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Protein

Centromere protein J

Gene

CENPJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797).1 Publication6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein domain specific binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-8854518 AURKA Activation by TPX2

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9HC77

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centromere protein J
Short name:
CENP-J
Alternative name(s):
Centrosomal P4.1-associated protein
LAG-3-associated protein
LYST-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CENPJ
Synonyms:CPAP, LAP, LIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000151849.14

Human Gene Nomenclature Database

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HGNCi
HGNC:17272 CENPJ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609279 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HC77

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly 6, primary, autosomal recessive (MCPH6)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
See also OMIM:608393
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0324331235E → V in MCPH6; reduced interaction with STIL. 2 PublicationsCorresponds to variant dbSNP:rs121434311EnsemblClinVar.1
Seckel syndrome 4 (SCKL4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
See also OMIM:613676

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi338F → A: Decreases interaction with alpha/beta-tubulin; when associated with A-339 and A-341. 1 Publication1
Mutagenesisi339E → A: Decreases interaction with alpha/beta-tubulin; when associated with A-338 and A-341. 1 Publication1
Mutagenesisi341Y → A: Decreases interaction with alpha/beta-tubulin; when associated with A-338 and A-339. 1 Publication1
Mutagenesisi343E → A: Slightly decreases interaction with alpha/beta-tubulin; causes overly long daughter centrioles and enhances ciliary length; when associated with A-344. 1 Publication1
Mutagenesisi344E → A: Slightly decreases interaction with alpha/beta-tubulin; causes overly long daughter centrioles and enhances ciliary length; when associated with A-343. 1 Publication1
Mutagenesisi375F → A: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with A-385. 1 Publication1
Mutagenesisi375F → A: Strongly decreases interaction with alpha/beta-tubulin; causes shorter centrioles and doublet microtubules in cilia. 1 Publication1
Mutagenesisi377K → E: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with E-378. 1 Publication1
Mutagenesisi378R → E: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with E-377. 1 Publication1
Mutagenesisi385F → A: Decreases interaction with alpha/beta-tubulin; disrupts association with microtubule distal tip; no effect on association with microtubule lattice; when associated with A-375. 1 Publication1
Mutagenesisi589S → A: Abolishes phosphorylation by PLK2 and procentriole formation; when associated with A-595. 1 Publication1
Mutagenesisi595S → A: Abolishes phosphorylation by PLK2 and procentriole formation; when associated with A-589. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNET

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DisGeNETi
55835

MalaCards human disease database

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MalaCardsi
CENPJ
MIMi608393 phenotype
613676 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000151849

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2512 Autosomal recessive primary microcephaly
808 Seckel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26403

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CENPJ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62899891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894801 – 1338Centromere protein JAdd BLAST1338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei260PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei589Phosphoserine; by PLK21 Publication1
Modified residuei595Phosphoserine; by PLK2 and PLK41 Publication1
Modified residuei759PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-589 and Ser-595 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-595 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HC77

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HC77

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9HC77

PeptideAtlas

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PeptideAtlasi
Q9HC77

PRoteomics IDEntifications database

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PRIDEi
Q9HC77

ProteomicsDB human proteome resource

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ProteomicsDBi
81646

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9HC77

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9HC77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000151849 Expressed in 191 organ(s), highest expression level in left lobe of thyroid gland

CleanEx database of gene expression profiles

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CleanExi
HS_CENPJ

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HC77 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HC77 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA060426

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers (PubMed:27219064). Associates with microtubules plus ends; binds to beta-tublin subunits exposed on microtubule outer surface at its distal tip; also associates with microtubule lattice (PubMed:19131341, PubMed:27219064, PubMed:27306797). Associated with the gamma-tubulin complex. Interacts with the head domain of EPB41 (PubMed:11003675). Interacts with LYST (PubMed:11984006). Interacts with CEP152 (via C-terminus) (PubMed:20852615). Interacts with STIL (PubMed:22020124, PubMed:25385835). Forms a complex with STIL and SASS6 (PubMed:22020124).7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120939, 148 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1159 CPAP-STIL complex

Database of interacting proteins

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DIPi
DIP-49904N

Protein interaction database and analysis system

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IntActi
Q9HC77, 130 interactors

Molecular INTeraction database

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MINTi
Q9HC77

STRING: functional protein association networks

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STRINGi
9606.ENSP00000371308

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9HC77

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HC77

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 394Alpha/beta-tubulin binding1 PublicationAdd BLAST76
Regioni895 – 1338Interaction with STIL2 PublicationsAdd BLAST444

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEFU Eukaryota
ENOG4110DC4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063927

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111541

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050894

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HC77

KEGG Orthology (KO)

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KOi
K11502

Identification of Orthologs from Complete Genome Data

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OMAi
ENWEREK

Database of Orthologous Groups

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OrthoDBi
EOG091G00Z1

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9HC77

TreeFam database of animal gene trees

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TreeFami
TF343156

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033068 CENP-J
IPR009852 Tcp10_C_dom
IPR026581 TCP10_fam

