiENSG00000151849, Tissue enhanced (testis)
MalaCardsiCENPJ
MIMi608393, phenotype
609279, gene
613676, phenotype
neXtProtiNX_Q9HC77
OpenTargetsiENSG00000151849
Orphaneti2512, Autosomal recessive primary microcephaly
808, Seckel syndrome
PharmGKBiPA26403
VEuPathDBiHostDB:ENSG00000151849

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQR0, Eukaryota
GeneTreeiENSGT00530000063927
HOGENOMiCLU_008072_0_0_1
InParanoidiQ9HC77
OMAiEPLNFPD
OrthoDBi1249457at2759
PhylomeDBiQ9HC77
TreeFamiTF343156

Enzyme and pathway databases

PathwayCommonsiQ9HC77
ReactomeiR-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-8854518, AURKA Activation by TPX2
SignaLinkiQ9HC77
SIGNORiQ9HC77

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55835, 117 hits in 1047 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CENPJ, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CENPJ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55835
PharosiQ9HC77, Tbio

Protein Ontology

More...PROi		PR:Q9HC77
RNActiQ9HC77, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151849, Expressed in left lobe of thyroid gland and 206 other tissues
ExpressionAtlasiQ9HC77, baseline and differential
GenevisibleiQ9HC77, HS

Family and domain databases

InterProiView protein in InterPro
IPR033068, CENP-J
IPR009852, Tcp10_C_dom
IPR026581, TCP10_fam
PANTHERiPTHR10331, PTHR10331, 1 hit
PTHR10331:SF23, PTHR10331:SF23, 1 hit
PfamiView protein in Pfam
PF07202, Tcp10_C, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCENPJ_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC77
Secondary accession number(s): Q2KHM6
, Q5JPD5, Q5T6R5, Q96KS5, Q9C067
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 23, 2022
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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