The PANTHER Classification System

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PANTHERi
PTHR10331 PTHR10331, 1 hit
PTHR10331:SF23 PTHR10331:SF23, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07202 Tcp10_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HC77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFLMPTSSEL NSGQNFLTQW MTNPSRAGVI LNRGFPILEA DKEKRAAVDI
60 70 80 90 100
STSFPIKGTH FSDSFSFINE EDSLLEEQKL ESNNPYKPQS DKSETHTAFP
110 120 130 140 150
CIKKGPQVAA CHSAPGHQEE NKNDFIPDLA SEFKEGAYKD PLFKKLEQLK
160 170 180 190 200
EVQQKKQEQL KRQQLEQLQR LMEEQEKLLT MVSGQCTLPG LSLLPDDQSQ
210 220 230 240 250
KHRSPGNTTT GERATCCFPS YVYPDPTQEE TYPSNILSHE QSNFCRTAHG
260 270 280 290 300
DFVLTSKRAS PNLFSEAQYQ EAPVEKNNLK EENRNHPTGE SILCWEKVTE
310 320 330 340 350
QIQEANDKNL QKHDDSSEVA NIEERPIKAA IGERKQTFED YLEEQIQLEE
360 370 380 390 400
QELKQKQLKE AEGPLPIKAK PKQPFLKRGE GLARFTNAKS KFQKGKESKL
410 420 430 440 450
VTNQSTSEDQ PLFKMDRQQL QRKTALKNKE LCADNPILKK DSKARTKSGS
460 470 480 490 500
VTLSQKPKML KCSNRKSLSP SGLKIQTGKK CDGQFRDQIK FENKVTSNNK
510 520 530 540 550
ENVTECPKPC DTGCTGWNKT QGKDRLPLST GPASRLAAKS PIRETMKESE
560 570 580 590 600
SSLDVSLQKK LETWEREKEK ENLELDEFLF LEQAADEISF SSNSSFVLKI
610 620 630 640 650
LERDQQICKG HRMSSTPVKA VPQKTNPADP ISHCNRSEDL DHTAREKESE
660 670 680 690 700
CEVAPKQLHS LSSADELREQ PCKIRKAVQK STSENQTEWN ARDDEGVPNS
710 720 730 740 750
DSSTDSEEQL DVTIKPSTED RERGISSRED SPQVCDDKGP FKDTRTQEDK
760 770 780 790 800
RRDVDLDLSD KDYSSDESIM ESIKHKVSEP SRSSSLSLSK MDFDDERTWT
810 820 830 840 850
DLEENLCNHD VVLGNESTYG TPQTCYPNNE IGILDKTIKR KIAPVKRGED
860 870 880 890 900
LSKSRRSRSP PTSELMMKFF PSLKPKPKSD SHLGNELKLN ISQDQPPGDN
910 920 930 940 950
ARSQVLREKI IELETEIEKF KAENASLAKL RIERESALEK LRKEIADFEQ
960 970 980 990 1000
QKAKELARIE EFKKEEMRKL QKERKVFEKY TTAARTFPDK KEREEIQTLK
1010 1020 1030 1040 1050
QQIADLREDL KRKETKWSST HSRLRSQIQM LVRENTDLRE EIKVMERFRL
1060 1070 1080 1090 1100
DAWKRAEAIE SSLEVEKKDK LANTSVRFQN SQISSGTQVE KYKKNYLPMQ
1110 1120 1130 1140 1150
GNPPRRSKSA PPRDLGNLDK GQAASPREPL EPLNFPDPEY KEEEEDQDIQ
1160 1170 1180 1190 1200
GEISHPDGKV EKVYKNGCRV ILFPNGTRKE VSADGKTITV TFFNGDVKQV
1210 1220 1230 1240 1250
MPDQRVIYYY AAAQTTHTTY PEGLEVLHFS SGQIEKHYPD GRKEITFPDQ
1260 1270 1280 1290 1300
TVKNLFPDGQ EESIFPDGTI VRVQRDGNKL IEFNNGQREL HTAQFKRREY
1310 1320 1330
PDGTVKTVYA NGHQETKYRS GRIRVKDKEG NVLMDTEL
Length:1,338
Mass (Da):153,000
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4E6531B62A30F2D
GO
Isoform 2 (identifier: Q9HC77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1073-1086: NTSVRFQNSQISSG → AIHLEDPSLHLLVI
     1087-1338: Missing.

Note: No experimental confirmation available.
Show »
Length:1,086
Mass (Da):124,244
Checksum:i4AD0A29BE7DD1523
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VUX8F6VUX8_HUMAN
Centromere protein J
CENPJ
1,136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5L8H0Y5L8_HUMAN
Centromere protein J
CENPJ
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24209 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129L → R in AAG21074 (PubMed:11003675).Curated1
Sequence conflicti1142E → R in AAG49440 (PubMed:11984006).Curated1
Sequence conflicti1224L → W in AAG49440 (PubMed:11984006).Curated1
Sequence conflicti1333L → S in AAG21074 (PubMed:11003675).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03242721M → V. Corresponds to variant dbSNP:rs35498994EnsemblClinVar.1
Natural variantiVAR_03242855P → A. Corresponds to variant dbSNP:rs17081389EnsemblClinVar.1
Natural variantiVAR_03242963D → H. Corresponds to variant dbSNP:rs7336216EnsemblClinVar.1
Natural variantiVAR_03243085P → T. Corresponds to variant dbSNP:rs9511510EnsemblClinVar.1
Natural variantiVAR_032431151E → G. Corresponds to variant dbSNP:rs34177811EnsemblClinVar.1
Natural variantiVAR_032432879S → A. Corresponds to variant dbSNP:rs17402892EnsemblClinVar.1
Natural variantiVAR_0324331235E → V in MCPH6; reduced interaction with STIL. 2 PublicationsCorresponds to variant dbSNP:rs121434311EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0568311073 – 1086NTSVR…QISSG → AIHLEDPSLHLLVI in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0568321087 – 1338Missing in isoform 2. 1 PublicationAdd BLAST252

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF139625 mRNA Translation: AAG21074.1
AL833182 mRNA Translation: CAI46195.1
AL354798 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08354.1
BC024209 mRNA Translation: AAH24209.3 Different initiation.
BC113110 mRNA Translation: AAI13111.1
BC113662 mRNA Translation: AAI13663.1
BC113664 mRNA Translation: AAI13665.1
AJ303006 mRNA Translation: CAC80028.1
AF141337 mRNA Translation: AAG49440.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9310.1 [Q9HC77-1]

NCBI Reference Sequences

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RefSeqi
NP_060921.3, NM_018451.4 [Q9HC77-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.513379
Hs.741581

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000381884; ENSP00000371308; ENSG00000151849 [Q9HC77-1]
ENST00000616936; ENSP00000477511; ENSG00000151849 [Q9HC77-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55835

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55835

UCSC genome browser

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UCSCi
uc001upt.6 human [Q9HC77-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139625 mRNA Translation: AAG21074.1
AL833182 mRNA Translation: CAI46195.1
AL354798 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08354.1
BC024209 mRNA Translation: AAH24209.3 Different initiation.
BC113110 mRNA Translation: AAI13111.1
BC113662 mRNA Translation: AAI13663.1
BC113664 mRNA Translation: AAI13665.1
AJ303006 mRNA Translation: CAC80028.1
AF141337 mRNA Translation: AAG49440.1
CCDSiCCDS9310.1 [Q9HC77-1]
RefSeqiNP_060921.3, NM_018451.4 [Q9HC77-1]
UniGeneiHs.513379
Hs.741581

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EIBX-ray2.10F372-394[»]
5ITZX-ray2.20D311-422[»]
ProteinModelPortaliQ9HC77
SMRiQ9HC77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120939, 148 interactors
ComplexPortaliCPX-1159 CPAP-STIL complex
DIPiDIP-49904N
IntActiQ9HC77, 130 interactors
MINTiQ9HC77
STRINGi9606.ENSP00000371308

PTM databases

iPTMnetiQ9HC77
PhosphoSitePlusiQ9HC77

Polymorphism and mutation databases

BioMutaiCENPJ
DMDMi62899891

Proteomic databases

EPDiQ9HC77
MaxQBiQ9HC77
PaxDbiQ9HC77
PeptideAtlasiQ9HC77
PRIDEiQ9HC77
ProteomicsDBi81646

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381884; ENSP00000371308; ENSG00000151849 [Q9HC77-1]
ENST00000616936; ENSP00000477511; ENSG00000151849 [Q9HC77-2]
GeneIDi55835
KEGGihsa:55835
UCSCiuc001upt.6 human [Q9HC77-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55835
DisGeNETi55835
EuPathDBiHostDB:ENSG00000151849.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CENPJ
HGNCiHGNC:17272 CENPJ
HPAiHPA060426
MalaCardsiCENPJ
MIMi608393 phenotype
609279 gene
613676 phenotype
neXtProtiNX_Q9HC77
OpenTargetsiENSG00000151849
Orphaneti2512 Autosomal recessive primary microcephaly
808 Seckel syndrome
PharmGKBiPA26403

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEFU Eukaryota
ENOG4110DC4 LUCA
GeneTreeiENSGT00530000063927
HOGENOMiHOG000111541
HOVERGENiHBG050894
InParanoidiQ9HC77
KOiK11502
OMAiENWEREK
OrthoDBiEOG091G00Z1
PhylomeDBiQ9HC77
TreeFamiTF343156

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiQ9HC77

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CENPJ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55835

Protein Ontology

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PROi
PR:Q9HC77

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151849 Expressed in 191 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CENPJ
ExpressionAtlasiQ9HC77 baseline and differential
GenevisibleiQ9HC77 HS

Family and domain databases

InterProiView protein in InterPro
IPR033068 CENP-J
IPR009852 Tcp10_C_dom
IPR026581 TCP10_fam
PANTHERiPTHR10331 PTHR10331, 1 hit
PTHR10331:SF23 PTHR10331:SF23, 1 hit
PfamiView protein in Pfam
PF07202 Tcp10_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCENPJ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC77
Secondary accession number(s): Q2KHM6
, Q5JPD5, Q5T6R5, Q96KS5, Q9C067
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: December 5, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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